Genular: Defining Cellular Identity and Function

Details for: Noct

Gene ID: 12457

Symbol: Noct

Ensembl ID: ENSMUSG00000023087

Description: nocturnin

Associated with

3'-5'-rna exonuclease activity
(GO:0000175)
Catalytic activity
(GO:0003824)
Circadian regulation of gene expression
(GO:0032922)
Circadian rhythm
(GO:0007623)
Cytoplasm
(GO:0005737)
Deadenylation-dependent decapping of nuclear-transcribed mrna
(GO:0000290)
Hydrolase activity
(GO:0016787)
Metal ion binding
(GO:0046872)
Mitochondrion
(GO:0005739)
Mrna binding
(GO:0003729)
Mrna stabilization
(GO:0048255)
Nadph phosphatase activity
(GO:0102757)
Nadp metabolic process
(GO:0006739)
Nadp phosphatase activity
(GO:0019178)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of osteoblast differentiation
(GO:0045668)
Nucleus
(GO:0005634)
P-body
(GO:0000932)
P-body assembly
(GO:0033962)
Perinuclear region of cytoplasm
(GO:0048471)
Poly(a)-specific ribonuclease activity
(GO:0004535)
Positive regulation of fat cell differentiation
(GO:0045600)
Protein binding
(GO:0005515)
Regulation of circadian rhythm
(GO:0042752)
Regulation of embryonic development
(GO:0045995)
Response to extracellular stimulus
(GO:0009991)
Response to lipopolysaccharide
(GO:0032496)
Rhythmic process
(GO:0048511)
Rna binding
(GO:0003723)

Other Information

Proteins

Carbon catabolite repression 4-like protein

Genular Protein ID: 2910666354

Symbol: NOCT_MOUSE

Name: Carbon catabolite repression 4-like protein

UniProtKB Accession Codes:

O35710 Q9QZG9

Database IDs:

Citations:

PubMed ID: 9038221

Title: Characterization of two age-induced intracisternal A-particle-related transcripts in the mouse liver. Transcriptional read-through into an open reading frame with similarities to the yeast ccr4 transcription factor.

PubMed ID: 9038221

DOI: 10.1074/jbc.272.9.5995

PubMed ID: 10521507

Title: Characterization of a mammalian gene related to the yeast CCR4 general transcription factor and revealed by transposon insertion.

PubMed ID: 10521507

DOI: 10.1074/jbc.274.43.31068

PubMed ID: 11394964

Title: Rhythmic expression of nocturnin mRNA in multiple tissues of the mouse.

PubMed ID: 11394964

DOI: 10.1186/1471-213x-1-9

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 17400819

Title: Immediate early response of the circadian polyA ribonuclease nocturnin to two extracellular stimuli.

PubMed ID: 17400819

DOI: 10.1261/rna.286507

PubMed ID: 20392228

Title: Nocturnin: a circadian target of Pparg-induced adipogenesis.

PubMed ID: 20392228

DOI: 10.1111/j.1749-6632.2009.05221.x

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20685873

Title: Nocturnin suppresses igf1 expression in bone by targeting the 3' untranslated region of igf1 mRNA.

PubMed ID: 20685873

DOI: 10.1210/en.2010-0407

PubMed ID: 20498072

Title: A circadian-regulated gene, Nocturnin, promotes adipogenesis by stimulating PPAR-gamma nuclear translocation.

PubMed ID: 20498072

DOI: 10.1073/pnas.1000788107

PubMed ID: 22082366

Title: An essential role for the circadian-regulated gene nocturnin in osteogenesis: the importance of local timekeeping in skeletal homeostasis.

PubMed ID: 22082366

DOI: 10.1111/j.1749-6632.2011.06213.x

PubMed ID: 21820310

Title: Nocturnin regulates circadian trafficking of dietary lipid in intestinal enterocytes.

PubMed ID: 21820310

DOI: 10.1016/j.cub.2011.07.018

PubMed ID: 22073225

Title: The circadian deadenylase Nocturnin is necessary for stabilization of the iNOS mRNA in mice.

PubMed ID: 22073225

DOI: 10.1371/journal.pone.0026954

PubMed ID: 22331129

Title: The role of nocturnin in early adipogenesis and modulation of systemic insulin resistance in human.

PubMed ID: 22331129

DOI: 10.1038/oby.2012.37

PubMed ID: 23449310

Title: Functional analysis of nocturnin, a circadian deadenylase, at maternal-to-zygotic transition in mice.

PubMed ID: 23449310

DOI: 10.1262/jrd.2013-001

PubMed ID: 29860338

Title: The structure of human Nocturnin reveals a conserved ribonuclease domain that represses target transcript translation and abundance in cells.

PubMed ID: 29860338

DOI: 10.1093/nar/gky412

Sequence Information:

Length: 429
Mass: 48301
Checksum: CB9FB55D84E13942
Sequence:

MYQSPRRLCS ALLLRDAPGL RRTLVPGPRR TLAPPVLGSR PKSPQLQAAA ASGAARSRPR 
TVSSMGNGTS RLYSALAKTV NSSAAAQHPE YLVSTDPEHL EPIDPKELLE ECRAVLHTRP 
PRYQRDFVDL RTDCSSSHSP IRVMQWNILA QALGEGKDNF VQCPVEALKW EERKCLILEE 
ILAYQPDILC LQEVDHYFDT FQPLLSRLGY QGTFFPKPWS PCLDVEHNNG PDGCALFFLQ 
NRFKLISSTN IRLTAMTLKT NQVAIAQTLE CKESGRQFCI AVTHLKARTG WERFRSAQGC 
DLLQNLQNIT QGAKIPLIVC GDFNAEPTEE VYKHFASSSL NLNSAYKLLS PDGQSEPPYT 
TWKIRTSGEC RHTLDYIWYS RHALSVTSAL DLLTEEQIGP NRLPSFHYPS DHLSLVCDFS 
FNEEPHELF

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Noct

Associated with

Other Information

Characterization of two age-induced intracisternal A-particle-related transcripts in the mouse liver. Transcriptional read-through into an open reading frame with similarities to the yeast ccr4 transcription factor. PubMed ID: 9038221

Characterization of a mammalian gene related to the yeast CCR4 general transcription factor and revealed by transposon insertion. PubMed ID: 10521507

Rhythmic expression of nocturnin mRNA in multiple tissues of the mouse. PubMed ID: 11394964

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Immediate early response of the circadian polyA ribonuclease nocturnin to two extracellular stimuli. PubMed ID: 17400819

Nocturnin: a circadian target of Pparg-induced adipogenesis. PubMed ID: 20392228

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Nocturnin suppresses igf1 expression in bone by targeting the 3' untranslated region of igf1 mRNA. PubMed ID: 20685873

A circadian-regulated gene, Nocturnin, promotes adipogenesis by stimulating PPAR-gamma nuclear translocation. PubMed ID: 20498072

An essential role for the circadian-regulated gene nocturnin in osteogenesis: the importance of local timekeeping in skeletal homeostasis. PubMed ID: 22082366

Nocturnin regulates circadian trafficking of dietary lipid in intestinal enterocytes. PubMed ID: 21820310

The circadian deadenylase Nocturnin is necessary for stabilization of the iNOS mRNA in mice. PubMed ID: 22073225

The role of nocturnin in early adipogenesis and modulation of systemic insulin resistance in human. PubMed ID: 22331129

Functional analysis of nocturnin, a circadian deadenylase, at maternal-to-zygotic transition in mice. PubMed ID: 23449310

The structure of human Nocturnin reveals a conserved ribonuclease domain that represses target transcript translation and abundance in cells. PubMed ID: 29860338