Genular: Defining Cellular Identity and Function

Details for: Cd81

Gene ID: 12520

Symbol: Cd81

Ensembl ID: ENSMUSG00000037706

Description: CD81 antigen

Associated with

Adaptive immune system
(R-MMU-1280218)
Complement cascade
(R-MMU-166658)
Immune system
(R-MMU-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-MMU-198933)
Innate immune system
(R-MMU-168249)
Regulation of complement cascade
(R-MMU-977606)
Adaptive immune response
(GO:0002250)
Apical plasma membrane
(GO:0016324)
Basal plasma membrane
(GO:0009925)
Basolateral plasma membrane
(GO:0016323)
Cd4-positive, alpha-beta t cell costimulation
(GO:0035783)
Cellular response to low-density lipoprotein particle stimulus
(GO:0071404)
Cholesterol binding
(GO:0015485)
Extracellular exosome
(GO:0070062)
Humoral immune response mediated by circulating immunoglobulin
(GO:0002455)
Immune system process
(GO:0002376)
Immunological synapse
(GO:0001772)
Immunological synapse formation
(GO:0001771)
Integrin binding
(GO:0005178)
Lipid binding
(GO:0008289)
Macrophage fusion
(GO:0034238)
Membrane
(GO:0016020)
Mhc class ii protein binding
(GO:0042289)
Myoblast fusion involved in skeletal muscle regeneration
(GO:0014905)
Osteoclast fusion
(GO:0072675)
Plasma membrane
(GO:0005886)
Positive regulation of adaptive immune memory response
(GO:1905676)
Positive regulation of b cell activation
(GO:0050871)
Positive regulation of b cell proliferation
(GO:0030890)
Positive regulation of b cell receptor signaling pathway
(GO:0050861)
Positive regulation of cd4-positive, alpha-beta t cell proliferation
(GO:2000563)
Positive regulation of inflammatory response to antigenic stimulus
(GO:0002863)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of protein catabolic process in the vacuole
(GO:1904352)
Positive regulation of protein exit from endoplasmic reticulum
(GO:0070863)
Positive regulation of receptor clustering
(GO:1903911)
Positive regulation of t-helper 2 cell cytokine production
(GO:2000553)
Positive regulation of t cell activation via t cell receptor contact with antigen bound to mhc molecule on antigen presenting cell
(GO:2001190)
Positive regulation of t cell receptor signaling pathway
(GO:0050862)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Protein localization to lysosome
(GO:0061462)
Protein localization to plasma membrane
(GO:0072659)
Receptor internalization
(GO:0031623)
Regulation of cell motility
(GO:2000145)
Regulation of cell population proliferation
(GO:0042127)
Regulation of macrophage migration
(GO:1905521)
Regulation of protein stability
(GO:0031647)
Tetraspanin-enriched microdomain
(GO:0097197)
Transferrin receptor binding
(GO:1990459)
Vesicle
(GO:0031982)
Virus receptor activity
(GO:0001618)

Other Information

Proteins

CD81 antigen

Genular Protein ID: 1478953461

Symbol: CD81_MOUSE

Name: CD81 antigen

UniProtKB Accession Codes:

P35762 Q91V78

Database IDs:

Citations:

PubMed ID: 1650385

Title: Genomic organization and chromosomal localization of the TAPA-1 gene.

PubMed ID: 1650385

PubMed ID: 10915772

Title: Sequence conservation and variability of imprinting in the Beckwith-Wiedemann syndrome gene cluster in human and mouse.

PubMed ID: 10915772

DOI: 10.1093/hmg/9.12.1829

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11046035

Title: Allergen-induced airway hyperreactivity is diminished in CD81-deficient mice.

PubMed ID: 11046035

DOI: 10.4049/jimmunol.165.9.5054

PubMed ID: 11673522

Title: PGRL is a major CD81-associated protein on lymphocytes and distinguishes a new family of cell surface proteins.

PubMed ID: 11673522

DOI: 10.4049/jimmunol.167.9.5115

PubMed ID: 12796480

Title: Tetraspanins CD9 and CD81 function to prevent the fusion of mononuclear phagocytes.

PubMed ID: 12796480

DOI: 10.1083/jcb.200212031

PubMed ID: 12483205

Title: Hepatocyte CD81 is required for Plasmodium falciparum and Plasmodium yoelii sporozoite infectivity.

PubMed ID: 12483205

DOI: 10.1038/nm808

PubMed ID: 16380109

Title: Reduced fertility of female mice lacking CD81.

PubMed ID: 16380109

DOI: 10.1016/j.ydbio.2005.11.031

PubMed ID: 16395393

Title: Expression of the mouse fragilis gene products in immune cells and association with receptor signaling complexes.

PubMed ID: 16395393

DOI: 10.1038/sj.gene.6364278

PubMed ID: 18662991

Title: Double deficiency of tetraspanins CD9 and CD81 alters cell motility and protease production of macrophages and causes chronic obstructive pulmonary disease-like phenotype in mice.

PubMed ID: 18662991

DOI: 10.1074/jbc.m801902200

PubMed ID: 17290409

Title: Possible involvement of CD81 in acrosome reaction of sperm in mice.

PubMed ID: 17290409

DOI: 10.1002/mrd.20709

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23213457

Title: CD81 and CD9 work independently as extracellular components upon fusion of sperm and oocyte.

PubMed ID: 23213457

DOI: 10.1242/bio.20121420

PubMed ID: 23665349

Title: Regulation of liver growth by glypican 3, CD81, hedgehog, and Hhex.

PubMed ID: 23665349

DOI: 10.1016/j.ajpath.2013.03.013

PubMed ID: 23499492

Title: The actin and tetraspanin networks organize receptor nanoclusters to regulate B cell receptor-mediated signaling.

PubMed ID: 23499492

DOI: 10.1016/j.immuni.2012.11.019

PubMed ID: 23575678

Title: Normal muscle regeneration requires tight control of muscle cell fusion by tetraspanins CD9 and CD81.

PubMed ID: 23575678

DOI: 10.1038/ncomms2675

PubMed ID: 26116703

Title: An intramolecular bond at cluster of differentiation 81 ectodomain is important for hepatitis C virus entry.

PubMed ID: 26116703

DOI: 10.1096/fj.15-272880

Sequence Information:

Length: 236
Mass: 25815
Checksum: 7BDCB792E7F9FA4E
Sequence:

MGVEGCTKCI KYLLFVFNFV FWLAGGVILG VALWLRHDPQ TTSLLYLELG NKPAPNTFYV 
GIYILIAVGA VMMFVGFLGC YGAIQESQCL LGTFFTCLVI LFACEVAAGI WGFVNKDQIA 
KDVKQFYDQA LQQAVMDDDA NNAKAVVKTF HETLNCCGSN ALTTLTTTIL RNSLCPSGGN 
ILTPLLQQDC HQKIDELFSG KLYLIGIAAI VVAVIMIFEM ILSMVLCCGI RNSSVY

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Cd81

Associated with

Other Information

Genomic organization and chromosomal localization of the TAPA-1 gene. PubMed ID: 1650385

Sequence conservation and variability of imprinting in the Beckwith-Wiedemann syndrome gene cluster in human and mouse. PubMed ID: 10915772

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Allergen-induced airway hyperreactivity is diminished in CD81-deficient mice. PubMed ID: 11046035

PGRL is a major CD81-associated protein on lymphocytes and distinguishes a new family of cell surface proteins. PubMed ID: 11673522

Tetraspanins CD9 and CD81 function to prevent the fusion of mononuclear phagocytes. PubMed ID: 12796480

Hepatocyte CD81 is required for Plasmodium falciparum and Plasmodium yoelii sporozoite infectivity. PubMed ID: 12483205

Reduced fertility of female mice lacking CD81. PubMed ID: 16380109

Expression of the mouse fragilis gene products in immune cells and association with receptor signaling complexes. PubMed ID: 16395393

Double deficiency of tetraspanins CD9 and CD81 alters cell motility and protease production of macrophages and causes chronic obstructive pulmonary disease-like phenotype in mice. PubMed ID: 18662991

Possible involvement of CD81 in acrosome reaction of sperm in mice. PubMed ID: 17290409

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

CD81 and CD9 work independently as extracellular components upon fusion of sperm and oocyte. PubMed ID: 23213457

Regulation of liver growth by glypican 3, CD81, hedgehog, and Hhex. PubMed ID: 23665349

The actin and tetraspanin networks organize receptor nanoclusters to regulate B cell receptor-mediated signaling. PubMed ID: 23499492

Normal muscle regeneration requires tight control of muscle cell fusion by tetraspanins CD9 and CD81. PubMed ID: 23575678

An intramolecular bond at cluster of differentiation 81 ectodomain is important for hepatitis C virus entry. PubMed ID: 26116703