ACKR2 | ENSG00000144648 | NCBI 1238

Details for: ACKR2

Gene ID: 1238

Symbol: ACKR2

Ensembl ID: ENSG00000144648

Description: atypical chemokine receptor 2

Associated with

Chemokine receptors bind chemokines
(R-HSA-380108)
Class a/1 (rhodopsin-like receptors)
(R-HSA-373076)
Gpcr ligand binding
(R-HSA-500792)
Peptide ligand-binding receptors
(R-HSA-375276)
Signaling by gpcr
(R-HSA-372790)
Signal transduction
(R-HSA-162582)
Actin filament
(GO:0005884)
C-c chemokine binding
(GO:0019957)
C-c chemokine receptor activity
(GO:0016493)
Calcium-mediated signaling
(GO:0019722)
Cell chemotaxis
(GO:0060326)
Chemokine-mediated signaling pathway
(GO:0070098)
Chemokine receptor activity
(GO:0004950)
Cytosol
(GO:0005829)
Early endosome
(GO:0005769)
Endocytosis
(GO:0006897)
External side of plasma membrane
(GO:0009897)
G protein-coupled receptor signaling pathway
(GO:0007186)
Immune response
(GO:0006955)
Inflammatory response
(GO:0006954)
Intracellular membrane-bounded organelle
(GO:0043231)
Intracellular signal transduction
(GO:0035556)
Nuclear membrane
(GO:0031965)
Nucleoplasm
(GO:0005654)
Plasma membrane
(GO:0005886)
Positive regulation of cytosolic calcium ion concentration
(GO:0007204)
Protein binding
(GO:0005515)
Recycling endosome
(GO:0055037)
Scavenger receptor activity
(GO:0005044)

Other Information

Proteins

Atypical chemokine receptor 2

Genular Protein ID: 1417383055

Symbol: ACKR2_HUMAN

Name: Atypical chemokine receptor 2

UniProtKB Accession Codes:

O00590 B2R8Y8 O00537 Q53YA1 Q86UN9 Q96A02

Database IDs:

Citations:

PubMed ID: 9364936

Title: Cloning, expression, and chromosomal mapping of a novel human CC-chemokine receptor (CCR10) that displays high-affinity binding for MCP-1 and MCP-3.

PubMed ID: 9364936

DOI: 10.1089/dna.1997.16.1249

PubMed ID: 9405404

Title: Cloning and characterization of a novel promiscuous human beta-chemokine receptor D6.

PubMed ID: 9405404

DOI: 10.1074/jbc.272.51.32078

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11238036

Title: The beta-chemokine receptor D6 is expressed by lymphatic endothelium and a subset of vascular tumors.

PubMed ID: 11238036

DOI: 10.1016/s0002-9440(10)64035-7

PubMed ID: 18201974

Title: Multiple roles for the C-terminal tail of the chemokine scavenger D6.

PubMed ID: 18201974

DOI: 10.1074/jbc.m710128200

PubMed ID: 20373092

Title: Chemokine decoy receptors: structure-function and biological properties.

PubMed ID: 20373092

DOI: 10.1007/82_2010_19

PubMed ID: 22651933

Title: The atypical chemokine receptor D6 controls macrophage efferocytosis and cytokine secretion during the resolution of inflammation.

PubMed ID: 22651933

DOI: 10.1096/fj.11-194894

PubMed ID: 22698181

Title: The biochemistry and biology of the atypical chemokine receptors.

PubMed ID: 22698181

DOI: 10.1016/j.imlet.2012.04.004

PubMed ID: 23356288

Title: Atypical chemokine receptors: from silence to sound.

PubMed ID: 23356288

DOI: 10.1042/bst20120246

PubMed ID: 23479571

Title: An analysis of the function and expression of D6 on lymphatic endothelial cells.

PubMed ID: 23479571

DOI: 10.1182/blood-2012-04-425314

PubMed ID: 23125030

Title: Regulation of the immune and inflammatory responses by the 'atypical' chemokine receptor D6.

PubMed ID: 23125030

DOI: 10.1002/path.4123

PubMed ID: 22939232

Title: Review: Structure-function and biological properties of the atypical chemokine receptor D6.

PubMed ID: 22939232

DOI: 10.1016/j.molimm.2012.08.003

PubMed ID: 23633677

Title: Beta-arrestin-dependent activation of the cofilin pathway is required for the scavenging activity of the atypical chemokine receptor D6.

PubMed ID: 23633677

DOI: 10.1126/scisignal.2003627

Sequence Information:

Length: 384
Mass: 43443
Checksum: 464C5703C1DE9A6A
Sequence:

MAATASPQPL ATEDADSENS SFYYYDYLDE VAFMLCRKDA VVSFGKVFLP VFYSLIFVLG 
LSGNLLLLMV LLRYVPRRRM VEIYLLNLAI SNLLFLVTLP FWGISVAWHW VFGSFLCKMV 
STLYTINFYS GIFFISCMSL DKYLEIVHAQ PYHRLRTRAK SLLLATIVWA VSLAVSIPDM 
VFVQTHENPK GVWNCHADFG GHGTIWKLFL RFQQNLLGFL LPLLAMIFFY SRIGCVLVRL 
RPAGQGRALK IAAALVVAFF VLWFPYNLTL FLHTLLDLQV FGNCEVSQHL DYALQVTESI 
AFLHCCFSPI LYAFSSHRFR QYLKAFLAAV LGWHLAPGTA QASLSSCSES SILTAQEEMT 
GMNDLGERQS ENYPNKEDVG NKSA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ACKR2

Associated with

Other Information

Cloning, expression, and chromosomal mapping of a novel human CC-chemokine receptor (CCR10) that displays high-affinity binding for MCP-1 and MCP-3. PubMed ID: 9364936

Cloning and characterization of a novel promiscuous human beta-chemokine receptor D6. PubMed ID: 9405404

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The beta-chemokine receptor D6 is expressed by lymphatic endothelium and a subset of vascular tumors. PubMed ID: 11238036

Multiple roles for the C-terminal tail of the chemokine scavenger D6. PubMed ID: 18201974

Chemokine decoy receptors: structure-function and biological properties. PubMed ID: 20373092

The atypical chemokine receptor D6 controls macrophage efferocytosis and cytokine secretion during the resolution of inflammation. PubMed ID: 22651933

The biochemistry and biology of the atypical chemokine receptors. PubMed ID: 22698181

Atypical chemokine receptors: from silence to sound. PubMed ID: 23356288

An analysis of the function and expression of D6 on lymphatic endothelial cells. PubMed ID: 23479571

Regulation of the immune and inflammatory responses by the 'atypical' chemokine receptor D6. PubMed ID: 23125030

Review: Structure-function and biological properties of the atypical chemokine receptor D6. PubMed ID: 22939232

Beta-arrestin-dependent activation of the cofilin pathway is required for the scavenging activity of the atypical chemokine receptor D6. PubMed ID: 23633677