Genular: Defining Cellular Identity and Function

Details for: Ccnt1

Gene ID: 12455

Symbol: Ccnt1

Ensembl ID: ENSMUSG00000011960

Description: cyclin T1

Associated with

Esr-mediated signaling
(R-MMU-8939211)
Estrogen-dependent gene expression
(R-MMU-9018519)
Formation of rna pol ii elongation complex
(R-MMU-112382)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Rna polymerase ii pre-transcription events
(R-MMU-674695)
Rna polymerase ii transcribes snrna genes
(R-MMU-6807505)
Rna polymerase ii transcription
(R-MMU-73857)
Rna polymerase ii transcription elongation
(R-MMU-75955)
Signaling by nuclear receptors
(R-MMU-9006931)
Signaling by tgf-beta receptor complex
(R-MMU-170834)
Signaling by tgfb family members
(R-MMU-9006936)
Signal transduction
(R-MMU-162582)
Smad2/smad3:smad4 heterotrimer regulates transcription
(R-MMU-2173796)
Tp53 regulates transcription of dna repair genes
(R-MMU-6796648)
Transcriptional activity of smad2/smad3:smad4 heterotrimer
(R-MMU-2173793)
Transcriptional regulation by tp53
(R-MMU-3700989)
7sk snrna binding
(GO:0097322)
Cell cycle
(GO:0007049)
Cell division
(GO:0051301)
Chromatin binding
(GO:0003682)
Cyclin-dependent protein serine/threonine kinase activator activity
(GO:0061575)
Cyclin-dependent protein serine/threonine kinase regulator activity
(GO:0016538)
Cyclin/cdk positive transcription elongation factor complex
(GO:0008024)
Cytosol
(GO:0005829)
Dna-binding transcription factor binding
(GO:0140297)
Dna binding
(GO:0003677)
Molecular condensate scaffold activity
(GO:0140693)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
P-tefb complex
(GO:0070691)
Positive regulation by host of viral transcription
(GO:0043923)
Positive regulation of dna-templated transcription, elongation
(GO:0032786)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of transcription elongation by rna polymerase ii
(GO:0032968)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Protein phosphorylation
(GO:0006468)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase binding
(GO:0070063)
Snrna binding
(GO:0017069)
Transcription cis-regulatory region binding
(GO:0000976)

Other Information

Proteins

Cyclin-T1

Genular Protein ID: 1860834773

Symbol: CCNT1_MOUSE

Name: Cyclin-T1

UniProtKB Accession Codes:

Q9QWV9 Q3V0G4 Q9Z0U7

Database IDs:

Citations:

PubMed ID: 9843510

Title: Recruitment of a protein complex containing Tat and cyclin T1 to TAR governs the species specificity of HIV-1 Tat.

PubMed ID: 9843510

DOI: 10.1093/emboj/17.23.7056

PubMed ID: 9832504

Title: The interaction between HIV-1 Tat and human cyclin T1 requires zinc and a critical cysteine residue that is not conserved in the murine CycT1 protein.

PubMed ID: 9832504

DOI: 10.1101/gad.12.22.3512

PubMed ID: 10329126

Title: Role of the human and murine cyclin T proteins in regulating HIV-1 Tat-activation.

PubMed ID: 10329126

DOI: 10.1006/jmbi.1999.2664

PubMed ID: 9990016

Title: Interactions between human cyclin T, Tat, and the transactivation response element (TAR) are disrupted by a cysteine to tyrosine substitution found in mouse cyclin T.

PubMed ID: 9990016

DOI: 10.1073/pnas.96.4.1285

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 27292648

Title: T-bet activates Th1 genes through mediator and the super elongation complex.

PubMed ID: 27292648

DOI: 10.1016/j.celrep.2016.05.054

Sequence Information:

Length: 724
Mass: 80598
Checksum: 6D090F5CA7C3A79C
Sequence:

MEGERKNNNK RWYFTREQLE NSPSRRFGVD SDKELSYRQQ AANLLQDMGQ RLNVSQLTIN 
TAIVYMHRFY MIQSFTQFHR YSMAPAALFL AAKVEEQPKK LEHVIKVAHT CLHPQESLPD 
TRSEAYLQQV QDLVILESII LQTLGFELTI DHPHTHVVKC TQLVRASKDL AQTSYFMATN 
SLHLTTFSLQ YTPPVVACVC IHLACKWSNW EIPVSTDGKH WWEYVDATVT LELLDELTHE 
FLQILEKTPS RLKRIRNWRA YQAAMKTKPD DRGADENTSE QTILNMISQT SSDTTIAGLM 
SMSTASTSAV PSLPSSEESS SSLTSVDMLQ GERWLSSQPP FKLEAAQGHR TSESLALIGV 
DHSLQQDGSS AFGSQKQASK SVPSAKVSLK EYRAKHAEEL AAQKRQLENM EANVKSQYAY 
AAQNLLSHDS HSSVILKMPI ESSENPERPF LDKADKSALK MRLPVASGDK AVSSKPEEIK 
MRIKVHSAGD KHNSIEDSVT KSREHKEKQR THPSNHHHHH NHHSHRHSHL QLPAGPVSKR 
PSDPKHSSQT STLAHKTYSL SSTLSSSSST RKRGPPEETG AAVFDHPAKI AKSTKSSLNF 
PFPPLPTMTQ LPGHSSDTSG LPFSQPSCKT RVPHMKLDKG PPGANGHNAT QSIDYQDTVN 
MLHSLLSAQG VQPTQAPAFE FVHSYGEYMN PRAGAISSRS GTTDKPRPPP LPSEPPPPLP 
PLPK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ccnt1

Associated with

Other Information

Recruitment of a protein complex containing Tat and cyclin T1 to TAR governs the species specificity of HIV-1 Tat. PubMed ID: 9843510

The interaction between HIV-1 Tat and human cyclin T1 requires zinc and a critical cysteine residue that is not conserved in the murine CycT1 protein. PubMed ID: 9832504

Role of the human and murine cyclin T proteins in regulating HIV-1 Tat-activation. PubMed ID: 10329126

Interactions between human cyclin T, Tat, and the transactivation response element (TAR) are disrupted by a cysteine to tyrosine substitution found in mouse cyclin T. PubMed ID: 9990016

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

T-bet activates Th1 genes through mediator and the super elongation complex. PubMed ID: 27292648