Genular: Defining Cellular Identity and Function

Details for: Casp2

Gene ID: 12366

Symbol: Casp2

Ensembl ID: ENSMUSG00000029863

Description: caspase 2

Associated with

Cell death signalling via nrage, nrif and nade
(R-MMU-204998)
Death receptor signaling
(R-MMU-73887)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Nade modulates death signalling
(R-MMU-205025)
Nod1/2 signaling pathway
(R-MMU-168638)
Nucleotide-binding domain, leucine rich repeat containing receptor (nlr) signaling pathways
(R-MMU-168643)
P75 ntr receptor-mediated signalling
(R-MMU-193704)
Rna polymerase ii transcription
(R-MMU-73857)
Signal transduction
(R-MMU-162582)
Tp53 regulates transcription of caspase activators and caspases
(R-MMU-6803207)
Tp53 regulates transcription of cell death genes
(R-MMU-5633008)
Transcriptional regulation by tp53
(R-MMU-3700989)
Activation of cysteine-type endopeptidase activity involved in apoptotic process
(GO:0006919)
Apoptotic process
(GO:0006915)
Apoptotic signaling pathway
(GO:0097190)
Cysteine-type endopeptidase activity
(GO:0004197)
Cysteine-type endopeptidase activity involved in apoptotic process
(GO:0097153)
Cysteine-type endopeptidase activity involved in apoptotic signaling pathway
(GO:0097199)
Cysteine-type endopeptidase activity involved in execution phase of apoptosis
(GO:0097200)
Cysteine-type peptidase activity
(GO:0008234)
Cytoplasm
(GO:0005737)
Dna damage response
(GO:0006974)
Dna damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
(GO:0006977)
Ectopic germ cell programmed cell death
(GO:0035234)
Endopeptidase complex
(GO:1905369)
Extrinsic apoptotic signaling pathway in absence of ligand
(GO:0097192)
Hydrolase activity
(GO:0016787)
Identical protein binding
(GO:0042802)
Intrinsic apoptotic signaling pathway in response to dna damage
(GO:0008630)
Negative regulation of apoptotic process
(GO:0043066)
Nucleolus
(GO:0005730)
Nucleus
(GO:0005634)
Peptidase activity
(GO:0008233)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of apoptotic signaling pathway
(GO:2001235)
Positive regulation of neuron apoptotic process
(GO:0043525)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Protein processing
(GO:0016485)
Proteolysis
(GO:0006508)
Regulation of apoptotic process
(GO:0042981)

Other Information

Proteins

Caspase-2

Genular Protein ID: 3702549067

Symbol: CASP2_MOUSE

Name: Caspase-2

UniProtKB Accession Codes:

P29594 O08737 Q3TCM0 Q8C9H7 Q8K241

Database IDs:

Citations:

PubMed ID: 7958843

Title: Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 beta-converting enzyme.

PubMed ID: 7958843

DOI: 10.1101/gad.8.14.1613

PubMed ID: 9038361

Title: Characterization of seven murine caspase family members.

PubMed ID: 9038361

DOI: 10.1016/s0014-5793(97)00026-4

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1378265

Title: Identification of a set of genes with developmentally down-regulated expression in the mouse brain.

PubMed ID: 1378265

DOI: 10.1016/0006-291x(92)91747-e

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 452
Mass: 50661
Checksum: A4DE25A712FAB855
Sequence:

MAAPSGRSQS SLHRKGLMAA DRRSRILAVC GMHPDHQETL KKNRVVLAKQ LLLSELLEHL 
LEKDIITLEM RELIQAKGGS FSQNVELLNL LPKRGPQAFD AFCEALRETR QGHLEDLLLT 
TLSDIQHVLP PLSCDYDTSL PFSVCESCPP HKQLRLSTDA TEHSLDNGDG PPCLLVKPCT 
PEFYQAHYQL AYRLQSQPRG LALVLSNVHF TGEKDLEFRS GGDVDHTTLV TLFKLLGYNV 
HVLHDQTAQE MQEKLQNFAQ LPAHRVTDSC VVALLSHGVE GGIYGVDGKL LQLQEVFRLF 
DNANCPSLQN KPKMFFIQAC RGDETDRGVD QQDGKNHTQS PGCEESDAGK EELMKMRLPT 
RSDMICGYAC LKGNAAMRNT KRGSWYIEAL TQVFSERACD MHVADMLVKV NALIKEREGY 
APGTEFHRCK EMSEYCSTLC QQLYLFPGYP PT

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Casp2

Associated with

Other Information

Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 beta-converting enzyme. PubMed ID: 7958843

Characterization of seven murine caspase family members. PubMed ID: 9038361

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification of a set of genes with developmentally down-regulated expression in the mouse brain. PubMed ID: 1378265