Genular: Defining Cellular Identity and Function

Details for: Cd63

Gene ID: 12512

Symbol: Cd63

Ensembl ID: ENSMUSG00000025351

Description: CD63 antigen

Associated with

Hemostasis
(R-MMU-109582)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Neutrophil degranulation
(R-MMU-6798695)
Platelet activation, signaling and aggregation
(R-MMU-76002)
Platelet degranulation
(R-MMU-114608)
Response to elevated platelet cytosolic ca2+
(R-MMU-76005)
Cell-matrix adhesion
(GO:0007160)
Cell migration
(GO:0016477)
Cell surface
(GO:0009986)
Endosome
(GO:0005768)
Endosome lumen
(GO:0031904)
Endosome membrane
(GO:0010008)
Endosome to melanosome transport
(GO:0035646)
Epithelial cell differentiation
(GO:0030855)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Intracellular membrane-bounded organelle
(GO:0043231)
Late endosome
(GO:0005770)
Late endosome membrane
(GO:0031902)
Lysosomal membrane
(GO:0005765)
Lysosome
(GO:0005764)
Membrane
(GO:0016020)
Multivesicular body, internal vesicle
(GO:0097487)
Multivesicular body membrane
(GO:0032585)
Negative regulation of epithelial cell migration
(GO:0010633)
Nucleoplasm
(GO:0005654)
Pigmentation
(GO:0043473)
Pigment cell differentiation
(GO:0050931)
Pigment granule maturation
(GO:0048757)
Plasma membrane
(GO:0005886)
Positive regulation of cell adhesion
(GO:0045785)
Positive regulation of endocytosis
(GO:0045807)
Positive regulation of integrin-mediated signaling pathway
(GO:2001046)
Positive regulation of receptor internalization
(GO:0002092)
Protein-containing complex
(GO:0032991)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein localization
(GO:0008104)
Protein transport
(GO:0015031)
Regulation of potassium ion transmembrane transport
(GO:1901379)
Regulation of vascular endothelial growth factor signaling pathway
(GO:1900746)

Other Information

Proteins

CD63 antigen

Genular Protein ID: 2016891255

Symbol: CD63_MOUSE

Name: CD63 antigen

UniProtKB Accession Codes:

P41731

Database IDs:

Citations:

PubMed ID: 8148377

Title: Molecular cloning of the murine homologue of CD63/ME491 and detection of its strong expression in the kidney and activated macrophages.

PubMed ID: 8148377

DOI: 10.1016/0167-4781(94)90291-7

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19075008

Title: Deficiency of the tetraspanin CD63 associated with kidney pathology but normal lysosomal function.

PubMed ID: 19075008

DOI: 10.1128/mcb.01163-08

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21041449

Title: Palmitoylation-dependent association with CD63 targets the Ca2+ sensor synaptotagmin VII to lysosomes.

PubMed ID: 21041449

DOI: 10.1083/jcb.201003021

PubMed ID: 21803846

Title: CD63 is an essential cofactor to leukocyte recruitment by endothelial P-selectin.

PubMed ID: 21803846

DOI: 10.1182/blood-2010-11-321489

PubMed ID: 21962903

Title: The tetraspanin CD63 regulates ESCRT-independent and -dependent endosomal sorting during melanogenesis.

PubMed ID: 21962903

DOI: 10.1016/j.devcel.2011.08.019

PubMed ID: 23632027

Title: Tetraspanin CD63 promotes vascular endothelial growth factor receptor 2-beta1 integrin complex formation, thereby regulating activation and downstream signaling in endothelial cells in vitro and in vivo.

PubMed ID: 23632027

DOI: 10.1074/jbc.m113.468199

PubMed ID: 23945142

Title: The tetraspanin CD63 is required for efficient IgE-mediated mast cell degranulation and anaphylaxis.

PubMed ID: 23945142

DOI: 10.4049/jimmunol.1202323

PubMed ID: 26109643

Title: Bacterial membrane vesicles mediate the release of Mycobacterium tuberculosis lipoglycans and lipoproteins from infected macrophages.

PubMed ID: 26109643

DOI: 10.4049/jimmunol.1402894

Sequence Information:

Length: 238
Mass: 25767
Checksum: B57E47B31E13EED8
Sequence:

MAVEGGMKCV KFLLYVLLLA FCACAVGLIA IGVAVQVVLK QAITHETTAG SLLPVVIIAV 
GAFLFLVAFV GCCGACKENY CLMITFAIFL SLIMLVEVAV AIAGYVFRDQ VKSEFNKSFQ 
QQMQNYLKDN KTATILDKLQ KENNCCGASN YTDWENIPGM AKDRVPDSCC INITVGCGND 
FKESTIHTQG CVETIAIWLR KNILLVAAAA LGIAFVEVLG IIFSCCLVKS IRSGYEVM

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Cd63

Associated with

Other Information

Molecular cloning of the murine homologue of CD63/ME491 and detection of its strong expression in the kidney and activated macrophages. PubMed ID: 8148377

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Deficiency of the tetraspanin CD63 associated with kidney pathology but normal lysosomal function. PubMed ID: 19075008

Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins. PubMed ID: 19349973

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Palmitoylation-dependent association with CD63 targets the Ca2+ sensor synaptotagmin VII to lysosomes. PubMed ID: 21041449

CD63 is an essential cofactor to leukocyte recruitment by endothelial P-selectin. PubMed ID: 21803846

The tetraspanin CD63 regulates ESCRT-independent and -dependent endosomal sorting during melanogenesis. PubMed ID: 21962903

Tetraspanin CD63 promotes vascular endothelial growth factor receptor 2-beta1 integrin complex formation, thereby regulating activation and downstream signaling in endothelial cells in vitro and in vivo. PubMed ID: 23632027

The tetraspanin CD63 is required for efficient IgE-mediated mast cell degranulation and anaphylaxis. PubMed ID: 23945142

Bacterial membrane vesicles mediate the release of Mycobacterium tuberculosis lipoglycans and lipoproteins from infected macrophages. PubMed ID: 26109643