Details for: ADH1A

Gene ID: 124

Symbol: ADH1A

Ensembl ID: ENSG00000187758

Description: alcohol dehydrogenase 1A (class I), alpha polypeptide

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.1958
    Cell Significance Index: 17.6500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.0832
    Cell Significance Index: 214.9600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9944
    Cell Significance Index: 189.2400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5988
    Cell Significance Index: 59.2300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5469
    Cell Significance Index: 493.8100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.5355
    Cell Significance Index: 11.4100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.5132
    Cell Significance Index: 8.6500
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.3774
    Cell Significance Index: 3.2200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.3761
    Cell Significance Index: 12.0500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3722
    Cell Significance Index: 40.4800
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.3328
    Cell Significance Index: 3.6400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3254
    Cell Significance Index: 52.9300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3188
    Cell Significance Index: 19.1400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2373
    Cell Significance Index: 5.1400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.2263
    Cell Significance Index: 3.5900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2193
    Cell Significance Index: 15.1700
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 0.1971
    Cell Significance Index: 0.5200
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.1841
    Cell Significance Index: 1.0600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1341
    Cell Significance Index: 1.9200
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.1274
    Cell Significance Index: 0.4800
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.1002
    Cell Significance Index: 0.7600
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0844
    Cell Significance Index: 1.2100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0840
    Cell Significance Index: 1.6400
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.0789
    Cell Significance Index: 0.7500
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.0404
    Cell Significance Index: 0.2500
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.0389
    Cell Significance Index: 0.4700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0257
    Cell Significance Index: 0.7400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0235
    Cell Significance Index: 0.6300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0140
    Cell Significance Index: 0.3500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0135
    Cell Significance Index: 0.6100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0133
    Cell Significance Index: 0.2000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0122
    Cell Significance Index: 0.4300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0030
    Cell Significance Index: 5.5300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0029
    Cell Significance Index: 0.1800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0022
    Cell Significance Index: 3.3300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0019
    Cell Significance Index: 0.3500
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 0.0019
    Cell Significance Index: 0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0019
    Cell Significance Index: 3.6700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0006
    Cell Significance Index: 0.4100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0004
    Cell Significance Index: 0.4800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0005
    Cell Significance Index: -0.3100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0010
    Cell Significance Index: -0.3500
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.0014
    Cell Significance Index: -0.0100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0017
    Cell Significance Index: -0.9400
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0025
    Cell Significance Index: -0.0300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0029
    Cell Significance Index: -1.8300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0037
    Cell Significance Index: -0.7800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0040
    Cell Significance Index: -0.8100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0041
    Cell Significance Index: -0.4700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0044
    Cell Significance Index: -2.0100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0059
    Cell Significance Index: -1.0100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0063
    Cell Significance Index: -0.7700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0064
    Cell Significance Index: -0.8800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0079
    Cell Significance Index: -0.8200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0082
    Cell Significance Index: -0.4600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0095
    Cell Significance Index: -1.1100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0102
    Cell Significance Index: -0.5300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0103
    Cell Significance Index: -0.6300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0109
    Cell Significance Index: -1.5900
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0126
    Cell Significance Index: -0.1800
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0135
    Cell Significance Index: -0.1500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0143
    Cell Significance Index: -0.9600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0145
    Cell Significance Index: -0.3000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0149
    Cell Significance Index: -1.1400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0182
    Cell Significance Index: -0.3000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0182
    Cell Significance Index: -0.9200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0190
    Cell Significance Index: -0.3200
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.0228
    Cell Significance Index: -0.1800
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.0269
    Cell Significance Index: -0.2500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0270
    Cell Significance Index: -1.2700
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0291
    Cell Significance Index: -0.3800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0303
    Cell Significance Index: -1.0600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0307
    Cell Significance Index: -1.2600
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.0310
    Cell Significance Index: -0.3200
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0314
    Cell Significance Index: -0.4400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0315
    Cell Significance Index: -1.0300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0315
    Cell Significance Index: -0.4300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0339
    Cell Significance Index: -1.0800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0340
    Cell Significance Index: -0.9700
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0342
    Cell Significance Index: -0.3600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0347
    Cell Significance Index: -1.8100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0353
    Cell Significance Index: -1.5600
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.0373
    Cell Significance Index: -0.4700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0384
    Cell Significance Index: -1.0100
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0395
    Cell Significance Index: -0.6000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0397
    Cell Significance Index: -1.0600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0401
    Cell Significance Index: -1.5200
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: -0.0405
    Cell Significance Index: -0.4000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0423
    Cell Significance Index: -1.9700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0433
    Cell Significance Index: -1.3700
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0434
    Cell Significance Index: -0.5500
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0434
    Cell Significance Index: -0.5000
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0435
    Cell Significance Index: -0.5500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0441
    Cell Significance Index: -1.1000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0455
    Cell Significance Index: -0.9500
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0463
    Cell Significance Index: -0.4400
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0472
    Cell Significance Index: -0.9600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0474
    Cell Significance Index: -0.8200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0475
    Cell Significance Index: -1.1400
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0476
    Cell Significance Index: -0.3700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ADH1A is a class I alpha polypeptide, which is a member of the alcohol dehydrogenase family. It is highly expressed in tissues involved in the metabolism of ethanol and other alcohols, such as the liver and intestine. The ADH1A enzyme is a zinc-dependent enzyme, which means that it requires zinc ions to catalyze the conversion of substrates into products. This enzyme has a high Km value for ethanol, indicating that it is not the primary enzyme responsible for ethanol metabolism in the liver. **Pathways and Functions:** The ADH1A enzyme is involved in the following pathways: 1. **Alcohol Metabolism:** ADH1A plays a role in the metabolism of ethanol, converting it into acetaldehyde, which is then converted into acetate and eventually excreted from the body. 2. **Retinoic Acid Biosynthesis:** ADH1A is involved in the conversion of retinol into retinaldehyde, which is then converted into retinoic acid. This process is essential for the regulation of cell growth and differentiation. 3. **Zinc-Dependent Enzyme Activity:** ADH1A requires zinc ions to catalyze the conversion of substrates into products. Zinc ions bind to the active site of the enzyme, facilitating the reaction. 4. **Phase I Metabolism:** ADH1A is involved in the phase I metabolism of substances, converting them into more water-soluble compounds that can be easily excreted from the body. **Clinical Significance:** The ADH1A gene has several clinical implications: 1. **Alcohol Dependence:** Variations in the ADH1A gene have been associated with alcohol dependence and tolerance. 2. **Retinoid Disorders:** Mutations in the ADH1A gene have been linked to retinoid disorders, such as retinitis pigmentosa. 3. **Metabolic Disorders:** ADH1A deficiency has been associated with metabolic disorders, such as impaired glucose metabolism. 4. **Cancer:** The ADH1A enzyme has been implicated in the regulation of cell growth and differentiation, and its dysregulation has been associated with cancer development. In conclusion, the ADH1A gene plays a crucial role in the metabolism of ethanol and other substances, as well as the biosynthesis of retinoic acid. Its dysregulation has been associated with various clinical disorders, including alcohol dependence, retinoid disorders, metabolic disorders, and cancer. Further research is needed to fully understand the role of ADH1A in human health and disease.

Genular Protein ID: 2090515616

Symbol: ADH1A_HUMAN

Name: Alcohol dehydrogenase 1A

UniProtKB Accession Codes:

P07327 A8K3E3 Q17R68

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 36 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 DrugCentral 1 EC 2 EMBL 10 Ensembl 1 EvolutionaryTrace 1 GO 11 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 Rhea 4 SABIO-RK 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3013304

Title: cDNA and protein structure for the alpha subunit of human liver alcohol dehydrogenase.

PubMed ID: 3013304

DOI: 10.1021/bi00357a026

PubMed ID: 2935875

Title: Three human alcohol dehydrogenase subunits: cDNA structure and molecular and evolutionary divergence.

PubMed ID: 2935875

DOI: 10.1073/pnas.83.3.634

PubMed ID: 2920825

Title: Molecular structure of the human alcohol dehydrogenase 1 gene.

PubMed ID: 2920825

DOI: 10.1016/0014-5793(89)81217-7

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2347582

Title: The human class I alcohol dehydrogenase gene cluster: three genes are tandemly organized in an 80-kb-long segment of the genome.

PubMed ID: 2347582

DOI: 10.1016/0888-7543(90)90535-3

PubMed ID: 2738060

Title: Stereospecific oxidation of secondary alcohols by human alcohol dehydrogenases.

PubMed ID: 2738060

DOI: 10.1016/s0021-9258(18)60436-3

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 15449945

Title: Structure of three class I human alcohol dehydrogenases complexed with isoenzyme specific formamide inhibitors.

PubMed ID: 15449945

DOI: 10.1021/bi0489107

PubMed ID: 11274460

Title: Three-dimensional structures of the three human class I alcohol dehydrogenases.

PubMed ID: 11274460

DOI: 10.1110/ps.45001

Sequence Information:

  • Length: 375
  • Mass: 39859
  • Checksum: B6DF4D57080D9BC1
  • Sequence:
    • MSTAGKVIKC KAAVLWELKK PFSIEEVEVA PPKAHEVRIK MVAVGICGTD DHVVSGTMVT 
PLPVILGHEA AGIVESVGEG VTTVKPGDKV IPLAIPQCGK CRICKNPESN YCLKNDVSNP 
QGTLQDGTSR FTCRRKPIHH FLGISTFSQY TVVDENAVAK IDAASPLEKV CLIGCGFSTG 
YGSAVNVAKV TPGSTCAVFG LGGVGLSAIM GCKAAGAARI IAVDINKDKF AKAKELGATE 
CINPQDYKKP IQEVLKEMTD GGVDFSFEVI GRLDTMMASL LCCHEACGTS VIVGVPPDSQ 
NLSMNPMLLL TGRTWKGAIL GGFKSKECVP KLVADFMAKK FSLDALITHV LPFEKINEGF 
DLLHSGKSIR TILMF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.