Genular: Defining Cellular Identity and Function

Details for: Casp7

Gene ID: 12369

Symbol: Casp7

Ensembl ID: ENSMUSG00000025076

Description: caspase 7

Associated with

Activation of caspases through apoptosome-mediated cleavage
(R-MMU-111459)
Apoptosis
(R-MMU-109581)
Apoptotic cleavage of cellular proteins
(R-MMU-111465)
Apoptotic execution phase
(R-MMU-75153)
Apoptotic factor-mediated response
(R-MMU-111471)
Caspase-mediated cleavage of cytoskeletal proteins
(R-MMU-264870)
Cytochrome c-mediated apoptotic response
(R-MMU-111461)
Intrinsic pathway for apoptosis
(R-MMU-109606)
Programmed cell death
(R-MMU-5357801)
Smac(diablo)-mediated dissociation of iap:caspase complexes
(R-MMU-111464)
Smac (diablo) binds to iaps
(R-MMU-111463)
Smac, xiap-regulated apoptotic response
(R-MMU-111469)
Apoptotic process
(GO:0006915)
Aspartic-type endopeptidase activity
(GO:0004190)
Catalytic activity
(GO:0003824)
Cellular response to lipopolysaccharide
(GO:0071222)
Cellular response to staurosporine
(GO:0072734)
Cysteine-type endopeptidase activity
(GO:0004197)
Cysteine-type endopeptidase activity involved in apoptotic process
(GO:0097153)
Cysteine-type endopeptidase activity involved in execution phase of apoptosis
(GO:0097200)
Cysteine-type peptidase activity
(GO:0008234)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Defense response to bacterium
(GO:0042742)
Execution phase of apoptosis
(GO:0097194)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Fibroblast apoptotic process
(GO:0044346)
Heart development
(GO:0007507)
Hydrolase activity
(GO:0016787)
Lymphocyte apoptotic process
(GO:0070227)
Metabolic process
(GO:0008152)
Neuron apoptotic process
(GO:0051402)
Nucleus
(GO:0005634)
Peptidase activity
(GO:0008233)
Positive regulation of neuron apoptotic process
(GO:0043525)
Positive regulation of plasma membrane repair
(GO:1905686)
Protein binding
(GO:0005515)
Protein catabolic process
(GO:0030163)
Protein maturation
(GO:0051604)
Protein processing
(GO:0016485)
Proteolysis
(GO:0006508)
Response to uv
(GO:0009411)
Rna binding
(GO:0003723)

Other Information

Proteins

Apoptotic protease Mch-3

Genular Protein ID: 2530091461

Symbol: CASP7_MOUSE

Name: Apoptotic protease Mch-3

UniProtKB Accession Codes:

P97864 O08669

Database IDs:

Citations:

PubMed ID: 9070923

Title: Identification and mapping of Casp7, a cysteine protease resembling CPP32 beta, interleukin-1 beta converting enzyme, and CED-3.

PubMed ID: 9070923

DOI: 10.1006/geno.1996.4548

PubMed ID: 9125129

Title: Wortmannin enhances CPP32-like activity during neuronal differentiation of P19 embryonal carcinoma cells induced by retinoic acid.

PubMed ID: 9125129

DOI: 10.1006/bbrc.1997.6234

PubMed ID: 9038361

Title: Characterization of seven murine caspase family members.

PubMed ID: 9038361

DOI: 10.1016/s0014-5793(97)00026-4

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 16469926

Title: Caspases 3 and 7: key mediators of mitochondrial events of apoptosis.

PubMed ID: 16469926

DOI: 10.1126/science.1115035

PubMed ID: 18667412

Title: Targeted peptidecentric proteomics reveals caspase-7 as a substrate of the caspase-1 inflammasomes.

PubMed ID: 18667412

DOI: 10.1074/mcp.m800132-mcp200

PubMed ID: 19168786

Title: Caspase-7 deficiency protects from endotoxin-induced lymphocyte apoptosis and improves survival.

PubMed ID: 19168786

DOI: 10.1182/blood-2008-09-178038

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 22464733

Title: Inflammasome-activated caspase 7 cleaves PARP1 to enhance the expression of a subset of NF-kappaB target genes.

PubMed ID: 22464733

DOI: 10.1016/j.molcel.2012.02.016

PubMed ID: 22807671

Title: Membrane damage during Listeria monocytogenes infection triggers a caspase-7 dependent cytoprotective response.

PubMed ID: 22807671

DOI: 10.1371/journal.ppat.1002628

PubMed ID: 25231987

Title: Exposure of phosphatidylserine by Xk-related protein family members during apoptosis.

PubMed ID: 25231987

DOI: 10.1074/jbc.m114.583419

PubMed ID: 30878284

Title: Apoptotic caspases suppress type i interferon production via the cleavage of cGAS, MAVS, and IRF3.

PubMed ID: 30878284

DOI: 10.1016/j.molcel.2019.02.013

PubMed ID: 31251782

Title: Gasdermin-D and Caspase-7 are the key Caspase-1/8 substrates downstream of the NAIP5/NLRC4 inflammasome required for restriction of Legionella pneumophila.

PubMed ID: 31251782

DOI: 10.1371/journal.ppat.1007886

PubMed ID: 35705808

Title: Caspase-7 activates ASM to repair gasdermin and perforin pores.

PubMed ID: 35705808

DOI: 10.1038/s41586-022-04825-8

Sequence Information:

Length: 303
Mass: 34061
Checksum: 747787B5BDE5F744
Sequence:

MTDDQDCAAE LEKVDSSSED GVDAKPDRSS IISSILLKKK RNASAGPVRT GRDRVPTYLY 
RMDFQKMGKC IIINNKNFDK ATGMDVRNGT DKDAGALFKC FQNLGFEVTV HNDCSCAKMQ 
DLLRKASEED HSNSACFACV LLSHGEEDLI YGKDGVTPIK DLTAHFRGDR CKTLLEKPKL 
FFIQACRGTE LDDGIQADSG PINDIDANPR NKIPVEADFL FAYSTVPGYY SWRNPGKGSW 
FVQALCSILN EHGKDLEIMQ ILTRVNDRVA RHFESQSDDP RFNEKKQIPC MVSMLTKELY 
FSR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Casp7

Associated with

Other Information

Identification and mapping of Casp7, a cysteine protease resembling CPP32 beta, interleukin-1 beta converting enzyme, and CED-3. PubMed ID: 9070923

Wortmannin enhances CPP32-like activity during neuronal differentiation of P19 embryonal carcinoma cells induced by retinoic acid. PubMed ID: 9125129

Characterization of seven murine caspase family members. PubMed ID: 9038361

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

Caspases 3 and 7: key mediators of mitochondrial events of apoptosis. PubMed ID: 16469926

Targeted peptidecentric proteomics reveals caspase-7 as a substrate of the caspase-1 inflammasomes. PubMed ID: 18667412

Caspase-7 deficiency protects from endotoxin-induced lymphocyte apoptosis and improves survival. PubMed ID: 19168786

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Inflammasome-activated caspase 7 cleaves PARP1 to enhance the expression of a subset of NF-kappaB target genes. PubMed ID: 22464733

Membrane damage during Listeria monocytogenes infection triggers a caspase-7 dependent cytoprotective response. PubMed ID: 22807671

Exposure of phosphatidylserine by Xk-related protein family members during apoptosis. PubMed ID: 25231987

Apoptotic caspases suppress type i interferon production via the cleavage of cGAS, MAVS, and IRF3. PubMed ID: 30878284

Gasdermin-D and Caspase-7 are the key Caspase-1/8 substrates downstream of the NAIP5/NLRC4 inflammasome required for restriction of Legionella pneumophila. PubMed ID: 31251782

Caspase-7 activates ASM to repair gasdermin and perforin pores. PubMed ID: 35705808