Genular: Defining Cellular Identity and Function

Details for: Cd3e

Gene ID: 12501

Symbol: Cd3e

Ensembl ID: ENSMUSG00000032093

Description: CD3 antigen, epsilon polypeptide

Associated with

Adaptive immune system
(R-MMU-1280218)
Costimulation by the cd28 family
(R-MMU-388841)
Downstream tcr signaling
(R-MMU-202424)
Generation of second messenger molecules
(R-MMU-202433)
Immune system
(R-MMU-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-MMU-198933)
Pd-1 signaling
(R-MMU-389948)
Phosphorylation of cd3 and tcr zeta chains
(R-MMU-202427)
Tcr signaling
(R-MMU-202403)
Translocation of zap-70 to immunological synapse
(R-MMU-202430)
Adaptive immune response
(GO:0002250)
Alpha-beta t cell receptor complex
(GO:0042105)
Apoptotic signaling pathway
(GO:0097190)
Calcium-mediated signaling
(GO:0019722)
Cd4-positive, alpha-beta t cell proliferation
(GO:0035739)
Cell-cell junction
(GO:0005911)
Cell body
(GO:0044297)
Cell surface receptor signaling pathway
(GO:0007166)
Cerebellum development
(GO:0021549)
Dendrite development
(GO:0016358)
Dendritic spine
(GO:0043197)
Endoplasmic reticulum
(GO:0005783)
External side of plasma membrane
(GO:0009897)
Golgi apparatus
(GO:0005794)
Identical protein binding
(GO:0042802)
Immune system process
(GO:0002376)
Immunological synapse
(GO:0001772)
Interleukin-4 production
(GO:0032633)
Lymphocyte activation
(GO:0046649)
Membrane
(GO:0016020)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of smoothened signaling pathway
(GO:0045879)
Negative thymic t cell selection
(GO:0045060)
Peptidyl-tyrosine phosphorylation
(GO:0018108)
Plasma membrane
(GO:0005886)
Positive regulation of calcium-mediated signaling
(GO:0050850)
Positive regulation of cd4-positive, alpha-beta t cell proliferation
(GO:2000563)
Positive regulation of cell-cell adhesion mediated by integrin
(GO:0033634)
Positive regulation of cell-matrix adhesion
(GO:0001954)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of interleukin-2 production
(GO:0032743)
Positive regulation of interleukin-4 production
(GO:0032753)
Positive regulation of peptidyl-tyrosine phosphorylation
(GO:0050731)
Positive regulation of t cell activation
(GO:0050870)
Positive regulation of t cell anergy
(GO:0002669)
Positive regulation of t cell proliferation
(GO:0042102)
Positive regulation of type ii interferon production
(GO:0032729)
Positive thymic t cell selection
(GO:0045059)
Protein binding
(GO:0005515)
Response to nutrient
(GO:0007584)
Sh3 domain binding
(GO:0017124)
Smoothened signaling pathway
(GO:0007224)
T cell activation
(GO:0042110)
T cell anergy
(GO:0002870)
T cell costimulation
(GO:0031295)
T cell proliferation
(GO:0042098)
T cell receptor complex
(GO:0042101)
T cell receptor signaling pathway
(GO:0050852)
Transmembrane signaling receptor activity
(GO:0004888)
Type ii interferon production
(GO:0032609)

Other Information

Proteins

T-cell surface glycoprotein CD3 epsilon chain

Genular Protein ID: 2543033829

Symbol: CD3E_MOUSE

Name: T-cell surface glycoprotein CD3 epsilon chain

UniProtKB Accession Codes:

P22646

Database IDs:

Citations:

PubMed ID: 3478717

Title: Evolutionary relationship between the T3 chains of the T-cell receptor complex and the immunoglobulin supergene family.

PubMed ID: 3478717

DOI: 10.1073/pnas.84.21.7649

PubMed ID: 2973066

Title: Characterization and expression of the murine CD3-epsilon gene.

PubMed ID: 2973066

DOI: 10.1073/pnas.85.22.8623

PubMed ID: 9843989

Title: Specific requirement for CD3epsilon in T cell development.

PubMed ID: 9843989

DOI: 10.1073/pnas.95.25.14909

PubMed ID: 19956738

Title: A conserved CXXC motif in CD3epsilon is critical for T cell development and TCR signaling.

PubMed ID: 19956738

DOI: 10.1371/journal.pbio.1000253

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 11439187

Title: Mechanisms contributing to T cell receptor signaling and assembly revealed by the solution structure of an ectodomain fragment of the CD3 epsilon gamma heterodimer.

PubMed ID: 11439187

DOI: 10.1016/s0092-8674(01)00395-6

PubMed ID: 24470497

Title: Relevance of Nck-CD3 epsilon interaction for T cell activation in vivo.

PubMed ID: 24470497

DOI: 10.4049/jimmunol.1203414

PubMed ID: 24899501

Title: Membrane association of the CD3epsilon signaling domain is required for optimal T cell development and function.

PubMed ID: 24899501

DOI: 10.4049/jimmunol.1400322

Sequence Information:

Length: 189
Mass: 21393
Checksum: 5CE92F784FA13B96
Sequence:

MRWNTFWGIL CLSLLAVGTC QDDAENIEYK VSISGTSVEL TCPLDSDENL KWEKNGQELP 
QKHDKHLVLQ DFSEVEDSGY YVCYTPASNK NTYLYLKARV CEYCVEVDLT AVAIIIIVDI 
CITLGLLMVI YYWSKNRKAK AKPVTRGTGA GSRPRGQNKE RPPPVPNPDY EPIRKGQRDL 
YSGLNQRAV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Cd3e

Associated with

Other Information

Evolutionary relationship between the T3 chains of the T-cell receptor complex and the immunoglobulin supergene family. PubMed ID: 3478717

Characterization and expression of the murine CD3-epsilon gene. PubMed ID: 2973066

Specific requirement for CD3epsilon in T cell development. PubMed ID: 9843989

A conserved CXXC motif in CD3epsilon is critical for T cell development and TCR signaling. PubMed ID: 19956738

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Mechanisms contributing to T cell receptor signaling and assembly revealed by the solution structure of an ectodomain fragment of the CD3 epsilon gamma heterodimer. PubMed ID: 11439187

Relevance of Nck-CD3 epsilon interaction for T cell activation in vivo. PubMed ID: 24470497

Membrane association of the CD3epsilon signaling domain is required for optimal T cell development and function. PubMed ID: 24899501