Genular: Defining Cellular Identity and Function

Details for: Ctnna1

Gene ID: 12385

Symbol: Ctnna1

Ensembl ID: ENSMUSG00000037815

Description: catenin alpha 1

Associated with

Adherens junctions interactions
(R-MMU-418990)
Cell-cell communication
(R-MMU-1500931)
Cell-cell junction organization
(R-MMU-421270)
Cell junction organization
(R-MMU-446728)
Developmental biology
(R-MMU-1266738)
Myogenesis
(R-MMU-525793)
Rho gtpase effectors
(R-MMU-195258)
Rho gtpases activate iqgaps
(R-MMU-5626467)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signaling by rho gtpases
(R-MMU-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-MMU-9716542)
Signaling by vegf
(R-MMU-194138)
Signal transduction
(R-MMU-162582)
Vegfa-vegfr2 pathway
(R-MMU-4420097)
Vegfr2 mediated vascular permeability
(R-MMU-5218920)
Acrosomal vesicle
(GO:0001669)
Actin cytoskeleton
(GO:0015629)
Actin filament binding
(GO:0051015)
Adherens junction
(GO:0005912)
Anchoring junction
(GO:0070161)
Apical junction assembly
(GO:0043297)
Apoptotic process
(GO:0006915)
Beta-catenin binding
(GO:0008013)
Cadherin binding
(GO:0045296)
Catenin complex
(GO:0016342)
Cell-cell adhesion
(GO:0098609)
Cell-cell junction
(GO:0005911)
Cell adhesion
(GO:0007155)
Cell junction
(GO:0030054)
Cell migration
(GO:0016477)
Cell motility
(GO:0048870)
Cellular response to indole-3-methanol
(GO:0071681)
Cytoplasm
(GO:0005737)
Cytoskeleton
(GO:0005856)
Epithelial cell-cell adhesion
(GO:0090136)
Establishment or maintenance of cell polarity
(GO:0007163)
Extrinsic apoptotic signaling pathway in absence of ligand
(GO:0097192)
Flotillin complex
(GO:0016600)
Gamma-catenin binding
(GO:0045295)
Gap junction assembly
(GO:0016264)
Identical protein binding
(GO:0042802)
Integrin-mediated signaling pathway
(GO:0007229)
Intercalated disc
(GO:0014704)
Intracellular membrane-bounded organelle
(GO:0043231)
Lamellipodium
(GO:0030027)
Membrane
(GO:0016020)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of cell motility
(GO:2000146)
Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
(GO:2001240)
Negative regulation of integrin-mediated signaling pathway
(GO:2001045)
Negative regulation of neuroblast proliferation
(GO:0007406)
Negative regulation of protein localization to nucleus
(GO:1900181)
Neuroblast proliferation
(GO:0007405)
Plasma membrane
(GO:0005886)
Positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
(GO:2001241)
Positive regulation of smoothened signaling pathway
(GO:0045880)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein localization
(GO:0008104)
Regulation of cell population proliferation
(GO:0042127)
Smoothened signaling pathway
(GO:0007224)
Structural molecule activity
(GO:0005198)
Vinculin binding
(GO:0017166)
Zonula adherens
(GO:0005915)

Other Information

Proteins

Catenin alpha-1

Genular Protein ID: 2932665440

Symbol: CTNA1_MOUSE

Name: Catenin alpha-1

UniProtKB Accession Codes:

P26231

Database IDs:

Citations:

PubMed ID: 1924379

Title: The uvomorulin-anchorage protein alpha catenin is a vinculin homologue.

PubMed ID: 1924379

DOI: 10.1073/pnas.88.20.9156

PubMed ID: 1904011

Title: The 102 kd cadherin-associated protein: similarity to vinculin and posttranscriptional regulation of expression.

PubMed ID: 1904011

DOI: 10.1016/0092-8674(91)90392-c

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7982500

Title: Distinct cadherin-catenin complexes in Ca(2+)-dependent cell-cell adhesion.

PubMed ID: 7982500

DOI: 10.1016/0014-5793(94)01205-9

PubMed ID: 10026224

Title: Characterization of ZO-2 as a MAGUK family member associated with tight as well as adherens junctions with a binding affinity to occludin and alpha catenin.

PubMed ID: 10026224

DOI: 10.1074/jbc.274.9.5981

PubMed ID: 16325582

Title: Deconstructing the cadherin-catenin-actin complex.

PubMed ID: 16325582

DOI: 10.1016/j.cell.2005.09.020

PubMed ID: 16325583

Title: Alpha-catenin is a molecular switch that binds E-cadherin-beta-catenin and regulates actin-filament assembly.

PubMed ID: 16325583

DOI: 10.1016/j.cell.2005.09.021

PubMed ID: 18630941

Title: Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis.

PubMed ID: 18630941

DOI: 10.1021/pr800223m

PubMed ID: 18093941

Title: EPLIN mediates linkage of the cadherin catenin complex to F-actin and stabilizes the circumferential actin belt.

PubMed ID: 18093941

DOI: 10.1073/pnas.0710504105

PubMed ID: 19131326

Title: Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry.

PubMed ID: 19131326

DOI: 10.1074/mcp.m800451-mcp200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21145499

Title: The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-beta-SMAD pathway.

PubMed ID: 21145499

DOI: 10.1016/j.devcel.2010.11.012

PubMed ID: 25653389

Title: alpha-Catenin phosphorylation promotes intercellular adhesion through a dual-kinase mechanism.

PubMed ID: 25653389

DOI: 10.1242/jcs.163824

PubMed ID: 26691986

Title: Mutations in CTNNA1 cause butterfly-shaped pigment dystrophy and perturbed retinal pigment epithelium integrity.

PubMed ID: 26691986

DOI: 10.1038/ng.3474

PubMed ID: 10882138

Title: Structure of the dimerization and beta-catenin-binding region of alpha-catenin.

PubMed ID: 10882138

DOI: 10.1016/s1097-2765(00)80447-5

PubMed ID: 11907041

Title: Biochemical and structural definition of the l-afadin- and actin-binding sites of alpha-catenin.

PubMed ID: 11907041

DOI: 10.1074/jbc.m201463200

Sequence Information:

Length: 906
Mass: 100106
Checksum: 3ED1EC50925DBBB5
Sequence:

MTAVHAGNIN FKWDPKSLEI RTLAVERLLE PLVTQVTTLV NTNSKGPSNK KRGRSKKAHV 
LAASVEQATE NFLEKGDKIA KESQFLKEEL VVAVEDVRKQ GDLMKSAAGE FADDPCSSVK 
RGNMVRAARA LLSAVTRLLI LADMADVYKL LVQLKVVEDG ILKLRNAGNE QDLGIQYKAL 
KPEVDKLNIM AAKRQQELKD VGNRDQMAAA RGILQKNVPI LYTASQACLQ HPDVAAYKAN 
RDLIYKQLQQ AVTGISNAAQ ATASDDAAQH QGGSGGELAY ALNNFDKQII VDPLSFSEER 
FRPSLEERLE SIISGAALMA DSSCTRDDRR ERIVAECNAV RQALQDLLSE YMGNAGRKER 
SDALNSAIDK MTKKTRDLRR QLRKAVMDHV SDSFLETNVP LLVLIEAAKN GNEKEVKEYA 
QVFREHANKL IEVANLACSI SNNEEGVKLV RMSASQLEAL CPQVINAALA LAAKPQSKLA 
QENMDLFKEQ WEKQVRVLTD AVDDITSIDD FLAVSENHIL EDVNKCVIAL QEKDVDGLDR 
TAGAIRGRAA RVIHVVTSEM DNYEPGVYTE KVLEATKLLS NTVMPRFTEQ VEAAVEALSS 
DPAQPMDENE FIDASRLVYD GIRDIRKAVL MIRTPEELDD SDFETEDFDV RSRTSVQTED 
DQLIAGQSAR AIMAQLPQEQ KAKIAEQVAS FQEEKSKLDA EVSKWDDSGN DIIVLAKQMC 
MIMMEMTDFT RGKGPLKNTS DVISAAKKIA EAGSRMDKLG RTIADHCPDS ACKQDLLAYL 
QRIALYCHQL NICSKVKAEV QNLGGELVVS GVDSAMSLIQ AAKNLMNAVV QTVKASYVAS 
TKYQKSQGMA SLNLPAVSWK MKAPEKKPLV KREKQDETQT KIKRASQKKH VNPVQALSEF 
KAMDSI

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ctnna1

Associated with

Other Information

The uvomorulin-anchorage protein alpha catenin is a vinculin homologue. PubMed ID: 1924379

The 102 kd cadherin-associated protein: similarity to vinculin and posttranscriptional regulation of expression. PubMed ID: 1904011

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Distinct cadherin-catenin complexes in Ca(2+)-dependent cell-cell adhesion. PubMed ID: 7982500

Characterization of ZO-2 as a MAGUK family member associated with tight as well as adherens junctions with a binding affinity to occludin and alpha catenin. PubMed ID: 10026224

Deconstructing the cadherin-catenin-actin complex. PubMed ID: 16325582

Alpha-catenin is a molecular switch that binds E-cadherin-beta-catenin and regulates actin-filament assembly. PubMed ID: 16325583

Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis. PubMed ID: 18630941

EPLIN mediates linkage of the cadherin catenin complex to F-actin and stabilizes the circumferential actin belt. PubMed ID: 18093941

Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry. PubMed ID: 19131326

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-beta-SMAD pathway. PubMed ID: 21145499

alpha-Catenin phosphorylation promotes intercellular adhesion through a dual-kinase mechanism. PubMed ID: 25653389

Mutations in CTNNA1 cause butterfly-shaped pigment dystrophy and perturbed retinal pigment epithelium integrity. PubMed ID: 26691986

Structure of the dimerization and beta-catenin-binding region of alpha-catenin. PubMed ID: 10882138

Biochemical and structural definition of the l-afadin- and actin-binding sites of alpha-catenin. PubMed ID: 11907041