Genular: Defining Cellular Identity and Function

Details for: Cd22

Gene ID: 12483

Symbol: Cd22

Ensembl ID: ENSMUSG00000030577

Description: CD22 antigen

Associated with

Adaptive immune system
(R-MMU-1280218)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-MMU-983695)
Cd22 mediated bcr regulation
(R-MMU-5690714)
Immune system
(R-MMU-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-MMU-198933)
Signaling by the b cell receptor (bcr)
(R-MMU-983705)
B cell activation
(GO:0042113)
Carbohydrate binding
(GO:0030246)
Cd4 receptor binding
(GO:0042609)
Cell adhesion
(GO:0007155)
Cell surface
(GO:0009986)
Cell surface receptor signaling pathway
(GO:0007166)
Coreceptor activity
(GO:0015026)
Early endosome
(GO:0005769)
External side of plasma membrane
(GO:0009897)
Membrane
(GO:0016020)
Negative regulation of b cell receptor signaling pathway
(GO:0050859)
Negative regulation of calcium-mediated signaling
(GO:0050849)
Negative regulation of immunoglobulin production
(GO:0002638)
Neuronal cell body membrane
(GO:0032809)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Protein phosphatase binding
(GO:0019903)
Recycling endosome
(GO:0055037)
Regulation of b cell proliferation
(GO:0030888)
Regulation of endocytosis
(GO:0030100)
Regulation of immune response
(GO:0050776)
Sialic acid binding
(GO:0033691)

Other Information

Proteins

B-lymphocyte cell adhesion molecule

Genular Protein ID: 2275666508

Symbol: CD22_MOUSE

Name: B-lymphocyte cell adhesion molecule

UniProtKB Accession Codes:

P35329 Q3UP36 Q9JHL2 Q9JJX9 Q9JJY0 Q9JJY1 Q9R056 Q9R094 Q9WU51

Database IDs:

Citations:

PubMed ID: 8100843

Title: Organization of the murine Cd22 locus. Mapping to chromosome 7 and characterization of two alleles.

PubMed ID: 8100843

PubMed ID: 10501843

Title: Polymorphisms in the Cd22 gene of inbred mouse strains.

PubMed ID: 10501843

DOI: 10.1007/s002510050584

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 10975807

Title: Dysregulated expression of the Cd22 gene as a result of a short interspersed nucleotide element insertion in Cd22alpha lupus-prone mice.

PubMed ID: 10975807

DOI: 10.4049/jimmunol.165.6.2987

PubMed ID: 7533044

Title: Sialoadhesin, myelin-associated glycoprotein and CD22 define a new family of sialic acid-dependent adhesion molecules of the immunoglobulin superfamily.

PubMed ID: 7533044

DOI: 10.1016/s0960-9822(00)00220-7

PubMed ID: 9601638

Title: Defective negative regulation of antigen receptor signaling in Lyn-deficient B lymphocytes.

PubMed ID: 9601638

DOI: 10.1016/s0960-9822(98)70223-4

PubMed ID: 10373493

Title: Analysis of tyrosine phosphorylation-dependent interactions between stimulatory effector proteins and the B cell co-receptor CD22.

PubMed ID: 10373493

DOI: 10.1074/jbc.274.26.18769

PubMed ID: 10748054

Title: CD22 forms a quaternary complex with SHIP, Grb2, and Shc. A pathway for regulation of B lymphocyte antigen receptor-induced calcium flux.

PubMed ID: 10748054

DOI: 10.1074/jbc.m001892200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 868
Mass: 97181
Checksum: 763991EE28747E7F
Sequence:

MRVHYLWLLL ILGHVASARY SSANDWTVDH PQTLFAWEGA CIRIPCKYKT PLPKARLDNI 
LLFQNYEFDK ATKKFTGTVL YNATKTEKDP ESELYLSKQG RVTFLGNRID NCTLKIHPIR 
ANDSGNLGLR MTAGTERWME PIHLNVSEKP FQPYIQMPSE IRESQSVTLT CGLNFSCFGY 
DILLKWFLED SEITSITSSV TSITSSVTSS IKNVYTESKL TFQPKWTDHG KSVKCQVQHS 
SKVLSERTVR LDVKYTPKLE IKVNPTEVEK NNSVTMTCRV NSSNPKLRTV AVSWFKDGRP 
LEDQELEQEQ QMSKLILHSV TKDMRGKYRC QASNDIGPGE SEEVELTVHY APEPSRVHIY 
PSPAEEGQSV ELICESLASP SATNYTWYHN RKPIPGDTQE KLRIPKVSPW HAGNYSCLAE 
NRLGHGKIDQ EAKLDVHYAP KAVTTVIQSF TPILEGDSVT LVCRYNSSNP DVTSYRWNPQ 
GSGSVLKPGV LRIQKVTWDS MPVSCAACNH KCSWALPVIL NVHYAPRDVK VLKVSPASEI 
RAGQRVLLQC DFAESNPAEV RFFWKKNGSL VQEGRYLSFG SVSPEDSGNY NCMVNNSIGE 
TLSQAWNLQV LYAPRRLRVS ISPGDHVMEG KKATLSCESD ANPPISQYTW FDSSGQDLHS 
SGQKLRLEPL EVQHTGSYRC KGTNGIGTGE SPPSTLTVYY SPETIGKRVA LGLGFCLTIC 
ILAIWGMKIQ KKWKQNRSQQ GLQENSSGQS FFVRNKKARR TPLSEGPQSQ GCYNPAMDDT 
VSYAILRFPE SDTHNTGDAG TPATQAPPPN NSDSVTYSVI QKRPMGDYEN VNPSCPEDES 
IHYSELVQFG AGKRPQAKED VDYVTLKH

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Cd22

Associated with

Other Information

Organization of the murine Cd22 locus. Mapping to chromosome 7 and characterization of two alleles. PubMed ID: 8100843

Polymorphisms in the Cd22 gene of inbred mouse strains. PubMed ID: 10501843

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

Dysregulated expression of the Cd22 gene as a result of a short interspersed nucleotide element insertion in Cd22alpha lupus-prone mice. PubMed ID: 10975807

Sialoadhesin, myelin-associated glycoprotein and CD22 define a new family of sialic acid-dependent adhesion molecules of the immunoglobulin superfamily. PubMed ID: 7533044

Defective negative regulation of antigen receptor signaling in Lyn-deficient B lymphocytes. PubMed ID: 9601638

Analysis of tyrosine phosphorylation-dependent interactions between stimulatory effector proteins and the B cell co-receptor CD22. PubMed ID: 10373493

CD22 forms a quaternary complex with SHIP, Grb2, and Shc. A pathway for regulation of B lymphocyte antigen receptor-induced calcium flux. PubMed ID: 10748054

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079