Genular: Defining Cellular Identity and Function

Details for: Casp1

Gene ID: 12362

Symbol: Casp1

Ensembl ID: ENSMUSG00000025888

Description: caspase 1

Associated with

Cytokine signaling in immune system
(R-MMU-1280215)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Interleukin-1 family signaling
(R-MMU-446652)
Interleukin-1 processing
(R-MMU-448706)
Nod1/2 signaling pathway
(R-MMU-168638)
Nucleotide-binding domain, leucine rich repeat containing receptor (nlr) signaling pathways
(R-MMU-168643)
Programmed cell death
(R-MMU-5357801)
Regulated necrosis
(R-MMU-5218859)
Signaling by interleukins
(R-MMU-449147)
Aim2 inflammasome complex assembly
(GO:0140970)
Apoptotic process
(GO:0006915)
Canonical inflammasome complex
(GO:0061702)
Card domain binding
(GO:0050700)
Caspase binding
(GO:0089720)
Cellular response to lipopolysaccharide
(GO:0071222)
Cellular response to organic substance
(GO:0071310)
Cellular response to type ii interferon
(GO:0071346)
Cysteine-type endopeptidase activity
(GO:0004197)
Cysteine-type peptidase activity
(GO:0008234)
Cytokine precursor processing
(GO:0140447)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Defense response to bacterium
(GO:0042742)
Defense response to gram-negative bacterium
(GO:0050829)
Defense response to virus
(GO:0051607)
Endopeptidase activity
(GO:0004175)
Extracellular region
(GO:0005576)
Hydrolase activity
(GO:0016787)
Identical protein binding
(GO:0042802)
Interleukin-1 alpha production
(GO:0032610)
Interleukin-1 beta production
(GO:0032611)
Ipaf inflammasome complex
(GO:0072557)
Kinase binding
(GO:0019900)
Macrophage cytokine production
(GO:0010934)
Membrane
(GO:0016020)
Membrane hyperpolarization
(GO:0060081)
Memory
(GO:0007613)
Microglial cell activation
(GO:0001774)
Microtubule
(GO:0005874)
Mitochondrial depolarization
(GO:0051882)
Myoblast fusion
(GO:0007520)
Osmosensory signaling pathway
(GO:0007231)
Pattern recognition receptor signaling pathway
(GO:0002221)
Peptidase activity
(GO:0008233)
Plasma membrane
(GO:0005886)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of circadian sleep/wake cycle, non-rem sleep
(GO:0046010)
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
(GO:0043280)
Positive regulation of cytokine production
(GO:0001819)
Positive regulation of inflammatory response
(GO:0050729)
Positive regulation of interleukin-1 alpha production
(GO:0032730)
Positive regulation of interleukin-1 beta production
(GO:0032731)
Positive regulation of interleukin-18 production
(GO:0032741)
Positive regulation of macrophage cytokine production
(GO:0060907)
Positive regulation of tumor necrosis factor-mediated signaling pathway
(GO:1903265)
Programmed necrotic cell death
(GO:0097300)
Protein-containing complex
(GO:0032991)
Protein autoprocessing
(GO:0016540)
Protein binding
(GO:0005515)
Protein maturation
(GO:0051604)
Protein processing
(GO:0016485)
Proteolysis
(GO:0006508)
Pyroptosis
(GO:0070269)
Regulation of apoptotic process
(GO:0042981)
Regulation of autophagy
(GO:0010506)
Regulation of inflammatory response
(GO:0050727)
Response to atp
(GO:0033198)
Response to bacterium
(GO:0009617)
Response to hypoxia
(GO:0001666)
Response to lipopolysaccharide
(GO:0032496)
Response to organic cyclic compound
(GO:0014070)
Response to xenobiotic stimulus
(GO:0009410)
Scaffold protein binding
(GO:0097110)
Signaling receptor ligand precursor processing
(GO:0140448)

Other Information

Proteins

Caspase-1

Genular Protein ID: 2184581313

Symbol: CASP1_MOUSE

Name: Caspase-1

UniProtKB Accession Codes:

P29452

Database IDs:

Citations:

PubMed ID: 1431103

Title: Molecular cloning of the murine IL-1 beta converting enzyme cDNA.

PubMed ID: 1431103

PubMed ID: 8446594

Title: Interleukin 1 beta (IL-1 beta) processing in murine macrophages requires a structurally conserved homologue of human IL-1 beta converting enzyme.

PubMed ID: 8446594

DOI: 10.1073/pnas.90.5.1809

PubMed ID: 8034321

Title: The structure and complete nucleotide sequence of the murine gene encoding interleukin-1 beta converting enzyme (ICE).

PubMed ID: 8034321

DOI: 10.1006/geno.1994.1203

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9038361

Title: Characterization of seven murine caspase family members.

PubMed ID: 9038361

DOI: 10.1016/s0014-5793(97)00026-4

PubMed ID: 18667412

Title: Targeted peptidecentric proteomics reveals caspase-7 as a substrate of the caspase-1 inflammasomes.

PubMed ID: 18667412

DOI: 10.1074/mcp.m800132-mcp200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21147462

Title: Differential requirement for Caspase-1 autoproteolysis in pathogen-induced cell death and cytokine processing.

PubMed ID: 21147462

DOI: 10.1016/j.chom.2010.11.007

PubMed ID: 22464733

Title: Inflammasome-activated caspase 7 cleaves PARP1 to enhance the expression of a subset of NF-kappaB target genes.

PubMed ID: 22464733

DOI: 10.1016/j.molcel.2012.02.016

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 28314590

Title: Inflammasome activation triggers caspase-1-mediated cleavage of cGAS to regulate responses to DNA virus infection.

PubMed ID: 28314590

DOI: 10.1016/j.immuni.2017.02.011

PubMed ID: 30692621

Title: SERPINB1-mediated checkpoint of inflammatory caspase activation.

PubMed ID: 30692621

DOI: 10.1038/s41590-018-0303-z

PubMed ID: 32109412

Title: Structural mechanism for GSDMD targeting by autoprocessed caspases in pyroptosis.

PubMed ID: 32109412

DOI: 10.1016/j.cell.2020.02.002

PubMed ID: 34471287

Title: AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence.

PubMed ID: 34471287

DOI: 10.1038/s41586-021-03875-8

PubMed ID: 35705808

Title: Caspase-7 activates ASM to repair gasdermin and perforin pores.

PubMed ID: 35705808

DOI: 10.1038/s41586-022-04825-8

Sequence Information:

Length: 402
Mass: 45640
Checksum: 3BEBCEFA67C69B03
Sequence:

MADKILRAKR KQFINSVSIG TINGLLDELL EKRVLNQEEM DKIKLANITA MDKARDLCDH 
VSKKGPQASQ IFITYICNED CYLAGILELQ SAPSAETFVA TEDSKGGHPS SSETKEEQNK 
EDGTFPGLTG TLKFCPLEKA QKLWKENPSE IYPIMNTTTR TRLALIICNT EFQHLSPRVG 
AQVDLREMKL LLEDLGYTVK VKENLTALEM VKEVKEFAAC PEHKTSDSTF LVFMSHGIQE 
GICGTTYSNE VSDILKVDTI FQMMNTLKCP SLKDKPKVII IQACRGEKQG VVLLKDSVRD 
SEEDFLTDAI FEDDGIKKAH IEKDFIAFCS STPDNVSWRH PVRGSLFIES LIKHMKEYAW 
SCDLEDIFRK VRFSFEQPEF RLQMPTADRV TLTKRFYLFP GH

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Casp1

Associated with

Other Information

Molecular cloning of the murine IL-1 beta converting enzyme cDNA. PubMed ID: 1431103

Interleukin 1 beta (IL-1 beta) processing in murine macrophages requires a structurally conserved homologue of human IL-1 beta converting enzyme. PubMed ID: 8446594

The structure and complete nucleotide sequence of the murine gene encoding interleukin-1 beta converting enzyme (ICE). PubMed ID: 8034321

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Characterization of seven murine caspase family members. PubMed ID: 9038361

Targeted peptidecentric proteomics reveals caspase-7 as a substrate of the caspase-1 inflammasomes. PubMed ID: 18667412

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Differential requirement for Caspase-1 autoproteolysis in pathogen-induced cell death and cytokine processing. PubMed ID: 21147462

Inflammasome-activated caspase 7 cleaves PARP1 to enhance the expression of a subset of NF-kappaB target genes. PubMed ID: 22464733

Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. PubMed ID: 24129315

Inflammasome activation triggers caspase-1-mediated cleavage of cGAS to regulate responses to DNA virus infection. PubMed ID: 28314590

SERPINB1-mediated checkpoint of inflammatory caspase activation. PubMed ID: 30692621

Structural mechanism for GSDMD targeting by autoprocessed caspases in pyroptosis. PubMed ID: 32109412

AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence. PubMed ID: 34471287

Caspase-7 activates ASM to repair gasdermin and perforin pores. PubMed ID: 35705808