Details for: CCR8

Gene ID: 1237

Symbol: CCR8

Ensembl ID: ENSG00000179934

Description: C-C motif chemokine receptor 8

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.3140
    Cell Significance Index: 2.8400
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.2879
    Cell Significance Index: 2.5900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.1090
    Cell Significance Index: 3.2000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0396
    Cell Significance Index: 0.4100
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0360
    Cell Significance Index: 0.4600
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.0171
    Cell Significance Index: 0.1800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0050
    Cell Significance Index: 1.0000
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.0028
    Cell Significance Index: 0.0200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0022
    Cell Significance Index: 0.0600
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.0020
    Cell Significance Index: 0.0200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: 0.0007
    Cell Significance Index: 0.0300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0003
    Cell Significance Index: 0.6000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0003
    Cell Significance Index: -0.4900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0003
    Cell Significance Index: -0.4800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0009
    Cell Significance Index: -1.2100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0014
    Cell Significance Index: -0.0700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0015
    Cell Significance Index: -1.0900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0016
    Cell Significance Index: -1.0400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0020
    Cell Significance Index: -1.1300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0022
    Cell Significance Index: -0.7900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0022
    Cell Significance Index: -0.6300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0027
    Cell Significance Index: -1.2400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0029
    Cell Significance Index: -0.5800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0052
    Cell Significance Index: -0.9400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0062
    Cell Significance Index: -0.8500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0064
    Cell Significance Index: -1.0900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0067
    Cell Significance Index: -0.1700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0069
    Cell Significance Index: -1.0100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0070
    Cell Significance Index: -0.1500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0090
    Cell Significance Index: -0.9200
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.0098
    Cell Significance Index: -0.0300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0099
    Cell Significance Index: -1.1300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0104
    Cell Significance Index: -0.2900
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0132
    Cell Significance Index: -0.1600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0136
    Cell Significance Index: -1.6000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0143
    Cell Significance Index: -0.6500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0154
    Cell Significance Index: -0.7300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0158
    Cell Significance Index: -1.0600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0190
    Cell Significance Index: -0.4600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0190
    Cell Significance Index: -0.6700
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.0195
    Cell Significance Index: -0.1400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0196
    Cell Significance Index: -0.2900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0209
    Cell Significance Index: -1.1700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0215
    Cell Significance Index: -1.1200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0226
    Cell Significance Index: -0.3800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0232
    Cell Significance Index: -0.6100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0236
    Cell Significance Index: -0.5900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0272
    Cell Significance Index: -0.6800
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0277
    Cell Significance Index: -0.3000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0281
    Cell Significance Index: -0.9000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0281
    Cell Significance Index: -0.4900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0292
    Cell Significance Index: -1.2900
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0293
    Cell Significance Index: -0.3900
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0306
    Cell Significance Index: -0.5200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0318
    Cell Significance Index: -1.0400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0322
    Cell Significance Index: -0.8600
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.0332
    Cell Significance Index: -0.5700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0333
    Cell Significance Index: -1.2600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0335
    Cell Significance Index: -1.5600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0348
    Cell Significance Index: -0.6800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0357
    Cell Significance Index: -0.8900
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.0372
    Cell Significance Index: -0.4500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0378
    Cell Significance Index: -1.0800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0378
    Cell Significance Index: -0.4300
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0381
    Cell Significance Index: -0.4500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0383
    Cell Significance Index: -1.2100
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0387
    Cell Significance Index: -0.5500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0391
    Cell Significance Index: -0.5600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0412
    Cell Significance Index: -1.0500
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0421
    Cell Significance Index: -0.6300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0431
    Cell Significance Index: -0.9000
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0440
    Cell Significance Index: -0.6100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0444
    Cell Significance Index: -1.2800
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0445
    Cell Significance Index: -0.7200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0445
    Cell Significance Index: -1.5700
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0452
    Cell Significance Index: -0.5700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0466
    Cell Significance Index: -1.0200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0474
    Cell Significance Index: -1.2100
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0479
    Cell Significance Index: -0.4600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0481
    Cell Significance Index: -1.0200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0486
    Cell Significance Index: -1.0500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0503
    Cell Significance Index: -0.8700
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.0504
    Cell Significance Index: -0.5500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0505
    Cell Significance Index: -1.2100
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0522
    Cell Significance Index: -0.7100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0528
    Cell Significance Index: -1.0600
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0533
    Cell Significance Index: -0.7800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0536
    Cell Significance Index: -1.0600
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0539
    Cell Significance Index: -0.6300
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0544
    Cell Significance Index: -1.0700
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0545
    Cell Significance Index: -0.8800
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0549
    Cell Significance Index: -0.8000
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0552
    Cell Significance Index: -1.1000
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.0557
    Cell Significance Index: -0.6100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0594
    Cell Significance Index: -1.0000
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0597
    Cell Significance Index: -0.8200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0598
    Cell Significance Index: -1.4600
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.0613
    Cell Significance Index: -0.8400
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -0.0616
    Cell Significance Index: -0.4700
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0626
    Cell Significance Index: -0.8100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular Expression:** CCR8 is expressed in a wide range of cell types, including progenitor cells, endothelial cells, goblet cells, and immune cells such as GABAergic interneurons and neoplastic cells. 2. **Chemokine Receptor Activity:** CCR8 is a C-C chemokine receptor that binds to various chemokines, including CCL4 and CCL22, which are involved in immune regulation and inflammation. 3. **Signaling Pathways:** CCR8 activates multiple signaling pathways, including calcium-mediated signaling, cell adhesion, and chemotaxis, which are critical for immune responses and tissue homeostasis. 4. **GPCR Characteristics:** CCR8 exhibits characteristics typical of GPCRs, including ligand-binding, G-protein coupled signaling, and downstream signaling events. **Pathways and Functions:** 1. **Immune Regulation:** CCR8 plays a role in regulating immune responses, including the recruitment of immune cells to sites of inflammation and the modulation of cytokine production. 2. **Chemotaxis:** CCR8 is involved in the chemotaxis of immune cells, including T cells and dendritic cells, which is essential for the initiation of immune responses. 3. **Inflammation:** CCR8 is also involved in the regulation of inflammation, including the recruitment of immune cells to sites of inflammation and the production of pro-inflammatory cytokines. 4. **Cancer Progression:** Recent studies suggest that CCR8 may be involved in the progression of various cancers, including leukemia and lymphoma, by promoting tumor cell migration and invasion. **Clinical Significance:** 1. **Inflammatory Diseases:** CCR8 may play a role in the pathogenesis of inflammatory diseases, including rheumatoid arthritis, multiple sclerosis, and asthma. 2. **Cancer Therapy:** Targeting CCR8 may provide a novel therapeutic strategy for the treatment of various cancers, including leukemia and lymphoma. 3. **Immunotherapy:** CCR8 may also be a target for immunotherapeutic approaches, including checkpoint inhibitors and adoptive T-cell therapy. 4. **Neurological Disorders:** CCR8 has been implicated in the pathogenesis of neurological disorders, including multiple sclerosis and Parkinson's disease, and may be a potential target for therapeutic interventions. In conclusion, CCR8 is a complex chemokine receptor that plays a multifaceted role in immune regulation, inflammation, and potentially, cancer progression. Further research is needed to fully elucidate the functions of CCR8 and to explore its therapeutic potential.

Genular Protein ID: 3531062816

Symbol: CCR8_HUMAN

Name: C-C chemokine receptor type 8

UniProtKB Accession Codes:

P51685 B2RC64 Q3KNQ8 Q3KNR3 Q9BYX5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EMBL 14 EMDB 3 Ensembl 1 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8886020

Title: Molecular cloning and RNA expression of two new human chemokine receptor-like genes.

PubMed ID: 8886020

DOI: 10.1006/bbrc.1996.1595

PubMed ID: 8977299

Title: Molecular cloning and chromosomal mapping of a novel human gene, ChemR1, expressed in T lymphocytes and polymorphonuclear cells and encoding a putative chemokine receptor.

PubMed ID: 8977299

DOI: 10.1002/eji.1830261230

PubMed ID: 9207005

Title: Identification of CCR8: a human monocyte and thymus receptor for the CC chemokine I-309.

PubMed ID: 9207005

DOI: 10.1084/jem.186.1.165

PubMed ID: 8816377

Title: Molecular cloning of TER1, a chemokine receptor-like gene expressed by lymphoid tissues.

PubMed ID: 8816377

PubMed ID: 12551893

Title: Genomic organization and evolution of the CX3CR1/CCR8 chemokine receptor locus.

PubMed ID: 12551893

DOI: 10.1074/jbc.m211422200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9521068

Title: Identification of the CC chemokines TARC and macrophage inflammatory protein-1 beta as novel functional ligands for the CCR8 receptor.

PubMed ID: 9521068

DOI: 10.1002/(sici)1521-4141(199802)28:02<582::aid-immu582>3.0.co;2-a

PubMed ID: 9469461

Title: Identification of CCR8 as the specific receptor for the human beta-chemokine I-309: cloning and molecular characterization of murine CCR8 as the receptor for TCA-3.

PubMed ID: 9469461

PubMed ID: 10540332

Title: The assignment of chemokine-chemokine receptor pairs: TARC and MIP-1 beta are not ligands for human CC-chemokine receptor 8.

PubMed ID: 10540332

DOI: 10.1002/(sici)1521-4141(199910)29:10<3210::aid-immu3210>3.0.co;2-w

Sequence Information:

  • Length: 355
  • Mass: 40844
  • Checksum: BC14A153CF695361
  • Sequence:
    • MDYTLDLSVT TVTDYYYPDI FSSPCDAELI QTNGKLLLAV FYCLLFVFSL LGNSLVILVL 
VVCKKLRSIT DVYLLNLALS DLLFVFSFPF QTYYLLDQWV FGTVMCKVVS GFYYIGFYSS 
MFFITLMSVD RYLAVVHAVY ALKVRTIRMG TTLCLAVWLT AIMATIPLLV FYQVASEDGV 
LQCYSFYNQQ TLKWKIFTNF KMNILGLLIP FTIFMFCYIK ILHQLKRCQN HNKTKAIRLV 
LIVVIASLLF WVPFNVVLFL TSLHSMHILD GCSISQQLTY ATHVTEIISF THCCVNPVIY 
AFVGEKFKKH LSEIFQKSCS QIFNYLGRQM PRESCEKSSS CQQHSSRSSS VDYIL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.