Details for: CCR6

Gene ID: 1235

Symbol: CCR6

Ensembl ID: ENSG00000112486

Description: C-C motif chemokine receptor 6

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 2.46
    Marker Score: 7054
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 2.1
    Marker Score: 2273
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.99
    Marker Score: 1983
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.76
    Marker Score: 4567
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.75
    Marker Score: 3319
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.51
    Marker Score: 10027
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.47
    Marker Score: 3034
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.22
    Marker Score: 7418
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.21
    Marker Score: 3615
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4803
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.06
    Marker Score: 636
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.06
    Marker Score: 32706
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251793
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 1.02
    Marker Score: 235
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1
    Marker Score: 15724
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71813
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48037
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 500
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 454
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.93
    Marker Score: 2369
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.93
    Marker Score: 1622
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 367
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.9
    Marker Score: 799
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 319
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.89
    Marker Score: 600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.87
    Marker Score: 361
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.84
    Marker Score: 4774
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.78
    Marker Score: 699
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 696
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 389
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.74
    Marker Score: 1202
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.74
    Marker Score: 562
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.7
    Marker Score: 153
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 0.63
    Marker Score: 408
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.63
    Marker Score: 2693
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.58
    Marker Score: 3705
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.57
    Marker Score: 240
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.57
    Marker Score: 129
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.57
    Marker Score: 288
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.56
    Marker Score: 520
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.55
    Marker Score: 1580
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.55
    Marker Score: 264
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.54
    Marker Score: 144
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.54
    Marker Score: 347.5
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.53
    Marker Score: 425
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.53
    Marker Score: 168
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.52
    Marker Score: 562
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.5
    Marker Score: 768
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.5
    Marker Score: 26174
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.45
    Marker Score: 344
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.43
    Marker Score: 316
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: 0.42
    Marker Score: 101
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 0.42
    Marker Score: 214
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.41
    Marker Score: 4096
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.4
    Marker Score: 446
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.39
    Marker Score: 139
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 0.39
    Marker Score: 820
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.39
    Marker Score: 330
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.39
    Marker Score: 257
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.37
    Marker Score: 172
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.37
    Marker Score: 269
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.37
    Marker Score: 224
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.37
    Marker Score: 224
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.37
    Marker Score: 347
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.37
    Marker Score: 154
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.36
    Marker Score: 129
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.35
    Marker Score: 156
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.35
    Marker Score: 198
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.34
    Marker Score: 797
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.33
    Marker Score: 196
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.33
    Marker Score: 357
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.32
    Marker Score: 181
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.31
    Marker Score: 199
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.31
    Marker Score: 226
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.3
    Marker Score: 683
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.29
    Marker Score: 277
  • Cell Name: CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human (CL0001074)
    Fold Change: 0.29
    Marker Score: 80
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.29
    Marker Score: 87
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.28
    Marker Score: 87
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.28
    Marker Score: 183
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.28
    Marker Score: 171
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: 0.27
    Marker Score: 80
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.26
    Marker Score: 113
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.25
    Marker Score: 200
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.25
    Marker Score: 249
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 0.25
    Marker Score: 67
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.25
    Marker Score: 306
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.24
    Marker Score: 166
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.24
    Marker Score: 228
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.24
    Marker Score: 407
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.24
    Marker Score: 76
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.23
    Marker Score: 136
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.23
    Marker Score: 137
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.23
    Marker Score: 2626
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.22
    Marker Score: 347
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.22
    Marker Score: 66
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.22
    Marker Score: 133
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 0.22
    Marker Score: 76

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Other Information

**Key characteristics:** * CCR6 is a single-pass membrane protein with a molecular weight of approximately 120 kDa. * It is expressed in high levels in the retina, where it is expressed on cone cells and other retinal cells. * It is also expressed in other tissues, including the gut, where it is expressed on epithelial cells. **Pathways and functions:** * CCR6 is a key receptor for the chemokine SDF-1 (stromal cell factor-1). * It is involved in the regulation of immune responses by facilitating the migration and activation of immune cells to sites of inflammation and infection. * It is also involved in the regulation of epithelial cell migration and differentiation. **Clinical significance:** * Mutations in CCR6 have been linked to a number of human diseases, including retinal disorders, inflammatory bowel diseases, and cancer. * Targeting CCR6 with antibodies or small molecules is a promising new strategy for the treatment of these diseases. **Additional information:** * CCR6 is a highly conserved protein, with a similar protein found in other mammals. * It is a member of the chemokine receptor superfamily, which is a large family of cell surface receptors that are expressed on a variety of immune cells. * CCR6 is a well-studied receptor, and there are a number of drugs that target it for the treatment of inflammatory diseases.

Genular Protein ID: 2538711107

Symbol: CCR6_HUMAN

Name: C-C chemokine receptor type 6

UniProtKB Accession Codes:

P51684 E1P5C6 P78553 Q92846

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 EMDB 1 Ensembl 4 GO 30 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9169459

Title: Identification of CCR6, the specific receptor for a novel lymphocyte-directed CC chemokine LARC.

PubMed ID: 9169459

DOI: 10.1074/jbc.272.23.14893

PubMed ID: 8886020

Title: Molecular cloning and RNA expression of two new human chemokine receptor-like genes.

PubMed ID: 8886020

DOI: 10.1006/bbrc.1996.1595

PubMed ID: 9070937

Title: Cloning of STRL22, a new human gene encoding a G-protein-coupled receptor related to chemokine receptors and located on chromosome 6q27.

PubMed ID: 9070937

DOI: 10.1006/geno.1996.4544

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12081481

Title: Mutating the four extracellular cysteines in the chemokine receptor CCR6 reveals their differing roles in receptor trafficking, ligand binding, and signaling.

PubMed ID: 12081481

DOI: 10.1021/bi025855y

PubMed ID: 20068036

Title: Specific binding and chemotactic activity of mBD4 and its functional orthologue hBD2 to CCR6-expressing cells.

PubMed ID: 20068036

DOI: 10.1074/jbc.m109.091090

PubMed ID: 21376174

Title: CCR6 as a mediator of immunity in the lung and gut.

PubMed ID: 21376174

DOI: 10.1016/j.yexcr.2010.12.018

PubMed ID: 23765988

Title: A role for the chemokine receptor CCR6 in mammalian sperm motility and chemotaxis.

PubMed ID: 23765988

DOI: 10.1002/jcp.24418

PubMed ID: 25122636

Title: Deficient human beta-defensin 1 underlies male infertility associated with poor sperm motility and genital tract infection.

PubMed ID: 25122636

DOI: 10.1126/scitranslmed.3009071

PubMed ID: 25585877

Title: The relationship between CCR6 and its binding partners: does the CCR6-CCL20 axis have to be extended?

PubMed ID: 25585877

DOI: 10.1016/j.cyto.2014.11.029

Sequence Information:

  • Length: 374
  • Mass: 42494
  • Checksum: D7F963534E990BC4
  • Sequence:
    • MSGESMNFSD VFDSSEDYFV SVNTSYYSVD SEMLLCSLQE VRQFSRLFVP IAYSLICVFG 
LLGNILVVIT FAFYKKARSM TDVYLLNMAI ADILFVLTLP FWAVSHATGA WVFSNATCKL 
LKGIYAINFN CGMLLLTCIS MDRYIAIVQA TKSFRLRSRT LPRSKIICLV VWGLSVIISS 
STFVFNQKYN TQGSDVCEPK YQTVSEPIRW KLLMLGLELL FGFFIPLMFM IFCYTFIVKT 
LVQAQNSKRH KAIRVIIAVV LVFLACQIPH NMVLLVTAAN LGKMNRSCQS EKLIGYTKTV 
TEVLAFLHCC LNPVLYAFIG QKFRNYFLKI LKDLWCVRRK YKSSGFSCAG RYSENISRQT 
SETADNDNAS SFTM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.