Details for: ABCC2

Gene ID: 1244

Symbol: ABCC2

Ensembl ID: ENSG00000023839

Description: ATP binding cassette subfamily C member 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 14.5086
    Cell Significance Index: -3.6800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 9.3783
    Cell Significance Index: -3.8100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 4.1823
    Cell Significance Index: 70.4500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 3.3337
    Cell Significance Index: 661.5900
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.8023
    Cell Significance Index: 4.6200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7938
    Cell Significance Index: 22.8700
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.7485
    Cell Significance Index: 12.5900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6010
    Cell Significance Index: 114.3700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.5853
    Cell Significance Index: 8.8200
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.4673
    Cell Significance Index: 1.7600
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 0.4326
    Cell Significance Index: 6.9800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.4026
    Cell Significance Index: 6.9000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.3973
    Cell Significance Index: 6.3000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.3705
    Cell Significance Index: 3.8400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3087
    Cell Significance Index: 18.5300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.2425
    Cell Significance Index: 3.5800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1957
    Cell Significance Index: 176.7500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.1844
    Cell Significance Index: 4.5000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1837
    Cell Significance Index: 3.9800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1704
    Cell Significance Index: 10.7400
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.1639
    Cell Significance Index: 1.5800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1503
    Cell Significance Index: 16.3500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1209
    Cell Significance Index: 6.1100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1136
    Cell Significance Index: 11.2400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.1125
    Cell Significance Index: 2.2000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1095
    Cell Significance Index: 7.5800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0747
    Cell Significance Index: 10.8600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0667
    Cell Significance Index: 10.8500
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.0577
    Cell Significance Index: 0.8100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0475
    Cell Significance Index: 1.2200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0445
    Cell Significance Index: 8.9300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0396
    Cell Significance Index: 1.0600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0388
    Cell Significance Index: 0.9700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0360
    Cell Significance Index: 2.0200
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.0347
    Cell Significance Index: 0.2700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.0337
    Cell Significance Index: 0.4800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0251
    Cell Significance Index: 4.5300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0208
    Cell Significance Index: 7.4600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0162
    Cell Significance Index: 11.1700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.0133
    Cell Significance Index: 0.0900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0103
    Cell Significance Index: 0.1400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0050
    Cell Significance Index: 2.7500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0047
    Cell Significance Index: 0.1000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0043
    Cell Significance Index: 8.1900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0040
    Cell Significance Index: 0.1400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0022
    Cell Significance Index: 3.3300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0011
    Cell Significance Index: 0.7000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0007
    Cell Significance Index: 1.2700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0005
    Cell Significance Index: 0.6800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0004
    Cell Significance Index: -0.0100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0007
    Cell Significance Index: -0.3100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0024
    Cell Significance Index: -0.1100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0027
    Cell Significance Index: -0.1400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0051
    Cell Significance Index: -3.7800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0053
    Cell Significance Index: -3.9200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0053
    Cell Significance Index: -4.0300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0066
    Cell Significance Index: -4.1500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0068
    Cell Significance Index: -0.5200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0070
    Cell Significance Index: -3.9200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0083
    Cell Significance Index: -1.0200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0086
    Cell Significance Index: -0.2300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0099
    Cell Significance Index: -0.4300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0102
    Cell Significance Index: -1.7400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0105
    Cell Significance Index: -3.0200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0133
    Cell Significance Index: -1.5500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0147
    Cell Significance Index: -0.2100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0180
    Cell Significance Index: -0.8400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0198
    Cell Significance Index: -4.1800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0200
    Cell Significance Index: -2.5600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0218
    Cell Significance Index: -2.2300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0222
    Cell Significance Index: -1.4900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0227
    Cell Significance Index: -1.1800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0233
    Cell Significance Index: -0.5800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0235
    Cell Significance Index: -0.2800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0241
    Cell Significance Index: -3.3100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0253
    Cell Significance Index: -1.5500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0268
    Cell Significance Index: -3.0700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0295
    Cell Significance Index: -3.0700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0322
    Cell Significance Index: -4.1600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0334
    Cell Significance Index: -3.9400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0358
    Cell Significance Index: -0.7700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0369
    Cell Significance Index: -1.6300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0373
    Cell Significance Index: -2.2900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0375
    Cell Significance Index: -1.4200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0473
    Cell Significance Index: -3.7500
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0477
    Cell Significance Index: -0.6700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0557
    Cell Significance Index: -4.1500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0572
    Cell Significance Index: -3.6900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0597
    Cell Significance Index: -2.8100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0694
    Cell Significance Index: -2.4300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0739
    Cell Significance Index: -3.8800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0763
    Cell Significance Index: -2.4300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0800
    Cell Significance Index: -2.6200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0852
    Cell Significance Index: -2.4300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0853
    Cell Significance Index: -1.8100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0856
    Cell Significance Index: -2.3300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0967
    Cell Significance Index: -3.0600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0994
    Cell Significance Index: -2.4800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1018
    Cell Significance Index: -2.2000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1045
    Cell Significance Index: -2.8000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** ABCC2 is a transmembrane protein that belongs to the ATP-binding cassette (ABC) transporter family. Its structure consists of two transmembrane domains, a hydrophilic N-terminus, and a C-terminal cytoplasmic domain. ABCC2 has been shown to have a wide range of substrate specificity, including xenobiotics, glutathione conjugates, and organic anions. The gene is highly expressed in tissues involved in drug metabolism, such as the liver and kidney, and is also present in the retina, where it plays a role in the transport of bilirubin. **Pathways and Functions** ABCC2 is involved in several cellular processes, including: 1. **Xenobiotic export**: ABCC2 facilitates the efflux of xenobiotics, such as drugs and environmental toxins, from cells, which helps to protect the cell from toxic substances. 2. **Glutathione conjugate transport**: ABCC2 is involved in the transport of glutathione conjugates, which are formed during the detoxification of xenobiotics. 3. **Organic anion transport**: ABCC2 transports a wide range of organic anions, including bilirubin and bile salts. 4. **Regulation of gene expression**: ABCC2 has been shown to have negative regulatory effects on gene expression, which helps to control the levels of certain proteins in the cell. 5. **Metabolism of small molecules**: ABCC2 is involved in the transport of small molecules, such as porphyrins, across cell membranes. **Clinical Significance** Defects in ABCC2 have been associated with various diseases, including: 1. **Disorders of transmembrane transporters**: Mutations in ABCC2 have been linked to disorders of transmembrane transporters, such as multidrug resistance and impaired bilirubin transport. 2. **Drug metabolism**: ABCC2 plays a role in the metabolism of certain drugs, such as atorvastatin and paracetamol, and defects in the gene can lead to impaired drug metabolism. 3. **Bile acid and bilirubin transport**: ABCC2 is involved in the transport of bile acids and bilirubin across cell membranes, and defects in the gene can lead to impaired bile acid and bilirubin transport. 4. **Neurological disorders**: ABCC2 has been implicated in the transport of neuroactive substances across the blood-brain barrier, and defects in the gene have been linked to neurological disorders, such as epilepsy and Parkinson's disease. In conclusion, ABCC2 is a critical gene involved in the transport of various substances across cell membranes. Its defects have been associated with various diseases, including disorders of transmembrane transporters, drug metabolism, and neurological disorders. Further research is needed to fully understand the role of ABCC2 in human health and disease.

Genular Protein ID: 3832813308

Symbol: MRP2_HUMAN

Name: ATP-binding cassette sub-family C member 2

UniProtKB Accession Codes:

Q92887 B2RMT8 Q14022 Q5T2B1 Q92500 Q92798 Q99663 Q9UMS2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 4 CTD 1 ChEBI 38 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 97 DrugCentral 1 EC 2 EMBL 39 EMDB 6 Ensembl 1 ExpressionAtlas 1 GO 26 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 6 RefSeq 1 Rhea 11 SABIO-RK 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissLipids 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8797578

Title: A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation.

PubMed ID: 8797578

PubMed ID: 8662992

Title: cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats.

PubMed ID: 8662992

DOI: 10.1074/jbc.271.25.15091

PubMed ID: 10464142

Title: Exon-intron organization of the human multidrug-resistance protein 2 (MRP2) gene mutated in Dubin-Johnson syndrome.

PubMed ID: 10464142

DOI: 10.1016/s0016-5085(99)70459-2

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10421658

Title: Transport of monoglucuronosyl and bisglucuronosyl bilirubin by recombinant human and rat multidrug resistance protein 2.

PubMed ID: 10421658

DOI: 10.1002/hep.510300220

PubMed ID: 10220572

Title: Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells.

PubMed ID: 10220572

PubMed ID: 11500505

Title: Mutation of Trp1254 in the multispecific organic anion transporter, multidrug resistance protein 2 (MRP2) (ABCC2), alters substrate specificity and results in loss of methotrexate transport activity.

PubMed ID: 11500505

DOI: 10.1074/jbc.m105160200

PubMed ID: 12441801

Title: Multidrug resistance protein 2 (MRP2) transports HIV protease inhibitors, and transport can be enhanced by other drugs.

PubMed ID: 12441801

DOI: 10.1097/00002030-200211220-00009

PubMed ID: 16332456

Title: Transport by vesicles of glycine- and taurine-conjugated bile salts and taurolithocholate 3-sulfate: a comparison of human BSEP with rat Bsep.

PubMed ID: 16332456

DOI: 10.1016/j.bbalip.2005.10.006

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28408210

Title: The Organic Anion-Transporting Peptide 2B1 Is Localized in the Basolateral Membrane of the Human Jejunum and Caco-2 Monolayers.

PubMed ID: 28408210

DOI: 10.1016/j.xphs.2017.04.001

PubMed ID: 9425227

Title: Mutations in the canalicular multispecific organic anion transporter (cMOAT) gene, a novel ABC transporter, in patients with hyperbilirubinemia II/Dubin-Johnson syndrome.

PubMed ID: 9425227

DOI: 10.1093/hmg/7.2.203

PubMed ID: 10053008

Title: Genomic structure of the canalicular multispecific organic anion-transporter gene (MRP2/cMOAT) and mutations in the ATP-binding-cassette region in Dubin-Johnson syndrome.

PubMed ID: 10053008

DOI: 10.1086/302292

PubMed ID: 11093739

Title: Impaired protein maturation of the conjugate export pump multidrug resistance protein 2 as a consequence of a deletion mutation in Dubin-Johnson syndrome.

PubMed ID: 11093739

DOI: 10.1053/jhep.2000.19791

PubMed ID: 11477083

Title: Identification and functional analysis of two novel mutations in the multidrug resistance protein 2 gene in Israeli patients with Dubin-Johnson syndrome.

PubMed ID: 11477083

DOI: 10.1074/jbc.m105047200

PubMed ID: 11266082

Title: Polymorphism of the ABC transporter genes, MDR1, MRP1 and MRP2/cMOAT, in healthy Japanese subjects.

PubMed ID: 11266082

DOI: 10.1097/00008571-200103000-00008

PubMed ID: 22290738

Title: Functional characterization of protein variants of the human multidrug transporter ABCC2 by a novel targeted expression system in fibrosarcoma cells.

PubMed ID: 22290738

DOI: 10.1002/humu.22041

PubMed ID: 25336012

Title: Neonatal Dubin-Johnson syndrome: novel compound heterozygous mutation in the ABCC2 gene.

PubMed ID: 25336012

DOI: 10.1111/ped.12404

Sequence Information:

  • Length: 1545
  • Mass: 174207
  • Checksum: C5F8984FFCDF9799
  • Sequence:
    • MLEKFCNSTF WNSSFLDSPE ADLPLCFEQT VLVWIPLGYL WLLAPWQLLH VYKSRTKRSS 
TTKLYLAKQV FVGFLLILAA IELALVLTED SGQATVPAVR YTNPSLYLGT WLLVLLIQYS 
RQWCVQKNSW FLSLFWILSI LCGTFQFQTL IRTLLQGDNS NLAYSCLFFI SYGFQILILI 
FSAFSENNES SNNPSSIASF LSSITYSWYD SIILKGYKRP LTLEDVWEVD EEMKTKTLVS 
KFETHMKREL QKARRALQRR QEKSSQQNSG ARLPGLNKNQ SQSQDALVLE DVEKKKKKSG 
TKKDVPKSWL MKALFKTFYM VLLKSFLLKL VNDIFTFVSP QLLKLLISFA SDRDTYLWIG 
YLCAILLFTA ALIQSFCLQC YFQLCFKLGV KVRTAIMASV YKKALTLSNL ARKEYTVGET 
VNLMSVDAQK LMDVTNFMHM LWSSVLQIVL SIFFLWRELG PSVLAGVGVM VLVIPINAIL 
STKSKTIQVK NMKNKDKRLK IMNEILSGIK ILKYFAWEPS FRDQVQNLRK KELKNLLAFS 
QLQCVVIFVF QLTPVLVSVV TFSVYVLVDS NNILDAQKAF TSITLFNILR FPLSMLPMMI 
SSMLQASVST ERLEKYLGGD DLDTSAIRHD CNFDKAMQFS EASFTWEHDS EATVRDVNLD 
IMAGQLVAVI GPVGSGKSSL ISAMLGEMEN VHGHITIKGT TAYVPQQSWI QNGTIKDNIL 
FGTEFNEKRY QQVLEACALL PDLEMLPGGD LAEIGEKGIN LSGGQKQRIS LARATYQNLD 
IYLLDDPLSA VDAHVGKHIF NKVLGPNGLL KGKTRLLVTH SMHFLPQVDE IVVLGNGTIV 
EKGSYSALLA KKGEFAKNLK TFLRHTGPEE EATVHDGSEE EDDDYGLISS VEEIPEDAAS 
ITMRRENSFR RTLSRSSRSN GRHLKSLRNS LKTRNVNSLK EDEELVKGQK LIKKEFIETG 
KVKFSIYLEY LQAIGLFSIF FIILAFVMNS VAFIGSNLWL SAWTSDSKIF NSTDYPASQR 
DMRVGVYGAL GLAQGIFVFI AHFWSAFGFV HASNILHKQL LNNILRAPMR FFDTTPTGRI 
VNRFAGDIST VDDTLPQSLR SWITCFLGII STLVMICMAT PVFTIIVIPL GIIYVSVQMF 
YVSTSRQLRR LDSVTRSPIY SHFSETVSGL PVIRAFEHQQ RFLKHNEVRI DTNQKCVFSW 
ITSNRWLAIR LELVGNLTVF FSALMMVIYR DTLSGDTVGF VLSNALNITQ TLNWLVRMTS 
EIETNIVAVE RITEYTKVEN EAPWVTDKRP PPDWPSKGKI QFNNYQVRYR PELDLVLRGI 
TCDIGSMEKI GVVGRTGAGK SSLTNCLFRI LEAAGGQIII DGVDIASIGL HDLREKLTII 
PQDPILFSGS LRMNLDPFNN YSDEEIWKAL ELAHLKSFVA SLQLGLSHEV TEAGGNLSIG 
QRQLLCLGRA LLRKSKILVL DEATAAVDLE TDNLIQTTIQ NEFAHCTVIT IAHRLHTIMD 
SDKVMVLDNG KIIECGSPEE LLQIPGPFYF MAKEAGIENV NSTKF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.