Genular: Defining Cellular Identity and Function

Details for: Ccna2

Gene ID: 12428

Symbol: Ccna2

Ensembl ID: ENSMUSG00000027715

Description: cyclin A2

Associated with

Activation of apc/c and apc/c:cdc20 mediated degradation of mitotic proteins
(R-MMU-176814)
Apc/c-mediated degradation of cell cycle proteins
(R-MMU-174143)
Apc/c:cdc20 mediated degradation of mitotic proteins
(R-MMU-176409)
Apc:cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
(R-MMU-179419)
Cdc20:phospho-apc/c mediated degradation of cyclin a
(R-MMU-174184)
Cdk-mediated phosphorylation and removal of cdc6
(R-MMU-69017)
Cell cycle, mitotic
(R-MMU-69278)
Cell cycle checkpoints
(R-MMU-69620)
Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular senescence
(R-MMU-2559583)
Chromosome maintenance
(R-MMU-73886)
Cyclin a/b1/b2 associated events during g2/m transition
(R-MMU-69273)
Cyclin a:cdk2-associated events at s phase entry
(R-MMU-69656)
Cyclin e associated events during g1/s transition
(R-MMU-69202)
Deubiquitination
(R-MMU-5688426)
Dna damage/telomere stress induced senescence
(R-MMU-2559586)
Dna double-strand break repair
(R-MMU-5693532)
Dna repair
(R-MMU-73894)
Dna replication
(R-MMU-69306)
Extension of telomeres
(R-MMU-180786)
G0 and early g1
(R-MMU-1538133)
G1/s dna damage checkpoints
(R-MMU-69615)
G1/s transition
(R-MMU-69206)
G2 phase
(R-MMU-68911)
G2/m transition
(R-MMU-69275)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Hdr through homologous recombination (hrr) or single strand annealing (ssa)
(R-MMU-5693567)
Homology directed repair
(R-MMU-5693538)
Metabolism of proteins
(R-MMU-392499)
Mitotic g1 phase and g1/s transition
(R-MMU-453279)
Mitotic g2-g2/m phases
(R-MMU-453274)
Orc1 removal from chromatin
(R-MMU-68949)
P53-dependent g1 dna damage response
(R-MMU-69563)
P53-dependent g1/s dna damage checkpoint
(R-MMU-69580)
Processing of dna double-strand break ends
(R-MMU-5693607)
Regulation of apc/c activators between g1/s and early anaphase
(R-MMU-176408)
Regulation of mitotic cell cycle
(R-MMU-453276)
Regulation of tp53 activity
(R-MMU-5633007)
Regulation of tp53 activity through phosphorylation
(R-MMU-6804756)
Regulation of tp53 degradation
(R-MMU-6804757)
Regulation of tp53 expression and degradation
(R-MMU-6806003)
Rna polymerase ii transcription
(R-MMU-73857)
Scf(skp2)-mediated degradation of p27/p21
(R-MMU-187577)
Senescence-associated secretory phenotype (sasp)
(R-MMU-2559582)
S phase
(R-MMU-69242)
Switching of origins to a post-replicative state
(R-MMU-69052)
Synthesis of dna
(R-MMU-69239)
Telomere extension by telomerase
(R-MMU-171319)
Telomere maintenance
(R-MMU-157579)
Tp53 regulates transcription of cell cycle genes
(R-MMU-6791312)
Tp53 regulates transcription of genes involved in g1 cell cycle arrest
(R-MMU-6804116)
Transcriptional regulation by tp53
(R-MMU-3700989)
Ub-specific processing proteases
(R-MMU-5689880)
Cell cycle
(GO:0007049)
Cell cycle g1/s phase transition
(GO:0044843)
Cell division
(GO:0051301)
Centrosome
(GO:0005813)
Cyclin-dependent protein kinase holoenzyme complex
(GO:0000307)
Cyclin-dependent protein serine/threonine kinase regulator activity
(GO:0016538)
Cyclin a2-cdk1 complex
(GO:0097122)
Cyclin a2-cdk2 complex
(GO:0097124)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dna-templated transcription
(GO:0006351)
Female pronucleus
(GO:0001939)
G1/s transition of mitotic cell cycle
(GO:0000082)
G2/m transition of mitotic cell cycle
(GO:0000086)
Male pronucleus
(GO:0001940)
Mitotic cell cycle phase transition
(GO:0044772)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of dna biosynthetic process
(GO:2000573)
Positive regulation of fibroblast proliferation
(GO:0048146)
Post-translational protein modification
(GO:0043687)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Protein kinase binding
(GO:0019901)
Regulation of cyclin-dependent protein serine/threonine kinase activity
(GO:0000079)
Regulation of dna replication
(GO:0006275)

Other Information

Proteins

CCNA2_MOUSE

Genular Protein ID: 4026961079

Symbol: CCNA2_MOUSE

Name: N/A

UniProtKB Accession Codes:

P51943 Q61459 Q8BRG1

Database IDs:

Citations:

PubMed ID: 8575639

Title: The developmentally restricted pattern of expression in the male germ line of a murine cyclin A, cyclin A2, suggests roles in both mitotic and meiotic cell cycles.

PubMed ID: 8575639

DOI: 10.1006/dbio.1996.0007

PubMed ID: 8565853

Title: A distinct cyclin A is expressed in germ cells in the mouse.

PubMed ID: 8565853

DOI: 10.1242/dev.122.1.53

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10068472

Title: Regulation of meiosis during mammalian spermatogenesis: the A-type cyclins and their associated cyclin-dependent kinases are differentially expressed in the germ-cell lineage.

PubMed ID: 10068472

DOI: 10.1006/dbio.1998.9156

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 32973148

Title: Cross-regulation of viral kinases with cyclin A secures shutoff of host DNA synthesis.

PubMed ID: 32973148

DOI: 10.1038/s41467-020-18542-1

Sequence Information:

Length: 422
Mass: 47269
Checksum: 1818B92552E4D0D1
Sequence:

MPGTSRHSGR DAGSALLSLH QEDQENVNPE KLAPAQQPRA QAVLKAGNVR GPAPQQKLKT 
RRVAPLKDLP INDEHVTAGP SWKAVSKQPA FTIHVDEAEE TQKRPAELKE TECEDALAFN 
AAVSLPGARK PLTPLDYPMD GSFESPHAMD MSIVLEDKPV NVNEVPDYQE DIHTYLREME 
VKCKPKVGYM KRQPDITNSM RAILVDWLVE VGEEYKLQNE TLHLAVNYID RFLSSMSVLR 
GKLQLVGTAA MLLASKFEEI YPPEVAEFVY ITDDTYSKKQ VLRMEHLVLK VLAFDLAAPT 
VNQFLTQYFL HLQPANCKVE SLAMFLGELS LIDADPYLKY LPSLIAGAAF HLALYTVTGQ 
SWPESLAQQT GYTLESLKPC LVDLHQTYLK APQHAQQSIR EKYKHSKYHS VSLLNPPETL 
SV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ccna2

Associated with

Other Information

The developmentally restricted pattern of expression in the male germ line of a murine cyclin A, cyclin A2, suggests roles in both mitotic and meiotic cell cycles. PubMed ID: 8575639

A distinct cyclin A is expressed in germ cells in the mouse. PubMed ID: 8565853

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Regulation of meiosis during mammalian spermatogenesis: the A-type cyclins and their associated cyclin-dependent kinases are differentially expressed in the germ-cell lineage. PubMed ID: 10068472

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Cross-regulation of viral kinases with cyclin A secures shutoff of host DNA synthesis. PubMed ID: 32973148