Genular: Defining Cellular Identity and Function

Details for: Cav1

Gene ID: 12389

Symbol: Cav1

Ensembl ID: ENSMUSG00000007655

Description: caveolin 1, caveolae protein

Associated with

Basigin interactions
(R-MMU-210991)
Cdc42 gtpase cycle
(R-MMU-9013148)
Cell surface interactions at the vascular wall
(R-MMU-202733)
Disassembly of the destruction complex and recruitment of axin to the membrane
(R-MMU-4641262)
Enos activation
(R-MMU-203615)
Esr-mediated signaling
(R-MMU-8939211)
Extra-nuclear estrogen signaling
(R-MMU-9009391)
Hemostasis
(R-MMU-109582)
Metabolism
(R-MMU-1430728)
Metabolism of nitric oxide: nos3 activation and regulation
(R-MMU-202131)
Nostrin mediated enos trafficking
(R-MMU-203641)
Rac1 gtpase cycle
(R-MMU-9013149)
Rac2 gtpase cycle
(R-MMU-9013404)
Rac3 gtpase cycle
(R-MMU-9013423)
Rhoa gtpase cycle
(R-MMU-8980692)
Rhob gtpase cycle
(R-MMU-9013026)
Rhoc gtpase cycle
(R-MMU-9013106)
Rhod gtpase cycle
(R-MMU-9013405)
Rhof gtpase cycle
(R-MMU-9035034)
Rhog gtpase cycle
(R-MMU-9013408)
Rho gtpase cycle
(R-MMU-9012999)
Rhoh gtpase cycle
(R-MMU-9013407)
Rhoq gtpase cycle
(R-MMU-9013406)
Rnd1 gtpase cycle
(R-MMU-9696273)
Rnd2 gtpase cycle
(R-MMU-9696270)
Rnd3 gtpase cycle
(R-MMU-9696264)
Signaling by nuclear receptors
(R-MMU-9006931)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signaling by rho gtpases
(R-MMU-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-MMU-9716542)
Signaling by vegf
(R-MMU-194138)
Signaling by wnt
(R-MMU-195721)
Signal transduction
(R-MMU-162582)
Tcf dependent signaling in response to wnt
(R-MMU-201681)
Vegfa-vegfr2 pathway
(R-MMU-4420097)
Vegfr2 mediated vascular permeability
(R-MMU-5218920)
Angiogenesis
(GO:0001525)
Atpase binding
(GO:0051117)
Calcium ion transport
(GO:0006816)
Cell population proliferation
(GO:0008283)
Endocytosis
(GO:0006897)
Endothelial cell proliferation
(GO:0001935)
Enzyme binding
(GO:0019899)
Glandular epithelial cell differentiation
(GO:0002067)
Identical protein binding
(GO:0042802)
Intracellular calcium ion homeostasis
(GO:0006874)
Inward rectifier potassium channel inhibitor activity
(GO:0070320)
Kinase binding
(GO:0019900)
Lactation
(GO:0007595)
Mapk cascade
(GO:0000165)
Molecular adaptor activity
(GO:0060090)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of cytokine-mediated signaling pathway
(GO:0001960)
Negative regulation of endothelial cell proliferation
(GO:0001937)
Negative regulation of muscle cell apoptotic process
(GO:0010656)
Negative regulation of signal transduction
(GO:0009968)
Negative regulation of smooth muscle cell migration
(GO:0014912)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nitric-oxide synthase binding
(GO:0050998)
Nitric oxide biosynthetic process
(GO:0006809)
Oxysterol binding
(GO:0008142)
Peptidase activator activity
(GO:0016504)
Positive regulation of calcium ion transport into cytosol
(GO:0010524)
Positive regulation of cholesterol efflux
(GO:0010875)
Positive regulation of endothelial cell proliferation
(GO:0001938)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of signal transduction
(GO:0009967)
Post-transcriptional regulation of gene expression
(GO:0010608)
Protein-containing complex binding
(GO:0044877)
Protein-macromolecule adaptor activity
(GO:0030674)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Protein kinase binding
(GO:0019901)
Protein localization
(GO:0008104)
Protein transport
(GO:0015031)
Protein tyrosine kinase inhibitor activity
(GO:0030292)
Receptor-mediated endocytosis of virus by host cell
(GO:0019065)
Receptor serine/threonine kinase binding
(GO:0033612)
Regulation of smooth muscle contraction
(GO:0006940)
Regulation of the force of heart contraction
(GO:0002026)
Regulation of the force of heart contraction by chemical signal
(GO:0003057)
Response to bacterium
(GO:0009617)
Response to hypoxia
(GO:0001666)
Response to ischemia
(GO:0002931)
Response to mechanical stimulus
(GO:0009612)
Signaling receptor binding
(GO:0005102)
Skeletal muscle tissue development
(GO:0007519)
Small gtpase binding
(GO:0031267)
Snare binding
(GO:0000149)
Syntaxin binding
(GO:0019905)
Transmembrane transporter binding
(GO:0044325)
Triglyceride metabolic process
(GO:0006641)
Tyrosine phosphorylation of stat protein
(GO:0007260)
Vasculogenesis
(GO:0001570)

Other Information

Proteins

Caveolin-1

Genular Protein ID: 2134543410

Symbol: CAV1_MOUSE

Name: Caveolin-1

UniProtKB Accession Codes:

P49817 Q8C1X7 Q8CBP4 Q9QYH3 Q9QYH4

Database IDs:

Citations:

PubMed ID: 7926819

Title: The primary sequence of murine caveolin reveals a conserved consensus site for phosphorylation by protein kinase C.

PubMed ID: 7926819

DOI: 10.1016/0378-1119(94)90087-6

PubMed ID: 10631317

Title: Caveolin-1 isoforms are encoded in distinct mRNAs: identification of mouse caveolin-1 mRNA variants caused by alternative transcription initiation and splicing.

PubMed ID: 10631317

DOI: 10.1016/s0014-5793(99)01730-5

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7608210

Title: Caveolin isoforms differ in their N-terminal protein sequence and subcellular distribution. Identification and epitope mapping of an isoform-specific monoclonal antibody probe.

PubMed ID: 7608210

DOI: 10.1074/jbc.270.27.16395

PubMed ID: 10816572

Title: Caveolin-1 expression inhibits Wnt/beta-catenin/Lef-1 signaling by recruiting beta-catenin to caveolae membrane domains.

PubMed ID: 10816572

DOI: 10.1074/jbc.m002020200

PubMed ID: 12036959

Title: The insulin receptor catalyzes the tyrosine phosphorylation of caveolin-1.

PubMed ID: 12036959

DOI: 10.1074/jbc.m203375200

PubMed ID: 12531427

Title: c-Abl is required for oxidative stress-induced phosphorylation of caveolin-1 on tyrosine 14.

PubMed ID: 12531427

DOI: 10.1016/s0898-6568(02)00090-6

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 16877379

Title: A functional interaction between sprouty proteins and caveolin-1.

PubMed ID: 16877379

DOI: 10.1074/jbc.m603921200

PubMed ID: 19546242

Title: MURC/Cavin-4 and cavin family members form tissue-specific caveolar complexes.

PubMed ID: 19546242

DOI: 10.1083/jcb.200903053

PubMed ID: 19131326

Title: Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry.

PubMed ID: 19131326

DOI: 10.1074/mcp.m800451-mcp200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21610094

Title: Essential role of PACSIN2/syndapin-II in caveolae membrane sculpting.

PubMed ID: 21610094

DOI: 10.1242/jcs.086264

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

PubMed ID: 30188967

Title: Fam198a, a member of secreted kinase, secrets through caveolae biogenesis pathway.

PubMed ID: 30188967

DOI: 10.1093/abbs/gmy105

Sequence Information:

Length: 178
Mass: 20539
Checksum: CF88FE9B1D3D67AE
Sequence:

MSGGKYVDSE GHLYTVPIRE QGNIYKPNNK AMADEVTEKQ VYDAHTKEID LVNRDPKHLN 
DDVVKIDFED VIAEPEGTHS FDGIWKASFT TFTVTKYWFY RLLSTIFGIP MALIWGIYFA 
ILSFLHIWAV VPCIKSFLIE IQCISRVYSI YVHTFCDPLF EAIGKIFSNI RISTQKEI

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Cav1

Associated with

Other Information

The primary sequence of murine caveolin reveals a conserved consensus site for phosphorylation by protein kinase C. PubMed ID: 7926819

Caveolin-1 isoforms are encoded in distinct mRNAs: identification of mouse caveolin-1 mRNA variants caused by alternative transcription initiation and splicing. PubMed ID: 10631317

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Caveolin isoforms differ in their N-terminal protein sequence and subcellular distribution. Identification and epitope mapping of an isoform-specific monoclonal antibody probe. PubMed ID: 7608210

Caveolin-1 expression inhibits Wnt/beta-catenin/Lef-1 signaling by recruiting beta-catenin to caveolae membrane domains. PubMed ID: 10816572

The insulin receptor catalyzes the tyrosine phosphorylation of caveolin-1. PubMed ID: 12036959

c-Abl is required for oxidative stress-induced phosphorylation of caveolin-1 on tyrosine 14. PubMed ID: 12531427

Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. PubMed ID: 15592455

A functional interaction between sprouty proteins and caveolin-1. PubMed ID: 16877379

MURC/Cavin-4 and cavin family members form tissue-specific caveolar complexes. PubMed ID: 19546242

Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry. PubMed ID: 19131326

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Essential role of PACSIN2/syndapin-II in caveolae membrane sculpting. PubMed ID: 21610094

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. PubMed ID: 23806337

Fam198a, a member of secreted kinase, secrets through caveolae biogenesis pathway. PubMed ID: 30188967