Details for: CCR7

Gene ID: 1236

Symbol: CCR7

Ensembl ID: ENSG00000126353

Description: C-C motif chemokine receptor 7

Associated with

  • Chemokine receptors bind chemokines
    (R-HSA-380108)
  • Class a/1 (rhodopsin-like receptors)
    (R-HSA-373076)
  • G alpha (i) signalling events
    (R-HSA-418594)
  • Gpcr downstream signalling
    (R-HSA-388396)
  • Gpcr ligand binding
    (R-HSA-500792)
  • Peptide ligand-binding receptors
    (R-HSA-375276)
  • Signaling by gpcr
    (R-HSA-372790)
  • Signal transduction
    (R-HSA-162582)
  • C-c chemokine receptor activity
    (GO:0016493)
  • C-c motif chemokine 19 receptor activity
    (GO:0038117)
  • C-c motif chemokine 21 receptor activity
    (GO:0038121)
  • Calcium-mediated signaling
    (GO:0019722)
  • Cell chemotaxis
    (GO:0060326)
  • Cell surface
    (GO:0009986)
  • Cellular response to cytokine stimulus
    (GO:0071345)
  • Chemokine (c-c motif) ligand 19 binding
    (GO:0035757)
  • Chemokine (c-c motif) ligand 19 signaling pathway
    (GO:0038115)
  • Chemokine (c-c motif) ligand 21 binding
    (GO:0035758)
  • Chemokine (c-c motif) ligand 21 signaling pathway
    (GO:0038116)
  • Dendritic cell chemotaxis
    (GO:0002407)
  • Establishment of t cell polarity
    (GO:0001768)
  • External side of plasma membrane
    (GO:0009897)
  • G protein-coupled receptor activity
    (GO:0004930)
  • G protein-coupled receptor signaling pathway
    (GO:0007186)
  • Homeostasis of number of cells
    (GO:0048872)
  • Immune response
    (GO:0006955)
  • Inflammatory response
    (GO:0006954)
  • Lymphocyte migration into lymph node
    (GO:0097022)
  • Mature conventional dendritic cell differentiation
    (GO:0097029)
  • Mitochondrion
    (GO:0005739)
  • Myeloid dendritic cell chemotaxis
    (GO:0002408)
  • Negative regulation of dendritic cell apoptotic process
    (GO:2000669)
  • Negative regulation of interleukin-12 production
    (GO:0032695)
  • Negative thymic t cell selection
    (GO:0045060)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of actin filament polymerization
    (GO:0030838)
  • Positive regulation of canonical nf-kappab signal transduction
    (GO:0043123)
  • Positive regulation of cell-matrix adhesion
    (GO:0001954)
  • Positive regulation of cell adhesion
    (GO:0045785)
  • Positive regulation of cell motility
    (GO:2000147)
  • Positive regulation of cytosolic calcium ion concentration
    (GO:0007204)
  • Positive regulation of dendritic cell antigen processing and presentation
    (GO:0002606)
  • Positive regulation of dendritic cell chemotaxis
    (GO:2000510)
  • Positive regulation of erk1 and erk2 cascade
    (GO:0070374)
  • Positive regulation of filopodium assembly
    (GO:0051491)
  • Positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation
    (GO:2000526)
  • Positive regulation of humoral immune response
    (GO:0002922)
  • Positive regulation of hypersensitivity
    (GO:0002885)
  • Positive regulation of immunological synapse formation
    (GO:2000522)
  • Positive regulation of interleukin-12 production
    (GO:0032735)
  • Positive regulation of jnk cascade
    (GO:0046330)
  • Positive regulation of neutrophil chemotaxis
    (GO:0090023)
  • Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0051897)
  • Positive regulation of protein kinase activity
    (GO:0045860)
  • Positive regulation of pseudopodium assembly
    (GO:0031274)
  • Positive regulation of t cell costimulation
    (GO:2000525)
  • Positive regulation of t cell receptor signaling pathway
    (GO:0050862)
  • Regulation of dendritic cell dendrite assembly
    (GO:2000547)
  • Regulation of interleukin-1 beta production
    (GO:0032651)
  • Regulation of type ii interferon production
    (GO:0032649)
  • Release of sequestered calcium ion into cytosol
    (GO:0051209)
  • Response to lipopolysaccharide
    (GO:0032496)
  • Response to nitric oxide
    (GO:0071731)
  • Response to prostaglandin e
    (GO:0034695)
  • Ruffle organization
    (GO:0031529)

Other Information

Genular Protein ID: 4268403927

Symbol: CCR7_HUMAN

Name: C-C chemokine receptor type 7

UniProtKB Accession Codes:

P32248

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 ExpressionAtlas 1 GO 55 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 2 PRINTS 3 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 5 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8383238

Title: Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors.

PubMed ID: 8383238

DOI: 10.1128/jvi.67.4.2209-2220.1993

PubMed ID: 7851893

Title: Cloning of human and mouse EBI1, a lymphoid-specific G-protein-coupled receptor encoded on human chromosome 17q12-q21.2.

PubMed ID: 7851893

DOI: 10.1006/geno.1994.1553

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 378
  • Mass: 42874
  • Checksum: D4CB4213841A1BD4
  • Sequence:
    • MDLGKPMKSV LVVALLVIFQ VCLCQDEVTD DYIGDNTTVD YTLFESLCSK KDVRNFKAWF 
LPIMYSIICF VGLLGNGLVV LTYIYFKRLK TMTDTYLLNL AVADILFLLT LPFWAYSAAK 
SWVFGVHFCK LIFAIYKMSF FSGMLLLLCI SIDRYVAIVQ AVSAHRHRAR VLLISKLSCV 
GIWILATVLS IPELLYSDLQ RSSSEQAMRC SLITEHVEAF ITIQVAQMVI GFLVPLLAMS 
FCYLVIIRTL LQARNFERNK AIKVIIAVVV VFIVFQLPYN GVVLAQTVAN FNITSSTCEL 
SKQLNIAYDV TYSLACVRCC VNPFLYAFIG VKFRNDLFKL FKDLGCLSQE QLRQWSSCRH 
IRRSSMSVEA ETTTTFSP

Genular Protein ID: 2159885216

Symbol: J3KSS9_HUMAN

Name: N/A

UniProtKB Accession Codes:

J3KSS9

Database IDs:

ARBA 7 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 6 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 4 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 3 PROSITE 3 PeptideAtlas 2 Pfam 1 Proteomes 2 RefSeq 3 RuleBase 1 SAM 2 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

Sequence Information:

  • Length: 372
  • Mass: 42232
  • Checksum: 6BAC116ADF458B5B
  • Sequence:
    • MKSVLVVALL VIFQVCLCQD EVTDDYIGDN TTVDYTLFES LCSKKDVRNF KAWFLPIMYS 
IICFVGLLGN GLVVLTYIYF KRLKTMTDTY LLNLAVADIL FLLTLPFWAY SAAKSWVFGV 
HFCKLIFAIY KMSFFSGMLL LLCISIDRYV AIVQAVSAHR HRARVLLISK LSCVGIWILA 
TVLSIPELLY SDLQRSSSEQ AMRCSLITEH VEAFITIQVA QMVIGFLVPL LAMSFCYLVI 
IRTLLQARNF ERNKAIKVII AVVVVFIVFQ LPYNGVVLAQ TVANFNITSS TCELSKQLNI 
AYDVTYSLAC VRCCVNPFLY AFIGVKFRND LFKLFKDLGC LSQEQLRQWS SCRHIRRSSM 
SVEAETTTTF SP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.