Genular: Defining Cellular Identity and Function

Details for: Casp4

Gene ID: 12363

Symbol: Casp4

Ensembl ID: ENSMUSG00000033538

Description: caspase 4, apoptosis-related cysteine peptidase

Associated with

Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Nod1/2 signaling pathway
(R-MMU-168638)
Nucleotide-binding domain, leucine rich repeat containing receptor (nlr) signaling pathways
(R-MMU-168643)
Regulated necrosis
(R-MMU-5218859)
Actin filament organization
(GO:0007015)
Apoptotic process
(GO:0006915)
Canonical inflammasome complex
(GO:0061702)
Card domain binding
(GO:0050700)
Cysteine-type endopeptidase activity
(GO:0004197)
Cysteine-type endopeptidase activity involved in apoptotic process
(GO:0097153)
Cysteine-type peptidase activity
(GO:0008234)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Defense response to bacterium
(GO:0042742)
Defense response to gram-positive bacterium
(GO:0050830)
Detection of lipopolysaccharide
(GO:0032497)
Ectopic germ cell programmed cell death
(GO:0035234)
Endoplasmic reticulum
(GO:0005783)
Extracellular region
(GO:0005576)
Hydrolase activity
(GO:0016787)
Immune system process
(GO:0002376)
Inflammatory response
(GO:0006954)
Innate immune response
(GO:0045087)
Interleukin-1 beta production
(GO:0032611)
Lipid binding
(GO:0008289)
Lipopolysaccharide binding
(GO:0001530)
Macrophage cytokine production
(GO:0010934)
Membrane
(GO:0016020)
Mitochondrion
(GO:0005739)
Neuronal cell body
(GO:0043025)
Nlrp1 inflammasome complex
(GO:0072558)
Non-canonical inflammasome complex
(GO:0160074)
Non-canonical inflammasome complex assembly
(GO:0160075)
Peptidase activity
(GO:0008233)
Plasma membrane
(GO:0005886)
Positive regulation of inflammatory response
(GO:0050729)
Positive regulation of interleukin-1 beta production
(GO:0032731)
Positive regulation of interleukin-18-mediated signaling pathway
(GO:2000494)
Positive regulation of macrophage cytokine production
(GO:0060907)
Positive regulation of neuron apoptotic process
(GO:0043525)
Positive regulation of nlrp3 inflammasome complex assembly
(GO:1900227)
Programmed cell death
(GO:0012501)
Protein-containing complex
(GO:0032991)
Protein autoprocessing
(GO:0016540)
Protein binding
(GO:0005515)
Protein maturation
(GO:0051604)
Proteolysis
(GO:0006508)
Pyroptosis
(GO:0070269)
Regulation of apoptotic process
(GO:0042981)
Regulation of inflammatory response
(GO:0050727)
Scaffold protein binding
(GO:0097110)

Other Information

Proteins

CASP4_MOUSE

Genular Protein ID: 3394585807

Symbol: CASP4_MOUSE

Name: N/A

UniProtKB Accession Codes:

P70343 C6L648 O08735 Q3TAF3 Q6P8H1

Database IDs:

Citations:

PubMed ID: 8702803

Title: Identification and characterization of Ich-3, a member of the interleukin-1beta converting enzyme (ICE)/Ced-3 family and an upstream regulator of ICE.

PubMed ID: 8702803

DOI: 10.1074/jbc.271.34.20580

PubMed ID: 9038361

Title: Characterization of seven murine caspase family members.

PubMed ID: 9038361

DOI: 10.1016/s0014-5793(97)00026-4

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10986288

Title: Expression analysis of the human caspase-1 subfamily reveals specific regulation of the CASP5 gene by lipopolysaccharide and interferon-gamma.

PubMed ID: 10986288

DOI: 10.1074/jbc.m007255200

PubMed ID: 16670335

Title: C/EBP homologous protein (CHOP) is crucial for the induction of caspase-11 and the pathogenesis of lipopolysaccharide-induced inflammation.

PubMed ID: 16670335

DOI: 10.4049/jimmunol.176.10.6245

PubMed ID: 22002608

Title: Non-canonical inflammasome activation targets caspase-11.

PubMed ID: 22002608

DOI: 10.1038/nature10558

PubMed ID: 22895188

Title: Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1.

PubMed ID: 22895188

DOI: 10.1038/nature11419

PubMed ID: 23348507

Title: Caspase-11 protects against bacteria that escape the vacuole.

PubMed ID: 23348507

DOI: 10.1126/science.1230751

PubMed ID: 23887873

Title: Noncanonical inflammasome activation by intracellular LPS independent of TLR4.

PubMed ID: 23887873

DOI: 10.1126/science.1240248

PubMed ID: 24031018

Title: Cytoplasmic LPS activates caspase-11: implications in TLR4-independent endotoxic shock.

PubMed ID: 24031018

DOI: 10.1126/science.1240988

PubMed ID: 25121752

Title: Noncanonical inflammasome activation of caspase-4/caspase-11 mediates epithelial defenses against enteric bacterial pathogens.

PubMed ID: 25121752

DOI: 10.1016/j.chom.2014.07.002

PubMed ID: 25119034

Title: Inflammatory caspases are innate immune receptors for intracellular LPS.

PubMed ID: 25119034

DOI: 10.1038/nature13683

PubMed ID: 26173909

Title: Caspase-11 activates a canonical NLRP3 inflammasome by promoting K(+) efflux.

PubMed ID: 26173909

DOI: 10.1002/eji.201545772

PubMed ID: 26320999

Title: Canonical inflammasomes drive IFN-gamma to prime caspase-11 in defense against a cytosol-invasive bacterium.

PubMed ID: 26320999

DOI: 10.1016/j.chom.2015.07.016

PubMed ID: 26375003

Title: Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death.

PubMed ID: 26375003

DOI: 10.1038/nature15514

PubMed ID: 26375259

Title: Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling.

PubMed ID: 26375259

DOI: 10.1038/nature15541

PubMed ID: 27103670

Title: An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells.

PubMed ID: 27103670

DOI: 10.1126/science.aaf3036

PubMed ID: 28314590

Title: Inflammasome activation triggers caspase-1-mediated cleavage of cGAS to regulate responses to DNA virus infection.

PubMed ID: 28314590

DOI: 10.1016/j.immuni.2017.02.011

PubMed ID: 30392956

Title: The NLRP6 inflammasome recognizes lipoteichoic acid and regulates Gram-positive pathogen infection.

PubMed ID: 30392956

DOI: 10.1016/j.cell.2018.09.047

PubMed ID: 30135078

Title: Caspase-11 auto-proteolysis is crucial for noncanonical inflammasome activation.

PubMed ID: 30135078

DOI: 10.1084/jem.20180589

PubMed ID: 29520027

Title: The oxidized phospholipid oxPAPC protects from septic shock by targeting the non-canonical inflammasome in macrophages.

PubMed ID: 29520027

DOI: 10.1038/s41467-018-03409-3

PubMed ID: 30589883

Title: Guanylate-binding protein 5 licenses caspase-11 for Gasdermin-D mediated host resistance to Brucella abortus infection.

PubMed ID: 30589883

DOI: 10.1371/journal.ppat.1007519

PubMed ID: 30692621

Title: SERPINB1-mediated checkpoint of inflammatory caspase activation.

PubMed ID: 30692621

DOI: 10.1038/s41590-018-0303-z

PubMed ID: 32554464

Title: Extended subsite profiling of the pyroptosis effector protein gasdermin D reveals a region recognized by inflammatory caspase-11.

PubMed ID: 32554464

DOI: 10.1074/jbc.ra120.014259

PubMed ID: 34671164

Title: Shigella evades pyroptosis by arginine ADP-riboxanation of caspase-11.

PubMed ID: 34671164

DOI: 10.1038/s41586-021-04020-1

PubMed ID: 37001519

Title: The orphan receptor Nur77 binds cytoplasmic LPS to activate the non-canonical NLRP3 inflammasome.

PubMed ID: 37001519

DOI: 10.1016/j.immuni.2023.03.003

PubMed ID: 32109412

Title: Structural mechanism for GSDMD targeting by autoprocessed caspases in pyroptosis.

PubMed ID: 32109412

DOI: 10.1016/j.cell.2020.02.002

Sequence Information:

Length: 373
Mass: 42742
Checksum: 110D7AA75E71C2B3
Sequence:

MAENKHPDKP LKVLEQLGKE VLTEYLEKLV QSNVLKLKEE DKQKFNNAER SDKRWVFVDA 
MKKKHSKVGE MLLQTFFSVD PGSHHGEANL EMEEPEESLN TLKLCSPEEF TRLCREKTQE 
IYPIKEANGR TRKALIICNT EFKHLSLRYG ANFDIIGMKG LLEDLGYDVV VKEELTAEGM 
ESEMKDFAAL SEHQTSDSTF LVLMSHGTLH GICGTMHSEK TPDVLQYDTI YQIFNNCHCP 
GLRDKPKVII VQACRGGNSG EMWIRESSKP QLCRGVDLPR NMEADAVKLS HVEKDFIAFY 
STTPHHLSYR DKTGGSYFIT RLISCFRKHA CSCHLFDIFL KVQQSFEKAS IHSQMPTIDR 
ATLTRYFYLF PGN

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Casp4

Associated with

Other Information

Identification and characterization of Ich-3, a member of the interleukin-1beta converting enzyme (ICE)/Ced-3 family and an upstream regulator of ICE. PubMed ID: 8702803

Characterization of seven murine caspase family members. PubMed ID: 9038361

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Expression analysis of the human caspase-1 subfamily reveals specific regulation of the CASP5 gene by lipopolysaccharide and interferon-gamma. PubMed ID: 10986288

C/EBP homologous protein (CHOP) is crucial for the induction of caspase-11 and the pathogenesis of lipopolysaccharide-induced inflammation. PubMed ID: 16670335

Non-canonical inflammasome activation targets caspase-11. PubMed ID: 22002608

Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1. PubMed ID: 22895188

Caspase-11 protects against bacteria that escape the vacuole. PubMed ID: 23348507

Noncanonical inflammasome activation by intracellular LPS independent of TLR4. PubMed ID: 23887873

Cytoplasmic LPS activates caspase-11: implications in TLR4-independent endotoxic shock. PubMed ID: 24031018

Noncanonical inflammasome activation of caspase-4/caspase-11 mediates epithelial defenses against enteric bacterial pathogens. PubMed ID: 25121752

Inflammatory caspases are innate immune receptors for intracellular LPS. PubMed ID: 25119034

Caspase-11 activates a canonical NLRP3 inflammasome by promoting K(+) efflux. PubMed ID: 26173909

Canonical inflammasomes drive IFN-gamma to prime caspase-11 in defense against a cytosol-invasive bacterium. PubMed ID: 26320999

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. PubMed ID: 26375003

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling. PubMed ID: 26375259

An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells. PubMed ID: 27103670

Inflammasome activation triggers caspase-1-mediated cleavage of cGAS to regulate responses to DNA virus infection. PubMed ID: 28314590

The NLRP6 inflammasome recognizes lipoteichoic acid and regulates Gram-positive pathogen infection. PubMed ID: 30392956

Caspase-11 auto-proteolysis is crucial for noncanonical inflammasome activation. PubMed ID: 30135078

The oxidized phospholipid oxPAPC protects from septic shock by targeting the non-canonical inflammasome in macrophages. PubMed ID: 29520027

Guanylate-binding protein 5 licenses caspase-11 for Gasdermin-D mediated host resistance to Brucella abortus infection. PubMed ID: 30589883

SERPINB1-mediated checkpoint of inflammatory caspase activation. PubMed ID: 30692621

Extended subsite profiling of the pyroptosis effector protein gasdermin D reveals a region recognized by inflammatory caspase-11. PubMed ID: 32554464

Shigella evades pyroptosis by arginine ADP-riboxanation of caspase-11. PubMed ID: 34671164

The orphan receptor Nur77 binds cytoplasmic LPS to activate the non-canonical NLRP3 inflammasome. PubMed ID: 37001519

Structural mechanism for GSDMD targeting by autoprocessed caspases in pyroptosis. PubMed ID: 32109412