Genular: Defining Cellular Identity and Function

Details for: Runx2

Gene ID: 12393

Symbol: Runx2

Ensembl ID: ENSMUSG00000039153

Description: runt related transcription factor 2

Associated with

Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Regulation of runx2 expression and activity
(R-MMU-8939902)
Rna polymerase ii transcription
(R-MMU-73857)
Runx2 regulates bone development
(R-MMU-8941326)
Runx2 regulates osteoblast differentiation
(R-MMU-8940973)
Transcriptional regulation by runx2
(R-MMU-8878166)
Atp binding
(GO:0005524)
Bhlh transcription factor binding
(GO:0043425)
Bmp signaling pathway
(GO:0030509)
Bone mineralization
(GO:0030282)
Cell differentiation
(GO:0030154)
Cell maturation
(GO:0048469)
Cell population proliferation
(GO:0008283)
Chondrocyte development
(GO:0002063)
Chondrocyte differentiation
(GO:0002062)
Chromatin
(GO:0000785)
Chromatin binding
(GO:0003682)
Chromatin dna binding
(GO:0031490)
Cis-regulatory region sequence-specific dna binding
(GO:0000987)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-binding transcription factor binding
(GO:0140297)
Dna binding
(GO:0003677)
Embryonic cranial skeleton morphogenesis
(GO:0048701)
Embryonic forelimb morphogenesis
(GO:0035115)
Endochondral ossification
(GO:0001958)
Epithelial cell proliferation
(GO:0050673)
Gene expression
(GO:0010467)
General transcription initiation factor binding
(GO:0140296)
Hemopoiesis
(GO:0030097)
Histone deacetylase binding
(GO:0042826)
Ligamentous ossification
(GO:0036076)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of smoothened signaling pathway
(GO:0045879)
Neuron differentiation
(GO:0030182)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Odontogenesis of dentin-containing tooth
(GO:0042475)
Ossification
(GO:0001503)
Osteoblast development
(GO:0002076)
Osteoblast differentiation
(GO:0001649)
Osteoblast fate commitment
(GO:0002051)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of chondrocyte differentiation
(GO:0032332)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of epithelial cell proliferation
(GO:0050679)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of ossification
(GO:0045778)
Positive regulation of osteoblast differentiation
(GO:0045669)
Positive regulation of stem cell proliferation
(GO:2000648)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Regulation of cell differentiation
(GO:0045595)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of fibroblast growth factor receptor signaling pathway
(GO:0040036)
Regulation of gene expression
(GO:0010468)
Regulation of odontogenesis of dentin-containing tooth
(GO:0042487)
Regulation of ossification
(GO:0030278)
Regulation of osteoblast differentiation
(GO:0045667)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to sodium phosphate
(GO:1904383)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Sequence-specific double-stranded dna binding
(GO:1990837)
Skeletal system development
(GO:0001501)
Skeletal system morphogenesis
(GO:0048705)
Smad protein signal transduction
(GO:0060395)
Smoothened signaling pathway
(GO:0007224)
Stem cell differentiation
(GO:0048863)
Stem cell proliferation
(GO:0072089)
T cell differentiation
(GO:0030217)
Transcription cis-regulatory region binding
(GO:0000976)

Other Information

Proteins

Genular Protein ID: 1196375124

Symbol: RUNX2_MOUSE

Name: Acute myeloid leukemia 3 protein

UniProtKB Accession Codes:

Q08775 O35183 Q08776 Q9JLN0 Q9QUQ6 Q9QY29 Q9R0U4 Q9Z2J7

Database IDs:

Citations:

PubMed ID: 8341710

Title: PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene.

PubMed ID: 8341710

DOI: 10.1073/pnas.90.14.6859

PubMed ID: 9182762

Title: Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation.

PubMed ID: 9182762

DOI: 10.1016/s0092-8674(00)80257-3

PubMed ID: 9238031

Title: Proviral insertions induce the expression of bone-specific isoforms of PEBP2alphaA (CBFA1): evidence for a new myc collaborating oncogene.

PubMed ID: 9238031

DOI: 10.1073/pnas.94.16.8646

PubMed ID: 9651525

Title: Genomic structure and isoform expression of the mouse, rat and human Cbfa1/Osf2 transcription factor.

PubMed ID: 9651525

DOI: 10.1016/s0378-1119(98)00227-3

PubMed ID: 10524201

Title: Isolation and characterization of the distal promoter region of mouse Cbfa1.

PubMed ID: 10524201

DOI: 10.1016/s0167-4781(99)00113-x

PubMed ID: 8386878

Title: Molecular cloning and characterization of PEBP2 beta, the heterodimeric partner of a novel Drosophila runt-related DNA binding protein PEBP2 alpha.

PubMed ID: 8386878

DOI: 10.1006/viro.1993.1262

PubMed ID: 9182763

Title: Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts.

PubMed ID: 9182763

DOI: 10.1016/s0092-8674(00)80258-5

PubMed ID: 10660618

Title: MAPK pathways activate and phosphorylate the osteoblast-specific transcription factor, Cbfa1.

PubMed ID: 10660618

DOI: 10.1074/jbc.275.6.4453

PubMed ID: 15557274

Title: The interferon-inducible p204 protein acts as a transcriptional coactivator of Cbfa1 and enhances osteoblast differentiation.

PubMed ID: 15557274

DOI: 10.1074/jbc.m412604200

PubMed ID: 16751105

Title: SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation.

PubMed ID: 16751105

DOI: 10.1016/j.cell.2006.05.012

PubMed ID: 16728642

Title: Regulation of adult bone mass by the zinc finger adapter protein Schnurri-3.

PubMed ID: 16728642

DOI: 10.1126/science.1126313

PubMed ID: 17960593

Title: p68 (Ddx5) interacts with Runx2 and regulates osteoblast differentiation.

PubMed ID: 17960593

DOI: 10.1002/jcb.21526

PubMed ID: 20484411

Title: Runx2 trans-activation mediated by the MSX2-interacting nuclear target requires homeodomain interacting protein kinase-3.

PubMed ID: 20484411

DOI: 10.1210/me.2010-0029

PubMed ID: 21239498

Title: Parathyroid hormone-responsive Smad3-related factor, Tmem119, promotes osteoblast differentiation and interacts with the bone morphogenetic protein-Runx2 pathway.

PubMed ID: 21239498

DOI: 10.1074/jbc.m110.179127

PubMed ID: 21471200

Title: Foxo1 mediates insulin-like growth factor 1 (IGF1)/insulin regulation of osteocalcin expression by antagonizing Runx2 in osteoblasts.

PubMed ID: 21471200

DOI: 10.1074/jbc.m110.197905

PubMed ID: 24028588

Title: Msx1 regulates proliferation and differentiation of mouse dental mesenchymal cells in culture.

PubMed ID: 24028588

DOI: 10.1111/eos.12078

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 29148101

Title: Homeobox protein MSX-1 inhibits expression of bone morphogenetic protein 2, bone morphogenetic protein 4, and lymphoid enhancer-binding factor 1 via Wnt/beta-catenin signaling to prevent differentiation of dental mesenchymal cells during the late bell stage.

PubMed ID: 29148101

DOI: 10.1111/eos.12390

PubMed ID: 35922041

Title: IPO7 Promotes Odontoblastic Differentiation and Inhibits Osteoblastic Differentiation Through Regulation of RUNX2 Expression and Translocation.

PubMed ID: 35922041

DOI: 10.1093/stmcls/sxac055

Sequence Information:

Length: 607
Mass: 66205
Checksum: E87A4497ED19EE0E
Sequence:

MLHSPHKQPQ NHKCGANFLQ EDCKKALAFK WLISAGHYQP PRPTESVSAL TTVHAGIFKA 
ASSIYNRGHK FYLEKKGGTM ASNSLFSAVT PCQQSFFWDP STSRRFSPPS SSLQPGKMSD 
VSPVVAAQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQEAAA AAAAAAAAAA AAAAAVPRLR 
PPHDNRTMVE IIADHPAELV RTDSPNFLCS VLPSHWRCNK TLPVAFKVVA LGEVPDGTVV 
TVMAGNDENY SAELRNASAV MKNQVARFND LRFVGRSGRG KSFTLTITVF TNPPQVATYH 
RAIKVTVDGP REPRRHRQKL DDSKPSLFSD RLSDLGRIPH PSMRVGVPPQ NPRPSLNSAP 
SPFNPQGQSQ ITDPRQAQSS PPWSYDQSYP SYLSQMTSPS IHSTTPLSST RGTGLPAITD 
VPRRISDDDT ATSDFCLWPS SLSKKSQAGA SELGPFSDPR QFPSISSLTE SRFSNPRMHY 
PATFTYTPPV TSGMSLGMSA TTHYHTYLPP PYPGSSQSQS GPFQTSSTPY LYYGTSSASY 
QFPMVPGGDR SPSRMVPPCT TTSNGSTLLN PNLPNQNDGV DADGSHSSSP TVLNSSGRMD 
ESVWRPY

Genular Protein ID: 3344212086

Symbol: E0CZ12_MOUSE

Name: N/A

UniProtKB Accession Codes:

E0CZ12

Database IDs:

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

Length: 421
Mass: 45574
Checksum: 897080C3565FA953
Sequence:

MRIPVDPSTS RRFSPPSSSL QPGKMSDVSP VVAAQQQQQQ QQQQQQQQQQ QQQQQQQQQQ 
QQQEAAAAAA AAAAAAAAAA AAVPRLRPPH DNRTMVEIIA DHPAELVRTD SPNFLCSVLP 
SHWRCNKTLP VAFKVVALGE VPDGTVVTVM AGNDENYSAE LRNASAVMKN QVARFNDLRF 
VGRSGRDPRQ AQSSPPWSYD QSYPSYLSQM TSPSIHSTTP LSSTRGTGLP AITDVPRRIS 
DDDTATSDFC LWPSSLSKKS QAGASELGPF SDPRQFPSIS SLTESRFSNP RMHYPATFTY 
TPPVTSGMSL GMSATTHYHT YLPPPYPGSS QSQSGPFQTS STPYLYYGTS SASYQFPMVP 
GGDRSPSRMV PPCTTTSNGS TLLNPNLPNQ NDGVDADGSH SSSPTVLNSS GRMDESVWRP 
Y

Genular Protein ID: 936465164

Symbol: Q9Z2T9_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q9Z2T9

Database IDs:

Sequence Information:

Length: 95
Mass: 10459
Checksum: CF83AD4331FBA161
Sequence:

MLHSPHKQPQ NHKCGANFLQ EDCKKALAFK WLISAGHYQP PRPTESVSAL TTVHAGIFKA 
ASSIYNRGHK FYLEKKGGTM ASNSLFSAVT PCQQS

Genular Protein ID: 607728401

Symbol: F8WHN7_MOUSE

Name: N/A

UniProtKB Accession Codes:

F8WHN7

Database IDs:

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

Sequence Information:

Length: 514
Mass: 55880
Checksum: 5E9442CF0D73142D
Sequence:

MRIPVDPSTS RRFSPPSSSL QPGKMSDVSP VVAAQQQQQQ QQQQQQQQQQ QQQQQQQQQQ 
QQQEAAAAAA AAAAAAAAAA AAVPRLRPPH DNRTMVEIIA DHPAELVRTD SPNFLCSVLP 
SHWRCNKTLP VAFKVVALGE VPDGTVVTVM AGNDENYSAE LRNASAVMKN QVARFNDLRF 
VGRSGRGKSF TLTITVFTNP PQVATYHRAI KVTVDGPREP RRHRQKLDDS KPSLFSDRLS 
DLGRIPHPSM RVGVPPQNPR PSLNSAPSPF NPQGQSQITD PRQAQSSPPW SYDQSYPSYL 
SQMTSPSIHS TTPLSSTRGT GLPAITDVPR RISDDDTATS DFCLWPSSLS KKSQAGASEL 
GPFSDPRQFP SISSLTESRF SNPRMHYPAT FTYTPPVTSG MSLGMSATTH YHTYLPPPYP 
GSSQSQSGPF QTSSTPYLYY GTSSASYQFP MVPGGDRSPS RMVPPCTTTS NGSTLLNPNL 
PNQNDGVDAD GSHSSSPTVL NSSGRMDESV WRPY

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Runx2

Associated with

Other Information

PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene. PubMed ID: 8341710

Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. PubMed ID: 9182762

Proviral insertions induce the expression of bone-specific isoforms of PEBP2alphaA (CBFA1): evidence for a new myc collaborating oncogene. PubMed ID: 9238031

Genomic structure and isoform expression of the mouse, rat and human Cbfa1/Osf2 transcription factor. PubMed ID: 9651525

Isolation and characterization of the distal promoter region of mouse Cbfa1. PubMed ID: 10524201

Molecular cloning and characterization of PEBP2 beta, the heterodimeric partner of a novel Drosophila runt-related DNA binding protein PEBP2 alpha. PubMed ID: 8386878

Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. PubMed ID: 9182763

MAPK pathways activate and phosphorylate the osteoblast-specific transcription factor, Cbfa1. PubMed ID: 10660618

The interferon-inducible p204 protein acts as a transcriptional coactivator of Cbfa1 and enhances osteoblast differentiation. PubMed ID: 15557274

SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation. PubMed ID: 16751105

Regulation of adult bone mass by the zinc finger adapter protein Schnurri-3. PubMed ID: 16728642

p68 (Ddx5) interacts with Runx2 and regulates osteoblast differentiation. PubMed ID: 17960593

Runx2 trans-activation mediated by the MSX2-interacting nuclear target requires homeodomain interacting protein kinase-3. PubMed ID: 20484411

Parathyroid hormone-responsive Smad3-related factor, Tmem119, promotes osteoblast differentiation and interacts with the bone morphogenetic protein-Runx2 pathway. PubMed ID: 21239498

Foxo1 mediates insulin-like growth factor 1 (IGF1)/insulin regulation of osteocalcin expression by antagonizing Runx2 in osteoblasts. PubMed ID: 21471200

Msx1 regulates proliferation and differentiation of mouse dental mesenchymal cells in culture. PubMed ID: 24028588

Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. PubMed ID: 24129315

Homeobox protein MSX-1 inhibits expression of bone morphogenetic protein 2, bone morphogenetic protein 4, and lymphoid enhancer-binding factor 1 via Wnt/beta-catenin signaling to prevent differentiation of dental mesenchymal cells during the late bell stage. PubMed ID: 29148101

IPO7 Promotes Odontoblastic Differentiation and Inhibits Osteoblastic Differentiation Through Regulation of RUNX2 Expression and Translocation. PubMed ID: 35922041

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. PubMed ID: 24129315

Database document:

PubMed ID: 8341710

PubMed ID: 9182762

PubMed ID: 9238031

PubMed ID: 9651525

PubMed ID: 10524201

PubMed ID: 8386878

PubMed ID: 9182763

PubMed ID: 10660618

PubMed ID: 15557274

PubMed ID: 16751105

PubMed ID: 16728642

PubMed ID: 17960593

PubMed ID: 20484411

PubMed ID: 21239498

PubMed ID: 21471200

PubMed ID: 24028588

PubMed ID: 24129315

PubMed ID: 29148101

PubMed ID: 35922041

PubMed ID: 19468303

PubMed ID: 19468303

PubMed ID: 24129315