Details for: CCR7

Gene ID: 1236

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: CCR7

Ensembl ID: ENSG00000126353

Description: C-C motif chemokine receptor 7

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

  • Chemokine receptors bind chemokines
    (R-HSA-380108)
  • Class a/1 (rhodopsin-like receptors)
    (R-HSA-373076)
  • G alpha (i) signalling events
    (R-HSA-418594)
  • Gpcr downstream signalling
    (R-HSA-388396)
  • Gpcr ligand binding
    (R-HSA-500792)
  • Peptide ligand-binding receptors
    (R-HSA-375276)
  • Signaling by gpcr
    (R-HSA-372790)
  • Signal transduction
    (R-HSA-162582)
  • C-c chemokine receptor activity
    (GO:0016493)
  • C-c motif chemokine 19 receptor activity
    (GO:0038117)
  • C-c motif chemokine 21 receptor activity
    (GO:0038121)
  • Calcium-mediated signaling
    (GO:0019722)
  • Cell chemotaxis
    (GO:0060326)
  • Cell surface
    (GO:0009986)
  • Cellular response to cytokine stimulus
    (GO:0071345)
  • Chemokine (c-c motif) ligand 19 binding
    (GO:0035757)
  • Chemokine (c-c motif) ligand 19 signaling pathway
    (GO:0038115)
  • Chemokine (c-c motif) ligand 21 binding
    (GO:0035758)
  • Chemokine (c-c motif) ligand 21 signaling pathway
    (GO:0038116)
  • Dendritic cell chemotaxis
    (GO:0002407)
  • Establishment of t cell polarity
    (GO:0001768)
  • External side of plasma membrane
    (GO:0009897)
  • G protein-coupled receptor activity
    (GO:0004930)
  • G protein-coupled receptor signaling pathway
    (GO:0007186)
  • Homeostasis of number of cells
    (GO:0048872)
  • Immune response
    (GO:0006955)
  • Inflammatory response
    (GO:0006954)
  • Lymphocyte migration into lymph node
    (GO:0097022)
  • Mature conventional dendritic cell differentiation
    (GO:0097029)
  • Mitochondrion
    (GO:0005739)
  • Myeloid dendritic cell chemotaxis
    (GO:0002408)
  • Negative regulation of dendritic cell apoptotic process
    (GO:2000669)
  • Negative regulation of interleukin-12 production
    (GO:0032695)
  • Negative thymic t cell selection
    (GO:0045060)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of actin filament polymerization
    (GO:0030838)
  • Positive regulation of canonical nf-kappab signal transduction
    (GO:0043123)
  • Positive regulation of cell-matrix adhesion
    (GO:0001954)
  • Positive regulation of cell adhesion
    (GO:0045785)
  • Positive regulation of cell motility
    (GO:2000147)
  • Positive regulation of cytosolic calcium ion concentration
    (GO:0007204)
  • Positive regulation of dendritic cell antigen processing and presentation
    (GO:0002606)
  • Positive regulation of dendritic cell chemotaxis
    (GO:2000510)
  • Positive regulation of erk1 and erk2 cascade
    (GO:0070374)
  • Positive regulation of filopodium assembly
    (GO:0051491)
  • Positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation
    (GO:2000526)
  • Positive regulation of humoral immune response
    (GO:0002922)
  • Positive regulation of hypersensitivity
    (GO:0002885)
  • Positive regulation of immunological synapse formation
    (GO:2000522)
  • Positive regulation of interleukin-12 production
    (GO:0032735)
  • Positive regulation of jnk cascade
    (GO:0046330)
  • Positive regulation of neutrophil chemotaxis
    (GO:0090023)
  • Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0051897)
  • Positive regulation of protein kinase activity
    (GO:0045860)
  • Positive regulation of pseudopodium assembly
    (GO:0031274)
  • Positive regulation of t cell costimulation
    (GO:2000525)
  • Positive regulation of t cell receptor signaling pathway
    (GO:0050862)
  • Regulation of dendritic cell dendrite assembly
    (GO:2000547)
  • Regulation of interleukin-1 beta production
    (GO:0032651)
  • Regulation of type ii interferon production
    (GO:0032649)
  • Release of sequestered calcium ion into cytosol
    (GO:0051209)
  • Response to lipopolysaccharide
    (GO:0032496)
  • Response to nitric oxide
    (GO:0071731)
  • Response to prostaglandin e
    (GO:0034695)
  • Ruffle organization
    (GO:0031529)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • naive thymus-derived CD8-positive, alpha-beta T cell CL0000900
    CSI 33.15
    rCSI 23.28%
    PRS 49.95
  • dendritic cell, human CL0001056
    CSI 28.29
    rCSI 43.45%
    PRS 26.52
  • central memory CD8-positive, alpha-beta T cell CL0000907
    CSI 21.36
    rCSI 14.39%
    PRS 27.31
  • naive thymus-derived CD4-positive, alpha-beta T cell CL0000895
    CSI 20.91
    rCSI 26.27%
    PRS 72.3
  • Langerhans cell CL0000453
    CSI 20.63
    rCSI 31.52%
    PRS 38.41
  • CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920
    CSI 18.36
    rCSI 36.6%
    PRS 36.92
  • T-helper 17 cell CL0000899
    CSI 17.8
    rCSI 14.14%
    PRS 39.29
  • mononuclear phagocyte CL0000113
    CSI 12.51
    rCSI 27.53%
    PRS 25.32
  • CD4-positive helper T cell CL0000492
    CSI 12.43
    rCSI 9.4%
    PRS 30.32
  • naive T cell CL0000898
    CSI 8.5
    rCSI 5.92%
    PRS 31.22
  • myeloid dendritic cell CL0000782
    CSI 6.89
    rCSI 9.99%
    PRS 33.49
  • T follicular helper cell CL0002038
    CSI 6.58
    rCSI 4.93%
    PRS 34.76
  • double negative thymocyte CL0002489
    CSI 5.82
    rCSI 4.05%
    PRS 26.63
  • activated CD4-positive, alpha-beta T cell CL0000896
    CSI 5.19
    rCSI 4.8%
    PRS 39.6
  • effector memory CD4-positive, alpha-beta T cell CL0000905
    CSI 4.84
    rCSI 6.59%
    PRS 50.08
  • alpha-beta T cell CL0000789
    CSI 4.64
    rCSI 5.44%
    PRS 30.64
  • regulatory T cell CL0000815
    CSI 4.59
    rCSI 5.33%
    PRS 55.69
  • CD4-positive, alpha-beta thymocyte CL0000810
    CSI 4.54
    rCSI 3.63%
    PRS 39.08
  • CD1c-positive myeloid dendritic cell CL0002399
    CSI 4.4
    rCSI 5.31%
    PRS 26.65
  • early lymphoid progenitor CL0000936
    CSI 3.79
    rCSI 3.33%
    PRS 25.49
  • IgG plasma cell CL0000985
    CSI 3.66
    rCSI 4.38%
    PRS 38.22
  • immature B cell CL0000816
    CSI 3.23
    rCSI 2.4%
    PRS 32.49
  • CD4-positive, alpha-beta memory T cell CL0000897
    CSI 2.75
    rCSI 1.97%
    PRS 30.55
  • central memory CD4-positive, alpha-beta T cell CL0000904
    CSI 2.66
    rCSI 1.57%
    PRS 31.04
  • plasmacytoid dendritic cell, human CL0001058
    CSI 2.61
    rCSI 1.82%
    PRS 23.57
  • follicular B cell CL0000843
    CSI 2.48
    rCSI 9.03%
    PRS 64.35
  • mature T cell CL0002419
    CSI 2.38
    rCSI 1.85%
    PRS 32.49
  • memory B cell CL0000787
    CSI 2.34
    rCSI 2.31%
    PRS 67.57
  • mature B cell CL0000785
    CSI 2.16
    rCSI 1.87%
    PRS 27.81
  • group 3 innate lymphoid cell CL0001071
    CSI 1.85
    rCSI 1.39%
    PRS 23.6
  • CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792
    CSI 1.79
    rCSI 1.76%
    PRS 34.27
  • memory T cell CL0000813
    CSI 1.52
    rCSI 2.92%
    PRS 49.09
  • common lymphoid progenitor CL0000051
    CSI 1.44
    rCSI 1.92%
    PRS 41.5
  • transitional stage B cell CL0000818
    CSI 1.38
    rCSI 4.51%
    PRS 55.8
  • class switched memory B cell CL0000972
    CSI 1.13
    rCSI 0.84%
    PRS 37.04
  • CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell CL0000915
    CSI 1.1
    rCSI 5.01%
    PRS 64.83
  • unswitched memory B cell CL0000970
    CSI 1.01
    rCSI 0.85%
    PRS 34.78
  • plasmablast CL0000980
    CSI 0.98
    rCSI 0.77%
    PRS 26.78
  • erythrocyte CL0000232
    CSI 0.86
    rCSI 1.95%
    PRS 29.14
  • placental villous trophoblast CL2000060
    CSI 0.83
    rCSI 1.28%
    PRS 20.63
  • syncytiotrophoblast cell CL0000525
    CSI 0.78
    rCSI 2.24%
    PRS 40
  • inflammatory macrophage CL0000863
    CSI 0.73
    rCSI 1.25%
    PRS 43.98
  • natural T-regulatory cell CL0000903
    CSI 0.71
    rCSI 1.35%
    PRS 56.63
  • innate lymphoid cell CL0001065
    CSI 0.65
    rCSI 1.35%
    PRS 32.74
  • mature alpha-beta T cell CL0000791
    CSI 0.64
    rCSI 2.33%
    PRS 37.87
  • double negative T regulatory cell CL0011024
    CSI 0.57
    rCSI 10.78%
    PRS 78.95
  • activated CD4-positive, alpha-beta T cell, human CL0001043
    CSI 0.48
    rCSI 1.16%
    PRS 78.6
  • helper T cell CL0000912
    CSI 0.24
    rCSI 0.34%
    PRS 30.72
  • CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203
    CSI 0.24
    rCSI 0.28%
    PRS 26.93
  • activated CD8-positive, alpha-beta T cell, human CL0001049
    CSI 0.15
    rCSI 0.26%
    PRS 42.02
  • B-2 B cell CL0000822
    CSI 0.12
    rCSI 2.51%
    PRS 77.78
  • mature NK T cell CL0000814
    CSI -1
    rCSI -1.28%
    PRS 67.98

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [CCR7](/details-gene/1236), or C-C motif chemokine receptor 7, is a protein-coding gene located on chromosome 17q21.2. It encodes a G protein-coupled receptor that is fundamental to the adaptive immune system. Functionally, [CCR7](/details-gene/1236) acts as the receptor for the chemokines CCL19 and CCL21, playing a critical role in directing the migration and homing of various immune cells, particularly to secondary lymphoid organs. Expression data from the **Overall** context reveals its highest significance in naive lymphocyte populations, such as [naive thymus-derived CD8-positive, alpha-beta T cell](/details-cell/CL0000900) and [naive thymus-derived CD4-positive, alpha-beta T cell](/details-cell/CL0000895), as well as in professional antigen-presenting cells like the [dendritic cell, human](/details-cell/CL0001056). This specific expression pattern underscores its essential function in orchestrating the initial interactions between T cells and dendritic cells that are required to launch an adaptive immune response. The gene was initially identified as an Epstein-Barr virus-induced gene [Link](https://doi.org/10.1128/jvi.67.4.2209-2220.1993) and is associated with clinical phenotypes documented in OMIM ([600242](https://omim.org/entry/600242)). ## Cellular Roles and Expression Landscape The expression profile of [CCR7](/details-gene/1236) firmly establishes it as a key regulator of immune cell trafficking and positioning within the lymphoid system. **Overall**, the gene exhibits its highest significance in cell types central to the initiation and maintenance of adaptive immunity. It is a defining marker for naive T lymphocytes, with exceptionally high cell significance index (CSI) scores in [naive thymus-derived CD8-positive, alpha-beta T cell](/details-cell/CL0000900) (CSI: 33.15) and [naive thymus-derived CD4-positive, alpha-beta T cell](/details-cell/CL0000895) (CSI: 20.91). Its high significance extends to [central memory CD8-positive, alpha-beta T cell](/details-cell/CL0000907) (CSI: 21.36), indicating a sustained role in the homing of memory cells that reside within lymphoid tissues. Furthermore, [CCR7](/details-gene/1236) is a critical marker for antigen-presenting cells (APCs) responsible for activating naive T cells, showing high significance in [dendritic cell, human](/details-cell/CL0001056) (CSI: 28.29) and [Langerhans cell](/details-cell/CL0000453) (CSI: 20.63). This dual expression in both APCs and naive T cells is essential for their co-localization within the T cell zones of lymph nodes. The gene's role is not limited to naive cells, as it is also significant in differentiated T cell subsets such as the [T-helper 17 cell](/details-cell/CL0000899) (CSI: 17.80), suggesting its involvement in the trafficking of specific effector lineages. Conversely, the low significance in cell types like the [mature NK T cell](/details-cell/CL0000814) (CSI: -1.00) highlights its specialized function, distinguishing it from a pan-lymphocyte marker and pointing towards a role specifically in conventional T cell and dendritic cell biology. ## Pathways and Molecular Function The molecular functions of [CCR7](/details-gene/1236) are intrinsically linked to its role as a chemokine receptor, mediating cellular responses to its ligands CCL19 and CCL21. Its annotation as having [C-c chemokine receptor activity](/details-ontology/GO0016493) and being part of the [Chemokine receptors bind chemokines](/details-pathway/R-HSA-380108) pathway confirms its primary function. Upon ligand binding, [CCR7](/details-gene/1236) initiates intracellular signaling cascades characteristic of GPCRs, primarily through [G alpha (i) signalling events](/details-pathway/R-HSA-418594). This signaling cascade is central to numerous biological processes that facilitate immune surveillance and response. The most prominent of these is [Cell chemotaxis](/details-ontology/GO0060326), particularly [Lymphocyte migration into lymph node](/details-ontology/GO0097022) and [Dendritic cell chemotaxis](/details-ontology/GO0002407). This directly explains its high expression in naive T cells and dendritic cells, which must migrate from the periphery to secondary lymphoid organs. Beyond migration, [CCR7](/details-gene/1236) signaling positively regulates processes crucial for T cell activation, including [Positive regulation of immunological synapse formation](/details-ontology/GO2000522) and [Positive regulation of T cell receptor signaling pathway](/details-ontology/GO0050862). It also appears to influence dendritic cell function through [Positive regulation of dendritic cell antigen processing and presentation](/details-ontology/GO0002606), suggesting that [CCR7](/details-gene/1236) not only brings immune cells together but also primes them for effective interaction. ## Research Directions The well-defined role of [CCR7](/details-gene/1236) in immune cell trafficking provides a solid foundation for further research into its nuanced roles in T cell differentiation, immune regulation, and pathology. **Proposed Hypotheses:** 1. **[CCR7](/details-gene/1236) downregulation is a prerequisite for effector memory T cell differentiation.** The observed high expression in naive and central memory T cells, contrasted with its known lower expression in effector memory cells that patrol peripheral tissues, suggests that the programmed downregulation of [CCR7](/details-gene/1236) is a critical checkpoint that permits T cells to exit lymphoid organs and acquire an effector phenotype. 2. **[CCR7](/details-gene/1236) signaling in dendritic cells directly modulates T cell polarization.** Given its high expression on both dendritic cells and T cells, it is hypothesized that beyond its migratory function, sustained CCL19/CCL21-[CCR7](/details-gene/1236) signaling at the immunological synapse provides a co-stimulatory signal that influences the differentiation outcome of naive T cells, for instance, promoting a T-helper 17 phenotype, a cell type where [CCR7](/details-gene/1236) shows significant expression. **Experimental Approach:** To test the first hypothesis, a conditional knockout mouse model could be employed. Specifically, a `Ccr7-floxed` mouse could be crossed with a mouse expressing Cre recombinase under the control of an activation-inducible promoter (e.g., `CD4-Cre` or `Lck-Cre` for pan-T cell deletion, or an inducible system). Following a viral infection challenge (e.g., with LCMV), antigen-specific CD8+ T cells could be tracked via flow cytometry. The hypothesis predicts that T cells lacking [CCR7](/details-gene/1236) will fail to establish a central memory population within lymph nodes and will instead be skewed towards an effector or effector memory phenotype (CCR7-, CD62L-) located predominantly in non-lymphoid tissues like the spleen, liver, and lungs. **Therapeutic Potential:** As a cell surface G protein-coupled receptor, [CCR7](/details-gene/1236) is a highly druggable target. Its central role in lymphocyte and dendritic cell homing to lymphoid tissues makes it an attractive therapeutic target for conditions characterized by aberrant immune cell migration. **Inhibition** of [CCR7](/details-gene/1236) signaling, using monoclonal antibodies or small molecule antagonists, could be a powerful strategy for treating autoimmune diseases (e.g., rheumatoid arthritis, multiple sclerosis) or preventing organ transplant rejection by blocking the migration of immune cells to sites of inflammation or the allograft. Furthermore, because many cancers (such as lymphomas and melanomas) exploit the CCR7-CCL21 axis to metastasize to lymph nodes, [CCR7](/details-gene/1236) inhibitors represent a promising anti-metastatic therapy.

Genular Protein ID: 4268403927

Symbol: CCR7_HUMAN

Name: C-C chemokine receptor type 7

UniProtKB Accession Codes:

P32248

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 ExpressionAtlas 1 GO 55 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 2 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 5 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8383238

Title: Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors.

PubMed ID: 8383238

DOI: 10.1128/jvi.67.4.2209-2220.1993

PubMed ID: 7851893

Title: Cloning of human and mouse EBI1, a lymphoid-specific G-protein-coupled receptor encoded on human chromosome 17q12-q21.2.

PubMed ID: 7851893

DOI: 10.1006/geno.1994.1553

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 378
  • Mass: 42874
  • Checksum: D4CB4213841A1BD4
  • Sequence:
    • MDLGKPMKSV LVVALLVIFQ VCLCQDEVTD DYIGDNTTVD YTLFESLCSK KDVRNFKAWF 
LPIMYSIICF VGLLGNGLVV LTYIYFKRLK TMTDTYLLNL AVADILFLLT LPFWAYSAAK 
SWVFGVHFCK LIFAIYKMSF FSGMLLLLCI SIDRYVAIVQ AVSAHRHRAR VLLISKLSCV 
GIWILATVLS IPELLYSDLQ RSSSEQAMRC SLITEHVEAF ITIQVAQMVI GFLVPLLAMS 
FCYLVIIRTL LQARNFERNK AIKVIIAVVV VFIVFQLPYN GVVLAQTVAN FNITSSTCEL 
SKQLNIAYDV TYSLACVRCC VNPFLYAFIG VKFRNDLFKL FKDLGCLSQE QLRQWSSCRH 
IRRSSMSVEA ETTTTFSP

Genular Protein ID: 2159885216

Symbol: J3KSS9_HUMAN

Name: N/A

UniProtKB Accession Codes:

J3KSS9

Database IDs:

ARBA 5 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 6 Gene3D 1 GeneTree 1 HGNC 1 InterPro 5 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 3 PROSITE 3 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 3 RuleBase 1 SAM 2 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

Sequence Information:

  • Length: 372
  • Mass: 42232
  • Checksum: 6BAC116ADF458B5B
  • Sequence:
    • MKSVLVVALL VIFQVCLCQD EVTDDYIGDN TTVDYTLFES LCSKKDVRNF KAWFLPIMYS 
IICFVGLLGN GLVVLTYIYF KRLKTMTDTY LLNLAVADIL FLLTLPFWAY SAAKSWVFGV 
HFCKLIFAIY KMSFFSGMLL LLCISIDRYV AIVQAVSAHR HRARVLLISK LSCVGIWILA 
TVLSIPELLY SDLQRSSSEQ AMRCSLITEH VEAFITIQVA QMVIGFLVPL LAMSFCYLVI 
IRTLLQARNF ERNKAIKVII AVVVVFIVFQ LPYNGVVLAQ TVANFNITSS TCELSKQLNI 
AYDVTYSLAC VRCCVNPFLY AFIGVKFRND LFKLFKDLGC LSQEQLRQWS SCRHIRRSSM 
SVEAETTTTF SP