Genular: Defining Cellular Identity and Function

Details for: Casp6

Gene ID: 12368

Symbol: Casp6

Ensembl ID: ENSMUSG00000027997

Description: caspase 6

Associated with

Apoptosis
(R-MMU-109581)
Apoptotic cleavage of cellular proteins
(R-MMU-111465)
Apoptotic execution phase
(R-MMU-75153)
Breakdown of the nuclear lamina
(R-MMU-352238)
Caspase-mediated cleavage of cytoskeletal proteins
(R-MMU-264870)
Programmed cell death
(R-MMU-5357801)
Activation of innate immune response
(GO:0002218)
Acute inflammatory response to non-antigenic stimulus
(GO:0002525)
Apoptotic process
(GO:0006915)
Axon
(GO:0030424)
Axonal fasciculation
(GO:0007413)
Cellular response to staurosporine
(GO:0072734)
Cysteine-type endopeptidase activity
(GO:0004197)
Cysteine-type endopeptidase activity involved in apoptotic process
(GO:0097153)
Cysteine-type endopeptidase activity involved in execution phase of apoptosis
(GO:0097200)
Cysteine-type peptidase activity
(GO:0008234)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Endopeptidase activity
(GO:0004175)
Hepatocyte apoptotic process
(GO:0097284)
Hydrolase activity
(GO:0016787)
Identical protein binding
(GO:0042802)
Intrinsic apoptotic signaling pathway by p53 class mediator
(GO:0072332)
Neuronal cell body
(GO:0043025)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Peptidase activity
(GO:0008233)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of necroptotic process
(GO:0060545)
Positive regulation of neuron apoptotic process
(GO:0043525)
Positive regulation of retinal cell programmed cell death
(GO:0046670)
Protein autoprocessing
(GO:0016540)
Protein binding
(GO:0005515)
Proteolysis
(GO:0006508)
Pyroptosis
(GO:0070269)
Regulation of apoptotic process
(GO:0042981)
Regulation of programmed cell death
(GO:0043067)
Response to cytokine
(GO:0034097)
Response to glucose
(GO:0009749)
Response to hydrogen peroxide
(GO:0042542)
Response to iron ion
(GO:0010039)

Other Information

Proteins

CASP6_MOUSE

Genular Protein ID: 1705181408

Symbol: CASP6_MOUSE

Name: N/A

UniProtKB Accession Codes:

O08738

Database IDs:

Citations:

PubMed ID: 9038361

Title: Characterization of seven murine caspase family members.

PubMed ID: 9038361

DOI: 10.1016/s0014-5793(97)00026-4

PubMed ID: 11062535

Title: Deficiency in caspase-9 or caspase-3 induces compensatory caspase activation.

PubMed ID: 11062535

DOI: 10.1038/81343

PubMed ID: 18981099

Title: Caspase 6 regulates B cell activation and differentiation into plasma cells.

PubMed ID: 18981099

DOI: 10.4049/jimmunol.181.10.6810

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 22555455

Title: The caspase 6 derived N-terminal fragment of DJ-1 promotes apoptosis via increased ROS production.

PubMed ID: 22555455

DOI: 10.1038/cdd.2012.55

PubMed ID: 23695670

Title: Distinct pathways mediate axon degeneration during apoptosis and axon-specific pruning.

PubMed ID: 23695670

DOI: 10.1038/ncomms2910

PubMed ID: 25231987

Title: Exposure of phosphatidylserine by Xk-related protein family members during apoptosis.

PubMed ID: 25231987

DOI: 10.1074/jbc.m114.583419

PubMed ID: 29863787

Title: Regulation of B-lineage cells by caspase 6.

PubMed ID: 29863787

DOI: 10.1111/imcb.12172

PubMed ID: 32298652

Title: Caspase-6 is a key regulator of innate immunity, inflammasome activation, and host defense.

PubMed ID: 32298652

DOI: 10.1016/j.cell.2020.03.040

PubMed ID: 32029622

Title: An AMPK-caspase-6 axis controls liver damage in nonalcoholic steatohepatitis.

PubMed ID: 32029622

DOI: 10.1126/science.aay0542

PubMed ID: 35922005

Title: Coronaviruses exploit a host cysteine-aspartic protease for replication.

PubMed ID: 35922005

DOI: 10.1038/s41586-022-05148-4

Sequence Information:

Length: 276
Mass: 31595
Checksum: 5965DE9321126B6C
Sequence:

MTETDGFYKS REVFDPAEQY KMDHKRRGVA LIFNHERFFW HLTLPERRGT NADRDNLTRR 
FSDLGFEVKC FNDLRAEELL LKIHEVSTSS HIDADCFICV FLSHGEGNHV YAYDAKIEIQ 
TLTGLFKGDK CQSLVGKPKI FIIQACRGSQ HDVPVVPLDM VDHQTDKLDN VTQVDAASVY 
TLPAGADFLM CYSVAEGYYS HRETVNGSWY IQDLCEMLAR YGSSLEFTEL LTLVNRKVSQ 
RRVDFCKDPD AIGKKQVPCF ASMLTKKLHF CPKPSK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Casp6

Associated with

Other Information

Characterization of seven murine caspase family members. PubMed ID: 9038361

Deficiency in caspase-9 or caspase-3 induces compensatory caspase activation. PubMed ID: 11062535

Caspase 6 regulates B cell activation and differentiation into plasma cells. PubMed ID: 18981099

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

The caspase 6 derived N-terminal fragment of DJ-1 promotes apoptosis via increased ROS production. PubMed ID: 22555455

Distinct pathways mediate axon degeneration during apoptosis and axon-specific pruning. PubMed ID: 23695670

Exposure of phosphatidylserine by Xk-related protein family members during apoptosis. PubMed ID: 25231987

Regulation of B-lineage cells by caspase 6. PubMed ID: 29863787

Caspase-6 is a key regulator of innate immunity, inflammasome activation, and host defense. PubMed ID: 32298652

An AMPK-caspase-6 axis controls liver damage in nonalcoholic steatohepatitis. PubMed ID: 32029622

Coronaviruses exploit a host cysteine-aspartic protease for replication. PubMed ID: 35922005