Details for: CMKLR1

Gene ID: 1240

Symbol: CMKLR1

Ensembl ID: ENSG00000174600

Description: chemerin chemokine-like receptor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 59.7897
    Cell Significance Index: -9.3000
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 11.7077
    Cell Significance Index: 169.9800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 7.5672
    Cell Significance Index: -9.3300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 7.5622
    Cell Significance Index: -7.2200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 3.2983
    Cell Significance Index: 51.0300
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 1.5239
    Cell Significance Index: 4.0200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.3900
    Cell Significance Index: 11.3400
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.2882
    Cell Significance Index: 2.9900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1605
    Cell Significance Index: 57.5800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.1578
    Cell Significance Index: 3.0800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1030
    Cell Significance Index: 5.2000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0760
    Cell Significance Index: 15.0900
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.0031
    Cell Significance Index: 0.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0042
    Cell Significance Index: -7.9500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0079
    Cell Significance Index: -14.5300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0087
    Cell Significance Index: -13.3800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0106
    Cell Significance Index: -6.7600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0114
    Cell Significance Index: -15.5300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0119
    Cell Significance Index: -8.8000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0121
    Cell Significance Index: -9.1500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0139
    Cell Significance Index: -1.4200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0155
    Cell Significance Index: -3.1000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0156
    Cell Significance Index: -8.7700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0183
    Cell Significance Index: -10.0100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0185
    Cell Significance Index: -8.4000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0239
    Cell Significance Index: -6.8900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0335
    Cell Significance Index: -6.0300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0353
    Cell Significance Index: -7.4300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0429
    Cell Significance Index: -6.2400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0513
    Cell Significance Index: -8.7600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0524
    Cell Significance Index: -6.7200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0543
    Cell Significance Index: -6.6800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0630
    Cell Significance Index: -8.6500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0689
    Cell Significance Index: -8.9100
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0710
    Cell Significance Index: -1.0200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0726
    Cell Significance Index: -3.7800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0737
    Cell Significance Index: -8.5900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0751
    Cell Significance Index: -8.8600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0851
    Cell Significance Index: -9.7600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0861
    Cell Significance Index: -3.7400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0912
    Cell Significance Index: -9.5000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1024
    Cell Significance Index: -7.8600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1085
    Cell Significance Index: -2.0100
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.1172
    Cell Significance Index: -1.4500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1193
    Cell Significance Index: -8.9000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1335
    Cell Significance Index: -8.6100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1341
    Cell Significance Index: -9.0200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1353
    Cell Significance Index: -8.5300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1378
    Cell Significance Index: -8.4700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1417
    Cell Significance Index: -3.7900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1421
    Cell Significance Index: -6.6800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1515
    Cell Significance Index: -2.1700
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1648
    Cell Significance Index: -2.1900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1845
    Cell Significance Index: -10.3600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1887
    Cell Significance Index: -9.8000
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1908
    Cell Significance Index: -2.7900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2152
    Cell Significance Index: -9.5200
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.2285
    Cell Significance Index: -2.7500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2349
    Cell Significance Index: -10.9500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2375
    Cell Significance Index: -8.3200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2403
    Cell Significance Index: -8.3500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2519
    Cell Significance Index: -7.2200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2572
    Cell Significance Index: -9.7400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2601
    Cell Significance Index: -7.2700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2628
    Cell Significance Index: -8.6100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2634
    Cell Significance Index: -8.3900
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.2683
    Cell Significance Index: -2.4600
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.2713
    Cell Significance Index: -3.1900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2727
    Cell Significance Index: -5.8300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2762
    Cell Significance Index: -7.1000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2798
    Cell Significance Index: -8.2400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2899
    Cell Significance Index: -7.2300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2949
    Cell Significance Index: -8.6600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2987
    Cell Significance Index: -8.0100
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.3097
    Cell Significance Index: -5.2600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3103
    Cell Significance Index: -8.2900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3163
    Cell Significance Index: -6.6200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3225
    Cell Significance Index: -11.8400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3276
    Cell Significance Index: -9.3500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3342
    Cell Significance Index: -6.7100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.3398
    Cell Significance Index: -8.2300
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.3438
    Cell Significance Index: -3.5100
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: -0.3507
    Cell Significance Index: -3.8300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.3509
    Cell Significance Index: -12.3300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3510
    Cell Significance Index: -9.2300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.3603
    Cell Significance Index: -9.1800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3616
    Cell Significance Index: -9.0200
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.3636
    Cell Significance Index: -7.2500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3680
    Cell Significance Index: -9.4000
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.3750
    Cell Significance Index: -7.6300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3752
    Cell Significance Index: -6.2800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.3877
    Cell Significance Index: -7.5800
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.3886
    Cell Significance Index: -4.1400
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.3916
    Cell Significance Index: -5.0600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3978
    Cell Significance Index: -8.7100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3982
    Cell Significance Index: -9.5500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.4003
    Cell Significance Index: -5.4900
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.4028
    Cell Significance Index: -6.3900
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.4129
    Cell Significance Index: -3.4900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.4173
    Cell Significance Index: -7.3800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CMKLR1 is a member of the Class A/1 rhodopsin-like receptor family, characterized by its seven transmembrane domains and ability to bind to chemokines and adipokinetic hormones. The receptor is expressed in various cell types, including immune cells, endothelial cells, and epithelial cells. CMKLR1 has been shown to play a role in the regulation of immune responses, including the production of cytokines, chemokines, and other immune-related molecules. **Pathways and Functions:** CMKLR1 is involved in several signaling pathways, including: 1. Chemokine-mediated signaling pathway: CMKLR1 binds to chemokines, such as CCL2 and CCL5, triggering the activation of G-proteins and the production of cytokines and chemokines. 2. Adipokinetic hormone receptor activity: CMKLR1 binds to adipokinetic hormones, such as adiponectin, regulating glucose and lipid metabolism. 3. Immune response: CMKLR1 plays a role in the regulation of immune responses, including the production of cytokines, chemokines, and other immune-related molecules. 4. Inflammatory response: CMKLR1 is involved in the regulation of inflammatory responses, including the production of pro-inflammatory cytokines and chemokines. 5. Signaling by GPCRs: CMKLR1 is a GPCR, and its signaling pathway involves the activation of G-proteins and the production of second messengers. **Clinical Significance:** CMKLR1 has been implicated in various immune-related disorders, including: 1. Autoimmune diseases: CMKLR1 has been shown to play a role in the regulation of immune responses in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. Inflammatory disorders: CMKLR1 is involved in the regulation of inflammatory responses, making it a potential target for the treatment of inflammatory disorders, such as asthma and inflammatory bowel disease. 3. Cancer: CMKLR1 has been shown to play a role in the regulation of immune responses in cancer, making it a potential target for the treatment of cancer. 4. Obesity and metabolic disorders: CMKLR1 has been implicated in the regulation of glucose and lipid metabolism, making it a potential target for the treatment of obesity and metabolic disorders. In conclusion, CMKLR1 is a multifunctional receptor that plays a critical role in the regulation of immune responses, inflammation, and tissue development. Further research is needed to fully understand the functions of CMKLR1 and its potential applications in the treatment of immune-related disorders.

Genular Protein ID: 85519369

Symbol: CML1_HUMAN

Name: Chemokine-like receptor 1

UniProtKB Accession Codes:

Q99788 A8K6Y5 O75748 Q3KP37 Q5U0H0 Q99789

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 14 EMDB 2 Ensembl 4 ExpressionAtlas 1 GO 22 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 5 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9144535

Title: A novel G protein-coupled receptor with homology to neuropeptide and chemoattractant receptors expressed during bone development.

PubMed ID: 9144535

DOI: 10.1006/bbrc.1997.6455

PubMed ID: 9603476

Title: ChemR23, a putative chemoattractant receptor, is expressed in monocyte-derived dendritic cells and macrophages and is a coreceptor for SIV and some primary HIV-1 strains.

PubMed ID: 9603476

DOI: 10.1002/(sici)1521-4141(199805)28:05<1689::aid-immu1689>3.0.co;2-i

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8976386

Title: Molecular cloning of a novel receptor (CMKLR1) with homology to the chemotactic factor receptors.

PubMed ID: 8976386

DOI: 10.1159/000134436

PubMed ID: 14675762

Title: Characterization of human circulating TIG2 as a ligand for the orphan receptor ChemR23.

PubMed ID: 14675762

DOI: 10.1016/s0014-5793(03)01312-7

PubMed ID: 14530373

Title: Specific recruitment of antigen-presenting cells by chemerin, a novel processed ligand from human inflammatory fluids.

PubMed ID: 14530373

DOI: 10.1084/jem.20030382

PubMed ID: 14759258

Title: An unappreciated role for RNA surveillance.

PubMed ID: 14759258

DOI: 10.1186/gb-2004-5-2-r8

PubMed ID: 15728234

Title: Role of ChemR23 in directing the migration of myeloid and plasmacytoid dendritic cells to lymphoid organs and inflamed skin.

PubMed ID: 15728234

DOI: 10.1084/jem.20041310

PubMed ID: 15753205

Title: Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1.

PubMed ID: 15753205

DOI: 10.1084/jem.20042031

PubMed ID: 16863918

Title: Chemokine-like receptor 1 expression by macrophages in vivo: regulation by TGF-beta and TLR ligands.

PubMed ID: 16863918

DOI: 10.1016/j.exphem.2006.03.011

PubMed ID: 18242188

Title: Chemerin enhances insulin signaling and potentiates insulin-stimulated glucose uptake in 3T3-L1 adipocytes.

PubMed ID: 18242188

DOI: 10.1016/j.febslet.2008.01.023

PubMed ID: 20044979

Title: Identification of chemerin receptor (ChemR23) in human endothelial cells: chemerin-induced endothelial angiogenesis.

PubMed ID: 20044979

DOI: 10.1016/j.bbrc.2009.12.150

PubMed ID: 27716822

Title: Signaling properties of chemerin receptors CMKLR1, GPR1 and CCRL2.

PubMed ID: 27716822

DOI: 10.1371/journal.pone.0164179

PubMed ID: 29279348

Title: International Union of Basic and Clinical Pharmacology CIII: Chemerin Receptors CMKLR1 (Chemerin1) and GPR1 (Chemerin2) Nomenclature, Pharmacology, and Function.

PubMed ID: 29279348

DOI: 10.1124/pr.116.013177

Sequence Information:

  • Length: 373
  • Mass: 42322
  • Checksum: 5244B9738EC93834
  • Sequence:
    • MRMEDEDYNT SISYGDEYPD YLDSIVVLED LSPLEARVTR IFLVVVYSIV CFLGILGNGL 
VIIIATFKMK KTVNMVWFLN LAVADFLFNV FLPIHITYAA MDYHWVFGTA MCKISNFLLI 
HNMFTSVFLL TIISSDRCIS VLLPVWSQNH RSVRLAYMAC MVIWVLAFFL SSPSLVFRDT 
ANLHGKISCF NNFSLSTPGS SSWPTHSQMD PVGYSRHMVV TVTRFLCGFL VPVLIITACY 
LTIVCKLQRN RLAKTKKPFK IIVTIIITFF LCWCPYHTLN LLELHHTAMP GSVFSLGLPL 
ATALAIANSC MNPILYVFMG QDFKKFKVAL FSRLVNALSE DTGHSSYPSH RSFTKMSSMN 
ERTSMNERET GML

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.