Details for: ADH1B

Gene ID: 125

Symbol: ADH1B

Ensembl ID: ENSG00000196616

Description: alcohol dehydrogenase 1B (class I), beta polypeptide

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 6
    Marker Score: 2,915
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 3.94
    Marker Score: 2,594
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 3.91
    Marker Score: 1,429
  • Cell Name: fat cell (CL0000136)
    Fold Change: 3.41
    Marker Score: 1,905
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 3.21
    Marker Score: 8,403
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 2.8
    Marker Score: 15,055
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.7
    Marker Score: 1,239
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 2.58
    Marker Score: 1,437
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 2.2
    Marker Score: 14,172
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 2.07
    Marker Score: 8,912
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.98
    Marker Score: 456
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.74
    Marker Score: 3,348
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.65
    Marker Score: 407
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1,162
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.52
    Marker Score: 1,633
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169,979
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.42
    Marker Score: 1,417
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 864
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.25
    Marker Score: 849
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 1.25
    Marker Score: 353
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 1.14
    Marker Score: 491
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.05
    Marker Score: 6,337
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.03
    Marker Score: 790
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.01
    Marker Score: 1,555
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 1.01
    Marker Score: 312
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,814
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,039
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 1
    Marker Score: 262
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 503
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 457
  • Cell Name: adipose microvascular endothelial cell (CL2000072)
    Fold Change: 0.97
    Marker Score: 287
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.95
    Marker Score: 953
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,298
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.93
    Marker Score: 349
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 370
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,740
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.91
    Marker Score: 881
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.91
    Marker Score: 377
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.89
    Marker Score: 30,387
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.87
    Marker Score: 319
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.82
    Marker Score: 240
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.82
    Marker Score: 212
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.81
    Marker Score: 182
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.81
    Marker Score: 326
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,256
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.77
    Marker Score: 950
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.75
    Marker Score: 197
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 683
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.74
    Marker Score: 856
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.74
    Marker Score: 3,111
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.73
    Marker Score: 202
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 0.65
    Marker Score: 185
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.65
    Marker Score: 463
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.62
    Marker Score: 9,928
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.62
    Marker Score: 135
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.6
    Marker Score: 1,705
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.59
    Marker Score: 563
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.59
    Marker Score: 388
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.58
    Marker Score: 373
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.58
    Marker Score: 151
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 147
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.55
    Marker Score: 230
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.54
    Marker Score: 3,265
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.53
    Marker Score: 6,953
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.5
    Marker Score: 188
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.49
    Marker Score: 576
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.49
    Marker Score: 280
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.48
    Marker Score: 344
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.46
    Marker Score: 570
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.45
    Marker Score: 245
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.44
    Marker Score: 292
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.44
    Marker Score: 300
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.41
    Marker Score: 1,708
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.4
    Marker Score: 255
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.4
    Marker Score: 362
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.39
    Marker Score: 124
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.39
    Marker Score: 344
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.38
    Marker Score: 94
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.37
    Marker Score: 118
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 368
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.36
    Marker Score: 208
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.33
    Marker Score: 5,111
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.32
    Marker Score: 146
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.32
    Marker Score: 445
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.32
    Marker Score: 1,382
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.31
    Marker Score: 500
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.31
    Marker Score: 75
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.28
    Marker Score: 517
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.27
    Marker Score: 843
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.26
    Marker Score: 127
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.26
    Marker Score: 157
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.26
    Marker Score: 520
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.24
    Marker Score: 3,258
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.24
    Marker Score: 858

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The ADH1B gene is a member of the ADH family of enzymes, which are involved in the oxidation of alcohols, including ethanol. The ADH1B enzyme is a zinc-dependent, cytosolic enzyme that exhibits high specificity for ethanol, allowing for efficient metabolism of this toxic compound. Additionally, ADH1B is involved in the metabolism of retinoids, including retinol, retinoic acid, and retinyl esters, which are essential for maintaining normal vision and development. **Pathways and Functions:** The ADH1B gene is involved in several metabolic pathways, including: 1. **Alcohol dehydrogenase activity**: ADH1B catalyzes the oxidation of ethanol to acetaldehyde, a potent toxin that can cause cellular damage. 2. **Zinc-dependent oxidations**: ADH1B utilizes zinc ions as cofactors to facilitate the oxidation of various alcohols. 3. **Biological oxidations**: ADH1B participates in the oxidation of retinoids, including retinol, retinoic acid, and retinyl esters. 4. **Metabolism**: ADH1B is involved in the metabolic processing of ethanol and retinoids, regulating their levels and activity within cells. **Clinical Significance:** Dysregulation of the ADH1B gene has been implicated in various diseases and conditions, including: 1. **Alcohol use disorder**: Variants of the ADH1B gene have been associated with increased susceptibility to alcohol dependence and addiction. 2. **Retinopathy**: ADH1B deficiency has been linked to retinopathy, a condition characterized by damage to the retina and vision impairment. 3. **Metabolic disorders**: ADH1B is also involved in the metabolism of other compounds, such as retinoids, which can contribute to the development of metabolic disorders, such as obesity and diabetes. In conclusion, the ADH1B gene plays a vital role in various metabolic processes, including the oxidation of ethanol and the metabolism of retinoids. Understanding the functions and clinical significance of the ADH1B gene will provide valuable insights into the molecular mechanisms underlying its role in human health and disease, ultimately informing the development of novel therapeutic strategies for the treatment of related disorders.

Genular Protein ID: 1850908328

Symbol: ADH1B_HUMAN

Name: Alcohol dehydrogenase 1B

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2986130

Title: Molecular cloning of a full-length cDNA for human alcohol dehydrogenase.

PubMed ID: 2986130

DOI: 10.1073/pnas.82.9.2703

PubMed ID: 3000832

Title: cDNA clones coding for the beta-subunit of human liver alcohol dehydrogenase have differently sized 3'-non-coding regions.

PubMed ID: 3000832

DOI: 10.1016/0014-5793(86)80111-9

PubMed ID: 2935533

Title: Molecular analysis of the human class I alcohol dehydrogenase gene family and nucleotide sequence of the gene encoding the beta subunit.

PubMed ID: 2935533

DOI: 10.1016/s0021-9258(17)35892-1

PubMed ID: 2935875

Title: Three human alcohol dehydrogenase subunits: cDNA structure and molecular and evolutionary divergence.

PubMed ID: 2935875

DOI: 10.1073/pnas.83.3.634

PubMed ID: 2679216

Title: Nucleotide sequence of the ADH2(3) gene encoding the human alcohol dehydrogenase beta 3 subunit.

PubMed ID: 2679216

DOI: 10.1111/j.1530-0277.1989.tb00383.x

PubMed ID: 2547609

Title: The genes for human alcohol dehydrogenases beta 1 and beta 2 differ by only one nucleotide.

PubMed ID: 2547609

DOI: 10.1111/j.1432-1033.1989.tb14931.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 6391920

Title: Human liver alcohol dehydrogenase. 1. The primary structure of the beta 1 beta 1 isoenzyme.

PubMed ID: 6391920

DOI: 10.1111/j.1432-1033.1984.tb08573.x

PubMed ID: 3397059

Title: Genotyping of human alcohol dehydrogenases at the ADH2 and ADH3 loci following DNA sequence amplification.

PubMed ID: 3397059

DOI: 10.1016/0888-7543(88)90004-3

PubMed ID: 15369820

Title: Kinetics of human alcohol dehydrogenase with ring-oxidized retinoids: effect of Tween 80.

PubMed ID: 15369820

DOI: 10.1016/j.abb.2004.07.002

PubMed ID: 16787387

Title: Comparative functional analysis of human medium-chain dehydrogenases, short-chain dehydrogenases/reductases and aldo-keto reductases with retinoids.

PubMed ID: 16787387

DOI: 10.1042/bj20051988

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 6374651

Title: Human liver alcohol dehydrogenase: amino acid substitution in the beta 2 beta 2 Oriental isozyme explains functional properties, establishes an active site structure, and parallels mutational exchanges in the yeast enzyme.

PubMed ID: 6374651

DOI: 10.1073/pnas.81.10.3024

PubMed ID: 3619918

Title: The human beta 3 alcohol dehydrogenase subunit differs from beta 1 by a Cys for Arg-369 substitution which decreases NAD(H) binding.

PubMed ID: 3619918

DOI: 10.1016/0006-291x(87)90779-0

PubMed ID: 1896463

Title: Structure of human beta 1 beta 1 alcohol dehydrogenase: catalytic effects of non-active-site substitutions.

PubMed ID: 1896463

DOI: 10.1073/pnas.88.18.8149

PubMed ID: 8201622

Title: Structures of three human beta alcohol dehydrogenase variants. Correlations with their functional differences.

PubMed ID: 8201622

DOI: 10.1006/jmbi.1994.1382

PubMed ID: 8663387

Title: X-ray structure of human beta3beta3 alcohol dehydrogenase. The contribution of ionic interactions to coenzyme binding.

PubMed ID: 8663387

DOI: 10.1074/jbc.271.29.17057

PubMed ID: 11274460

Title: Three-dimensional structures of the three human class I alcohol dehydrogenases.

PubMed ID: 11274460

DOI: 10.1110/ps.45001

PubMed ID: 10733556

Title: Genetic polymorphism of alcohol dehydrogenase in Europeans: the ADH2*2 allele decreases the risk for alcoholism and is associated with ADH3*1.

PubMed ID: 10733556

DOI: 10.1053/he.2000.5978

Sequence Information:

  • Length: 375
  • Mass: 39835
  • Checksum: 2C5104F834950B1A
  • Sequence:
  • MSTAGKVIKC KAAVLWEVKK PFSIEDVEVA PPKAYEVRIK MVAVGICHTD DHVVSGNLVT 
    PLPVILGHEA AGIVESVGEG VTTVKPGDKV IPLFTPQCGK CRVCKNPESN YCLKNDLGNP 
    RGTLQDGTRR FTCRGKPIHH FLGTSTFSQY TVVDENAVAK IDAASPLEKV CLIGCGFSTG 
    YGSAVNVAKV TPGSTCAVFG LGGVGLSAVM GCKAAGAARI IAVDINKDKF AKAKELGATE 
    CINPQDYKKP IQEVLKEMTD GGVDFSFEVI GRLDTMMASL LCCHEACGTS VIVGVPPASQ 
    NLSINPMLLL TGRTWKGAVY GGFKSKEGIP KLVADFMAKK FSLDALITHV LPFEKINEGF 
    DLLHSGKSIR TVLTF

Genular Protein ID: 2405567327

Symbol: D6RHZ6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 335
  • Mass: 35393
  • Checksum: EC18CCAAE3CEC385
  • Sequence:
  • MVAVGICHTD DHVVSGNLVT PLPVILGHEA AGIVESVGEG VTTVKPGDKV IPLFTPQCGK 
    CRVCKNPESN YCLKNDLGNP RGTLQDGTRR FTCRGKPIHH FLGTSTFSQY TVVDENAVAK 
    IDAASPLEKV CLIGCGFSTG YGSAVNVAKV TPGSTCAVFG LGGVGLSAVM GCKAAGAARI 
    IAVDINKDKF AKAKELGATE CINPQDYKKP IQEVLKEMTD GGVDFSFEVI GRLDTMMASL 
    LCCHEACGTS VIVGVPPASQ NLSINPMLLL TGRTWKGAVY GGFKSKEGIP KLVADFMAKK 
    FSLDALITHV LPFEKINEGF DLLHSGKSIR TVLTF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.