Genular: Defining Cellular Identity and Function

Details for: Casp3

Gene ID: 12367

Symbol: Casp3

Ensembl ID: ENSMUSG00000031628

Description: caspase 3

Associated with

Activation of caspases through apoptosome-mediated cleavage
(R-MMU-111459)
Apoptosis
(R-MMU-109581)
Apoptosis induced dna fragmentation
(R-MMU-140342)
Apoptotic cleavage of cell adhesion proteins
(R-MMU-351906)
Apoptotic cleavage of cellular proteins
(R-MMU-111465)
Apoptotic execution phase
(R-MMU-75153)
Apoptotic factor-mediated response
(R-MMU-111471)
Caspase-mediated cleavage of cytoskeletal proteins
(R-MMU-264870)
Caspase activation via dependence receptors in the absence of ligand
(R-MMU-418889)
Caspase activation via extrinsic apoptotic signalling pathway
(R-MMU-5357769)
Cell death signalling via nrage, nrif and nade
(R-MMU-204998)
Cytochrome c-mediated apoptotic response
(R-MMU-111461)
Cytokine signaling in immune system
(R-MMU-1280215)
Death receptor signaling
(R-MMU-73887)
Immune system
(R-MMU-168256)
Intrinsic pathway for apoptosis
(R-MMU-109606)
Nade modulates death signalling
(R-MMU-205025)
Other interleukin signaling
(R-MMU-449836)
P75 ntr receptor-mediated signalling
(R-MMU-193704)
Programmed cell death
(R-MMU-5357801)
Regulated necrosis
(R-MMU-5218859)
Signaling by hippo
(R-MMU-2028269)
Signaling by interleukins
(R-MMU-449147)
Signal transduction
(R-MMU-162582)
Smac, xiap-regulated apoptotic response
(R-MMU-111469)
Anterior neural tube closure
(GO:0061713)
Apoptotic process
(GO:0006915)
Aspartic-type endopeptidase activity
(GO:0004190)
Axonal fasciculation
(GO:0007413)
B cell homeostasis
(GO:0001782)
Cell fate commitment
(GO:0045165)
Cellular response to organic substance
(GO:0071310)
Cellular response to staurosporine
(GO:0072734)
Cyclin-dependent protein serine/threonine kinase inhibitor activity
(GO:0004861)
Cysteine-type endopeptidase activity
(GO:0004197)
Cysteine-type endopeptidase activity involved in apoptotic process
(GO:0097153)
Cysteine-type endopeptidase activity involved in apoptotic signaling pathway
(GO:0097199)
Cysteine-type endopeptidase activity involved in execution phase of apoptosis
(GO:0097200)
Cysteine-type peptidase activity
(GO:0008234)
Death receptor binding
(GO:0005123)
Dna damage response
(GO:0006974)
Endopeptidase activity
(GO:0004175)
Enzyme activator activity
(GO:0008047)
Erythrocyte differentiation
(GO:0030218)
Execution phase of apoptosis
(GO:0097194)
Fibroblast apoptotic process
(GO:0044346)
Glial cell apoptotic process
(GO:0034349)
Heart development
(GO:0007507)
Hydrolase activity
(GO:0016787)
Intracellular signal transduction
(GO:0035556)
Intrinsic apoptotic signaling pathway
(GO:0097193)
Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
(GO:0070059)
Intrinsic apoptotic signaling pathway in response to osmotic stress
(GO:0008627)
Keratinocyte differentiation
(GO:0030216)
Learning or memory
(GO:0007611)
Negative regulation of activated t cell proliferation
(GO:0046007)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of b cell proliferation
(GO:0030889)
Negative regulation of cell cycle
(GO:0045786)
Negative regulation of cyclin-dependent protein serine/threonine kinase activity
(GO:0045736)
Negative regulation of cytokine production
(GO:0001818)
Neuron apoptotic process
(GO:0051402)
Neuron differentiation
(GO:0030182)
Neurotrophin trk receptor signaling pathway
(GO:0048011)
Peptidase activity
(GO:0008233)
Phospholipase a2 activator activity
(GO:0016005)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of neuron apoptotic process
(GO:0043525)
Protease binding
(GO:0002020)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein catabolic process
(GO:0030163)
Protein maturation
(GO:0051604)
Protein processing
(GO:0016485)
Proteolysis
(GO:0006508)
Pyroptosis
(GO:0070269)
Regulation of protein stability
(GO:0031647)
Response to glucose
(GO:0009749)
Response to hydrogen peroxide
(GO:0042542)
Response to organic substance
(GO:0010033)
Response to uv
(GO:0009411)
Response to wounding
(GO:0009611)
Sensory perception of sound
(GO:0007605)
T cell homeostasis
(GO:0043029)

Other Information

Proteins

Caspase-3

Genular Protein ID: 360897847

Symbol: CASP3_MOUSE

Name: Caspase-3

UniProtKB Accession Codes:

P70677 O08668 Q8CHV5 Q9QWI4

Database IDs:

Citations:

PubMed ID: 8761296

Title: Molecular characterization of mouse and rat CPP32 beta gene encoding a cysteine protease resembling interleukin-1 beta converting enzyme and CED-3.

PubMed ID: 8761296

PubMed ID: 9070890

Title: Specific expression of CPP32 in sensory neurons of mouse embryos and activation of CPP32 in the apoptosis induced by a withdrawal of NGF.

PubMed ID: 9070890

DOI: 10.1006/bbrc.1996.6002

PubMed ID: 9038361

Title: Characterization of seven murine caspase family members.

PubMed ID: 9038361

DOI: 10.1016/s0014-5793(97)00026-4

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8934524

Title: Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice.

PubMed ID: 8934524

DOI: 10.1038/384368a0

PubMed ID: 12124386

Title: The role of Asp-462 in regulating Akt activity.

PubMed ID: 12124386

DOI: 10.1074/jbc.m203805200

PubMed ID: 15345747

Title: Phosphoproteomic analysis of the developing mouse brain.

PubMed ID: 15345747

DOI: 10.1074/mcp.m400085-mcp200

PubMed ID: 16469926

Title: Caspases 3 and 7: key mediators of mitochondrial events of apoptosis.

PubMed ID: 16469926

DOI: 10.1126/science.1115035

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

PubMed ID: 25231987

Title: Exposure of phosphatidylserine by Xk-related protein family members during apoptosis.

PubMed ID: 25231987

DOI: 10.1074/jbc.m114.583419

PubMed ID: 30878284

Title: Apoptotic caspases suppress type i interferon production via the cleavage of cGAS, MAVS, and IRF3.

PubMed ID: 30878284

DOI: 10.1016/j.molcel.2019.02.013

PubMed ID: 33725486

Title: Caspase cleavage releases a nuclear protein fragment that stimulates phospholipid scrambling at the plasma membrane.

PubMed ID: 33725486

DOI: 10.1016/j.molcel.2021.02.025

Sequence Information:

Length: 277
Mass: 31475
Checksum: CE91598F74826605
Sequence:

MENNKTSVDS KSINNFEVKT IHGSKSVDSG IYLDSSYKMD YPEMGICIII NNKNFHKSTG 
MSSRSGTDVD AANLRETFMG LKYQVRNKND LTREDILELM DSVSKEDHSK RSSFVCVILS 
HGDEGVIYGT NGPVELKKLT SFFRGDYCRS LTGKPKLFII QACRGTELDC GIETDSGTDE 
EMACQKIPVE ADFLYAYSTA PGYYSWRNSK DGSWFIQSLC SMLKLYAHKL EFMHILTRVN 
RKVATEFESF SLDSTFHAKK QIPCIVSMLT KELYFYH

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Casp3

Associated with

Other Information

Molecular characterization of mouse and rat CPP32 beta gene encoding a cysteine protease resembling interleukin-1 beta converting enzyme and CED-3. PubMed ID: 8761296

Specific expression of CPP32 in sensory neurons of mouse embryos and activation of CPP32 in the apoptosis induced by a withdrawal of NGF. PubMed ID: 9070890

Characterization of seven murine caspase family members. PubMed ID: 9038361

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice. PubMed ID: 8934524

The role of Asp-462 in regulating Akt activity. PubMed ID: 12124386

Phosphoproteomic analysis of the developing mouse brain. PubMed ID: 15345747

Caspases 3 and 7: key mediators of mitochondrial events of apoptosis. PubMed ID: 16469926

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. PubMed ID: 23806337

Exposure of phosphatidylserine by Xk-related protein family members during apoptosis. PubMed ID: 25231987

Apoptotic caspases suppress type i interferon production via the cleavage of cGAS, MAVS, and IRF3. PubMed ID: 30878284

Caspase cleavage releases a nuclear protein fragment that stimulates phospholipid scrambling at the plasma membrane. PubMed ID: 33725486