Genular: Defining Cellular Identity and Function

Details for: Ccna1

Gene ID: 12427

Symbol: Ccna1

Ensembl ID: ENSMUSG00000027793

Description: cyclin A1

Associated with

Activation of apc/c and apc/c:cdc20 mediated degradation of mitotic proteins
(R-MMU-176814)
Apc/c-mediated degradation of cell cycle proteins
(R-MMU-174143)
Apc/c:cdc20 mediated degradation of mitotic proteins
(R-MMU-176409)
Apc:cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
(R-MMU-179419)
Cdc20:phospho-apc/c mediated degradation of cyclin a
(R-MMU-174184)
Cdk-mediated phosphorylation and removal of cdc6
(R-MMU-69017)
Cell cycle, mitotic
(R-MMU-69278)
Cell cycle checkpoints
(R-MMU-69620)
Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular senescence
(R-MMU-2559583)
Chromosome maintenance
(R-MMU-73886)
Cyclin a/b1/b2 associated events during g2/m transition
(R-MMU-69273)
Cyclin a:cdk2-associated events at s phase entry
(R-MMU-69656)
Cyclin e associated events during g1/s transition
(R-MMU-69202)
Deubiquitination
(R-MMU-5688426)
Dna damage/telomere stress induced senescence
(R-MMU-2559586)
Dna double-strand break repair
(R-MMU-5693532)
Dna repair
(R-MMU-73894)
Dna replication
(R-MMU-69306)
Extension of telomeres
(R-MMU-180786)
G0 and early g1
(R-MMU-1538133)
G1/s dna damage checkpoints
(R-MMU-69615)
G1/s transition
(R-MMU-69206)
G2 phase
(R-MMU-68911)
G2/m transition
(R-MMU-69275)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Hdr through homologous recombination (hrr) or single strand annealing (ssa)
(R-MMU-5693567)
Homology directed repair
(R-MMU-5693538)
Metabolism of proteins
(R-MMU-392499)
Mitotic g1 phase and g1/s transition
(R-MMU-453279)
Mitotic g2-g2/m phases
(R-MMU-453274)
Orc1 removal from chromatin
(R-MMU-68949)
P53-dependent g1 dna damage response
(R-MMU-69563)
P53-dependent g1/s dna damage checkpoint
(R-MMU-69580)
Post-translational protein modification
(R-MMU-597592)
Processing of dna double-strand break ends
(R-MMU-5693607)
Regulation of apc/c activators between g1/s and early anaphase
(R-MMU-176408)
Regulation of mitotic cell cycle
(R-MMU-453276)
Regulation of tp53 activity
(R-MMU-5633007)
Regulation of tp53 activity through phosphorylation
(R-MMU-6804756)
Regulation of tp53 degradation
(R-MMU-6804757)
Regulation of tp53 expression and degradation
(R-MMU-6806003)
Rna polymerase ii transcription
(R-MMU-73857)
Scf(skp2)-mediated degradation of p27/p21
(R-MMU-187577)
Senescence-associated secretory phenotype (sasp)
(R-MMU-2559582)
S phase
(R-MMU-69242)
Switching of origins to a post-replicative state
(R-MMU-69052)
Synthesis of dna
(R-MMU-69239)
Telomere extension by telomerase
(R-MMU-171319)
Telomere maintenance
(R-MMU-157579)
Tp53 regulates transcription of cell cycle genes
(R-MMU-6791312)
Tp53 regulates transcription of genes involved in g1 cell cycle arrest
(R-MMU-6804116)
Transcriptional regulation by tp53
(R-MMU-3700989)
Ub-specific processing proteases
(R-MMU-5689880)
Cell cycle
(GO:0007049)
Cell differentiation
(GO:0030154)
Cell division
(GO:0051301)
Centrosome
(GO:0005813)
Cyclin-dependent protein serine/threonine kinase regulator activity
(GO:0016538)
Cyclin a1-cdk2 complex
(GO:0097123)
Cyclin a2-cdk2 complex
(GO:0097124)
Cytoplasm
(GO:0005737)
Cytoskeleton
(GO:0005856)
Meiotic cell cycle
(GO:0051321)
Microtubule cytoskeleton
(GO:0015630)
Mitotic cell cycle phase transition
(GO:0044772)
Multicellular organism development
(GO:0007275)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)
Regulation of cyclin-dependent protein serine/threonine kinase activity
(GO:0000079)
Spermatogenesis
(GO:0007283)

Other Information

Proteins

Cyclin-A1

Genular Protein ID: 504570479

Symbol: CCNA1_MOUSE

Name: Cyclin-A1

UniProtKB Accession Codes:

Q61456 Q8C5U1

Database IDs:

Citations:

PubMed ID: 8565853

Title: A distinct cyclin A is expressed in germ cells in the mouse.

PubMed ID: 8565853

DOI: 10.1242/dev.122.1.53

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9843212

Title: Cyclin A1 is required for meiosis in the male mouse.

PubMed ID: 9843212

DOI: 10.1038/3855

PubMed ID: 10068472

Title: Regulation of meiosis during mammalian spermatogenesis: the A-type cyclins and their associated cyclin-dependent kinases are differentially expressed in the germ-cell lineage.

PubMed ID: 10068472

DOI: 10.1006/dbio.1998.9156

PubMed ID: 11585773

Title: Cables enhances cdk2 tyrosine 15 phosphorylation by Wee1, inhibits cell growth, and is lost in many human colon and squamous cancers.

PubMed ID: 11585773

Sequence Information:

Length: 421
Mass: 47772
Checksum: FF717D0065B954E9
Sequence:

MHRQSSKSGV ALPPVGQGPD ACQMLSRAQL GQDPPQRTVL GVLTENEQYR RTCGQEITAI 
RCFSGSENVF PAAGKKVLSD HGVNEPAKRG FDIYMDDPEQ GDRDTCSGKE GIIFEDVYEV 
DTSMLKSDLH FLLDFNTVSP MLVDPTTHAQ SEEATDFGSD VINVTEYAEE IHRYLREAEV 
RHRPKAHYMR KQPDITEGMR AILVDWLVEV GEEYKLRTET LYLAVNFLDR FLSCMSVLRG 
KLQLVGTAAI LLASKYEEIY PPDVDEFVYI TDDTYTKRQL LRMEHLLLKV LAFDLTVPTT 
NQFLLQYLRR QGVCIRTENL AKYVAELSLL EADPFLKYLP SLVAAAAYCL ANYIVNRHFW 
PETLAAFTGY SLNEIVPCLS ELHKACLSIP HRPQQAIREK YKASKYLHVS LMEPPVVLPL 
Q

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ccna1

Associated with

Other Information

A distinct cyclin A is expressed in germ cells in the mouse. PubMed ID: 8565853

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Cyclin A1 is required for meiosis in the male mouse. PubMed ID: 9843212

Regulation of meiosis during mammalian spermatogenesis: the A-type cyclins and their associated cyclin-dependent kinases are differentially expressed in the germ-cell lineage. PubMed ID: 10068472