Genular: Defining Cellular Identity and Function

Details for: Casr

Gene ID: 12374

Symbol: Casr

Ensembl ID: ENSMUSG00000051980

Description: calcium-sensing receptor

Associated with

Class c/3 (metabotropic glutamate/pheromone receptors)
(R-MMU-420499)
G alpha (i) signalling events
(R-MMU-418594)
G alpha (q) signalling events
(R-MMU-416476)
Gpcr downstream signalling
(R-MMU-388396)
Gpcr ligand binding
(R-MMU-500792)
Signaling by gpcr
(R-MMU-372790)
Adenylate cyclase-inhibiting g protein-coupled receptor signaling pathway
(GO:0007193)
Amino acid binding
(GO:0016597)
Apical plasma membrane
(GO:0016324)
Axon
(GO:0030424)
Axon terminus
(GO:0043679)
Basolateral plasma membrane
(GO:0016323)
Bile acid secretion
(GO:0032782)
Branching morphogenesis of an epithelial tube
(GO:0048754)
Calcium ion binding
(GO:0005509)
Calcium ion import
(GO:0070509)
Cell surface
(GO:0009986)
Chloride transmembrane transport
(GO:1902476)
Detection of calcium ion
(GO:0005513)
G protein-coupled receptor activity
(GO:0004930)
G protein-coupled receptor signaling pathway
(GO:0007186)
Identical protein binding
(GO:0042802)
Integrin binding
(GO:0005178)
Intracellular calcium ion homeostasis
(GO:0006874)
Jnk cascade
(GO:0007254)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Neuronal cell body
(GO:0043025)
Ossification
(GO:0001503)
Phospholipase c-activating g protein-coupled receptor signaling pathway
(GO:0007200)
Plasma membrane
(GO:0005886)
Positive regulation of atp-dependent activity
(GO:0032781)
Positive regulation of calcium ion import
(GO:0090280)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of insulin secretion
(GO:0032024)
Positive regulation of positive chemotaxis
(GO:0050927)
Positive regulation of vasoconstriction
(GO:0045907)
Protein homodimerization activity
(GO:0042803)
Protein kinase binding
(GO:0019901)
Regulation of calcium ion transport
(GO:0051924)
Signal transduction
(GO:0007165)
Transmembrane transporter binding
(GO:0044325)
Vasodilation
(GO:0042311)

Other Information

Proteins

Extracellular calcium-sensing receptor

Genular Protein ID: 3832332026

Symbol: CASR_MOUSE

Name: Extracellular calcium-sensing receptor

UniProtKB Accession Codes:

Q9QY96 G3UX06 O08968 O88519 Q9QY95 Q9QZU8 Q9R1D6 Q9R1Y2

Database IDs:

Citations:

PubMed ID: 10625662

Title: The calcium sensing receptor and its alternatively spliced form in murine epidermal differentiation.

PubMed ID: 10625662

DOI: 10.1074/jbc.275.2.1183

PubMed ID: 10652312

Title: Sensing of extracellular cations in CasR-deficient osteoblasts. Evidence for a novel cation-sensing mechanism.

PubMed ID: 10652312

DOI: 10.1074/jbc.275.5.3256

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 10579354

Title: Expression and signal transduction of calcium-sensing receptors in cartilage and bone.

PubMed ID: 10579354

DOI: 10.1210/endo.140.12.7190

PubMed ID: 9076582

Title: A distinct cation-sensing mechanism in MC3T3-E1 osteoblasts functionally related to the calcium receptor.

PubMed ID: 9076582

DOI: 10.1359/jbmr.1997.12.3.393

PubMed ID: 7493018

Title: A mouse model of human familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism.

PubMed ID: 7493018

DOI: 10.1038/ng1295-389

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 1079
Mass: 120903
Checksum: 8AEF586CDCD93CB3
Sequence:

MAWFGYCLAL LALTWHSSAY GPDQRAQKKG DIILGGLFPI HFGVAAKDQD LKSRPESVEC 
IRYNFRGFRW LQAMIFAIEE INSSPALLPN MTLGYRIFDT CNTVSKALEA TLSFVAQNKI 
DSLNLDEFCN CSEHIPSTIA VVGATGSGVS TAVANLLGLF YIPQVSYASS SRLLSNKNQF 
KSFLRTIPND EHQATAMADI IEYFRWNWVG TIAADDDYGR PGIEKFREEA EERDICIDFS 
ELISQYSDEE EIQQVVEVIQ NSTAKVIVVF SSGPDLEPLI KEIVRRNITG RIWLASEAWA 
SSSLIAMPEY FHVVGGTIGF GLKAGQIPGF REFLQKVHPR KSVHNGFAKE FWEETFNCHL 
QDGAKGPLPV DTFVRSHEEG GNRLLNSSTA FRPLCTGDEN INSVETPYMD YEHLRISYNV 
YLAVYSIAHA LQDIYTCLPG RGLFTNGSCA DIKKVEAWQV LKHLRHLNFT NNMGEQVTFD 
ECGDLVGNYS IINWHLSPED GSIVFKEVGY YNVYAKKGER LFINEGKILW SGFSREVPFS 
NCSRDCQAGT RKGIIEGEPT CCFECVECPD GEYSGETDAS ACDKCPDDFW SNENHTSCIA 
KEIEFLAWTE PFGIALTLFA VLGIFLTAFV LGVFIKFRNT PIVKATNREL SYLLLFSLLC 
CFSSSLFFIG EPQDWTCRLR QPAFGISFVL CISCILVKTN RVLLVFEAKI PTSFHRKWWG 
LNLQFLLVFL CTFMQIVICI IWLYTAPPSS YRNHELEDEI IFITCHEGSL MALGSLIGYT 
CLLAAICFFF AFKSRKLPEN FNEAKFITFS MLIFFIVWIS FIPAYASTYG KFVSAVEVIA 
ILAASFGLLA CIFFNKVYII LFKPSRNTIE EVRSSTAAHA FKVAARATLR RPNISRKRSS 
SLGGSTGSIP SSSISSKSNS EDRFPQPERQ KQQQPLALTQ QEQQQQPLTL QPQQQQQPQQ 
PRCKQKVIFG SGTVTFSLSF DEPQKNAMAH RNSMRQNSLE AQKSNDTLNR HQALLPLQCA 
EADSEMTIQE TGLQGPMVGD HQPEIESPDE MSPALVMSTS RSFVISGGGS SVTENILHS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Casr

Associated with

Other Information

The calcium sensing receptor and its alternatively spliced form in murine epidermal differentiation. PubMed ID: 10625662

Sensing of extracellular cations in CasR-deficient osteoblasts. Evidence for a novel cation-sensing mechanism. PubMed ID: 10652312

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

Expression and signal transduction of calcium-sensing receptors in cartilage and bone. PubMed ID: 10579354

A distinct cation-sensing mechanism in MC3T3-E1 osteoblasts functionally related to the calcium receptor. PubMed ID: 9076582

A mouse model of human familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism. PubMed ID: 7493018

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079