Genular: Defining Cellular Identity and Function

Details for: Cbfb

Gene ID: 12400

Symbol: Cbfb

Ensembl ID: ENSMUSG00000031885

Description: core binding factor beta

Associated with

Esr-mediated signaling
(R-MMU-8939211)
Estrogen-dependent gene expression
(R-MMU-9018519)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Regulation of runx1 expression and activity
(R-MMU-8934593)
Regulation of runx3 expression and activity
(R-MMU-8941858)
Rna polymerase ii transcription
(R-MMU-73857)
Runx1 and foxp3 control the development of regulatory t lymphocytes (tregs)
(R-MMU-8877330)
Runx1 interacts with co-factors whose precise effect on runx1 targets is not known
(R-MMU-8939243)
Runx1 regulates estrogen receptor mediated transcription
(R-MMU-8931987)
Runx1 regulates genes involved in megakaryocyte differentiation and platelet function
(R-MMU-8936459)
Runx1 regulates transcription of genes involved in bcr signaling
(R-MMU-8939245)
Runx1 regulates transcription of genes involved in differentiation of hscs
(R-MMU-8939236)
Runx1 regulates transcription of genes involved in differentiation of myeloid cells
(R-MMU-8939246)
Runx1 regulates transcription of genes involved in interleukin signaling
(R-MMU-8939247)
Runx2 regulates bone development
(R-MMU-8941326)
Runx3 regulates p14-arf
(R-MMU-8951936)
Signaling by nuclear receptors
(R-MMU-9006931)
Signal transduction
(R-MMU-162582)
Transcriptional regulation by runx1
(R-MMU-8878171)
Transcriptional regulation by runx2
(R-MMU-8878166)
Transcriptional regulation by runx3
(R-MMU-8878159)
Cell maturation
(GO:0048469)
Core-binding factor complex
(GO:0016513)
Definitive hemopoiesis
(GO:0060216)
Dna binding
(GO:0003677)
Lymphocyte differentiation
(GO:0030098)
Myeloid cell differentiation
(GO:0030099)
Negative regulation of cd4-positive, alpha-beta t cell differentiation
(GO:0043371)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Ossification
(GO:0001503)
Osteoblast differentiation
(GO:0001649)
Positive regulation of cd8-positive, alpha-beta t cell differentiation
(GO:0043378)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein polyubiquitination
(GO:0000209)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Sequence-specific dna binding
(GO:0043565)
Transcription coactivator activity
(GO:0003713)

Other Information

Proteins

Core-binding factor subunit beta

Genular Protein ID: 2614632064

Symbol: PEBB_MOUSE

Name: Core-binding factor subunit beta

UniProtKB Accession Codes:

Q08024 Q08025 Q62050 Q62051 Q8C282 Q8CGD5

Database IDs:

Citations:

PubMed ID: 8386878

Title: Molecular cloning and characterization of PEBP2 beta, the heterodimeric partner of a novel Drosophila runt-related DNA binding protein PEBP2 alpha.

PubMed ID: 8386878

DOI: 10.1006/viro.1993.1262

PubMed ID: 8497254

Title: Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor.

PubMed ID: 8497254

DOI: 10.1128/mcb.13.6.3324-3339.1993

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 22193545

Title: The histone- and PRMT5-associated protein COPR5 is required for myogenic differentiation.

PubMed ID: 22193545

DOI: 10.1038/cdd.2011.193

PubMed ID: 11257229

Title: Structural analyses of DNA recognition by the AML1/Runx-1 Runt domain and its allosteric control by CBFbeta.

PubMed ID: 11257229

DOI: 10.1016/s0092-8674(01)00271-9

PubMed ID: 10404216

Title: Solution structure of core binding factor beta and map of the CBF alpha binding site.

PubMed ID: 10404216

DOI: 10.1038/10670

PubMed ID: 11560490

Title: Structure and backbone dynamics of Apo-CBFbeta in solution.

PubMed ID: 11560490

DOI: 10.1021/bi010713+

PubMed ID: 18258917

Title: Repression of the transcription factor Th-POK by Runx complexes in cytotoxic T cell development.

PubMed ID: 18258917

DOI: 10.1126/science.1151844

Sequence Information:

Length: 187
Mass: 22030
Checksum: 0B2E6101A35D0FD8
Sequence:

MPRVVPDQRS KFENEEFFRK LSRECEIKYT GFRDRPHEER QTRFQNACRD GRSEIAFVAT 
GTNLSLQFFP ASWQGEQRQT PSREYVDLER EAGKVYLKAP MILNGVCVIW KGWIDLHRLD 
GMGCLEFDEE RAQQEDALAQ QAFEEARRRT REFEDRDRSH REEMEARRQQ DPSPGSNLGG 
GDDLKLR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Cbfb

Associated with

Other Information

Molecular cloning and characterization of PEBP2 beta, the heterodimeric partner of a novel Drosophila runt-related DNA binding protein PEBP2 alpha. PubMed ID: 8386878

Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor. PubMed ID: 8497254

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

The histone- and PRMT5-associated protein COPR5 is required for myogenic differentiation. PubMed ID: 22193545

Structural analyses of DNA recognition by the AML1/Runx-1 Runt domain and its allosteric control by CBFbeta. PubMed ID: 11257229

Solution structure of core binding factor beta and map of the CBF alpha binding site. PubMed ID: 10404216

Structure and backbone dynamics of Apo-CBFbeta in solution. PubMed ID: 11560490

Repression of the transcription factor Th-POK by Runx complexes in cytotoxic T cell development. PubMed ID: 18258917