Genular: Defining Cellular Identity and Function

Details for: Casq2

Gene ID: 12373

Symbol: Casq2

Ensembl ID: ENSMUSG00000027861

Description: calsequestrin 2

Associated with

Cardiac conduction
(R-MMU-5576891)
Ion channel transport
(R-MMU-983712)
Ion homeostasis
(R-MMU-5578775)
Muscle contraction
(R-MMU-397014)
Stimuli-sensing channels
(R-MMU-2672351)
Transport of small molecules
(R-MMU-382551)
Calcium-dependent protein binding
(GO:0048306)
Calcium ion binding
(GO:0005509)
Calcium ion sequestering activity
(GO:0140314)
Cardiac muscle contraction
(GO:0060048)
Cellular response to caffeine
(GO:0071313)
Cytoplasm
(GO:0005737)
Intracellular calcium ion homeostasis
(GO:0006874)
Ion binding
(GO:0043167)
Junctional membrane complex
(GO:0030314)
Metal ion binding
(GO:0046872)
Negative regulation of potassium ion transmembrane transporter activity
(GO:1901017)
Negative regulation of potassium ion transport
(GO:0043267)
Negative regulation of ryanodine-sensitive calcium-release channel activity
(GO:0060315)
Protein homodimerization activity
(GO:0042803)
Protein kinase c binding
(GO:0005080)
Protein polymerization
(GO:0051258)
Regulation of cardiac muscle cell contraction
(GO:0086004)
Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
(GO:0010881)
Regulation of cell communication by electrical coupling
(GO:0010649)
Regulation of heart rate
(GO:0002027)
Regulation of membrane repolarization
(GO:0060306)
Regulation of muscle contraction
(GO:0006937)
Regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
(GO:0010880)
Sarcomere organization
(GO:0045214)
Sarcoplasmic reticulum
(GO:0016529)
Sarcoplasmic reticulum lumen
(GO:0033018)
Sequestering of calcium ion
(GO:0051208)
Z disc
(GO:0030018)

Other Information

Proteins

Calsequestrin-2

Genular Protein ID: 2847285632

Symbol: CASQ2_MOUSE

Name: Calsequestrin-2

UniProtKB Accession Codes:

O09161 O88505 Q56A03

Database IDs:

Citations:

PubMed ID: 9795116

Title: Cloning of the genes encoding mouse cardiac and skeletal calsequestrins: expression pattern during embryogenesis.

PubMed ID: 9795116

DOI: 10.1016/s0378-1119(98)00372-2

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16932808

Title: Casq2 deletion causes sarcoplasmic reticulum volume increase, premature Ca2+ release, and catecholaminergic polymorphic ventricular tachycardia.

PubMed ID: 16932808

DOI: 10.1172/jci29128

PubMed ID: 17607358

Title: Calsequestrin 2 (CASQ2) mutations increase expression of calreticulin and ryanodine receptors, causing catecholaminergic polymorphic ventricular tachycardia.

PubMed ID: 17607358

DOI: 10.1172/jci31080

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 19920148

Title: The calsequestrin mutation CASQ2D307H does not affect protein stability and targeting to the junctional sarcoplasmic reticulum but compromises its dynamic regulation of calcium buffering.

PubMed ID: 19920148

DOI: 10.1074/jbc.m109.053892

Sequence Information:

Length: 415
Mass: 48176
Checksum: 82D7680878A6E3B5
Sequence:

MKRIYLLMVG VYLLSLSGAE EGLNFPTYDG KDRVVSLSEK NLKQMLKRYD LLCLYYHEPV 
SSDKVSQKQF QLKEIVLELV AQVLEHKNIG FVMVDSRKEA KLAKRLGFSE EGSLYVLKGD 
RTIEFDGEFA ADVLVEFLLD LIEDPVEIVN NKLEVQAFER IEDQTKLLGF FKNEDSEYYK 
AFQEAAEHFQ PYIKFFATFD KAVAKKLSLK MNEVGFYEPF MDEPNVIPNK PYTEEELVEF 
VKEHQRPTLR RLRPEDMFET WEDDLNGIHI VAFAEKSDPD GYEFLEILKQ VARDNTDNPD 
LSILWIDPDD FPLLVAYWEK TFKIDLFKPQ IGVVNVTDAD SIWMEIPDDD DLPTAEELED 
WIEDVLSGKI NTEDDDNEDE DDDGDDNDDD DDDDDDNDNS DEDNEDSDDD DDDDE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Casq2

Associated with

Other Information

Cloning of the genes encoding mouse cardiac and skeletal calsequestrins: expression pattern during embryogenesis. PubMed ID: 9795116

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Casq2 deletion causes sarcoplasmic reticulum volume increase, premature Ca2+ release, and catecholaminergic polymorphic ventricular tachycardia. PubMed ID: 16932808

Calsequestrin 2 (CASQ2) mutations increase expression of calreticulin and ryanodine receptors, causing catecholaminergic polymorphic ventricular tachycardia. PubMed ID: 17607358

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079