Genular: Defining Cellular Identity and Function

Details for: Ccnd1

Gene ID: 12443

Symbol: Ccnd1

Ensembl ID: ENSMUSG00000070348

Description: cyclin D1

Associated with

Cell cycle, mitotic
(R-MMU-69278)
Chromatin modifying enzymes
(R-MMU-3247509)
Chromatin organization
(R-MMU-4839726)
Cyclin a:cdk2-associated events at s phase entry
(R-MMU-69656)
Cyclin d associated events in g1
(R-MMU-69231)
Cyclin e associated events during g1/s transition
(R-MMU-69202)
Drug-mediated inhibition of cdk4/cdk6 activity
(R-MMU-9754119)
G1 phase
(R-MMU-69236)
G1/s transition
(R-MMU-69206)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Mitotic g1 phase and g1/s transition
(R-MMU-453279)
Ptk6 regulates cell cycle
(R-MMU-8849470)
Regulation of runx1 expression and activity
(R-MMU-8934593)
Rmts methylate histone arginines
(R-MMU-3214858)
Rna polymerase ii transcription
(R-MMU-73857)
Runx3 regulates p14-arf
(R-MMU-8951936)
Scf(skp2)-mediated degradation of p27/p21
(R-MMU-187577)
Signaling by non-receptor tyrosine kinases
(R-MMU-9006927)
Signaling by ptk6
(R-MMU-8848021)
Signal transduction
(R-MMU-162582)
S phase
(R-MMU-69242)
Transcriptional regulation by runx1
(R-MMU-8878171)
Transcriptional regulation by runx2
(R-MMU-8878166)
Transcriptional regulation by runx3
(R-MMU-8878159)
Ubiquitin-dependent degradation of cyclin d
(R-MMU-75815)
Bicellular tight junction
(GO:0005923)
Cell cycle
(GO:0007049)
Cell division
(GO:0051301)
Cell population proliferation
(GO:0008283)
Cellular response to organic substance
(GO:0071310)
Centrosome
(GO:0005813)
Cyclin-dependent protein kinase holoenzyme complex
(GO:0000307)
Cyclin-dependent protein serine/threonine kinase activator activity
(GO:0061575)
Cyclin-dependent protein serine/threonine kinase regulator activity
(GO:0016538)
Cyclin d1-cdk4 complex
(GO:0097128)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dna damage response
(GO:0006974)
Endoplasmic reticulum unfolded protein response
(GO:0030968)
Enzyme binding
(GO:0019899)
Fat cell differentiation
(GO:0045444)
G1/s transition of mitotic cell cycle
(GO:0000082)
Histone deacetylase binding
(GO:0042826)
Kinase activity
(GO:0016301)
Lactation
(GO:0007595)
Leydig cell differentiation
(GO:0033327)
Liver regeneration
(GO:0097421)
Mammary gland alveolus development
(GO:0060749)
Mammary gland epithelial cell proliferation
(GO:0033598)
Membrane
(GO:0016020)
Mitotic g1 dna damage checkpoint signaling
(GO:0031571)
Negative regulation of epithelial cell differentiation
(GO:0030857)
Negative regulation of neuron apoptotic process
(GO:0043524)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Neuron differentiation
(GO:0030182)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of cyclin-dependent protein serine/threonine kinase activity
(GO:0045737)
Positive regulation of g1/s transition of mitotic cell cycle
(GO:1900087)
Positive regulation of g2/m transition of mitotic cell cycle
(GO:0010971)
Positive regulation of mammary gland epithelial cell proliferation
(GO:0033601)
Positive regulation of protein phosphorylation
(GO:0001934)
Proline-rich region binding
(GO:0070064)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein kinase binding
(GO:0019901)
Protein phosphorylation
(GO:0006468)
Re-entry into mitotic cell cycle
(GO:0000320)
Regulation of cell cycle
(GO:0051726)
Regulation of cyclin-dependent protein serine/threonine kinase activity
(GO:0000079)
Regulation of g1/s transition of mitotic cell cycle
(GO:2000045)
Response to leptin
(GO:0044321)
Response to organonitrogen compound
(GO:0010243)
Response to uv-a
(GO:0070141)
Transcription corepressor activity
(GO:0003714)
Transcription repressor complex
(GO:0017053)
Wnt signaling pathway
(GO:0016055)

Other Information

Proteins

G1/S-specific cyclin-D1

Genular Protein ID: 1084053470

Symbol: CCND1_MOUSE

Name: G1/S-specific cyclin-D1

UniProtKB Accession Codes:

P25322

Database IDs:

Citations:

PubMed ID: 1827757

Title: Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle.

PubMed ID: 1827757

DOI: 10.1016/0092-8674(91)90101-4

PubMed ID: 7774959

Title: Genomic organization of the mouse cyclin D1 gene (Cyl-1).

PubMed ID: 7774959

DOI: 10.1016/0888-7543(95)80112-y

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8534916

Title: Redistribution of the CDK inhibitor p27 between different cyclin.CDK complexes in the mouse fibroblast cell cycle and in cells arrested with lovastatin or ultraviolet irradiation.

PubMed ID: 8534916

DOI: 10.1091/mbc.6.9.1197

PubMed ID: 17081987

Title: Phosphorylation-dependent ubiquitination of cyclin D1 by the SCF(FBX4-alphaB crystallin) complex.

PubMed ID: 17081987

DOI: 10.1016/j.molcel.2006.09.007

PubMed ID: 19767775

Title: Lysine 269 is essential for cyclin D1 ubiquitylation by the SCF(Fbx4/alphaB-crystallin) ligase and subsequent proteasome-dependent degradation.

PubMed ID: 19767775

DOI: 10.1038/onc.2009.287

PubMed ID: 22510880

Title: Nuclear receptor binding protein 1 regulates intestinal progenitor cell homeostasis and tumour formation.

PubMed ID: 22510880

DOI: 10.1038/emboj.2012.91

PubMed ID: 33854232

Title: AMBRA1 regulates cyclin D to guard S-phase entry and genomic integrity.

PubMed ID: 33854232

DOI: 10.1038/s41586-021-03422-5

Sequence Information:

Length: 295
Mass: 33429
Checksum: 3A79736B4163251B
Sequence:

MEHQLLCCEV ETIRRAYPDT NLLNDRVLRA MLKTEETCAP SVSYFKCVQK EIVPSMRKIV 
ATWMLEVCEE QKCEEEVFPL AMNYLDRFLS LEPLKKSRLQ LLGATCMFVA SKMKETIPLT 
AEKLCIYTDN SIRPEELLQM ELLLVNKLKW NLAAMTPHDF IEHFLSKMPE ADENKQTIRK 
HAQTFVALCA TDVKFISNPP SMVAAGSVVA AMQGLNLGSP NNFLSCYRTT HFLSRVIKCD 
PDCLRACQEQ IEALLESSLR QAQQNVDPKA TEEEGEVEEE AGLACTPTDV RDVDI

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ccnd1

Associated with

Other Information

Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle. PubMed ID: 1827757

Genomic organization of the mouse cyclin D1 gene (Cyl-1). PubMed ID: 7774959

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Redistribution of the CDK inhibitor p27 between different cyclin.CDK complexes in the mouse fibroblast cell cycle and in cells arrested with lovastatin or ultraviolet irradiation. PubMed ID: 8534916

Phosphorylation-dependent ubiquitination of cyclin D1 by the SCF(FBX4-alphaB crystallin) complex. PubMed ID: 17081987

Lysine 269 is essential for cyclin D1 ubiquitylation by the SCF(Fbx4/alphaB-crystallin) ligase and subsequent proteasome-dependent degradation. PubMed ID: 19767775

Nuclear receptor binding protein 1 regulates intestinal progenitor cell homeostasis and tumour formation. PubMed ID: 22510880

AMBRA1 regulates cyclin D to guard S-phase entry and genomic integrity. PubMed ID: 33854232