Genular: Defining Cellular Identity and Function

Details for: Ctnnb1

Gene ID: 12387

Symbol: Ctnnb1

Ensembl ID: ENSMUSG00000006932

Description: catenin beta 1

Associated with

Adherens junctions interactions
(R-MMU-418990)
Apoptosis
(R-MMU-109581)
Apoptotic cleavage of cell adhesion proteins
(R-MMU-351906)
Apoptotic cleavage of cellular proteins
(R-MMU-111465)
Apoptotic execution phase
(R-MMU-75153)
Beta-catenin independent wnt signaling
(R-MMU-3858494)
Beta-catenin phosphorylation cascade
(R-MMU-196299)
Ca2+ pathway
(R-MMU-4086398)
Cell-cell communication
(R-MMU-1500931)
Cell-cell junction organization
(R-MMU-421270)
Cell junction organization
(R-MMU-446728)
Cytosolic sensors of pathogen-associated dna
(R-MMU-1834949)
Deactivation of the beta-catenin transactivating complex
(R-MMU-3769402)
Degradation of beta-catenin by the destruction complex
(R-MMU-195253)
Developmental biology
(R-MMU-1266738)
Disassembly of the destruction complex and recruitment of axin to the membrane
(R-MMU-4641262)
Formation of the beta-catenin:tcf transactivating complex
(R-MMU-201722)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Lrr flii-interacting protein 1 (lrrfip1) activates type i ifn production
(R-MMU-3134973)
Myogenesis
(R-MMU-525793)
Programmed cell death
(R-MMU-5357801)
Regulation of cdh11 expression and function
(R-MMU-9759475)
Regulation of cdh11 function
(R-MMU-9762292)
Regulation of expression and function of type ii classical cadherins
(R-MMU-9764260)
Regulation of homotypic cell-cell adhesion
(R-MMU-9759476)
Rho gtpase effectors
(R-MMU-195258)
Rho gtpases activate iqgaps
(R-MMU-5626467)
Rna polymerase ii transcription
(R-MMU-73857)
Runx3 regulates wnt signaling
(R-MMU-8951430)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signaling by rho gtpases
(R-MMU-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-MMU-9716542)
Signaling by vegf
(R-MMU-194138)
Signaling by wnt
(R-MMU-195721)
Signal transduction
(R-MMU-162582)
Tcf dependent signaling in response to wnt
(R-MMU-201681)
Transcriptional regulation by runx3
(R-MMU-8878159)
Vegfa-vegfr2 pathway
(R-MMU-4420097)
Vegfr2 mediated vascular permeability
(R-MMU-5218920)
Alpha-catenin binding
(GO:0045294)
Branching involved in blood vessel morphogenesis
(GO:0001569)
Branching involved in ureteric bud morphogenesis
(GO:0001658)
Cadherin binding
(GO:0045296)
Cell fate specification
(GO:0001708)
Cell morphogenesis
(GO:0000902)
Chromatin binding
(GO:0003682)
Delta-catenin binding
(GO:0070097)
Disordered domain specific binding
(GO:0097718)
Dna-binding transcription factor binding
(GO:0140297)
Embryonic axis specification
(GO:0000578)
Endoderm formation
(GO:0001706)
Enzyme binding
(GO:0019899)
Gastrulation with mouth forming second
(GO:0001702)
I-smad binding
(GO:0070411)
In utero embryonic development
(GO:0001701)
Ionotropic glutamate receptor binding
(GO:0035255)
Kinase binding
(GO:0019900)
Mapk cascade
(GO:0000165)
Molecular function activator activity
(GO:0140677)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nitric-oxide synthase binding
(GO:0050998)
Nuclear estrogen receptor binding
(GO:0030331)
Nuclear receptor binding
(GO:0016922)
Nucleic acid binding
(GO:0003676)
Osteoblast differentiation
(GO:0001649)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Protein phosphatase binding
(GO:0019903)
Protein polyubiquitination
(GO:0000209)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Signaling receptor binding
(GO:0005102)
Skeletal system development
(GO:0001501)
Smad binding
(GO:0046332)
Transcription coactivator activity
(GO:0003713)
Transcription coregulator binding
(GO:0001221)
Transcription corepressor binding
(GO:0001222)
Transcription factor binding
(GO:0008134)
Transmembrane transporter binding
(GO:0044325)
Ubiquitin protein ligase binding
(GO:0031625)
Vasculogenesis
(GO:0001570)

Other Information

Proteins

CTNB1_MOUSE

Genular Protein ID: 3306914790

Symbol: CTNB1_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q02248 Q922W1 Q9D335

Database IDs:

Citations:

PubMed ID: 1509266

Title: Plakoglobin and beta-catenin: distinct but closely related.

PubMed ID: 1509266

DOI: 10.1126/science.257.5073.1142-a

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7982500

Title: Distinct cadherin-catenin complexes in Ca(2+)-dependent cell-cell adhesion.

PubMed ID: 7982500

DOI: 10.1016/0014-5793(94)01205-9

PubMed ID: 9783587

Title: The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors.

PubMed ID: 9783587

DOI: 10.1038/26989

PubMed ID: 10581160

Title: A GSK3beta phosphorylation site in axin modulates interaction with beta-catenin and Tcf-mediated gene expression.

PubMed ID: 10581160

DOI: 10.1006/bbrc.1999.1760

PubMed ID: 10772923

Title: MAGI-1 interacts with beta-catenin and is associated with cell-cell adhesion structures.

PubMed ID: 10772923

DOI: 10.1006/bbrc.2000.2471

PubMed ID: 11590244

Title: AlphaT-catenin: a novel tissue-specific beta-catenin-binding protein mediating strong cell-cell adhesion.

PubMed ID: 11590244

DOI: 10.1242/jcs.114.17.3177

PubMed ID: 12874278

Title: The PDZ protein tax-interacting protein-1 inhibits beta-catenin transcriptional activity and growth of colorectal cancer cells.

PubMed ID: 12874278

DOI: 10.1074/jbc.m306324200

PubMed ID: 12640114

Title: p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction.

PubMed ID: 12640114

DOI: 10.1128/mcb.23.7.2287-2297.2003

PubMed ID: 14687547

Title: RORalpha coordinates reciprocal signaling in cerebellar development through sonic hedgehog and calcium-dependent pathways.

PubMed ID: 14687547

DOI: 10.1016/s0896-6273(03)00769-4

PubMed ID: 15063782

Title: Cyclin-dependent kinase 2 regulates the interaction of Axin with beta-catenin.

PubMed ID: 15063782

DOI: 10.1016/j.bbrc.2004.03.065

PubMed ID: 15132997

Title: Interactions between Sox9 and beta-catenin control chondrocyte differentiation.

PubMed ID: 15132997

DOI: 10.1101/gad.1171104

PubMed ID: 16325582

Title: Deconstructing the cadherin-catenin-actin complex.

PubMed ID: 16325582

DOI: 10.1016/j.cell.2005.09.020

PubMed ID: 17052462

Title: Crystal structure of a beta-catenin/BCL9/Tcf4 complex.

PubMed ID: 17052462

DOI: 10.1016/j.molcel.2006.09.001

PubMed ID: 17289029

Title: The Kruppel-like zinc finger protein Glis2 functions as a negative modulator of the Wnt/beta-catenin signaling pathway.

PubMed ID: 17289029

DOI: 10.1016/j.febslet.2007.01.058

PubMed ID: 17925400

Title: The intercalated disc protein, mXin{alpha}, is capable of interacting with beta-catenin and bundling actin filaments.

PubMed ID: 17925400

DOI: 10.1074/jbc.m707639200

PubMed ID: 17344318

Title: Role of GAC63 in transcriptional activation mediated by beta-catenin.

PubMed ID: 17344318

DOI: 10.1093/nar/gkm095

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 18093941

Title: EPLIN mediates linkage of the cadherin catenin complex to F-actin and stabilizes the circumferential actin belt.

PubMed ID: 18093941

DOI: 10.1073/pnas.0710504105

PubMed ID: 19816403

Title: The kinase TNIK is an essential activator of Wnt target genes.

PubMed ID: 19816403

DOI: 10.1038/emboj.2009.285

PubMed ID: 19458197

Title: Scribble interacts with beta-catenin to localize synaptic vesicles to synapses.

PubMed ID: 19458197

DOI: 10.1091/mbc.e08-12-1172

PubMed ID: 20307497

Title: Homeodomain-interacting protein kinase 2 (HIPK2) targets beta-catenin for phosphorylation and proteasomal degradation.

PubMed ID: 20307497

DOI: 10.1016/j.bbrc.2010.03.099

PubMed ID: 20361929

Title: AMP-activated protein kinase (AMPK) cross-talks with canonical Wnt signaling via phosphorylation of beta-catenin at Ser 552.

PubMed ID: 20361929

DOI: 10.1016/j.bbrc.2010.03.161

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20413591

Title: The TRPV4 channel contributes to intercellular junction formation in keratinocytes.

PubMed ID: 20413591

DOI: 10.1074/jbc.m110.103606

PubMed ID: 20086044

Title: Vinculin regulates cell-surface E-cadherin expression by binding to beta-catenin.

PubMed ID: 20086044

DOI: 10.1242/jcs.056432

PubMed ID: 10679188

Title: Regulation of beta-catenin signaling in the Wnt pathway.

PubMed ID: 10679188

DOI: 10.1006/bbrc.1999.1860

PubMed ID: 20705246

Title: S-nitrosylation of beta-catenin by eNOS-derived NO promotes VEGF-induced endothelial cell permeability.

PubMed ID: 20705246

DOI: 10.1016/j.molcel.2010.07.013

PubMed ID: 21325504

Title: Frizzled3 is required for neurogenesis and target innervation during sympathetic nervous system development.

PubMed ID: 21325504

DOI: 10.1523/jneurosci.4243-10.2011

PubMed ID: 21623382

Title: Defective Wnt-dependent cerebellar midline fusion in a mouse model of Joubert syndrome.

PubMed ID: 21623382

DOI: 10.1038/nm.2380

PubMed ID: 22510880

Title: Nuclear receptor binding protein 1 regulates intestinal progenitor cell homeostasis and tumour formation.

PubMed ID: 22510880

DOI: 10.1038/emboj.2012.91

PubMed ID: 25232112

Title: Dlg5 regulates dendritic spine formation and synaptogenesis by controlling subcellular N-cadherin localization.

PubMed ID: 25232112

DOI: 10.1523/jneurosci.1280-14.2014

PubMed ID: 25979161

Title: Transmembrane protein 64 reciprocally regulates osteoblast and adipocyte differentiation by modulating Wnt/beta-catenin signaling.

PubMed ID: 25979161

DOI: 10.1016/j.bone.2015.05.009

PubMed ID: 29148101

Title: Homeobox protein MSX-1 inhibits expression of bone morphogenetic protein 2, bone morphogenetic protein 4, and lymphoid enhancer-binding factor 1 via Wnt/beta-catenin signaling to prevent differentiation of dental mesenchymal cells during the late bell stage.

PubMed ID: 29148101

DOI: 10.1111/eos.12390

PubMed ID: 30389919

Title: ARTS mediates apoptosis and regeneration of the intestinal stem cell niche.

PubMed ID: 30389919

DOI: 10.1038/s41467-018-06941-4

PubMed ID: 31073040

Title: LMBR1L regulates lymphopoiesis through Wnt/beta-catenin signaling.

PubMed ID: 31073040

DOI: 10.1126/science.aau0812

PubMed ID: 32533114

Title: ADNP promotes neural differentiation by modulating Wnt/beta-catenin signaling.

PubMed ID: 32533114

DOI: 10.1038/s41467-020-16799-0

PubMed ID: 9298899

Title: Three-dimensional structure of the armadillo repeat region of beta-catenin.

PubMed ID: 9298899

DOI: 10.1016/s0092-8674(00)80352-9

PubMed ID: 10882138

Title: Structure of the dimerization and beta-catenin-binding region of alpha-catenin.

PubMed ID: 10882138

DOI: 10.1016/s1097-2765(00)80447-5

PubMed ID: 11348595

Title: The structure of the beta-catenin/E-cadherin complex and the molecular basis of diverse ligand recognition by beta-catenin.

PubMed ID: 11348595

DOI: 10.1016/s0092-8674(01)00330-0

PubMed ID: 11707392

Title: Molecular mechanisms of beta-catenin recognition by adenomatous polyposis coli revealed by the structure of an APC-beta-catenin complex.

PubMed ID: 11707392

DOI: 10.1093/emboj/20.22.6203

PubMed ID: 12408825

Title: ICAT inhibits beta-catenin binding to Tcf/Lef-family transcription factors and the general coactivator p300 using independent structural modules.

PubMed ID: 12408825

DOI: 10.1016/s1097-2765(02)00631-7

Sequence Information:

Length: 781
Mass: 85471
Checksum: D708F170A3FBED6E
Sequence:

MATQADLMEL DMAMEPDRKA AVSHWQQQSY LDSGIHSGAT TTAPSLSGKG NPEEEDVDTS 
QVLYEWEQGF SQSFTQEQVA DIDGQYAMTR AQRVRAAMFP ETLDEGMQIP STQFDAAHPT 
NVQRLAEPSQ MLKHAVVNLI NYQDDAELAT RAIPELTKLL NDEDQVVVNK AAVMVHQLSK 
KEASRHAIMR SPQMVSAIVR TMQNTNDVET ARCTAGTLHN LSHHREGLLA IFKSGGIPAL 
VKMLGSPVDS VLFYAITTLH NLLLHQEGAK MAVRLAGGLQ KMVALLNKTN VKFLAITTDC 
LQILAYGNQE SKLIILASGG PQALVNIMRT YTYEKLLWTT SRVLKVLSVC SSNKPAIVEA 
GGMQALGLHL TDPSQRLVQN CLWTLRNLSD AATKQEGMEG LLGTLVQLLG SDDINVVTCA 
AGILSNLTCN NYKNKMMVCQ VGGIEALVRT VLRAGDREDI TEPAICALRH LTSRHQEAEM 
AQNAVRLHYG LPVVVKLLHP PSHWPLIKAT VGLIRNLALC PANHAPLREQ GAIPRLVQLL 
VRAHQDTQRR TSMGGTQQQF VEGVRMEEIV EGCTGALHIL ARDVHNRIVI RGLNTIPLFV 
QLLYSPIENI QRVAAGVLCE LAQDKEAAEA IEAEGATAPL TELLHSRNEG VATYAAAVLF 
RMSEDKPQDY KKRLSVELTS SLFRTEPMAW NETADLGLDI GAQGEALGYR QDDPSYRSFH 
SGGYGQDALG MDPMMEHEMG GHHPGADYPV DGLPDLGHAQ DLMDGLPPGD SNQLAWFDTD 
L

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ctnnb1

Associated with

Other Information

Plakoglobin and beta-catenin: distinct but closely related. PubMed ID: 1509266

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Distinct cadherin-catenin complexes in Ca(2+)-dependent cell-cell adhesion. PubMed ID: 7982500

The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors. PubMed ID: 9783587

A GSK3beta phosphorylation site in axin modulates interaction with beta-catenin and Tcf-mediated gene expression. PubMed ID: 10581160

MAGI-1 interacts with beta-catenin and is associated with cell-cell adhesion structures. PubMed ID: 10772923

AlphaT-catenin: a novel tissue-specific beta-catenin-binding protein mediating strong cell-cell adhesion. PubMed ID: 11590244

The PDZ protein tax-interacting protein-1 inhibits beta-catenin transcriptional activity and growth of colorectal cancer cells. PubMed ID: 12874278

p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction. PubMed ID: 12640114

RORalpha coordinates reciprocal signaling in cerebellar development through sonic hedgehog and calcium-dependent pathways. PubMed ID: 14687547

Cyclin-dependent kinase 2 regulates the interaction of Axin with beta-catenin. PubMed ID: 15063782

Interactions between Sox9 and beta-catenin control chondrocyte differentiation. PubMed ID: 15132997

Deconstructing the cadherin-catenin-actin complex. PubMed ID: 16325582

Crystal structure of a beta-catenin/BCL9/Tcf4 complex. PubMed ID: 17052462

The Kruppel-like zinc finger protein Glis2 functions as a negative modulator of the Wnt/beta-catenin signaling pathway. PubMed ID: 17289029

The intercalated disc protein, mXin{alpha}, is capable of interacting with beta-catenin and bundling actin filaments. PubMed ID: 17925400

Role of GAC63 in transcriptional activation mediated by beta-catenin. PubMed ID: 17344318

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

EPLIN mediates linkage of the cadherin catenin complex to F-actin and stabilizes the circumferential actin belt. PubMed ID: 18093941

The kinase TNIK is an essential activator of Wnt target genes. PubMed ID: 19816403

Scribble interacts with beta-catenin to localize synaptic vesicles to synapses. PubMed ID: 19458197

Homeodomain-interacting protein kinase 2 (HIPK2) targets beta-catenin for phosphorylation and proteasomal degradation. PubMed ID: 20307497

AMP-activated protein kinase (AMPK) cross-talks with canonical Wnt signaling via phosphorylation of beta-catenin at Ser 552. PubMed ID: 20361929

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

The TRPV4 channel contributes to intercellular junction formation in keratinocytes. PubMed ID: 20413591

Vinculin regulates cell-surface E-cadherin expression by binding to beta-catenin. PubMed ID: 20086044

Regulation of beta-catenin signaling in the Wnt pathway. PubMed ID: 10679188

S-nitrosylation of beta-catenin by eNOS-derived NO promotes VEGF-induced endothelial cell permeability. PubMed ID: 20705246

Frizzled3 is required for neurogenesis and target innervation during sympathetic nervous system development. PubMed ID: 21325504

Defective Wnt-dependent cerebellar midline fusion in a mouse model of Joubert syndrome. PubMed ID: 21623382

Nuclear receptor binding protein 1 regulates intestinal progenitor cell homeostasis and tumour formation. PubMed ID: 22510880

Dlg5 regulates dendritic spine formation and synaptogenesis by controlling subcellular N-cadherin localization. PubMed ID: 25232112

Transmembrane protein 64 reciprocally regulates osteoblast and adipocyte differentiation by modulating Wnt/beta-catenin signaling. PubMed ID: 25979161

Homeobox protein MSX-1 inhibits expression of bone morphogenetic protein 2, bone morphogenetic protein 4, and lymphoid enhancer-binding factor 1 via Wnt/beta-catenin signaling to prevent differentiation of dental mesenchymal cells during the late bell stage. PubMed ID: 29148101

ARTS mediates apoptosis and regeneration of the intestinal stem cell niche. PubMed ID: 30389919

LMBR1L regulates lymphopoiesis through Wnt/beta-catenin signaling. PubMed ID: 31073040

ADNP promotes neural differentiation by modulating Wnt/beta-catenin signaling. PubMed ID: 32533114

Three-dimensional structure of the armadillo repeat region of beta-catenin. PubMed ID: 9298899

Structure of the dimerization and beta-catenin-binding region of alpha-catenin. PubMed ID: 10882138

The structure of the beta-catenin/E-cadherin complex and the molecular basis of diverse ligand recognition by beta-catenin. PubMed ID: 11348595

Molecular mechanisms of beta-catenin recognition by adenomatous polyposis coli revealed by the structure of an APC-beta-catenin complex. PubMed ID: 11707392

ICAT inhibits beta-catenin binding to Tcf/Lef-family transcription factors and the general coactivator p300 using independent structural modules. PubMed ID: 12408825