Genular: Defining Cellular Identity and Function

Details for: Ccne1

Gene ID: 12447

Symbol: Ccne1

Ensembl ID: ENSMUSG00000002068

Description: cyclin E1

Associated with

Cdk-mediated phosphorylation and removal of cdc6
(R-MMU-69017)
Cell cycle, mitotic
(R-MMU-69278)
Cell cycle checkpoints
(R-MMU-69620)
Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular senescence
(R-MMU-2559583)
Cyclin a:cdk2-associated events at s phase entry
(R-MMU-69656)
Cyclin d associated events in g1
(R-MMU-69231)
Cyclin e associated events during g1/s transition
(R-MMU-69202)
Dna damage/telomere stress induced senescence
(R-MMU-2559586)
Dna replication
(R-MMU-69306)
G0 and early g1
(R-MMU-1538133)
G1 phase
(R-MMU-69236)
G1/s dna damage checkpoints
(R-MMU-69615)
G1/s transition
(R-MMU-69206)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Mitotic g1 phase and g1/s transition
(R-MMU-453279)
P53-dependent g1 dna damage response
(R-MMU-69563)
P53-dependent g1/s dna damage checkpoint
(R-MMU-69580)
Phosphorylation of proteins involved in g1/s transition by active cyclin e:cdk2 complexes
(R-MMU-69200)
Ptk6 regulates cell cycle
(R-MMU-8849470)
Rhobtb3 atpase cycle
(R-MMU-9706019)
Rna polymerase ii transcription
(R-MMU-73857)
Scf(skp2)-mediated degradation of p27/p21
(R-MMU-187577)
Signaling by non-receptor tyrosine kinases
(R-MMU-9006927)
Signaling by ptk6
(R-MMU-8848021)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-MMU-9716542)
Signal transduction
(R-MMU-162582)
S phase
(R-MMU-69242)
Switching of origins to a post-replicative state
(R-MMU-69052)
Synthesis of dna
(R-MMU-69239)
Tp53 regulates transcription of cell cycle genes
(R-MMU-6791312)
Tp53 regulates transcription of genes involved in g1 cell cycle arrest
(R-MMU-6804116)
Transcriptional regulation by tp53
(R-MMU-3700989)
Cell cycle
(GO:0007049)
Cell division
(GO:0051301)
Centrosome
(GO:0005813)
Chromosome organization involved in meiotic cell cycle
(GO:0070192)
Cyclin-dependent protein kinase holoenzyme complex
(GO:0000307)
Cyclin-dependent protein serine/threonine kinase regulator activity
(GO:0016538)
Cyclin e1-cdk2 complex
(GO:0097134)
Cytoplasm
(GO:0005737)
Dna replication initiation
(GO:0006270)
G1/s transition of mitotic cell cycle
(GO:0000082)
Homologous chromosome pairing at meiosis
(GO:0007129)
Kinase activity
(GO:0016301)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of cell differentiation
(GO:0045597)
Positive regulation of g1/s transition of mitotic cell cycle
(GO:1900087)
Positive regulation of mesenchymal stem cell proliferation
(GO:1902462)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Protein phosphorylation
(GO:0006468)
Regulation of cell cycle
(GO:0051726)
Regulation of cyclin-dependent protein serine/threonine kinase activity
(GO:0000079)
Regulation of protein localization
(GO:0032880)
Telomere maintenance
(GO:0000723)
Wnt signaling pathway
(GO:0016055)

Other Information

Proteins

G1/S-specific cyclin-E1

Genular Protein ID: 2966474358

Symbol: CCNE1_MOUSE

Name: G1/S-specific cyclin-E1

UniProtKB Accession Codes:

Q61457 Q05BA1 Q05BA6 Q05BB7

Database IDs:

Citations:

PubMed ID: 8003041

Title: Molecular cloning and characterization of murine cyclin E.

PubMed ID: 8003041

DOI: 10.1006/bbrc.1994.1800

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11585773

Title: Cables enhances cdk2 tyrosine 15 phosphorylation by Wee1, inhibits cell growth, and is lost in many human colon and squamous cancers.

PubMed ID: 11585773

Sequence Information:

Length: 408
Mass: 46986
Checksum: 4916B5D7117ADA69
Sequence:

MPRERDSTDH SNMKEEGGSD LSVRSRKRKA NVAVFLQDPD EEIAKIDKTV KSEDSSQPWD 
DNSACVDPCS FIPTPNKEED NELEYPRTAF QPRKIRPPRA SPLPVLNWGN REEVWRIMLN 
KEKTYLRDEH FLQRHPLLQA RMRAVLLDWL MEVCEVYKLH RETFYLAQDF FDRYMASQHN 
IIKTLLQLIG ISALFIASKL EEIYPPKLHQ FAYVTDGACS GDEILTMELM MMKALKWRLS 
PLTIVSWLNV YVQVAYVNDT GEVLMPQYPQ QVFVQIAELL DLCVLDVGCL EFPYGVLAAS 
ALYHFSSLEL MQKVSGYQWC DIEKCVKWMV PFAMVIREMG SSKLKHFRGV PMEDSHNIQT 
HTNSLDLLDK AQAKKAILSE QNRISPPPSV VLTPPPSSKK QSSEQETE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.