Genular: Defining Cellular Identity and Function

Details for: Cd19

Gene ID: 12478

Symbol: Cd19

Ensembl ID: ENSMUSG00000030724

Description: CD19 antigen

Associated with

Adaptive immune system
(R-MMU-1280218)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-MMU-983695)
Complement cascade
(R-MMU-166658)
Immune system
(R-MMU-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-MMU-198933)
Innate immune system
(R-MMU-168249)
Intracellular signaling by second messengers
(R-MMU-9006925)
Negative regulation of the pi3k/akt network
(R-MMU-199418)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-MMU-6811558)
Pip3 activates akt signaling
(R-MMU-1257604)
Regulation of complement cascade
(R-MMU-977606)
Signaling by the b cell receptor (bcr)
(R-MMU-983705)
Signal transduction
(R-MMU-162582)
Adaptive immune response
(GO:0002250)
Antigen receptor-mediated signaling pathway
(GO:0050851)
B-1 b cell differentiation
(GO:0001923)
B cell mediated immunity
(GO:0019724)
B cell proliferation involved in immune response
(GO:0002322)
B cell receptor signaling pathway
(GO:0050853)
External side of plasma membrane
(GO:0009897)
Immune system process
(GO:0002376)
Immunoglobulin mediated immune response
(GO:0016064)
Membrane
(GO:0016020)
Plasma membrane
(GO:0005886)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Positive regulation of release of sequestered calcium ion into cytosol
(GO:0051281)
Protein-containing complex
(GO:0032991)
Regulation of b cell activation
(GO:0050864)
Regulation of b cell receptor signaling pathway
(GO:0050855)

Other Information

Proteins

B-lymphocyte antigen CD19
Q3TQG5_MOUSE

Genular Protein ID: 3964734408

Symbol: CD19_MOUSE

Name: B-lymphocyte antigen CD19

UniProtKB Accession Codes:

P25918 Q542B2

Database IDs:

Citations:

PubMed ID: 1714482

Title: Structure and domain organization of the CD19 antigen of human, mouse, and guinea pig B lymphocytes. Conservation of the extensive cytoplasmic domain.

PubMed ID: 1714482

PubMed ID: 1370948

Title: Structure of the genes encoding the CD19 antigen of human and mouse B lymphocytes.

PubMed ID: 1370948

DOI: 10.1007/bf00189519

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 2472450

Title: Isolation of cDNAs encoding the CD19 antigen of human and mouse B lymphocytes. A new member of the immunoglobulin superfamily.

PubMed ID: 2472450

PubMed ID: 1375324

Title: The promoter of the CD19 gene is a target for the B-cell-specific transcription factor BSAP.

PubMed ID: 1375324

DOI: 10.1128/mcb.12.6.2662-2672.1992

PubMed ID: 7542548

Title: Abnormal B lymphocyte development, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule.

PubMed ID: 7542548

DOI: 10.1016/1074-7613(95)90157-4

PubMed ID: 7543183

Title: Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice.

PubMed ID: 7543183

DOI: 10.1038/376352a0

PubMed ID: 9382888

Title: Qualitative regulation of B cell antigen receptor signaling by CD19: selective requirement for PI3-kinase activation, inositol-1,4,5-trisphosphate production and Ca2+ mobilization.

PubMed ID: 9382888

DOI: 10.1084/jem.186.11.1897

PubMed ID: 9317126

Title: Regulation of B lymphocyte development and activation by the CD19/CD21/CD81/Leu 13 complex requires the cytoplasmic domain of CD19.

PubMed ID: 9317126

PubMed ID: 12387743

Title: The physiologic role of CD19 cytoplasmic tyrosines.

PubMed ID: 12387743

DOI: 10.1016/s1074-7613(02)00426-0

PubMed ID: 15378723

Title: Phosphoproteome analysis of mouse liver using immobilized metal affinity purification and linear ion trap mass spectrometry.

PubMed ID: 15378723

DOI: 10.1002/rcm.1604

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20101619

Title: Differential phosphorylation of functional tyrosines in CD19 modulates B-lymphocyte activation.

PubMed ID: 20101619

DOI: 10.1002/eji.200939848

Sequence Information:

Length: 547
Mass: 60149
Checksum: DDC34A3E23410C8D
Sequence:

MPSPLPVSFL LFLTLVGGRP QKSLLVEVEE GGNVVLPCLP DSSPVSSEKL AWYRGNQSTP 
FLELSPGSPG LGLHVGSLGI LLVIVNVSDH MGGFYLCQKR PPFKDIWQPA WTVNVEDSGE 
MFRWNASDVR DLDCDLRNRS SGSHRSTSGS QLYVWAKDHP KVWGTKPVCA PRGSSLNQSL 
INQDLTVAPG STLWLSCGVP PVPVAKGSIS WTHVHPRRPN VSLLSLSLGG EHPVREMWVW 
GSLLLLPQAT ALDEGTYYCL RGNLTIERHV KVIARSAVWL WLLRTGGWIV PVVTLVYVIF 
CMVSLVAFLY CQRAFILRRK RKRMTDPARR FFKVTPPSGN GTQNQYGNVL SLPTSTSGQA 
HAQRWAAGLG SVPGSYGNPR IQVQDTGAQS HETGLEEEGE AYEEPDSEEG SEFYENDSNL 
GQDQVSQDGS GYENPEDEPM GPEEEDSFSN AESYENADEE LAQPVGRMMD FLSPHGSAWD 
PSREASSLGS QSYEDMRGIL YAAPQLHSIQ SGPSHEEDAD SYENMDKSDD LEPAWEGEGH 
MGTWGTT

Genular Protein ID: 3964799028

Symbol: Q3TQG5_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3TQG5

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 427
Mass: 47224
Checksum: EDA80118F9DE14A8
Sequence:

MFRWNASDVR DLDCDLRNRS SGSHRSTSGS QLYVWAKDHP KVWGTKPVCA PRGSSLNQSL 
INQDLTVAPG STLWLSCGVP PVPVAKGSIS WTHVHPRRPN VSLLSLSLGG EHPVREMWVW 
GSLLLLPQAT ALDEGTYYCL RGNLTIERHV KVIARSAVWL WLLRTGGWIV PVVTLVYVIF 
CMVSLVAFLY CQRAFILRRK RKRMTDPARR FFKVTPPSGN GTQNQYGNVL SLPTSTSGQA 
HAQRWAAGLG SVPGSYGNPR IQVQDTGAQS HETGLEEEGE AYEEPDSEEG SEFYENDSNL 
GQDQVSQDGS GYENPEDEPM GPEEEDSFSN AESYENADEE LAQPVGRMMD FLSPHGSAWD 
PSREASSLGS QSYEDMRGIL YAAPQLHSIQ SGPSHEEDAD SYENMDKSDD LEPAWEGEGH 
MGTWGTT

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Cd19

Associated with

Other Information

Structure and domain organization of the CD19 antigen of human, mouse, and guinea pig B lymphocytes. Conservation of the extensive cytoplasmic domain. PubMed ID: 1714482

Structure of the genes encoding the CD19 antigen of human and mouse B lymphocytes. PubMed ID: 1370948

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Isolation of cDNAs encoding the CD19 antigen of human and mouse B lymphocytes. A new member of the immunoglobulin superfamily. PubMed ID: 2472450

The promoter of the CD19 gene is a target for the B-cell-specific transcription factor BSAP. PubMed ID: 1375324

Abnormal B lymphocyte development, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule. PubMed ID: 7542548

Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice. PubMed ID: 7543183

Qualitative regulation of B cell antigen receptor signaling by CD19: selective requirement for PI3-kinase activation, inositol-1,4,5-trisphosphate production and Ca2+ mobilization. PubMed ID: 9382888

Regulation of B lymphocyte development and activation by the CD19/CD21/CD81/Leu 13 complex requires the cytoplasmic domain of CD19. PubMed ID: 9317126

The physiologic role of CD19 cytoplasmic tyrosines. PubMed ID: 12387743

Phosphoproteome analysis of mouse liver using immobilized metal affinity purification and linear ion trap mass spectrometry. PubMed ID: 15378723

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Differential phosphorylation of functional tyrosines in CD19 modulates B-lymphocyte activation. PubMed ID: 20101619

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073