Genular: Defining Cellular Identity and Function

Details for: Cd4

Gene ID: 12504

Symbol: Cd4

Ensembl ID: ENSMUSG00000023274

Description: CD4 antigen

Associated with

Adaptive immune system
(R-MMU-1280218)
Alpha-defensins
(R-MMU-1462054)
Antimicrobial peptides
(R-MMU-6803157)
Cargo recognition for clathrin-mediated endocytosis
(R-MMU-8856825)
Clathrin-mediated endocytosis
(R-MMU-8856828)
Costimulation by the cd28 family
(R-MMU-388841)
Cytokine signaling in immune system
(R-MMU-1280215)
Defensins
(R-MMU-1461973)
Downstream tcr signaling
(R-MMU-202424)
Generation of second messenger molecules
(R-MMU-202433)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Membrane trafficking
(R-MMU-199991)
Other interleukin signaling
(R-MMU-449836)
Pd-1 signaling
(R-MMU-389948)
Phosphorylation of cd3 and tcr zeta chains
(R-MMU-202427)
Signaling by interleukins
(R-MMU-449147)
Tcr signaling
(R-MMU-202403)
Translocation of zap-70 to immunological synapse
(R-MMU-202430)
Vesicle-mediated transport
(R-MMU-5653656)
Adaptive immune response
(GO:0002250)
Calcium-mediated signaling
(GO:0019722)
Cell adhesion
(GO:0007155)
Cell surface
(GO:0009986)
Cell surface receptor signaling pathway
(GO:0007166)
Cellular response to granulocyte macrophage colony-stimulating factor stimulus
(GO:0097011)
Coreceptor activity
(GO:0015026)
Cytokine production
(GO:0001816)
Defense response to gram-negative bacterium
(GO:0050829)
Endoplasmic reticulum lumen
(GO:0005788)
Endoplasmic reticulum membrane
(GO:0005789)
Enzyme binding
(GO:0019899)
External side of plasma membrane
(GO:0009897)
Helper t cell enhancement of adaptive immune response
(GO:0035397)
Identical protein binding
(GO:0042802)
Immune response
(GO:0006955)
Immune system process
(GO:0002376)
Immunoglobulin binding
(GO:0019865)
Interleukin-15-mediated signaling pathway
(GO:0035723)
Interleukin-16 binding
(GO:0042011)
Interleukin-16 receptor activity
(GO:0042012)
Lipid binding
(GO:0008289)
Macrophage differentiation
(GO:0030225)
Maintenance of protein location in cell
(GO:0032507)
Membrane
(GO:0016020)
Membrane raft
(GO:0045121)
Mhc class ii protein binding
(GO:0042289)
Mhc class ii protein complex binding
(GO:0023026)
Peptidyl-tyrosine phosphorylation
(GO:0018108)
Plasma membrane
(GO:0005886)
Positive regulation of calcium-mediated signaling
(GO:0050850)
Positive regulation of calcium ion transport into cytosol
(GO:0010524)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of kinase activity
(GO:0033674)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of monocyte differentiation
(GO:0045657)
Positive regulation of peptidyl-tyrosine phosphorylation
(GO:0050731)
Positive regulation of protein kinase activity
(GO:0045860)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of t cell activation
(GO:0050870)
Positive regulation of t cell proliferation
(GO:0042102)
Positive regulation of viral entry into host cell
(GO:0046598)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Protein kinase binding
(GO:0019901)
Protein tyrosine kinase binding
(GO:1990782)
Regulation of calcium ion transport
(GO:0051924)
Regulation of t cell activation
(GO:0050863)
Signaling receptor binding
(GO:0005102)
T cell activation
(GO:0042110)
T cell differentiation
(GO:0030217)
T cell selection
(GO:0045058)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

T-cell surface glycoprotein CD4

Genular Protein ID: 2384105129

Symbol: CD4_MOUSE

Name: T-cell surface glycoprotein CD4

UniProtKB Accession Codes:

P06332

Database IDs:

Citations:

PubMed ID: 3094146

Title: Isolation and sequence of L3T4 complementary DNA clones: expression in T cells and brain.

PubMed ID: 3094146

DOI: 10.1126/science.3094146

PubMed ID: 3027575

Title: Unusual intron in the immunoglobulin domain of the newly isolated murine CD4 (L3T4) gene.

PubMed ID: 3027575

DOI: 10.1038/325453a0

PubMed ID: 3326818

Title: L3T4 and the immunoglobulin gene superfamily: new relationships between the immune system and the nervous system.

PubMed ID: 3326818

DOI: 10.1111/j.1600-065x.1987.tb00529.x

PubMed ID: 2823269

Title: Structure of the mouse gene encoding CD4 and an unusual transcript in brain.

PubMed ID: 2823269

DOI: 10.1073/pnas.84.21.7644

PubMed ID: 9445485

Title: Comparative sequence analysis of a gene-rich cluster at human chromosome 12p13 and its syntenic region in mouse chromosome 6.

PubMed ID: 9445485

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3082751

Title: The L3T4 antigen in mouse and the sheep equivalent are immunoglobulin-like.

PubMed ID: 3082751

DOI: 10.1007/bf00377974

PubMed ID: 3086886

Title: Partial primary structure of the T4 antigens of mouse and sheep: assignment of intrachain disulfide bonds.

PubMed ID: 3086886

DOI: 10.1073/pnas.83.12.4499

PubMed ID: 3262426

Title: The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck.

PubMed ID: 3262426

DOI: 10.1016/0092-8674(88)90053-0

PubMed ID: 2784195

Title: Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck.

PubMed ID: 2784195

DOI: 10.1038/338257a0

PubMed ID: 2512251

Title: Phosphorylation and down-regulation of CD4 and CD8 in human CTLs and mouse L cells.

PubMed ID: 2512251

DOI: 10.1007/bf02421181

PubMed ID: 1832488

Title: Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4.

PubMed ID: 1832488

DOI: 10.1038/353180a0

PubMed ID: 10706685

Title: CD4 and CD8 expression by dendritic cell subtypes in mouse thymus and spleen.

PubMed ID: 10706685

DOI: 10.4049/jimmunol.164.6.2978

PubMed ID: 16709847

Title: Evidence for a domain-swapped CD4 dimer as the coreceptor for binding to class II MHC.

PubMed ID: 16709847

DOI: 10.4049/jimmunol.176.11.6873

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 457
Mass: 51297
Checksum: 1B1DA7527CB00F33
Sequence:

MCRAISLRRL LLLLLQLSQL LAVTQGKTLV LGKEGESAEL PCESSQKKIT VFTWKFSDQR 
KILGQHGKGV LIRGGSPSQF DRFDSKKGAW EKGSFPLIIN KLKMEDSQTY ICELENRKEE 
VELWVFKVTF SPGTSLLQGQ SLTLTLDSNS KVSNPLTECK HKKGKVVSGS KVLSMSNLRV 
QDSDFWNCTV TLDQKKNWFG MTLSVLGFQS TAITAYKSEG ESAEFSFPLN FAEENGWGEL 
MWKAEKDSFF QPWISFSIKN KEVSVQKSTK DLKLQLKETL PLTLKIPQVS LQFAGSGNLT 
LTLDKGTLHQ EVNLVVMKVA QLNNTLTCEV MGPTSPKMRL TLKQENQEAR VSEEQKVVQV 
VAPETGLWQC LLSEGDKVKM DSRIQVLSRG VNQTVFLACV LGGSFGFLGF LGLCILCCVR 
CRHQQRQAAR MSQIKRLLSE KKTCQCPHRM QKSHNLI

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Cd4

Associated with

Other Information

Isolation and sequence of L3T4 complementary DNA clones: expression in T cells and brain. PubMed ID: 3094146

Unusual intron in the immunoglobulin domain of the newly isolated murine CD4 (L3T4) gene. PubMed ID: 3027575

L3T4 and the immunoglobulin gene superfamily: new relationships between the immune system and the nervous system. PubMed ID: 3326818

Structure of the mouse gene encoding CD4 and an unusual transcript in brain. PubMed ID: 2823269

Comparative sequence analysis of a gene-rich cluster at human chromosome 12p13 and its syntenic region in mouse chromosome 6. PubMed ID: 9445485

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The L3T4 antigen in mouse and the sheep equivalent are immunoglobulin-like. PubMed ID: 3082751

Partial primary structure of the T4 antigens of mouse and sheep: assignment of intrachain disulfide bonds. PubMed ID: 3086886

The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck. PubMed ID: 3262426

Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck. PubMed ID: 2784195

Phosphorylation and down-regulation of CD4 and CD8 in human CTLs and mouse L cells. PubMed ID: 2512251

Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4. PubMed ID: 1832488

CD4 and CD8 expression by dendritic cell subtypes in mouse thymus and spleen. PubMed ID: 10706685

Evidence for a domain-swapped CD4 dimer as the coreceptor for binding to class II MHC. PubMed ID: 16709847

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079