Details for: Cbl
Associated with
Other Information
Genular Protein ID: 2664971547
Symbol: CBL_MOUSE
Name: E3 ubiquitin-protein ligase CBL
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2030914
Title: The sequences of the human and mouse c-cbl proto-oncogenes show v-cbl was generated by a large truncation encompassing a proline-rich domain and a leucine zipper-like motif.
PubMed ID: 2030914
PubMed ID: 16141072
Title: The transcriptional landscape of the mammalian genome.
PubMed ID: 16141072
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 7782294
Title: Tyrosine phosphorylation and translocation of the c-cbl protein after activation of tyrosine kinase signaling pathways.
PubMed ID: 7782294
PubMed ID: 8798454
Title: Differential intrinsic enzymatic activity of Syk and Zap-70 protein-tyrosine kinases.
PubMed ID: 8798454
PubMed ID: 8551236
Title: Association of tyrosine protein kinase Zap-70 with the protooncogene product p120c-cbl in T lymphocytes.
PubMed ID: 8551236
PubMed ID: 9722576
Title: Identification of vascular endothelial growth factor receptor-1 tyrosine phosphorylation sites and binding of SH2 domain-containing molecules.
PubMed ID: 9722576
PubMed ID: 9447983
Title: A novel, multifunctional c-Cbl binding protein in insulin receptor signaling in 3T3-L1 adipocytes.
PubMed ID: 9447983
DOI: 10.1128/mcb.18.2.872
PubMed ID: 9653117
Title: The tyrosine kinase regulator Cbl enhances the ubiquitination and degradation of the platelet-derived growth factor receptor alpha.
PubMed ID: 9653117
PubMed ID: 10092522
Title: The proto-oncogene p120(Cbl) is a downstream substrate of the Hck protein-tyrosine kinase.
PubMed ID: 10092522
PubMed ID: 10393178
Title: The Cbl protooncoprotein stimulates CSF-1 receptor multiubiquitination and endocytosis, and attenuates macrophage proliferation.
PubMed ID: 10393178
PubMed ID: 12024036
Title: Functional cooperation between c-Cbl and Src-like adaptor protein 2 in the negative regulation of T-cell receptor signaling.
PubMed ID: 12024036
PubMed ID: 12649282
Title: Vascular endothelial growth factor-dependent down-regulation of Flk-1/KDR involves Cbl-mediated ubiquitination. Consequences on nitric oxide production from endothelial cells.
PubMed ID: 12649282
PubMed ID: 12842890
Title: The roles of Cbl-b and c-Cbl in insulin-stimulated glucose transport.
PubMed ID: 12842890
PubMed ID: 15001553
Title: The c-Cbl/CD2AP complex regulates VEGF-induced endocytosis and degradation of Flt-1 (VEGFR-1).
PubMed ID: 15001553
PubMed ID: 17353186
Title: The Src-like adaptor protein 2 regulates colony-stimulating factor-1 receptor signaling and down-regulation.
PubMed ID: 17353186
PubMed ID: 17620338
Title: Binding of Cbl to a phospholipase Cgamma1-docking site on platelet-derived growth factor receptor beta provides a dual mechanism of negative regulation.
PubMed ID: 17620338
PubMed ID: 17947660
Title: Quantitative time-resolved phosphoproteomic analysis of mast cell signaling.
PubMed ID: 17947660
PubMed ID: 18602463
Title: Ataxin-2 associates with the endocytosis complex and affects EGF receptor trafficking.
PubMed ID: 18602463
PubMed ID: 18034775
Title: Ligand binding induces Cbl-dependent EphB1 receptor degradation through the lysosomal pathway.
PubMed ID: 18034775
PubMed ID: 19265199
Title: The D816V mutation of c-Kit circumvents a requirement for Src family kinases in c-Kit signal transduction.
PubMed ID: 19265199
PubMed ID: 21183079
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
PubMed ID: 21183079
PubMed ID: 20100865
Title: The SAM domains of Anks family proteins are critically involved in modulating the degradation of EphA receptors.
PubMed ID: 20100865
DOI: 10.1128/mcb.01605-09
PubMed ID: 21830225
Title: SH3KBP1-binding protein 1 prevents epidermal growth factor receptor degradation by the interruption of c-Cbl-CIN85 complex.
PubMed ID: 21830225
DOI: 10.1002/cbf.1792
PubMed ID: 23374343
Title: Induction of Siglec-G by RNA viruses inhibits the innate immune response by promoting RIG-I degradation.
PubMed ID: 23374343
PubMed ID: 29237719
Title: IFT20 modulates ciliary PDGFRalpha signaling by regulating the stability of Cbl E3 ubiquitin ligases.
PubMed ID: 29237719
Sequence Information:
- Length: 913
- Mass: 100564
- Checksum: 22F8A5C29F0262B8
- Sequence:
MAGNVKKSSG AGGGGSGGSG AGGLIGLMKD AFQPHHHHHH LSPHPPCTVD KKMVEKCWKL MDKVVRLCQN PKLALKNSPP YILDLLPDTY QHLRTVLSRY EGKMETLGEN EYFRVFMENL MKKTKQTISL FKEGKERMYE ENSQPRRNLT KLSLIFSHML AELKGIFPSG LFQGDTFRIT KADAAEFWRK AFGEKTIVPW KSFRQALHEV HPISSGLEAM ALKSTIDLTC NDYISVFEFD IFTRLFQPWS SLLRNWNSLA VTHPGYMAFL TYDEVKARLQ KFIHKPGSYI FRLSCTRLGQ WAIGYVTADG NILQTIPHNK PLFQALIDGF REGFYLFPDG RNQNPDLTGL CEPTPQDHIK VTQEQYELYC EMGSTFQLCK ICAENDKDVK IEPCGHLMCT SCLTSWQESE GQGCPFCRCE IKGTEPIVVD PFDPRGSGSL LRQGAEGAPS PNYDDDDDER ADDSLFMMKE LAGAKVERPS SPFSMAPQAS LPPVPPRLDL LQQRAPVPAS TSVLGTASKA ASGSLHKDKP LPIPPTLRDL PPPPPPDRPY SVGAETRPQR RPLPCTPGDC PSRDKLPPVP SSRPGDSWLS RPIPKVPVAT PNPGDPWNGR ELTNRHSLPF SLPSQMEPRA DVPRLGSTFS LDTSMTMNSS PVAGPESEHP KIKPSSSANA IYSLAARPLP MPKLPPGEQG ESEEDTEYMT PTSRPVGVQK PEPKRPLEAT QSSRACDCDQ QIDSCTYEAM YNIQSQALSV AENSASGEGN LATAHTSTGP EESENEDDGY DVPKPPVPAV LARRTLSDIS NASSSFGWLS LDGDPTNFNE GSQVPERPPK PFPRRINSER KASSYQQGGG ATANPVATAP SPQLSSEIER LMSQGYSYQD IQKALVIAHN NIEMAKNILR EFVSISSPAH VAT
Genular Protein ID: 2689327081
Symbol: A0A0X1KG61_MOUSE
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 17947660
Title: Quantitative time-resolved phosphoproteomic analysis of mast cell signaling.
PubMed ID: 17947660
PubMed ID: 19468303
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
PubMed ID: 19468303
PubMed ID: 21183079
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
PubMed ID: 21183079
Sequence Information:
- Length: 869
- Mass: 96000
- Checksum: E319E78BD850E65F
- Sequence:
MAGNVKKSSG AGGGGSGGSG AGGLIGLMKD AFQPHHHHHH LSPHPPCTVD KKMVEKCWKL MDKVVRLCQN PKLALKNSPP YILDLLPDTY QHLRTVLSRY EGKMETLGEN EYFRVFMENL MKKTKQTISL FKEGKERMYE ENSQPRRNLT KLSLIFSHML AELKGIFPSG LFQGDTFRIT KADAAEFWRK AFGEKTIVPW KSFRQALHEV HPISSGLEAM ALKSTIDLTC NDYISVFEFD IFTRLFQPWS SLLRNWNSLA VTHPGYMAFL TYDEVKARLQ KFIHKPGSYI FRLSCTRLGQ WAIGYVTADG NILQTIPHNK PLFQALIDGF REGFYLFPDG RNQNPDLTGL CEPTPQDHIK VTQEQYELYC EMGSTFQLCK ICAENDKDVK IEPCGHLMCT SCLTSWQESE GQGCPFCRCE IKGTEPIVVD PFDPRGSGSL LRQGAEGAPS PNYDDDDDER ADDSLFMMKE LAGAKAASGS LHKDKPLPIP PTLRDLPPPP PPDRPYSVGA ETRPQRRPLP CTPGDCPSRD KLPPVPSSRP GDSWLSRPIP KVPVATPNPG DPWNGRELTN RHSLPFSLPS QMEPRADVPR LGSTFSLDTS MTMNSSPVAG PESEHPKIKP SSSANAIYSL AARPLPMPKL PPGEQGESEE DTEYMTPTSR PVGVQKPEPK RPLEATQSSR ACDCDQQIDS CTYEAMYNIQ SQALSVAENS ASGEGNLATA HTSTGPEESE NEDDGYDVPK PPVPAVLARR TLSDISNASS SFGWLSLDGD PTNFNEGSQV PERPPKPFPR RINSERKASS YQQGGGATAN PVATAPSPQL SSEIERLMSQ GYSYQDIQKA LVIAHNNIEM AKNILREFVS ISSPAHVAT
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.