Genular: Defining Cellular Identity and Function

Details for: Cd86

Gene ID: 12524

Symbol: Cd86

Ensembl ID: ENSMUSG00000022901

Description: CD86 antigen

Associated with

Adaptive immune system
(R-MMU-1280218)
Cd28 co-stimulation
(R-MMU-389356)
Cd28 dependent pi3k/akt signaling
(R-MMU-389357)
Cd28 dependent vav1 pathway
(R-MMU-389359)
Costimulation by the cd28 family
(R-MMU-388841)
Ctla4 inhibitory signaling
(R-MMU-389513)
Immune system
(R-MMU-168256)
Intracellular signaling by second messengers
(R-MMU-9006925)
Negative regulation of the pi3k/akt network
(R-MMU-199418)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-MMU-6811558)
Pip3 activates akt signaling
(R-MMU-1257604)
Signal transduction
(R-MMU-162582)
Activation of phospholipase c activity
(GO:0007202)
Activation of protein kinase c activity
(GO:1990051)
Adaptive immune response
(GO:0002250)
B cell activation
(GO:0042113)
Cd40 signaling pathway
(GO:0023035)
Cell surface
(GO:0009986)
Cell surface receptor signaling pathway
(GO:0007166)
Cellular response to lipopolysaccharide
(GO:0071222)
Centriolar satellite
(GO:0034451)
Defense response to virus
(GO:0051607)
External side of plasma membrane
(GO:0009897)
Extracellular exosome
(GO:0070062)
Immune response
(GO:0006955)
Immune system process
(GO:0002376)
Intracellular membrane-bounded organelle
(GO:0043231)
Membrane
(GO:0016020)
Negative regulation of t cell anergy
(GO:0002668)
Negative regulation of t cell proliferation
(GO:0042130)
Plasma membrane
(GO:0005886)
Positive regulation of activated t cell proliferation
(GO:0042104)
Positive regulation of immunoglobulin production
(GO:0002639)
Positive regulation of non-canonical nf-kappab signal transduction
(GO:1901224)
Positive regulation of t cell proliferation
(GO:0042102)
Protein binding
(GO:0005515)
Receptor ligand activity
(GO:0048018)
Signaling receptor binding
(GO:0005102)
T cell activation
(GO:0042110)
T cell costimulation
(GO:0031295)
Toll-like receptor 3 signaling pathway
(GO:0034138)
Toll-like receptor signaling pathway
(GO:0002224)

Other Information

Proteins

T-lymphocyte activation antigen CD86
Q61238_MOUSE

Genular Protein ID: 2782348962

Symbol: CD86_MOUSE

Name: T-lymphocyte activation antigen CD86

UniProtKB Accession Codes:

P42082

Database IDs:

Citations:

PubMed ID: 7504059

Title: Murine B7-2, an alternative CTLA4 counter-receptor that costimulates T cell proliferation and interleukin 2 production.

PubMed ID: 7504059

DOI: 10.1084/jem.178.6.2185

PubMed ID: 7513726

Title: Molecular cloning and expression of early T cell costimulatory molecule-1 and its characterization as B7-2 molecule.

PubMed ID: 7513726

PubMed ID: 7499829

Title: Differential expression of alternate mB7-2 transcripts.

PubMed ID: 7499829

PubMed ID: 23241883

Title: Prohibitins and the cytoplasmic domain of CD86 cooperate to mediate CD86 signaling in B lymphocytes.

PubMed ID: 23241883

DOI: 10.4049/jimmunol.1201646

Sequence Information:

Length: 309
Mass: 34666
Checksum: 8F58DCD1FB81D5EA
Sequence:

MDPRCTMGLA ILIFVTVLLI SDAVSVETQA YFNGTAYLPC PFTKAQNISL SELVVFWQDQ 
QKLVLYEHYL GTEKLDSVNA KYLGRTSFDR NNWTLRLHNV QIKDMGSYDC FIQKKPPTGS 
IILQQTLTEL SVIANFSEPE IKLAQNVTGN SGINLTCTSK QGHPKPKKMY FLITNSTNEY 
GDNMQISQDN VTELFSISNS LSLSFPDGVW HMTVVCVLET ESMKISSKPL NFTQEFPSPQ 
TYWKEITASV TVALLLVMLL IIVCHKKPNQ PSRPSNTASK LERDSNADRE TINLKELEPQ 
IASAKPNAE

Genular Protein ID: 3735860934

Symbol: Q61238_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q61238

Database IDs:

Citations:

PubMed ID: 7499829

Title: Differential expression of alternate mB7-2 transcripts.

PubMed ID: 7499829

Sequence Information:

Length: 314
Mass: 35177
Checksum: 3D2683F36CADEDF4
Sequence:

MYVIKTCATC TMGLAILIFV TVLLISDAVS VETQAYFNGT AYLPCPFTKA QNISLSELVV 
FWQDQQKLVL YEHYLGTEKL DSVNAKYLGR TSFDRNNWTL RLHNVQIKDM GSYDCFIQKK 
PPTGSIILQQ TLTELSVIAN FSEPEIKLAQ NVTGNSGINL TCTSKQGHPK PKKMYFLITN 
STNEYGDNMQ ISQDNVTELF SISNSLSLSF PDGVWHMTVV CVLETESMKI SSKPLNFTQE 
FPSPQTYWKE ITASVTVALL LVMLLIIVCH KKPNQPSRPS NTASKLERDS NADRETINLK 
ELEPQIASAK PNAE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Cd86

Associated with

Other Information

Murine B7-2, an alternative CTLA4 counter-receptor that costimulates T cell proliferation and interleukin 2 production. PubMed ID: 7504059

Molecular cloning and expression of early T cell costimulatory molecule-1 and its characterization as B7-2 molecule. PubMed ID: 7513726

Differential expression of alternate mB7-2 transcripts. PubMed ID: 7499829

Prohibitins and the cytoplasmic domain of CD86 cooperate to mediate CD86 signaling in B lymphocytes. PubMed ID: 23241883

Differential expression of alternate mB7-2 transcripts. PubMed ID: 7499829

Database document:

PubMed ID: 7504059

PubMed ID: 7513726

PubMed ID: 7499829

PubMed ID: 23241883

PubMed ID: 7499829