Genular: Defining Cellular Identity and Function

Details for: Cbr1

Gene ID: 12408

Symbol: Cbr1

Ensembl ID: ENSMUSG00000051483

Description: carbonyl reductase 1

Associated with

Arachidonic acid metabolism
(R-MMU-2142753)
Fatty acid metabolism
(R-MMU-8978868)
Metabolism
(R-MMU-1430728)
Metabolism of lipids
(R-MMU-556833)
Synthesis of prostaglandins (pg) and thromboxanes (tx)
(R-MMU-2162123)
15-hydroxyprostaglandin-d dehydrogenase (nadp+) activity
(GO:0047020)
15-hydroxyprostaglandin dehydrogenase (nadp+) activity
(GO:0047021)
Alcohol dehydrogenase [nad(p)+] activity
(GO:0018455)
Carbonyl reductase (nadph) activity
(GO:0004090)
Cytoplasm
(GO:0005737)
Glucocorticoid metabolic process
(GO:0008211)
Lipid metabolic process
(GO:0006629)
Microvillus
(GO:0005902)
Oxidoreductase activity
(GO:0016491)
Oxidoreductase activity, acting on nad(p)h, quinone or similar compound as acceptor
(GO:0016655)
Oxidoreductase activity, acting on the ch-oh group of donors, nad or nadp as acceptor
(GO:0016616)
Positive regulation of reactive oxygen species metabolic process
(GO:2000379)
Prostaglandin-e2 9-reductase activity
(GO:0050221)
Vitamin k metabolic process
(GO:0042373)
Xenobiotic metabolic process
(GO:0006805)

Other Information

Proteins

15-hydroxyprostaglandin dehydrogenase [NADP(+)]

Genular Protein ID: 2322237357

Symbol: CBR1_MOUSE

Name: 15-hydroxyprostaglandin dehydrogenase [NADP(+)]

UniProtKB Accession Codes:

P48758 Q91X28

Database IDs:

Citations:

PubMed ID: 8661038

Title: Cloning a cDNA for carbonyl reductase (Cbr) from mouse cerebellum: murine genes that express cbr map to chromosomes 16 and 11.

PubMed ID: 8661038

DOI: 10.1006/geno.1996.0255

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 28878267

Title: Carbonyl reductase 1 catalyzes 20beta-reduction of glucocorticoids, modulating receptor activation and metabolic complications of obesity.

PubMed ID: 28878267

DOI: 10.1038/s41598-017-10410-1

PubMed ID: 33785425

Title: Carbonyl reductase 1 amplifies glucocorticoid action in adipose tissue and impairs glucose tolerance in lean mice.

PubMed ID: 33785425

DOI: 10.1016/j.molmet.2021.101225

Sequence Information:

Length: 277
Mass: 30641
Checksum: 6053423B6D5F82B7
Sequence:

MSSSRPVALV TGANKGIGFA ITRDLCRKFS GDVVLAARDE ERGQTAVQKL QAEGLSPRFH 
QLDIDNPQSI RALRDFLLKE YGGLDVLVNN AGIAFKVNDD TPFHIQAEVT MKTNFFGTRD 
VCKELLPLIK PQGRVVNVSS MVSLRALKNC RLELQQKFRS ETITEEELVG LMNKFVEDTK 
KGVHAEEGWP NSAYGVTKIG VTVLSRILAR KLNEQRRGDK ILLNACCPGW VRTDMAGPKA 
TKSPEEGAET PVYLALLPPD AEGPHGQFVQ DKKVEPW

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Cbr1

Associated with

Other Information

Cloning a cDNA for carbonyl reductase (Cbr) from mouse cerebellum: murine genes that express cbr map to chromosomes 16 and 11. PubMed ID: 8661038

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079