Details for: CCR6

Gene ID: 1235

Symbol: CCR6

Ensembl ID: ENSG00000112486

Description: C-C motif chemokine receptor 6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 13.1321
    Cell Significance Index: -5.3400
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.0375
    Cell Significance Index: 11.1100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.8799
    Cell Significance Index: 60.2100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.2546
    Cell Significance Index: 19.4100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.1307
    Cell Significance Index: 51.2500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9228
    Cell Significance Index: 175.6200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 0.8302
    Cell Significance Index: -2.5500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.6558
    Cell Significance Index: 19.2600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.5639
    Cell Significance Index: 12.0100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5277
    Cell Significance Index: 52.2000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4565
    Cell Significance Index: 412.1900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.3779
    Cell Significance Index: 7.8400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3691
    Cell Significance Index: 22.1600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3451
    Cell Significance Index: 37.5400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3412
    Cell Significance Index: 9.8300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2838
    Cell Significance Index: 46.1600
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.2739
    Cell Significance Index: 2.8400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2353
    Cell Significance Index: 46.7000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1812
    Cell Significance Index: 12.5300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1636
    Cell Significance Index: 5.7500
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.1116
    Cell Significance Index: 0.3400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0759
    Cell Significance Index: 8.9500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0631
    Cell Significance Index: 12.6600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0589
    Cell Significance Index: 0.9900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0296
    Cell Significance Index: 10.6300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0073
    Cell Significance Index: 0.1100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0024
    Cell Significance Index: -0.0600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0026
    Cell Significance Index: -0.3400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0037
    Cell Significance Index: -0.4300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0037
    Cell Significance Index: -2.0000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0053
    Cell Significance Index: -2.3600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0054
    Cell Significance Index: -4.0900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0063
    Cell Significance Index: -4.6400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0074
    Cell Significance Index: -5.4100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0080
    Cell Significance Index: -4.9900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0083
    Cell Significance Index: -4.7000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0138
    Cell Significance Index: -0.3000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0157
    Cell Significance Index: -4.5300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0172
    Cell Significance Index: -0.8700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0229
    Cell Significance Index: -4.8200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0242
    Cell Significance Index: -4.3700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0254
    Cell Significance Index: -4.3300
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.0269
    Cell Significance Index: -0.2700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0271
    Cell Significance Index: -1.1800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0285
    Cell Significance Index: -1.7500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0296
    Cell Significance Index: -4.0600
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: -0.0300
    Cell Significance Index: -0.1500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0321
    Cell Significance Index: -1.3100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0326
    Cell Significance Index: -2.1900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0355
    Cell Significance Index: -2.5100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0372
    Cell Significance Index: -1.0000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0389
    Cell Significance Index: -4.4600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0397
    Cell Significance Index: -4.8900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0434
    Cell Significance Index: -4.4300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0448
    Cell Significance Index: -1.9800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0470
    Cell Significance Index: -6.0700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0471
    Cell Significance Index: -1.7900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0528
    Cell Significance Index: -2.4600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0579
    Cell Significance Index: -2.7200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0580
    Cell Significance Index: -0.8300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0644
    Cell Significance Index: -2.0500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0653
    Cell Significance Index: -5.0100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0660
    Cell Significance Index: -4.9200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0684
    Cell Significance Index: -1.8300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0687
    Cell Significance Index: -4.3300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0714
    Cell Significance Index: -2.5000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0730
    Cell Significance Index: -1.2500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0764
    Cell Significance Index: -2.5000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0778
    Cell Significance Index: -0.8100
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.0792
    Cell Significance Index: -0.5700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0815
    Cell Significance Index: -5.0100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0846
    Cell Significance Index: -4.4400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0855
    Cell Significance Index: -2.4400
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0877
    Cell Significance Index: -0.8200
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0889
    Cell Significance Index: -1.3000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0891
    Cell Significance Index: -5.0000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0990
    Cell Significance Index: -6.3900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1110
    Cell Significance Index: -5.7800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1149
    Cell Significance Index: -3.2100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1175
    Cell Significance Index: -2.9300
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1231
    Cell Significance Index: -2.0900
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1254
    Cell Significance Index: -1.2100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1264
    Cell Significance Index: -4.6400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1266
    Cell Significance Index: -2.6500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1280
    Cell Significance Index: -2.7700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1290
    Cell Significance Index: -3.5100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1292
    Cell Significance Index: -1.5400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1300
    Cell Significance Index: -3.3200
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.1327
    Cell Significance Index: -2.2800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1327
    Cell Significance Index: -3.4100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1335
    Cell Significance Index: -3.3300
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.1338
    Cell Significance Index: -1.8200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1399
    Cell Significance Index: -2.9700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1521
    Cell Significance Index: -3.8000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1537
    Cell Significance Index: -3.0400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1576
    Cell Significance Index: -3.1700
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1619
    Cell Significance Index: -2.2200
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1651
    Cell Significance Index: -3.3600
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1669
    Cell Significance Index: -1.9700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1716
    Cell Significance Index: -3.9700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Chemokine Receptor:** CCR6 is a chemokine receptor that binds to various chemokines, such as CCL3, CCL4, and CCL20, which are involved in the regulation of immune responses. 2. **Cell Surface Signaling:** CCR6 is a transmembrane receptor that activates G-protein coupled signaling pathways upon ligand binding, leading to the regulation of various cellular processes. 3. **Chemotaxis:** CCR6 is involved in the chemotaxis of immune cells, including dendritic cells, T cells, and thymocytes, which is essential for their migration to sites of inflammation and immune responses. 4. **Dendritic Cell Function:** CCR6 is highly expressed on myeloid dendritic cells and plays a critical role in their chemotaxis and maturation, which is essential for the initiation of immune responses. **Pathways and Functions:** 1. **Antimicrobial Peptide Signaling:** CCR6 is involved in the regulation of antimicrobial peptide signaling, which is essential for the defense against pathogens. 2. **Beta Defensin Signaling:** CCR6 is also involved in the regulation of beta defensin signaling, which is critical for the innate immune response. 3. **Chemokine-Mediated Signaling:** CCR6 is a key player in chemokine-mediated signaling, which regulates the migration and activation of immune cells. 4. **Calcium-Mediated Signaling:** CCR6 is involved in calcium-mediated signaling, which is essential for the regulation of various cellular processes, including cell migration and proliferation. **Clinical Significance:** 1. **Inflammatory Diseases:** CCR6 has been implicated in the pathogenesis of inflammatory diseases, such as rheumatoid arthritis, multiple sclerosis, and psoriasis. 2. **Cancer:** CCR6 is overexpressed in various types of cancer, including leukemia, lymphoma, and melanoma, and has been identified as a potential therapeutic target. 3. **Immunodeficiency Disorders:** CCR6 has been associated with immunodeficiency disorders, such as chronic granulomatous disease and severe combined immunodeficiency. 4. **Neurological Disorders:** CCR6 has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, CCR6 is a critical regulator of immune responses and chemotaxis, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the mechanisms of CCR6 and its potential therapeutic applications.

Genular Protein ID: 2538711107

Symbol: CCR6_HUMAN

Name: C-C chemokine receptor type 6

UniProtKB Accession Codes:

P51684 E1P5C6 P78553 Q92846

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 EMDB 1 Ensembl 4 GO 30 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9169459

Title: Identification of CCR6, the specific receptor for a novel lymphocyte-directed CC chemokine LARC.

PubMed ID: 9169459

DOI: 10.1074/jbc.272.23.14893

PubMed ID: 8886020

Title: Molecular cloning and RNA expression of two new human chemokine receptor-like genes.

PubMed ID: 8886020

DOI: 10.1006/bbrc.1996.1595

PubMed ID: 9070937

Title: Cloning of STRL22, a new human gene encoding a G-protein-coupled receptor related to chemokine receptors and located on chromosome 6q27.

PubMed ID: 9070937

DOI: 10.1006/geno.1996.4544

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12081481

Title: Mutating the four extracellular cysteines in the chemokine receptor CCR6 reveals their differing roles in receptor trafficking, ligand binding, and signaling.

PubMed ID: 12081481

DOI: 10.1021/bi025855y

PubMed ID: 20068036

Title: Specific binding and chemotactic activity of mBD4 and its functional orthologue hBD2 to CCR6-expressing cells.

PubMed ID: 20068036

DOI: 10.1074/jbc.m109.091090

PubMed ID: 21376174

Title: CCR6 as a mediator of immunity in the lung and gut.

PubMed ID: 21376174

DOI: 10.1016/j.yexcr.2010.12.018

PubMed ID: 23765988

Title: A role for the chemokine receptor CCR6 in mammalian sperm motility and chemotaxis.

PubMed ID: 23765988

DOI: 10.1002/jcp.24418

PubMed ID: 25122636

Title: Deficient human beta-defensin 1 underlies male infertility associated with poor sperm motility and genital tract infection.

PubMed ID: 25122636

DOI: 10.1126/scitranslmed.3009071

PubMed ID: 25585877

Title: The relationship between CCR6 and its binding partners: does the CCR6-CCL20 axis have to be extended?

PubMed ID: 25585877

DOI: 10.1016/j.cyto.2014.11.029

Sequence Information:

  • Length: 374
  • Mass: 42494
  • Checksum: D7F963534E990BC4
  • Sequence:
    • MSGESMNFSD VFDSSEDYFV SVNTSYYSVD SEMLLCSLQE VRQFSRLFVP IAYSLICVFG 
LLGNILVVIT FAFYKKARSM TDVYLLNMAI ADILFVLTLP FWAVSHATGA WVFSNATCKL 
LKGIYAINFN CGMLLLTCIS MDRYIAIVQA TKSFRLRSRT LPRSKIICLV VWGLSVIISS 
STFVFNQKYN TQGSDVCEPK YQTVSEPIRW KLLMLGLELL FGFFIPLMFM IFCYTFIVKT 
LVQAQNSKRH KAIRVIIAVV LVFLACQIPH NMVLLVTAAN LGKMNRSCQS EKLIGYTKTV 
TEVLAFLHCC LNPVLYAFIG QKFRNYFLKI LKDLWCVRRK YKSSGFSCAG RYSENISRQT 
SETADNDNAS SFTM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.