Genular: Defining Cellular Identity and Function

Details for: Cd2ap

Gene ID: 12488

Symbol: Cd2ap

Ensembl ID: ENSMUSG00000061665

Description: CD2-associated protein

Associated with

Actin binding
(GO:0003779)
Actin filament
(GO:0005884)
Actin filament binding
(GO:0051015)
Actin filament organization
(GO:0007015)
Actin filament polymerization
(GO:0030041)
Adipose tissue development
(GO:0060612)
Apoptotic process
(GO:0006915)
Axon
(GO:0030424)
Beta-catenin binding
(GO:0008013)
Cadherin binding
(GO:0045296)
Cell-cell adhesion
(GO:0098609)
Cell-cell adhesion mediated by cadherin
(GO:0044331)
Cell-cell junction
(GO:0005911)
Cell-cell junction organization
(GO:0045216)
Cell cortex
(GO:0005938)
Cell cycle
(GO:0007049)
Cell differentiation
(GO:0030154)
Cell division
(GO:0051301)
Cell leading edge
(GO:0031252)
Cell migration
(GO:0016477)
Cell population proliferation
(GO:0008283)
Clathrin binding
(GO:0030276)
Collateral sprouting
(GO:0048668)
Cytoplasm
(GO:0005737)
Cytoskeleton
(GO:0005856)
Cytosol
(GO:0005829)
Dendrite
(GO:0030425)
Endocytic vesicle
(GO:0030139)
Endothelium development
(GO:0003158)
Erk1 and erk2 cascade
(GO:0070371)
Fibrillar center
(GO:0001650)
Filopodium assembly
(GO:0046847)
Gene expression
(GO:0010467)
Glomerulus development
(GO:0032835)
Glucose import
(GO:0046323)
Growth cone
(GO:0030426)
Identical protein binding
(GO:0042802)
Immunological synapse formation
(GO:0001771)
Inflammatory response
(GO:0006954)
Kidney development
(GO:0001822)
Late endosome
(GO:0005770)
Lipid metabolic process
(GO:0006629)
Liver development
(GO:0001889)
Localization of cell
(GO:0051674)
Lymph node development
(GO:0048535)
Maintenance of blood-brain barrier
(GO:0035633)
Male gonad development
(GO:0008584)
Membrane organization
(GO:0061024)
Negative regulation of neuron apoptotic process
(GO:0043524)
Negative regulation of small gtpase mediated signal transduction
(GO:0051058)
Negative regulation of transforming growth factor beta1 production
(GO:0032911)
Nerve growth factor signaling pathway
(GO:0038180)
Neuron projection development
(GO:0031175)
Neurotrophin signaling pathway
(GO:0038179)
Neurotrophin trk receptor signaling pathway
(GO:0048011)
Nuclear envelope lumen
(GO:0005641)
Phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0043491)
Phosphatidylinositol 3-kinase regulatory subunit binding
(GO:0036312)
Plasma membrane
(GO:0005886)
Podocyte differentiation
(GO:0072112)
Podosome
(GO:0002102)
Positive regulation of protein localization to nucleus
(GO:1900182)
Positive regulation of protein secretion
(GO:0050714)
Proteasome-mediated ubiquitin-dependent protein catabolic process
(GO:0043161)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein catabolic process
(GO:0030163)
Protein heterooligomerization
(GO:0051291)
Protein phosphorylation
(GO:0006468)
Protein secretion
(GO:0009306)
Protein transport
(GO:0015031)
Rab protein signal transduction
(GO:0032482)
Regulation of actin cytoskeleton organization
(GO:0032956)
Regulation of protein binding
(GO:0043393)
Regulation of receptor-mediated endocytosis
(GO:0048259)
Regulation of synaptic plasticity
(GO:0048167)
Renal albumin absorption
(GO:0097018)
Response to glial cell derived neurotrophic factor
(GO:1990790)
Response to insulin
(GO:0032868)
Response to oxidative stress
(GO:0006979)
Response to transforming growth factor beta
(GO:0071559)
Response to virus
(GO:0009615)
Response to wounding
(GO:0009611)
Ruffle
(GO:0001726)
Sh3 domain binding
(GO:0017124)
Stress-activated mapk cascade
(GO:0051403)
Synapse organization
(GO:0050808)
T cell receptor signaling pathway
(GO:0050852)
Transforming growth factor beta1 production
(GO:0032905)
Vascular endothelial growth factor receptor binding
(GO:0005172)
Vesicle organization
(GO:0016050)

Other Information

Proteins

CD2-associated protein

Genular Protein ID: 3385484297

Symbol: CD2AP_MOUSE

Name: CD2-associated protein

UniProtKB Accession Codes:

Q9JLQ0 E9QL86 O88903 Q8K4Z1 Q8VCI9

Database IDs:

Citations:

PubMed ID: 9741631

Title: A novel adaptor protein orchestrates receptor patterning and cytoskeletal polarity in T-cell contacts.

PubMed ID: 9741631

DOI: 10.1016/s0092-8674(00)81608-6

PubMed ID: 10913159

Title: In vivo interaction of the adapter protein CD2-associated protein with the type 2 polycystic kidney disease protein, polycystin-2.

PubMed ID: 10913159

DOI: 10.1074/jbc.m006624200

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10514378

Title: Congenital nephrotic syndrome in mice lacking CD2-associated protein.

PubMed ID: 10514378

DOI: 10.1126/science.286.5438.312

PubMed ID: 11733379

Title: CD2AP localizes to the slit diaphragm and binds to nephrin via a novel C-terminal domain.

PubMed ID: 11733379

DOI: 10.1016/s0002-9440(10)63080-5

PubMed ID: 11733557

Title: Podocin, a raft-associated component of the glomerular slit diaphragm, interacts with CD2AP and nephrin.

PubMed ID: 11733557

DOI: 10.1172/jci12849

PubMed ID: 12217865

Title: CD2-associated protein directly interacts with the actin cytoskeleton.

PubMed ID: 12217865

DOI: 10.1152/ajprenal.00312.2001

PubMed ID: 14736876

Title: A WT1 co-regulator controls podocyte phenotype by shuttling between adhesion structures and nucleus.

PubMed ID: 14736876

DOI: 10.1074/jbc.m314155200

PubMed ID: 17537921

Title: Nuclear relocation of the nephrin and CD2AP-binding protein dendrin promotes apoptosis of podocytes.

PubMed ID: 17537921

DOI: 10.1073/pnas.0700917104

PubMed ID: 18753381

Title: CD2AP and Cbl-3/Cbl-c constitute a critical checkpoint in the regulation of ret signal transduction.

PubMed ID: 18753381

DOI: 10.1523/jneurosci.2738-08.2008

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 17922258

Title: The high resolution NMR structure of the third SH3 domain of CD2AP.

PubMed ID: 17922258

DOI: 10.1007/s10858-007-9201-7

Sequence Information:

Length: 637
Mass: 70450
Checksum: 0B618FE82AF12332
Sequence:

MVDYIVEYDY DAVHDDELTI RVGEIIRNVK KLQEEGWLEG ELNGRRGMFP DNFVKEIKRE 
TEPKDDNLPI KRERQGNVAS LVQRISTYGL PAGGIQPHPQ TKAIKKKTKK RQCKVLFDYS 
PQNEDELELI VGDVIDVIEE VEEGWWSGTL NNKLGLFPSN FVKELESTED GETHNAQEES 
EVPLTGPTSP LPSPGNGSEP APGSVAQPKK IRGIGFGDIF KEGSVKLRTR TSSSETEEKK 
TEKPLILQPL GSRTQNVEVT KPDVDGKIKA KEYCRTLFPY TGTNEDELTF REGEIIHLIS 
KETGEAGWWK GELNGKEGVF PDNFAVQISE LDKDFPKPKK PPPPAKGPAP KPDLSAAEKK 
AFPLKAEEKD EKSLLEQKPS KPAAPQVPPK KPTAPTKASN LLRSPGAVYP KRPEKPVPPP 
PPAAKINGEV SIISSKIDTE PVSKPKLDPE QLPVRPKSVD LDAFVARNSK ETDDVNFDDI 
ASSENLLHLT ANRPKMPGRR LPGRFNGGHS PTQSPEKTLK LPKEDDSGNL KPLEFKKDAS 
YSSKSSLSTP SSASKVNTAA FLTPLELKAK AEADDGKRNS VDELRAQIIE LLCIVDALKK 
DHGKELEKLR KELEEEKAMR SNLEVEIAKL KKAVLLS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Cd2ap

Associated with

Other Information

A novel adaptor protein orchestrates receptor patterning and cytoskeletal polarity in T-cell contacts. PubMed ID: 9741631

In vivo interaction of the adapter protein CD2-associated protein with the type 2 polycystic kidney disease protein, polycystin-2. PubMed ID: 10913159

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Congenital nephrotic syndrome in mice lacking CD2-associated protein. PubMed ID: 10514378

CD2AP localizes to the slit diaphragm and binds to nephrin via a novel C-terminal domain. PubMed ID: 11733379

Podocin, a raft-associated component of the glomerular slit diaphragm, interacts with CD2AP and nephrin. PubMed ID: 11733557

CD2-associated protein directly interacts with the actin cytoskeleton. PubMed ID: 12217865

A WT1 co-regulator controls podocyte phenotype by shuttling between adhesion structures and nucleus. PubMed ID: 14736876

Nuclear relocation of the nephrin and CD2AP-binding protein dendrin promotes apoptosis of podocytes. PubMed ID: 17537921

CD2AP and Cbl-3/Cbl-c constitute a critical checkpoint in the regulation of ret signal transduction. PubMed ID: 18753381

The phagosomal proteome in interferon-gamma-activated macrophages. PubMed ID: 19144319

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

The high resolution NMR structure of the third SH3 domain of CD2AP. PubMed ID: 17922258