Genular: Defining Cellular Identity and Function

Details for: Ccr6

Gene ID: 12458

Symbol: Ccr6

Ensembl ID: ENSMUSG00000040899

Description: C-C motif chemokine receptor 6

Associated with

Antimicrobial peptides
(R-MMU-6803157)
Beta defensins
(R-MMU-1461957)
Chemokine receptors bind chemokines
(R-MMU-380108)
Class a/1 (rhodopsin-like receptors)
(R-MMU-373076)
Defensins
(R-MMU-1461973)
G alpha (i) signalling events
(R-MMU-418594)
Gpcr downstream signalling
(R-MMU-388396)
Gpcr ligand binding
(R-MMU-500792)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Peptide ligand-binding receptors
(R-MMU-375276)
Signaling by gpcr
(R-MMU-372790)
C-c chemokine binding
(GO:0019957)
C-c chemokine receptor activity
(GO:0016493)
Calcium-mediated signaling
(GO:0019722)
Cell chemotaxis
(GO:0060326)
Cell surface
(GO:0009986)
Chemokine receptor activity
(GO:0004950)
Chemotaxis
(GO:0006935)
Dn2 thymocyte differentiation
(GO:1904155)
Dn3 thymocyte differentiation
(GO:1904156)
External side of plasma membrane
(GO:0009897)
G protein-coupled receptor activity
(GO:0004930)
G protein-coupled receptor signaling pathway
(GO:0007186)
Immune response
(GO:0006955)
Isotype switching to iga isotypes
(GO:0048290)
Leukocyte migration involved in inflammatory response
(GO:0002523)
Lymphocyte migration
(GO:0072676)
Membrane
(GO:0016020)
Plasma membrane
(GO:0005886)
Positive regulation of cytosolic calcium ion concentration
(GO:0007204)
Positive regulation of dendritic cell chemotaxis
(GO:2000510)
Positive regulation of epithelial cell migration
(GO:0010634)
Positive regulation of flagellated sperm motility involved in capacitation
(GO:0060474)
Protein binding
(GO:0005515)
Regulation of t-helper 17 cell differentiation
(GO:2000319)
Regulation of t cell migration
(GO:2000404)
Signal transduction
(GO:0007165)
Sperm flagellum
(GO:0036126)
Sperm midpiece
(GO:0097225)
Sperm plasma membrane
(GO:0097524)
Sperm principal piece
(GO:0097228)
T cell migration
(GO:0072678)
Thymocyte migration
(GO:0072679)

Other Information

Proteins

C-C chemokine receptor type 6

Genular Protein ID: 2603071350

Symbol: CCR6_MOUSE

Name: C-C chemokine receptor type 6

UniProtKB Accession Codes:

O54689

Database IDs:

Citations:

PubMed ID: 9862452

Title: Molecular cloning, functional characterization and mRNA expression analysis of the murine chemokine receptor CCR6 and its specific ligand MIP-3alpha.

PubMed ID: 9862452

DOI: 10.1016/s0014-5793(98)01450-1

PubMed ID: 19050256

Title: CCR6 regulates the migration of inflammatory and regulatory T cells.

PubMed ID: 19050256

DOI: 10.4049/jimmunol.181.12.8391

PubMed ID: 19129757

Title: The roles of CCR6 in migration of Th17 cells and regulation of effector T-cell balance in the gut.

PubMed ID: 19129757

DOI: 10.1038/mi.2008.84

PubMed ID: 20068036

Title: Specific binding and chemotactic activity of mBD4 and its functional orthologue hBD2 to CCR6-expressing cells.

PubMed ID: 20068036

DOI: 10.1074/jbc.m109.091090

PubMed ID: 21376174

Title: CCR6 as a mediator of immunity in the lung and gut.

PubMed ID: 21376174

DOI: 10.1016/j.yexcr.2010.12.018

PubMed ID: 24638065

Title: CCR6 supports migration and differentiation of a subset of DN1 early thymocyte progenitors but is not required for thymic nTreg development.

PubMed ID: 24638065

DOI: 10.1038/icb.2014.14

PubMed ID: 23765988

Title: A role for the chemokine receptor CCR6 in mammalian sperm motility and chemotaxis.

PubMed ID: 23765988

DOI: 10.1002/jcp.24418

PubMed ID: 25122636

Title: Deficient human beta-defensin 1 underlies male infertility associated with poor sperm motility and genital tract infection.

PubMed ID: 25122636

DOI: 10.1126/scitranslmed.3009071

PubMed ID: 25505290

Title: CCR6-dependent positioning of memory B cells is essential for their ability to mount a recall response to antigen.

PubMed ID: 25505290

DOI: 10.4049/jimmunol.1401553

PubMed ID: 27174992

Title: IgA production requires B cell interaction with subepithelial dendritic cells in Peyer's patches.

PubMed ID: 27174992

DOI: 10.1126/science.aaf4822

Sequence Information:

Length: 367
Mass: 42103
Checksum: 6A309AF833B1117E
Sequence:

MNSTESYFGT DDYDNTEYYS IPPDHGPCSL EEVRNFTKVF VPIAYSLICV FGLLGNIMVV 
MTFAFYKKAR SMTDVYLLNM AITDILFVLT LPFWAVTHAT NTWVFSDALC KLMKGTYAVN 
FNCGMLLLAC ISMDRYIAIV QATKSFRVRS RTLTHSKVIC VAVWFISIII SSPTFIFNKK 
YELQDRDVCE PRYRSVSEPI TWKLLGMGLE LFFGFFTPLL FMVFCYLFII KTLVQAQNSK 
RHRAIRVVIA VVLVFLACQI PHNMVLLVTA VNTGKVGRSC STEKVLAYTR NVAEVLAFLH 
CCLNPVLYAF IGQKFRNYFM KIMKDVWCMR RKNKMPGFLC ARVYSESYIS RQTSETVEND 
NASSFTM

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ccr6

Associated with

Other Information

Molecular cloning, functional characterization and mRNA expression analysis of the murine chemokine receptor CCR6 and its specific ligand MIP-3alpha. PubMed ID: 9862452

CCR6 regulates the migration of inflammatory and regulatory T cells. PubMed ID: 19050256

The roles of CCR6 in migration of Th17 cells and regulation of effector T-cell balance in the gut. PubMed ID: 19129757

Specific binding and chemotactic activity of mBD4 and its functional orthologue hBD2 to CCR6-expressing cells. PubMed ID: 20068036

CCR6 as a mediator of immunity in the lung and gut. PubMed ID: 21376174

CCR6 supports migration and differentiation of a subset of DN1 early thymocyte progenitors but is not required for thymic nTreg development. PubMed ID: 24638065

A role for the chemokine receptor CCR6 in mammalian sperm motility and chemotaxis. PubMed ID: 23765988

Deficient human beta-defensin 1 underlies male infertility associated with poor sperm motility and genital tract infection. PubMed ID: 25122636

CCR6-dependent positioning of memory B cells is essential for their ability to mount a recall response to antigen. PubMed ID: 25505290

IgA production requires B cell interaction with subepithelial dendritic cells in Peyer's patches. PubMed ID: 27174992