Details for: ABCC2
Associated with
Cells (max top 100)
(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: 3.85
Marker Score: 32534 - Cell Name: enterocyte of colon (CL1000347)
Fold Change: 2.7
Marker Score: 4155 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 1.71
Marker Score: 11008 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 1.63
Marker Score: 8786 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.61
Marker Score: 1170 - Cell Name: hepatoblast (CL0005026)
Fold Change: 1.58
Marker Score: 5160 - Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 1.54
Marker Score: 6640 - Cell Name: mural cell (CL0008034)
Fold Change: 1.48
Marker Score: 169568 - Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 1.45
Marker Score: 652 - Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 1.22
Marker Score: 4327 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 1.04
Marker Score: 796 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71828 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48053 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.99
Marker Score: 508 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30409 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.98
Marker Score: 461 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2412 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.94
Marker Score: 388 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.93
Marker Score: 373 - Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 0.93
Marker Score: 350 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.92
Marker Score: 5266 - Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.92
Marker Score: 2170 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.92
Marker Score: 1487 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2741 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9
Marker Score: 325 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.88
Marker Score: 405 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5296 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.83
Marker Score: 13023 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.81
Marker Score: 1544 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.79
Marker Score: 1615 - Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 396 - Cell Name: hepatocyte (CL0000182)
Fold Change: 0.76
Marker Score: 519 - Cell Name: brush cell (CL0002204)
Fold Change: 0.76
Marker Score: 693 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.73
Marker Score: 3054.5 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 178 - Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 0.68
Marker Score: 726 - Cell Name: Kupffer cell (CL0000091)
Fold Change: 0.59
Marker Score: 595 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 0.59
Marker Score: 624 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.59
Marker Score: 375 - Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 450 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.47
Marker Score: 280 - Cell Name: keratocyte (CL0002363)
Fold Change: 0.46
Marker Score: 105 - Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.38
Marker Score: 181 - Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.37
Marker Score: 117 - Cell Name: enterocyte (CL0000584)
Fold Change: 0.31
Marker Score: 1495 - Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.31
Marker Score: 99 - Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 0.3
Marker Score: 122 - Cell Name: podocyte (CL0000653)
Fold Change: 0.28
Marker Score: 105 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.27
Marker Score: 1635 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.27
Marker Score: 669 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.26
Marker Score: 82 - Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.26
Marker Score: 68 - Cell Name: melanocyte (CL0000148)
Fold Change: 0.25
Marker Score: 103 - Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 0.24
Marker Score: 340 - Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 0.23
Marker Score: 112 - Cell Name: inflammatory macrophage (CL0000863)
Fold Change: 0.23
Marker Score: 71 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.22
Marker Score: 64 - Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.22
Marker Score: 92 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.22
Marker Score: 73 - Cell Name: retinal pigment epithelial cell (CL0002586)
Fold Change: 0.21
Marker Score: 61 - Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 0.2
Marker Score: 391 - Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.2
Marker Score: 88 - Cell Name: lens fiber cell (CL0011004)
Fold Change: 0.2
Marker Score: 62 - Cell Name: renal principal cell (CL0005009)
Fold Change: 0.19
Marker Score: 148 - Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 0.19
Marker Score: 315 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.19
Marker Score: 189 - Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
Fold Change: 0.17
Marker Score: 49 - Cell Name: fast muscle cell (CL0000190)
Fold Change: 0.17
Marker Score: 51 - Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 0.17
Marker Score: 256.5 - Cell Name: cholangiocyte (CL1000488)
Fold Change: 0.16
Marker Score: 61 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.16
Marker Score: 110 - Cell Name: ciliated cell (CL0000064)
Fold Change: 0.16
Marker Score: 553 - Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 0.16
Marker Score: 430 - Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.16
Marker Score: 41 - Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 0.16
Marker Score: 159 - Cell Name: germ cell (CL0000586)
Fold Change: 0.16
Marker Score: 276 - Cell Name: primordial germ cell (CL0000670)
Fold Change: 0.16
Marker Score: 195 - Cell Name: endothelial cell (CL0000115)
Fold Change: 0.15
Marker Score: 137.5 - Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 0.15
Marker Score: 55 - Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.14
Marker Score: 151.5 - Cell Name: lung goblet cell (CL1000143)
Fold Change: 0.14
Marker Score: 41 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 0.14
Marker Score: 93 - Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 0.14
Marker Score: 147 - Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 0.13
Marker Score: 70 - Cell Name: lymphocyte (CL0000542)
Fold Change: 0.13
Marker Score: 66 - Cell Name: adventitial cell (CL0002503)
Fold Change: 0.13
Marker Score: 32 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.13
Marker Score: 32 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 0.12
Marker Score: 4588 - Cell Name: Unknown (CL0000003)
Fold Change: 0.12
Marker Score: 384 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.12
Marker Score: 74 - Cell Name: astrocyte (CL0000127)
Fold Change: 0.12
Marker Score: 106 - Cell Name: fibroblast (CL0000057)
Fold Change: 0.12
Marker Score: 113 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 0.12
Marker Score: 484 - Cell Name: precursor B cell (CL0000817)
Fold Change: 0.12
Marker Score: 77 - Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: 0.12
Marker Score: 220 - Cell Name: Schwann cell (CL0002573)
Fold Change: 0.12
Marker Score: 40 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.12
Marker Score: 252.5 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.11
Marker Score: 1174 - Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 0.11
Marker Score: 108 - Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
Fold Change: 0.11
Marker Score: 31
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Other Information
Genular Protein ID: 3832813308
Symbol: MRP2_HUMAN
Name: ATP-binding cassette sub-family C member 2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8797578
Title: A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation.
PubMed ID: 8797578
PubMed ID: 8662992
Title: cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats.
PubMed ID: 8662992
PubMed ID: 10464142
Title: Exon-intron organization of the human multidrug-resistance protein 2 (MRP2) gene mutated in Dubin-Johnson syndrome.
PubMed ID: 10464142
PubMed ID: 15164054
Title: The DNA sequence and comparative analysis of human chromosome 10.
PubMed ID: 15164054
DOI: 10.1038/nature02462
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 10421658
Title: Transport of monoglucuronosyl and bisglucuronosyl bilirubin by recombinant human and rat multidrug resistance protein 2.
PubMed ID: 10421658
PubMed ID: 10220572
Title: Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells.
PubMed ID: 10220572
PubMed ID: 11500505
Title: Mutation of Trp1254 in the multispecific organic anion transporter, multidrug resistance protein 2 (MRP2) (ABCC2), alters substrate specificity and results in loss of methotrexate transport activity.
PubMed ID: 11500505
PubMed ID: 12441801
Title: Multidrug resistance protein 2 (MRP2) transports HIV protease inhibitors, and transport can be enhanced by other drugs.
PubMed ID: 12441801
PubMed ID: 16332456
Title: Transport by vesicles of glycine- and taurine-conjugated bile salts and taurolithocholate 3-sulfate: a comparison of human BSEP with rat Bsep.
PubMed ID: 16332456
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 28408210
Title: The Organic Anion-Transporting Peptide 2B1 Is Localized in the Basolateral Membrane of the Human Jejunum and Caco-2 Monolayers.
PubMed ID: 28408210
PubMed ID: 9425227
Title: Mutations in the canalicular multispecific organic anion transporter (cMOAT) gene, a novel ABC transporter, in patients with hyperbilirubinemia II/Dubin-Johnson syndrome.
PubMed ID: 9425227
DOI: 10.1093/hmg/7.2.203
PubMed ID: 10053008
Title: Genomic structure of the canalicular multispecific organic anion-transporter gene (MRP2/cMOAT) and mutations in the ATP-binding-cassette region in Dubin-Johnson syndrome.
PubMed ID: 10053008
DOI: 10.1086/302292
PubMed ID: 11093739
Title: Impaired protein maturation of the conjugate export pump multidrug resistance protein 2 as a consequence of a deletion mutation in Dubin-Johnson syndrome.
PubMed ID: 11093739
PubMed ID: 11477083
Title: Identification and functional analysis of two novel mutations in the multidrug resistance protein 2 gene in Israeli patients with Dubin-Johnson syndrome.
PubMed ID: 11477083
PubMed ID: 11266082
Title: Polymorphism of the ABC transporter genes, MDR1, MRP1 and MRP2/cMOAT, in healthy Japanese subjects.
PubMed ID: 11266082
PubMed ID: 22290738
Title: Functional characterization of protein variants of the human multidrug transporter ABCC2 by a novel targeted expression system in fibrosarcoma cells.
PubMed ID: 22290738
DOI: 10.1002/humu.22041
PubMed ID: 25336012
Title: Neonatal Dubin-Johnson syndrome: novel compound heterozygous mutation in the ABCC2 gene.
PubMed ID: 25336012
DOI: 10.1111/ped.12404
Sequence Information:
- Length: 1545
- Mass: 174207
- Checksum: C5F8984FFCDF9799
- Sequence:
MLEKFCNSTF WNSSFLDSPE ADLPLCFEQT VLVWIPLGYL WLLAPWQLLH VYKSRTKRSS TTKLYLAKQV FVGFLLILAA IELALVLTED SGQATVPAVR YTNPSLYLGT WLLVLLIQYS RQWCVQKNSW FLSLFWILSI LCGTFQFQTL IRTLLQGDNS NLAYSCLFFI SYGFQILILI FSAFSENNES SNNPSSIASF LSSITYSWYD SIILKGYKRP LTLEDVWEVD EEMKTKTLVS KFETHMKREL QKARRALQRR QEKSSQQNSG ARLPGLNKNQ SQSQDALVLE DVEKKKKKSG TKKDVPKSWL MKALFKTFYM VLLKSFLLKL VNDIFTFVSP QLLKLLISFA SDRDTYLWIG YLCAILLFTA ALIQSFCLQC YFQLCFKLGV KVRTAIMASV YKKALTLSNL ARKEYTVGET VNLMSVDAQK LMDVTNFMHM LWSSVLQIVL SIFFLWRELG PSVLAGVGVM VLVIPINAIL STKSKTIQVK NMKNKDKRLK IMNEILSGIK ILKYFAWEPS FRDQVQNLRK KELKNLLAFS QLQCVVIFVF QLTPVLVSVV TFSVYVLVDS NNILDAQKAF TSITLFNILR FPLSMLPMMI SSMLQASVST ERLEKYLGGD DLDTSAIRHD CNFDKAMQFS EASFTWEHDS EATVRDVNLD IMAGQLVAVI GPVGSGKSSL ISAMLGEMEN VHGHITIKGT TAYVPQQSWI QNGTIKDNIL FGTEFNEKRY QQVLEACALL PDLEMLPGGD LAEIGEKGIN LSGGQKQRIS LARATYQNLD IYLLDDPLSA VDAHVGKHIF NKVLGPNGLL KGKTRLLVTH SMHFLPQVDE IVVLGNGTIV EKGSYSALLA KKGEFAKNLK TFLRHTGPEE EATVHDGSEE EDDDYGLISS VEEIPEDAAS ITMRRENSFR RTLSRSSRSN GRHLKSLRNS LKTRNVNSLK EDEELVKGQK LIKKEFIETG KVKFSIYLEY LQAIGLFSIF FIILAFVMNS VAFIGSNLWL SAWTSDSKIF NSTDYPASQR DMRVGVYGAL GLAQGIFVFI AHFWSAFGFV HASNILHKQL LNNILRAPMR FFDTTPTGRI VNRFAGDIST VDDTLPQSLR SWITCFLGII STLVMICMAT PVFTIIVIPL GIIYVSVQMF YVSTSRQLRR LDSVTRSPIY SHFSETVSGL PVIRAFEHQQ RFLKHNEVRI DTNQKCVFSW ITSNRWLAIR LELVGNLTVF FSALMMVIYR DTLSGDTVGF VLSNALNITQ TLNWLVRMTS EIETNIVAVE RITEYTKVEN EAPWVTDKRP PPDWPSKGKI QFNNYQVRYR PELDLVLRGI TCDIGSMEKI GVVGRTGAGK SSLTNCLFRI LEAAGGQIII DGVDIASIGL HDLREKLTII PQDPILFSGS LRMNLDPFNN YSDEEIWKAL ELAHLKSFVA SLQLGLSHEV TEAGGNLSIG QRQLLCLGRA LLRKSKILVL DEATAAVDLE TDNLIQTTIQ NEFAHCTVIT IAHRLHTIMD SDKVMVLDNG KIIECGSPEE LLQIPGPFYF MAKEAGIENV NSTKF
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.