CCR6 | ENSG00000112486 | NCBI 1235

Details for: CCR6

Gene ID: 1235

Symbol: CCR6

Ensembl ID: ENSG00000112486

Description: C-C motif chemokine receptor 6

Associated with

Antimicrobial peptides
(R-HSA-6803157)
Beta defensins
(R-HSA-1461957)
Chemokine receptors bind chemokines
(R-HSA-380108)
Class a/1 (rhodopsin-like receptors)
(R-HSA-373076)
Defensins
(R-HSA-1461973)
G alpha (i) signalling events
(R-HSA-418594)
Gpcr downstream signalling
(R-HSA-388396)
Gpcr ligand binding
(R-HSA-500792)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Peptide ligand-binding receptors
(R-HSA-375276)
Signaling by gpcr
(R-HSA-372790)
C-c chemokine binding
(GO:0019957)
C-c chemokine receptor activity
(GO:0016493)
Calcium-mediated signaling
(GO:0019722)
Cell chemotaxis
(GO:0060326)
Cell surface
(GO:0009986)
Cellular defense response
(GO:0006968)
Chemokine-mediated signaling pathway
(GO:0070098)
Chemokine receptor activity
(GO:0004950)
Chemotaxis
(GO:0006935)
Dendritic cell chemotaxis
(GO:0002407)
Dn2 thymocyte differentiation
(GO:1904155)
Dn3 thymocyte differentiation
(GO:1904156)
External side of plasma membrane
(GO:0009897)
G protein-coupled receptor signaling pathway
(GO:0007186)
Humoral immune response
(GO:0006959)
Immune response
(GO:0006955)
Isotype switching to iga isotypes
(GO:0048290)
Leukocyte migration involved in inflammatory response
(GO:0002523)
Lymphocyte migration
(GO:0072676)
Plasma membrane
(GO:0005886)
Positive regulation of cytosolic calcium ion concentration
(GO:0007204)
Positive regulation of dendritic cell chemotaxis
(GO:2000510)
Positive regulation of flagellated sperm motility involved in capacitation
(GO:0060474)
Protein binding
(GO:0005515)
Regulation of t cell migration
(GO:2000404)
Signaling receptor activity
(GO:0038023)
Signal transduction
(GO:0007165)
Sperm flagellum
(GO:0036126)
Sperm midpiece
(GO:0097225)
Sperm plasma membrane
(GO:0097524)
Sperm principal piece
(GO:0097228)
T cell migration
(GO:0072678)
Thymocyte migration
(GO:0072679)

Other Information

Proteins

C-C chemokine receptor type 6

Genular Protein ID: 2538711107

Symbol: CCR6_HUMAN

Name: C-C chemokine receptor type 6

UniProtKB Accession Codes:

P51684 E1P5C6 P78553 Q92846

Database IDs:

Citations:

PubMed ID: 9169459

Title: Identification of CCR6, the specific receptor for a novel lymphocyte-directed CC chemokine LARC.

PubMed ID: 9169459

DOI: 10.1074/jbc.272.23.14893

PubMed ID: 8886020

Title: Molecular cloning and RNA expression of two new human chemokine receptor-like genes.

PubMed ID: 8886020

DOI: 10.1006/bbrc.1996.1595

PubMed ID: 9070937

Title: Cloning of STRL22, a new human gene encoding a G-protein-coupled receptor related to chemokine receptors and located on chromosome 6q27.

PubMed ID: 9070937

DOI: 10.1006/geno.1996.4544

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12081481

Title: Mutating the four extracellular cysteines in the chemokine receptor CCR6 reveals their differing roles in receptor trafficking, ligand binding, and signaling.

PubMed ID: 12081481

DOI: 10.1021/bi025855y

PubMed ID: 20068036

Title: Specific binding and chemotactic activity of mBD4 and its functional orthologue hBD2 to CCR6-expressing cells.

PubMed ID: 20068036

DOI: 10.1074/jbc.m109.091090

PubMed ID: 21376174

Title: CCR6 as a mediator of immunity in the lung and gut.

PubMed ID: 21376174

DOI: 10.1016/j.yexcr.2010.12.018

PubMed ID: 23765988

Title: A role for the chemokine receptor CCR6 in mammalian sperm motility and chemotaxis.

PubMed ID: 23765988

DOI: 10.1002/jcp.24418

PubMed ID: 25122636

Title: Deficient human beta-defensin 1 underlies male infertility associated with poor sperm motility and genital tract infection.

PubMed ID: 25122636

DOI: 10.1126/scitranslmed.3009071

PubMed ID: 25585877

Title: The relationship between CCR6 and its binding partners: does the CCR6-CCL20 axis have to be extended?

PubMed ID: 25585877

DOI: 10.1016/j.cyto.2014.11.029

Sequence Information:

Length: 374
Mass: 42494
Checksum: D7F963534E990BC4
Sequence:

MSGESMNFSD VFDSSEDYFV SVNTSYYSVD SEMLLCSLQE VRQFSRLFVP IAYSLICVFG 
LLGNILVVIT FAFYKKARSM TDVYLLNMAI ADILFVLTLP FWAVSHATGA WVFSNATCKL 
LKGIYAINFN CGMLLLTCIS MDRYIAIVQA TKSFRLRSRT LPRSKIICLV VWGLSVIISS 
STFVFNQKYN TQGSDVCEPK YQTVSEPIRW KLLMLGLELL FGFFIPLMFM IFCYTFIVKT 
LVQAQNSKRH KAIRVIIAVV LVFLACQIPH NMVLLVTAAN LGKMNRSCQS EKLIGYTKTV 
TEVLAFLHCC LNPVLYAFIG QKFRNYFLKI LKDLWCVRRK YKSSGFSCAG RYSENISRQT 
SETADNDNAS SFTM

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CCR6

Associated with

Other Information

Identification of CCR6, the specific receptor for a novel lymphocyte-directed CC chemokine LARC. PubMed ID: 9169459

Molecular cloning and RNA expression of two new human chemokine receptor-like genes. PubMed ID: 8886020

Cloning of STRL22, a new human gene encoding a G-protein-coupled receptor related to chemokine receptors and located on chromosome 6q27. PubMed ID: 9070937

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Mutating the four extracellular cysteines in the chemokine receptor CCR6 reveals their differing roles in receptor trafficking, ligand binding, and signaling. PubMed ID: 12081481

Specific binding and chemotactic activity of mBD4 and its functional orthologue hBD2 to CCR6-expressing cells. PubMed ID: 20068036

CCR6 as a mediator of immunity in the lung and gut. PubMed ID: 21376174

A role for the chemokine receptor CCR6 in mammalian sperm motility and chemotaxis. PubMed ID: 23765988

Deficient human beta-defensin 1 underlies male infertility associated with poor sperm motility and genital tract infection. PubMed ID: 25122636

The relationship between CCR6 and its binding partners: does the CCR6-CCL20 axis have to be extended? PubMed ID: 25585877