Gene ADH1A - ENSG00000187758 | NCBI Gene ID: 124

Details for: ADH1A

Gene ID: 124

Symbol: ADH1A

Ensembl ID: ENSG00000187758

Description: alcohol dehydrogenase 1A (class I), alpha polypeptide

Associated with

Abacavir adme
(R-HSA-2161522)
Abacavir metabolism
(R-HSA-2161541)
Biological oxidations
(R-HSA-211859)
Drug adme
(R-HSA-9748784)
Metabolism
(R-HSA-1430728)
Phase i - functionalization of compounds
(R-HSA-211945)
Ra biosynthesis pathway
(R-HSA-5365859)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by retinoic acid
(R-HSA-5362517)
Signal transduction
(R-HSA-162582)
Alcohol dehydrogenase (nad+) activity
(GO:0004022)
Alcohol dehydrogenase activity, zinc-dependent
(GO:0004024)
Alcohol metabolic process
(GO:0006066)
Butanol dehydrogenase activity
(GO:1990362)
Cytosol
(GO:0005829)
Ethanol oxidation
(GO:0006069)
Nad-retinol dehydrogenase activity
(GO:0004745)
Nucleoplasm
(GO:0005654)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Retinoic acid metabolic process
(GO:0042573)
Retinol metabolic process
(GO:0042572)
Zinc ion binding
(GO:0008270)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 2.31
Marker Score: 2324
Cell Name: hepatoblast (CL0005026)
Fold Change: 2.23
Marker Score: 7293.5
Cell Name: T cell (CL0000084)
Fold Change: 1.82
Marker Score: 3137
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.62
Marker Score: 1174
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 1.46
Marker Score: 673
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.46
Marker Score: 1457
Cell Name: plasma cell (CL0000786)
Fold Change: 1.46
Marker Score: 1626
Cell Name: Mueller cell (CL0000636)
Fold Change: 1.3
Marker Score: 1799
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.27
Marker Score: 858
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1.18
Marker Score: 489
Cell Name: goblet cell (CL0000160)
Fold Change: 1.15
Marker Score: 7655
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.15
Marker Score: 4817
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71827
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48053
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.99
Marker Score: 510
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.98
Marker Score: 464
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30409
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2412
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.94
Marker Score: 376
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5351
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2743
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.91
Marker Score: 328
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5296
Cell Name: mast cell (CL0000097)
Fold Change: 0.83
Marker Score: 484
Cell Name: B cell (CL0000236)
Fold Change: 0.79
Marker Score: 748
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1268
Cell Name: brush cell (CL0002204)
Fold Change: 0.77
Marker Score: 707
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.77
Marker Score: 399
Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 0.76
Marker Score: 286
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.74
Marker Score: 1179.5
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.73
Marker Score: 464
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 0.72
Marker Score: 4605
Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 0.62
Marker Score: 2671
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.59
Marker Score: 470
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.58
Marker Score: 1092
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.55
Marker Score: 175
Cell Name: basal cell (CL0000646)
Fold Change: 0.54
Marker Score: 702
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 0.51
Marker Score: 2741
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.47
Marker Score: 279
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.43
Marker Score: 869
Cell Name: adventitial cell (CL0002503)
Fold Change: 0.42
Marker Score: 103
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 0.37
Marker Score: 564
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.34
Marker Score: 205
Cell Name: hepatocyte (CL0000182)
Fold Change: 0.33
Marker Score: 227
Cell Name: erythroblast (CL0000765)
Fold Change: 0.33
Marker Score: 207
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.29
Marker Score: 4526
Cell Name: Kupffer cell (CL0000091)
Fold Change: 0.28
Marker Score: 285
Cell Name: mature NK T cell (CL0000814)
Fold Change: 0.27
Marker Score: 124
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.26
Marker Score: 125
Cell Name: erythrocyte (CL0000232)
Fold Change: 0.24
Marker Score: 132
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.23
Marker Score: 65
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.22
Marker Score: 75
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 0.22
Marker Score: 453
Cell Name: secretory cell (CL0000151)
Fold Change: 0.21
Marker Score: 389
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 0.2
Marker Score: 164
Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 0.19
Marker Score: 208
Cell Name: cholangiocyte (CL1000488)
Fold Change: 0.19
Marker Score: 71.5
Cell Name: pericyte (CL0000669)
Fold Change: 0.16
Marker Score: 94
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 0.16
Marker Score: 139
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.14
Marker Score: 62
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.14
Marker Score: 34
Cell Name: fibroblast (CL0000057)
Fold Change: 0.12
Marker Score: 118
Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 0.11
Marker Score: 21
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 0.1
Marker Score: 36
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 0.09
Marker Score: 23
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.09
Marker Score: 78
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 0.09
Marker Score: 19
Cell Name: inflammatory macrophage (CL0000863)
Fold Change: 0.08
Marker Score: 26
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 0.08
Marker Score: 51
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.08
Marker Score: 20
Cell Name: type L enteroendocrine cell (CL0002279)
Fold Change: 0.08
Marker Score: 21
Cell Name: M cell of gut (CL0000682)
Fold Change: 0.08
Marker Score: 20
Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: 0.08
Marker Score: 22
Cell Name: type D enteroendocrine cell (CL0000502)
Fold Change: 0.07
Marker Score: 23
Cell Name: bronchial smooth muscle cell (CL0002598)
Fold Change: 0.07
Marker Score: 21
Cell Name: oocyte (CL0000023)
Fold Change: 0.07
Marker Score: 18
Cell Name: type I enteroendocrine cell (CL0002277)
Fold Change: 0.07
Marker Score: 18
Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
Fold Change: 0.07
Marker Score: 19
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 0.07
Marker Score: 34
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.07
Marker Score: 393.5
Cell Name: epithelial cell (CL0000066)
Fold Change: 0.07
Marker Score: 104
Cell Name: keratocyte (CL0002363)
Fold Change: 0.07
Marker Score: 15
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.06
Marker Score: 87
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.06
Marker Score: 67.5
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 0.06
Marker Score: 165
Cell Name: reticular cell (CL0000432)
Fold Change: 0.06
Marker Score: 23
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.06
Marker Score: 15
Cell Name: precursor cell (CL0011115)
Fold Change: 0.06
Marker Score: 15
Cell Name: astrocyte (CL0000127)
Fold Change: 0.06
Marker Score: 53
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.06
Marker Score: 17
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.06
Marker Score: 18
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 0.06
Marker Score: 30
Cell Name: mesothelial cell (CL0000077)
Fold Change: 0.05
Marker Score: 22
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.05
Marker Score: 227
Cell Name: skin fibroblast (CL0002620)
Fold Change: 0.05
Marker Score: 14
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 0.05
Marker Score: 19
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 0.05
Marker Score: 16
Cell Name: lens fiber cell (CL0011004)
Fold Change: 0.05
Marker Score: 16
Cell Name: adipose microvascular endothelial cell (CL2000072)
Fold Change: 0.05
Marker Score: 15
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.05
Marker Score: 61

Hover over a box to see details here...

**Key characteristics:** - The ADH1A gene is located on chromosome 15q21.1. - It is a member of the alcohol dehydrogenase family of enzymes. - It is a highly regulated gene, with expression being influenced by various factors, including nutrition, hormones, and environmental toxins. **Pathways and functions:** - ADH1A enzyme catalyzes the oxidation of ethanol to acetaldehyde and NADH in the context of the alcoholic fermentation pathway. - It is involved in the metabolism of various drugs, including barbiturates and benzodiazepines. - It also plays a role in the metabolism of dietary compounds, such as butanol and methanol. **Clinical significance:** - Mutations in the ADH1A gene have been linked to various human diseases, including alcoholism, fatty liver disease, and cancer. - ADH1A inhibitors are being investigated as potential therapeutic agents for these diseases. **Additional notes:** - The ADH1A gene is also involved in the regulation of the immune response. - It is a key regulator of inflammation and immune cell function. - Aberrant expression of ADH1A has been linked to the pathogenesis of several autoimmune diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Alcohol dehydrogenase 1A

Genular Protein ID: 2090515616

Symbol: ADH1A_HUMAN

Name: Alcohol dehydrogenase 1A

UniProtKB Accession Codes:

P07327 A8K3E3 Q17R68

Database IDs:

Citations:

PubMed ID: 3013304

Title: cDNA and protein structure for the alpha subunit of human liver alcohol dehydrogenase.

PubMed ID: 3013304

DOI: 10.1021/bi00357a026

PubMed ID: 2935875

Title: Three human alcohol dehydrogenase subunits: cDNA structure and molecular and evolutionary divergence.

PubMed ID: 2935875

DOI: 10.1073/pnas.83.3.634

PubMed ID: 2920825

Title: Molecular structure of the human alcohol dehydrogenase 1 gene.

PubMed ID: 2920825

DOI: 10.1016/0014-5793(89)81217-7

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2347582

Title: The human class I alcohol dehydrogenase gene cluster: three genes are tandemly organized in an 80-kb-long segment of the genome.

PubMed ID: 2347582

DOI: 10.1016/0888-7543(90)90535-3

PubMed ID: 2738060

Title: Stereospecific oxidation of secondary alcohols by human alcohol dehydrogenases.

PubMed ID: 2738060

DOI: 10.1016/s0021-9258(18)60436-3

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 15449945

Title: Structure of three class I human alcohol dehydrogenases complexed with isoenzyme specific formamide inhibitors.

PubMed ID: 15449945

DOI: 10.1021/bi0489107

PubMed ID: 11274460

Title: Three-dimensional structures of the three human class I alcohol dehydrogenases.

PubMed ID: 11274460

DOI: 10.1110/ps.45001

Sequence Information:

Length: 375
Mass: 39859
Checksum: B6DF4D57080D9BC1
Sequence:

MSTAGKVIKC KAAVLWELKK PFSIEEVEVA PPKAHEVRIK MVAVGICGTD DHVVSGTMVT 
PLPVILGHEA AGIVESVGEG VTTVKPGDKV IPLAIPQCGK CRICKNPESN YCLKNDVSNP 
QGTLQDGTSR FTCRRKPIHH FLGISTFSQY TVVDENAVAK IDAASPLEKV CLIGCGFSTG 
YGSAVNVAKV TPGSTCAVFG LGGVGLSAIM GCKAAGAARI IAVDINKDKF AKAKELGATE 
CINPQDYKKP IQEVLKEMTD GGVDFSFEVI GRLDTMMASL LCCHEACGTS VIVGVPPDSQ 
NLSMNPMLLL TGRTWKGAIL GGFKSKECVP KLVADFMAKK FSLDALITHV LPFEKINEGF 
DLLHSGKSIR TILMF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: ADH1A

Associated with

Cells (max top 100)

Other Information

cDNA and protein structure for the alpha subunit of human liver alcohol dehydrogenase. PubMed ID: 3013304

Three human alcohol dehydrogenase subunits: cDNA structure and molecular and evolutionary divergence. PubMed ID: 2935875

Molecular structure of the human alcohol dehydrogenase 1 gene. PubMed ID: 2920825

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The human class I alcohol dehydrogenase gene cluster: three genes are tandemly organized in an 80-kb-long segment of the genome. PubMed ID: 2347582

Stereospecific oxidation of secondary alcohols by human alcohol dehydrogenases. PubMed ID: 2738060

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Structure of three class I human alcohol dehydrogenases complexed with isoenzyme specific formamide inhibitors. PubMed ID: 15449945

Three-dimensional structures of the three human class I alcohol dehydrogenases. PubMed ID: 11274460