Details for: ACKR2

Gene ID: 1238

Symbol: ACKR2

Ensembl ID: ENSG00000144648

Description: atypical chemokine receptor 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 18.5798
    Cell Significance Index: -2.8900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 11.4925
    Cell Significance Index: -2.9200
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: 3.8129
    Cell Significance Index: 27.4700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 2.2872
    Cell Significance Index: -2.8200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7586
    Cell Significance Index: 144.3700
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.6255
    Cell Significance Index: 6.0300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5198
    Cell Significance Index: 51.4200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.5052
    Cell Significance Index: 7.5700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4930
    Cell Significance Index: 13.2100
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.4873
    Cell Significance Index: 5.6700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4599
    Cell Significance Index: 415.2800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3859
    Cell Significance Index: 17.4900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2720
    Cell Significance Index: 44.2300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.2598
    Cell Significance Index: 4.3700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2472
    Cell Significance Index: 26.8900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1876
    Cell Significance Index: 4.0000
  • Cell Name: surface ectodermal cell (CL0000114)
    Fold Change: 0.1457
    Cell Significance Index: 1.1500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1455
    Cell Significance Index: 10.0700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1362
    Cell Significance Index: 2.9500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1271
    Cell Significance Index: 7.6300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1031
    Cell Significance Index: 2.9700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.1027
    Cell Significance Index: 1.6300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0847
    Cell Significance Index: 9.8800
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.0756
    Cell Significance Index: 0.8100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0730
    Cell Significance Index: 3.7900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0705
    Cell Significance Index: 1.0400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0529
    Cell Significance Index: 1.8600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0519
    Cell Significance Index: 14.9300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0498
    Cell Significance Index: 27.2000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0489
    Cell Significance Index: 3.0800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0465
    Cell Significance Index: 9.3200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0200
    Cell Significance Index: 0.5000
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.0192
    Cell Significance Index: 0.2100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0166
    Cell Significance Index: 0.2500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0139
    Cell Significance Index: 2.7500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0130
    Cell Significance Index: 0.6800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0126
    Cell Significance Index: 0.1800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0123
    Cell Significance Index: 0.2700
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.0105
    Cell Significance Index: 0.1000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0050
    Cell Significance Index: 0.2500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0025
    Cell Significance Index: 0.4500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0022
    Cell Significance Index: 4.1200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0020
    Cell Significance Index: 0.7000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0009
    Cell Significance Index: 1.6100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0004
    Cell Significance Index: -0.6200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0006
    Cell Significance Index: -0.4100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0013
    Cell Significance Index: -0.2000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0016
    Cell Significance Index: -2.2100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0026
    Cell Significance Index: -1.9100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0032
    Cell Significance Index: -0.1500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0035
    Cell Significance Index: -2.5700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0037
    Cell Significance Index: -2.7700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0041
    Cell Significance Index: -1.8000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0051
    Cell Significance Index: -2.9000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0064
    Cell Significance Index: -2.9100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0076
    Cell Significance Index: -0.9800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0090
    Cell Significance Index: -0.2400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0091
    Cell Significance Index: -1.1200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0132
    Cell Significance Index: -2.2600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0132
    Cell Significance Index: -1.8100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0153
    Cell Significance Index: -3.2300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0154
    Cell Significance Index: -0.6700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0161
    Cell Significance Index: -1.2000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0189
    Cell Significance Index: -2.4400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0192
    Cell Significance Index: -1.2900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0215
    Cell Significance Index: -0.4200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0238
    Cell Significance Index: -2.7300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0251
    Cell Significance Index: -1.9300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0267
    Cell Significance Index: -2.7300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0274
    Cell Significance Index: -2.8500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0285
    Cell Significance Index: -1.7500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0292
    Cell Significance Index: -3.4400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0321
    Cell Significance Index: -2.2700
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0325
    Cell Significance Index: -0.4200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0387
    Cell Significance Index: -1.7100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0394
    Cell Significance Index: -1.2600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0405
    Cell Significance Index: -3.2100
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0436
    Cell Significance Index: -0.6300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0446
    Cell Significance Index: -1.1500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0453
    Cell Significance Index: -1.7200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0456
    Cell Significance Index: -2.9400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0487
    Cell Significance Index: -1.6000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0492
    Cell Significance Index: -2.7600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0495
    Cell Significance Index: -0.5900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0517
    Cell Significance Index: -3.1800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0521
    Cell Significance Index: -0.9000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0521
    Cell Significance Index: -2.4500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0525
    Cell Significance Index: -1.4700
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0527
    Cell Significance Index: -0.3500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0568
    Cell Significance Index: -1.9900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0610
    Cell Significance Index: -2.5000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0628
    Cell Significance Index: -2.0100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0654
    Cell Significance Index: -1.9300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0661
    Cell Significance Index: -1.8000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0680
    Cell Significance Index: -1.1500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0684
    Cell Significance Index: -0.6300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0699
    Cell Significance Index: -1.8700
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.0712
    Cell Significance Index: -0.8600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0757
    Cell Significance Index: -2.7800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0784
    Cell Significance Index: -1.9600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** ACKR2 belongs to the class A/1 rhodopsin-like receptors, which are characterized by the presence of seven transmembrane helices and a characteristic three-helix bundle in the extracellular domain. This receptor is unique in its ability to bind to chemokines, which are small cytokines that play critical roles in the regulation of immune responses, and also exhibits scavenger receptor activity, allowing it to interact with various ligands, including lipids and proteins. ACKR2 is also capable of modulating calcium ion concentrations, which is essential for the regulation of various cellular processes, including cell signaling and immune responses. **Pathways and Functions** ACKR2 is involved in several signaling pathways, including: 1. **Chemokine-mediated signaling pathway**: ACKR2 binds to chemokines, which triggers a signaling cascade that regulates immune responses, including the recruitment of immune cells to sites of inflammation. 2. **Calcium-mediated signaling**: ACKR2 modulates calcium ion concentrations, which is essential for the regulation of various cellular processes, including cell signaling and immune responses. 3. **G protein-coupled receptor signaling pathway**: ACKR2 is a member of the GPCR family, which is characterized by the activation of G proteins upon ligand binding, leading to the regulation of various cellular processes. 4. **Inflammatory response**: ACKR2 is involved in the regulation of the inflammatory response, including the recruitment of immune cells to sites of inflammation and the modulation of cytokine production. ACKR2 also interacts with various ligands, including: 1. **Chemokines**: ACKR2 binds to chemokines, which triggers a signaling cascade that regulates immune responses. 2. **Lipids**: ACKR2 exhibits scavenger receptor activity, allowing it to interact with lipids, which is essential for the regulation of lipid metabolism and immune responses. 3. **Proteins**: ACKR2 interacts with various proteins, including chemokines and cytokines, which is essential for the regulation of immune responses and inflammation. **Clinical Significance** ACKR2 has been implicated in various diseases, including: 1. **Inflammatory disorders**: ACKR2 has been shown to play a role in the regulation of the inflammatory response, including the recruitment of immune cells to sites of inflammation. 2. **Cancer**: ACKR2 has been implicated in the regulation of cancer progression, including the promotion of tumor cell proliferation and metastasis. 3. **Cardiovascular disease**: ACKR2 has been shown to play a role in the regulation of lipid metabolism and cardiovascular disease. 4. **Neurological disorders**: ACKR2 has been implicated in the regulation of immune responses and neurological disorders, including multiple sclerosis and Alzheimer's disease. In conclusion, ACKR2 is a unique receptor that plays a critical role in the regulation of immune responses, inflammation, and various physiological processes. Further studies are needed to fully understand the mechanisms by which ACKR2 regulates these processes and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 1417383055

Symbol: ACKR2_HUMAN

Name: Atypical chemokine receptor 2

UniProtKB Accession Codes:

O00590 B2R8Y8 O00537 Q53YA1 Q86UN9 Q96A02

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 10 EMDB 3 Ensembl 2 ExpressionAtlas 1 GO 19 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PRINTS 3 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9364936

Title: Cloning, expression, and chromosomal mapping of a novel human CC-chemokine receptor (CCR10) that displays high-affinity binding for MCP-1 and MCP-3.

PubMed ID: 9364936

DOI: 10.1089/dna.1997.16.1249

PubMed ID: 9405404

Title: Cloning and characterization of a novel promiscuous human beta-chemokine receptor D6.

PubMed ID: 9405404

DOI: 10.1074/jbc.272.51.32078

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11238036

Title: The beta-chemokine receptor D6 is expressed by lymphatic endothelium and a subset of vascular tumors.

PubMed ID: 11238036

DOI: 10.1016/s0002-9440(10)64035-7

PubMed ID: 18201974

Title: Multiple roles for the C-terminal tail of the chemokine scavenger D6.

PubMed ID: 18201974

DOI: 10.1074/jbc.m710128200

PubMed ID: 20373092

Title: Chemokine decoy receptors: structure-function and biological properties.

PubMed ID: 20373092

DOI: 10.1007/82_2010_19

PubMed ID: 22651933

Title: The atypical chemokine receptor D6 controls macrophage efferocytosis and cytokine secretion during the resolution of inflammation.

PubMed ID: 22651933

DOI: 10.1096/fj.11-194894

PubMed ID: 22698181

Title: The biochemistry and biology of the atypical chemokine receptors.

PubMed ID: 22698181

DOI: 10.1016/j.imlet.2012.04.004

PubMed ID: 23356288

Title: Atypical chemokine receptors: from silence to sound.

PubMed ID: 23356288

DOI: 10.1042/bst20120246

PubMed ID: 23479571

Title: An analysis of the function and expression of D6 on lymphatic endothelial cells.

PubMed ID: 23479571

DOI: 10.1182/blood-2012-04-425314

PubMed ID: 23125030

Title: Regulation of the immune and inflammatory responses by the 'atypical' chemokine receptor D6.

PubMed ID: 23125030

DOI: 10.1002/path.4123

PubMed ID: 22939232

Title: Review: Structure-function and biological properties of the atypical chemokine receptor D6.

PubMed ID: 22939232

DOI: 10.1016/j.molimm.2012.08.003

PubMed ID: 23633677

Title: Beta-arrestin-dependent activation of the cofilin pathway is required for the scavenging activity of the atypical chemokine receptor D6.

PubMed ID: 23633677

DOI: 10.1126/scisignal.2003627

Sequence Information:

  • Length: 384
  • Mass: 43443
  • Checksum: 464C5703C1DE9A6A
  • Sequence:
    • MAATASPQPL ATEDADSENS SFYYYDYLDE VAFMLCRKDA VVSFGKVFLP VFYSLIFVLG 
LSGNLLLLMV LLRYVPRRRM VEIYLLNLAI SNLLFLVTLP FWGISVAWHW VFGSFLCKMV 
STLYTINFYS GIFFISCMSL DKYLEIVHAQ PYHRLRTRAK SLLLATIVWA VSLAVSIPDM 
VFVQTHENPK GVWNCHADFG GHGTIWKLFL RFQQNLLGFL LPLLAMIFFY SRIGCVLVRL 
RPAGQGRALK IAAALVVAFF VLWFPYNLTL FLHTLLDLQV FGNCEVSQHL DYALQVTESI 
AFLHCCFSPI LYAFSSHRFR QYLKAFLAAV LGWHLAPGTA QASLSSCSES SILTAQEEMT 
GMNDLGERQS ENYPNKEDVG NKSA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.