Details for: ABCC2

Gene ID: 1244

Symbol: ABCC2

Ensembl ID: ENSG00000023839

Description: ATP binding cassette subfamily C member 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 3.85
    Marker Score: 32534
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.7
    Marker Score: 4155
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.71
    Marker Score: 11008
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.63
    Marker Score: 8786
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1170
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.58
    Marker Score: 5160
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.54
    Marker Score: 6640
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169568
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.45
    Marker Score: 652
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.22
    Marker Score: 4327
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 796
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71828
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48053
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 508
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 461
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.94
    Marker Score: 388
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 373
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.93
    Marker Score: 350
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5266
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.92
    Marker Score: 2170
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.92
    Marker Score: 1487
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 325
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.88
    Marker Score: 405
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.83
    Marker Score: 13023
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.81
    Marker Score: 1544
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.79
    Marker Score: 1615
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.76
    Marker Score: 519
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 693
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.73
    Marker Score: 3054.5
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.68
    Marker Score: 726
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.59
    Marker Score: 595
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.59
    Marker Score: 624
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.59
    Marker Score: 375
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 450
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.47
    Marker Score: 280
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.46
    Marker Score: 105
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.38
    Marker Score: 181
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.37
    Marker Score: 117
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.31
    Marker Score: 1495
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.31
    Marker Score: 99
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.3
    Marker Score: 122
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.28
    Marker Score: 105
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.27
    Marker Score: 1635
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.27
    Marker Score: 669
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.26
    Marker Score: 82
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.26
    Marker Score: 68
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.25
    Marker Score: 103
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.24
    Marker Score: 340
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.23
    Marker Score: 112
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.23
    Marker Score: 71
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.22
    Marker Score: 92
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.21
    Marker Score: 61
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.2
    Marker Score: 391
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.2
    Marker Score: 88
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.2
    Marker Score: 62
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.19
    Marker Score: 148
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.19
    Marker Score: 315
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.19
    Marker Score: 189
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 0.17
    Marker Score: 49
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.17
    Marker Score: 51
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.17
    Marker Score: 256.5
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.16
    Marker Score: 61
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.16
    Marker Score: 110
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.16
    Marker Score: 553
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.16
    Marker Score: 430
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.16
    Marker Score: 41
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.16
    Marker Score: 159
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.16
    Marker Score: 276
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.16
    Marker Score: 195
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.15
    Marker Score: 137.5
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.15
    Marker Score: 55
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.14
    Marker Score: 151.5
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.14
    Marker Score: 41
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.14
    Marker Score: 93
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.14
    Marker Score: 147
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.13
    Marker Score: 70
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.13
    Marker Score: 66
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.13
    Marker Score: 32
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.13
    Marker Score: 32
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.12
    Marker Score: 4588
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.12
    Marker Score: 384
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.12
    Marker Score: 74
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.12
    Marker Score: 106
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.12
    Marker Score: 113
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.12
    Marker Score: 484
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.12
    Marker Score: 77
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.12
    Marker Score: 220
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.12
    Marker Score: 40
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.12
    Marker Score: 252.5
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.11
    Marker Score: 1174
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.11
    Marker Score: 108
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.11
    Marker Score: 31

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** * It is a type of protein that is responsible for the transport of molecules across cell membranes. * It is expressed in a variety of cell types, including retinal bipolar neurons, enterocytes, hepatocytes, and lung epithelial cells. * It is a highly conserved protein, with a similar sequence found in organisms from yeast to humans. * It is a heterodimeric protein, meaning it consists of two subunits that are held together by a disulfide bond. **Pathways and functions:** * MRP2_HUMAN is involved in the transport of various molecules, including ions, small molecules, and proteins. * It is responsible for the uptake of amino acids, nucleotides, and other small molecules into cells. * It is also involved in the efflux of molecules from cells, including the transport of drugs and other chemicals. * It is a key regulator of cellular metabolism, and its activity can be modulated by a variety of factors, including temperature, pH, and the presence of ligands. **Clinical significance:** * Mutations in the ABCC2 gene have been linked to a number of human diseases, including diabetes, cancer, and kidney disease. * These diseases are characterized by the accumulation of molecules in cells, which can lead to a variety of problems. * Targeting ABCC2 has been investigated as a potential treatment for these diseases. **Additional information:** * The ABCC2 gene is located on chromosome 17q21.1. * It is a highly expressed gene, with over 1,000 transcripts per cell. * It is regulated by a variety of factors, including hormones, growth factors, and environmental cues.

Genular Protein ID: 3832813308

Symbol: MRP2_HUMAN

Name: ATP-binding cassette sub-family C member 2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8797578

Title: A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation.

PubMed ID: 8797578

PubMed ID: 8662992

Title: cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats.

PubMed ID: 8662992

DOI: 10.1074/jbc.271.25.15091

PubMed ID: 10464142

Title: Exon-intron organization of the human multidrug-resistance protein 2 (MRP2) gene mutated in Dubin-Johnson syndrome.

PubMed ID: 10464142

DOI: 10.1016/s0016-5085(99)70459-2

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10421658

Title: Transport of monoglucuronosyl and bisglucuronosyl bilirubin by recombinant human and rat multidrug resistance protein 2.

PubMed ID: 10421658

DOI: 10.1002/hep.510300220

PubMed ID: 10220572

Title: Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells.

PubMed ID: 10220572

PubMed ID: 11500505

Title: Mutation of Trp1254 in the multispecific organic anion transporter, multidrug resistance protein 2 (MRP2) (ABCC2), alters substrate specificity and results in loss of methotrexate transport activity.

PubMed ID: 11500505

DOI: 10.1074/jbc.m105160200

PubMed ID: 12441801

Title: Multidrug resistance protein 2 (MRP2) transports HIV protease inhibitors, and transport can be enhanced by other drugs.

PubMed ID: 12441801

DOI: 10.1097/00002030-200211220-00009

PubMed ID: 16332456

Title: Transport by vesicles of glycine- and taurine-conjugated bile salts and taurolithocholate 3-sulfate: a comparison of human BSEP with rat Bsep.

PubMed ID: 16332456

DOI: 10.1016/j.bbalip.2005.10.006

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28408210

Title: The Organic Anion-Transporting Peptide 2B1 Is Localized in the Basolateral Membrane of the Human Jejunum and Caco-2 Monolayers.

PubMed ID: 28408210

DOI: 10.1016/j.xphs.2017.04.001

PubMed ID: 9425227

Title: Mutations in the canalicular multispecific organic anion transporter (cMOAT) gene, a novel ABC transporter, in patients with hyperbilirubinemia II/Dubin-Johnson syndrome.

PubMed ID: 9425227

DOI: 10.1093/hmg/7.2.203

PubMed ID: 10053008

Title: Genomic structure of the canalicular multispecific organic anion-transporter gene (MRP2/cMOAT) and mutations in the ATP-binding-cassette region in Dubin-Johnson syndrome.

PubMed ID: 10053008

DOI: 10.1086/302292

PubMed ID: 11093739

Title: Impaired protein maturation of the conjugate export pump multidrug resistance protein 2 as a consequence of a deletion mutation in Dubin-Johnson syndrome.

PubMed ID: 11093739

DOI: 10.1053/jhep.2000.19791

PubMed ID: 11477083

Title: Identification and functional analysis of two novel mutations in the multidrug resistance protein 2 gene in Israeli patients with Dubin-Johnson syndrome.

PubMed ID: 11477083

DOI: 10.1074/jbc.m105047200

PubMed ID: 11266082

Title: Polymorphism of the ABC transporter genes, MDR1, MRP1 and MRP2/cMOAT, in healthy Japanese subjects.

PubMed ID: 11266082

DOI: 10.1097/00008571-200103000-00008

PubMed ID: 22290738

Title: Functional characterization of protein variants of the human multidrug transporter ABCC2 by a novel targeted expression system in fibrosarcoma cells.

PubMed ID: 22290738

DOI: 10.1002/humu.22041

PubMed ID: 25336012

Title: Neonatal Dubin-Johnson syndrome: novel compound heterozygous mutation in the ABCC2 gene.

PubMed ID: 25336012

DOI: 10.1111/ped.12404

Sequence Information:

  • Length: 1545
  • Mass: 174207
  • Checksum: C5F8984FFCDF9799
  • Sequence:
  • MLEKFCNSTF WNSSFLDSPE ADLPLCFEQT VLVWIPLGYL WLLAPWQLLH VYKSRTKRSS 
    TTKLYLAKQV FVGFLLILAA IELALVLTED SGQATVPAVR YTNPSLYLGT WLLVLLIQYS 
    RQWCVQKNSW FLSLFWILSI LCGTFQFQTL IRTLLQGDNS NLAYSCLFFI SYGFQILILI 
    FSAFSENNES SNNPSSIASF LSSITYSWYD SIILKGYKRP LTLEDVWEVD EEMKTKTLVS 
    KFETHMKREL QKARRALQRR QEKSSQQNSG ARLPGLNKNQ SQSQDALVLE DVEKKKKKSG 
    TKKDVPKSWL MKALFKTFYM VLLKSFLLKL VNDIFTFVSP QLLKLLISFA SDRDTYLWIG 
    YLCAILLFTA ALIQSFCLQC YFQLCFKLGV KVRTAIMASV YKKALTLSNL ARKEYTVGET 
    VNLMSVDAQK LMDVTNFMHM LWSSVLQIVL SIFFLWRELG PSVLAGVGVM VLVIPINAIL 
    STKSKTIQVK NMKNKDKRLK IMNEILSGIK ILKYFAWEPS FRDQVQNLRK KELKNLLAFS 
    QLQCVVIFVF QLTPVLVSVV TFSVYVLVDS NNILDAQKAF TSITLFNILR FPLSMLPMMI 
    SSMLQASVST ERLEKYLGGD DLDTSAIRHD CNFDKAMQFS EASFTWEHDS EATVRDVNLD 
    IMAGQLVAVI GPVGSGKSSL ISAMLGEMEN VHGHITIKGT TAYVPQQSWI QNGTIKDNIL 
    FGTEFNEKRY QQVLEACALL PDLEMLPGGD LAEIGEKGIN LSGGQKQRIS LARATYQNLD 
    IYLLDDPLSA VDAHVGKHIF NKVLGPNGLL KGKTRLLVTH SMHFLPQVDE IVVLGNGTIV 
    EKGSYSALLA KKGEFAKNLK TFLRHTGPEE EATVHDGSEE EDDDYGLISS VEEIPEDAAS 
    ITMRRENSFR RTLSRSSRSN GRHLKSLRNS LKTRNVNSLK EDEELVKGQK LIKKEFIETG 
    KVKFSIYLEY LQAIGLFSIF FIILAFVMNS VAFIGSNLWL SAWTSDSKIF NSTDYPASQR 
    DMRVGVYGAL GLAQGIFVFI AHFWSAFGFV HASNILHKQL LNNILRAPMR FFDTTPTGRI 
    VNRFAGDIST VDDTLPQSLR SWITCFLGII STLVMICMAT PVFTIIVIPL GIIYVSVQMF 
    YVSTSRQLRR LDSVTRSPIY SHFSETVSGL PVIRAFEHQQ RFLKHNEVRI DTNQKCVFSW 
    ITSNRWLAIR LELVGNLTVF FSALMMVIYR DTLSGDTVGF VLSNALNITQ TLNWLVRMTS 
    EIETNIVAVE RITEYTKVEN EAPWVTDKRP PPDWPSKGKI QFNNYQVRYR PELDLVLRGI 
    TCDIGSMEKI GVVGRTGAGK SSLTNCLFRI LEAAGGQIII DGVDIASIGL HDLREKLTII 
    PQDPILFSGS LRMNLDPFNN YSDEEIWKAL ELAHLKSFVA SLQLGLSHEV TEAGGNLSIG 
    QRQLLCLGRA LLRKSKILVL DEATAAVDLE TDNLIQTTIQ NEFAHCTVIT IAHRLHTIMD 
    SDKVMVLDNG KIIECGSPEE LLQIPGPFYF MAKEAGIENV NSTKF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.