Genular: Defining Cellular Identity and Function

Details for: Cd8a

Gene ID: 12525

Symbol: Cd8a

Ensembl ID: ENSMUSG00000053977

Description: CD8 subunit alpha

Associated with

Adaptive immune system
(R-MMU-1280218)
Immune system
(R-MMU-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-MMU-198933)
Adaptive immune response
(GO:0002250)
Calcium-mediated signaling
(GO:0019722)
Cell surface
(GO:0009986)
Cell surface receptor signaling pathway
(GO:0007166)
Cytotoxic t cell differentiation
(GO:0045065)
Defense response to virus
(GO:0051607)
External side of plasma membrane
(GO:0009897)
Identical protein binding
(GO:0042802)
Immune system process
(GO:0002376)
Membrane
(GO:0016020)
Mhc class i protein complex binding
(GO:0023024)
Plasma membrane
(GO:0005886)
Plasma membrane raft
(GO:0044853)
Positive regulation of calcium-mediated signaling
(GO:0050850)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Receptor complex
(GO:0043235)
T cell activation
(GO:0042110)
T cell mediated immunity
(GO:0002456)
T cell receptor signaling pathway
(GO:0050852)

Other Information

Proteins

T-cell surface glycoprotein CD8 alpha chain
Q8CAX3_MOUSE

Genular Protein ID: 2607640108

Symbol: CD8A_MOUSE

Name: T-cell surface glycoprotein CD8 alpha chain

UniProtKB Accession Codes:

P01731

Database IDs:

Citations:

PubMed ID: 3927298

Title: Molecular cloning of Lyt-2, a membrane glycoprotein marking a subset of mouse T lymphocytes: molecular homology to its human counterpart, Leu-2/T8, and to immunoglobulin variable regions.

PubMed ID: 3927298

DOI: 10.1073/pnas.82.15.5126

PubMed ID: 3935316

Title: Two Lyt-2 polypeptides arise from a single gene by alternative splicing patterns of mRNA.

PubMed ID: 3935316

DOI: 10.1016/0092-8674(85)90020-0

PubMed ID: 3495785

Title: Isolation and characterization of the gene for the murine T cell differentiation antigen and immunoglobulin-related molecule, Lyt-2.

PubMed ID: 3495785

DOI: 10.1093/nar/15.10.4337

PubMed ID: 3267233

Title: Nucleotide sequence analysis of the C.AKR Lyt-2a gene: structural polymorphism in alleles encoding the Lyt-2.1 T-cell surface alloantigen.

PubMed ID: 3267233

DOI: 10.1007/bf00364233

PubMed ID: 3487583

Title: Structure, sequence, and polymorphism of the Lyt-2 T cell differentiation antigen gene.

PubMed ID: 3487583

PubMed ID: 2512251

Title: Phosphorylation and down-regulation of CD4 and CD8 in human CTLs and mouse L cells.

PubMed ID: 2512251

DOI: 10.1007/bf02421181

PubMed ID: 1673361

Title: CD8 is needed for development of cytotoxic T cells but not helper T cells.

PubMed ID: 1673361

DOI: 10.1016/0092-8674(91)90462-8

PubMed ID: 15105501

Title: CD8alphaalpha-mediated survival and differentiation of CD8 memory T cell precursors.

PubMed ID: 15105501

DOI: 10.1126/science.1092316

PubMed ID: 9806638

Title: Structural basis of CD8 coreceptor function revealed by crystallographic analysis of a murine CD8alphaalpha ectodomain fragment in complex with H-2Kb.

PubMed ID: 9806638

DOI: 10.1016/s1074-7613(00)80635-4

PubMed ID: 18929574

Title: The crystal structure of CD8 in complex with YTS156.7.7 Fab and interaction with other CD8 antibodies define the binding mode of CD8 alphabeta to MHC class I.

PubMed ID: 18929574

DOI: 10.1016/j.jmb.2008.09.069

Sequence Information:

Length: 247
Mass: 27456
Checksum: 22D0D78ECEC3EA04
Sequence:

MASPLTRFLS LNLLLLGESI ILGSGEAKPQ APELRIFPKK MDAELGQKVD LVCEVLGSVS 
QGCSWLFQNS SSKLPQPTFV VYMASSHNKI TWDEKLNSSK LFSAMRDTNN KYVLTLNKFS 
KENEGYYFCS VISNSVMYFS SVVPVLQKVN STTTKPVLRT PSPVHPTGTS QPQRPEDCRP 
RGSVKGTGLD FACDIYIWAP LAGICVALLL SLIITLICYH RSRKRVCKCP RPLVRQEGKP 
RPSEKIV

Genular Protein ID: 635784554

Symbol: Q8CAX3_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q8CAX3

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

Length: 222
Mass: 24513
Checksum: F0703C39859D4C8B
Sequence:

MASPLTRFLS LNLLLLGESI ILGSGEAKPQ APELRIFPKK MDAELGQKVD LVCEVLGSVS 
QGCSWLFQNS SSKLPQPTFV VYMASSHNKI TWDEKLNSSK LFSAMRDTNN KYVLTLNKFS 
KENEGYYFCS VISNSVMYFS SVVPVLQKVN STTTKPVLRT PSPVHPTGTS QPQRPEDCRP 
RGSVKGTGLD FACDIYIWAP LAGICVALLL SLIITLICYH SR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Cd8a

Associated with

Other Information

Molecular cloning of Lyt-2, a membrane glycoprotein marking a subset of mouse T lymphocytes: molecular homology to its human counterpart, Leu-2/T8, and to immunoglobulin variable regions. PubMed ID: 3927298

Two Lyt-2 polypeptides arise from a single gene by alternative splicing patterns of mRNA. PubMed ID: 3935316

Isolation and characterization of the gene for the murine T cell differentiation antigen and immunoglobulin-related molecule, Lyt-2. PubMed ID: 3495785

Nucleotide sequence analysis of the C.AKR Lyt-2a gene: structural polymorphism in alleles encoding the Lyt-2.1 T-cell surface alloantigen. PubMed ID: 3267233

Structure, sequence, and polymorphism of the Lyt-2 T cell differentiation antigen gene. PubMed ID: 3487583

Phosphorylation and down-regulation of CD4 and CD8 in human CTLs and mouse L cells. PubMed ID: 2512251

CD8 is needed for development of cytotoxic T cells but not helper T cells. PubMed ID: 1673361

CD8alphaalpha-mediated survival and differentiation of CD8 memory T cell precursors. PubMed ID: 15105501

Structural basis of CD8 coreceptor function revealed by crystallographic analysis of a murine CD8alphaalpha ectodomain fragment in complex with H-2Kb. PubMed ID: 9806638

The crystal structure of CD8 in complex with YTS156.7.7 Fab and interaction with other CD8 antibodies define the binding mode of CD8 alphabeta to MHC class I. PubMed ID: 18929574

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303