Details for: CMKLR1

Gene ID: 1240

Symbol: CMKLR1

Ensembl ID: ENSG00000174600

Description: chemerin chemokine-like receptor 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.66
    Marker Score: 3370
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.5
    Marker Score: 470
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 1.18
    Marker Score: 1041
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.14
    Marker Score: 1144
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.05
    Marker Score: 339
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251802
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 792
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71821
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48045
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.98
    Marker Score: 486
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.96
    Marker Score: 529
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5306
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2737
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.91
    Marker Score: 5475
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5286
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.84
    Marker Score: 507
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.84
    Marker Score: 13114
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1260
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 707
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.75
    Marker Score: 499
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.73
    Marker Score: 839
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.71
    Marker Score: 296
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.7
    Marker Score: 806
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.67
    Marker Score: 243
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.63
    Marker Score: 755
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.61
    Marker Score: 291
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.56
    Marker Score: 445
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 147
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.54
    Marker Score: 126
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.5
    Marker Score: 911
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.48
    Marker Score: 200
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.45
    Marker Score: 499
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.44
    Marker Score: 223
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.41
    Marker Score: 663
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.37
    Marker Score: 2224
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.34
    Marker Score: 1330
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.34
    Marker Score: 213
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.33
    Marker Score: 1389
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.33
    Marker Score: 650
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.33
    Marker Score: 183
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.33
    Marker Score: 144
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.32
    Marker Score: 84
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.32
    Marker Score: 464
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.31
    Marker Score: 404
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.3
    Marker Score: 163
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.3
    Marker Score: 1995
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.3
    Marker Score: 78
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.3
    Marker Score: 188
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.29
    Marker Score: 208
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.29
    Marker Score: 557
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.29
    Marker Score: 263
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 0.29
    Marker Score: 842
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.28
    Marker Score: 676
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.28
    Marker Score: 77
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.27
    Marker Score: 415
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.26
    Marker Score: 227
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.26
    Marker Score: 643
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.26
    Marker Score: 81
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.25
    Marker Score: 124
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.24
    Marker Score: 143
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.24
    Marker Score: 230
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.24
    Marker Score: 232
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.24
    Marker Score: 311
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.24
    Marker Score: 162
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.24
    Marker Score: 73
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.23
    Marker Score: 593
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.22
    Marker Score: 131
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.22
    Marker Score: 666
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.22
    Marker Score: 143
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.21
    Marker Score: 561
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.21
    Marker Score: 91
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.21
    Marker Score: 412
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.2
    Marker Score: 84
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.2
    Marker Score: 177
  • Cell Name: colon macrophage (CL0009038)
    Fold Change: 0.2
    Marker Score: 54
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.19
    Marker Score: 123
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.19
    Marker Score: 186
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.19
    Marker Score: 78
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.19
    Marker Score: 47
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.19
    Marker Score: 275
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.18
    Marker Score: 87
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.18
    Marker Score: 101
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.17
    Marker Score: 61
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.16
    Marker Score: 166
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.16
    Marker Score: 84.5
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.16
    Marker Score: 202
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.16
    Marker Score: 1901
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.16
    Marker Score: 9112
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.16
    Marker Score: 126
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.16
    Marker Score: 160
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.16
    Marker Score: 41
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.15
    Marker Score: 102
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.15
    Marker Score: 201
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.15
    Marker Score: 129

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Other Information

**Key characteristics:** - CMKLR1 is a single-pass transmembrane protein with a molecular weight of approximately 120 kDa. - It is expressed in high levels in immune cells, including macrophages, dendritic cells, and neutrophils. - It is also expressed in stromal cells, such as endothelial cells and fibroblasts. - CMKLR1 is a member of the class a/1 (rhodopsin-like receptors), which are a family of chemokine receptors that are expressed in immune cells. - It is a ligand for the G protein-coupled receptor Gpr1b. **Pathways and functions:** - CMKLR1 is a key regulator of inflammation. It is expressed in high levels in immune cells, and its expression and activity are often altered in inflammatory diseases. - CMKLR1 is a ligand for the G protein-coupled receptor Gpr1b. Gpr1b is a receptor for the adipokine leptin, which is a hormone that is produced by adipose tissue. - When CMKLR1 binds to leptin, it activates Gpr1b and triggers a signaling cascade that leads to the phosphorylation of STAT3, a transcription factor that is responsible for the expression of inflammatory genes. - Phosphorylation of STAT3 by Gpr1b leads to the transcription of inflammatory genes, including those involved in inflammation, such as IL-1β, IL-6, and TNF-α. - This leads to the recruitment of immune cells to the site of inflammation and the initiation of an inflammatory response. **Clinical significance:** - CMKLR1 is a potential therapeutic target for inflammatory diseases. - Blockade of CMKLR1 signaling has been shown to inhibit inflammation in animal models of disease. - Therefore, CMKLR1 is a promising target for the treatment of inflammatory diseases such as rheumatoid arthritis, asthma, and inflammatory bowel disease.

Genular Protein ID: 85519369

Symbol: CML1_HUMAN

Name: Chemokine-like receptor 1

UniProtKB Accession Codes:

Q99788 A8K6Y5 O75748 Q3KP37 Q5U0H0 Q99789

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 14 EMDB 1 Ensembl 4 ExpressionAtlas 1 GO 22 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRINTS 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 5 SAM 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9144535

Title: A novel G protein-coupled receptor with homology to neuropeptide and chemoattractant receptors expressed during bone development.

PubMed ID: 9144535

DOI: 10.1006/bbrc.1997.6455

PubMed ID: 9603476

Title: ChemR23, a putative chemoattractant receptor, is expressed in monocyte-derived dendritic cells and macrophages and is a coreceptor for SIV and some primary HIV-1 strains.

PubMed ID: 9603476

DOI: 10.1002/(sici)1521-4141(199805)28:05<1689::aid-immu1689>3.0.co;2-i

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8976386

Title: Molecular cloning of a novel receptor (CMKLR1) with homology to the chemotactic factor receptors.

PubMed ID: 8976386

DOI: 10.1159/000134436

PubMed ID: 14675762

Title: Characterization of human circulating TIG2 as a ligand for the orphan receptor ChemR23.

PubMed ID: 14675762

DOI: 10.1016/s0014-5793(03)01312-7

PubMed ID: 14530373

Title: Specific recruitment of antigen-presenting cells by chemerin, a novel processed ligand from human inflammatory fluids.

PubMed ID: 14530373

DOI: 10.1084/jem.20030382

PubMed ID: 14759258

Title: An unappreciated role for RNA surveillance.

PubMed ID: 14759258

DOI: 10.1186/gb-2004-5-2-r8

PubMed ID: 15728234

Title: Role of ChemR23 in directing the migration of myeloid and plasmacytoid dendritic cells to lymphoid organs and inflamed skin.

PubMed ID: 15728234

DOI: 10.1084/jem.20041310

PubMed ID: 15753205

Title: Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1.

PubMed ID: 15753205

DOI: 10.1084/jem.20042031

PubMed ID: 16863918

Title: Chemokine-like receptor 1 expression by macrophages in vivo: regulation by TGF-beta and TLR ligands.

PubMed ID: 16863918

DOI: 10.1016/j.exphem.2006.03.011

PubMed ID: 18242188

Title: Chemerin enhances insulin signaling and potentiates insulin-stimulated glucose uptake in 3T3-L1 adipocytes.

PubMed ID: 18242188

DOI: 10.1016/j.febslet.2008.01.023

PubMed ID: 20044979

Title: Identification of chemerin receptor (ChemR23) in human endothelial cells: chemerin-induced endothelial angiogenesis.

PubMed ID: 20044979

DOI: 10.1016/j.bbrc.2009.12.150

PubMed ID: 27716822

Title: Signaling properties of chemerin receptors CMKLR1, GPR1 and CCRL2.

PubMed ID: 27716822

DOI: 10.1371/journal.pone.0164179

PubMed ID: 29279348

Title: International Union of Basic and Clinical Pharmacology CIII: Chemerin Receptors CMKLR1 (Chemerin1) and GPR1 (Chemerin2) Nomenclature, Pharmacology, and Function.

PubMed ID: 29279348

DOI: 10.1124/pr.116.013177

Sequence Information:

  • Length: 373
  • Mass: 42322
  • Checksum: 5244B9738EC93834
  • Sequence:
    • MRMEDEDYNT SISYGDEYPD YLDSIVVLED LSPLEARVTR IFLVVVYSIV CFLGILGNGL 
VIIIATFKMK KTVNMVWFLN LAVADFLFNV FLPIHITYAA MDYHWVFGTA MCKISNFLLI 
HNMFTSVFLL TIISSDRCIS VLLPVWSQNH RSVRLAYMAC MVIWVLAFFL SSPSLVFRDT 
ANLHGKISCF NNFSLSTPGS SSWPTHSQMD PVGYSRHMVV TVTRFLCGFL VPVLIITACY 
LTIVCKLQRN RLAKTKKPFK IIVTIIITFF LCWCPYHTLN LLELHHTAMP GSVFSLGLPL 
ATALAIANSC MNPILYVFMG QDFKKFKVAL FSRLVNALSE DTGHSSYPSH RSFTKMSSMN 
ERTSMNERET GML

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.