Genular: Defining Cellular Identity and Function

Details for: Cdk1

Gene ID: 12534

Symbol: Cdk1

Ensembl ID: ENSMUSG00000019942

Description: cyclin dependent kinase 1

Associated with

Activation of apc/c and apc/c:cdc20 mediated degradation of mitotic proteins
(R-MMU-176814)
Activation of nima kinases nek9, nek6, nek7
(R-MMU-2980767)
Anchoring of the basal body to the plasma membrane
(R-MMU-5620912)
Antiviral mechanism by ifn-stimulated genes
(R-MMU-1169410)
Apc/c-mediated degradation of cell cycle proteins
(R-MMU-174143)
Apc/c:cdc20 mediated degradation of cyclin b
(R-MMU-174048)
Apc/c:cdc20 mediated degradation of mitotic proteins
(R-MMU-176409)
Apc:cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
(R-MMU-179419)
Aurka activation by tpx2
(R-MMU-8854518)
Cdc20:phospho-apc/c mediated degradation of cyclin a
(R-MMU-174184)
Cell cycle, mitotic
(R-MMU-69278)
Cell cycle checkpoints
(R-MMU-69620)
Centrosome maturation
(R-MMU-380287)
Chk1/chk2(cds1) mediated inactivation of cyclin b:cdk1 complex
(R-MMU-75035)
Cilium assembly
(R-MMU-5617833)
Condensation of prophase chromosomes
(R-MMU-2299718)
Cyclin a/b1/b2 associated events during g2/m transition
(R-MMU-69273)
Cytokine signaling in immune system
(R-MMU-1280215)
Depolymerization of the nuclear lamina
(R-MMU-4419969)
Deubiquitination
(R-MMU-5688426)
G2/m checkpoints
(R-MMU-69481)
G2/m dna damage checkpoint
(R-MMU-69473)
G2/m dna replication checkpoint
(R-MMU-69478)
G2/m transition
(R-MMU-69275)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Immune system
(R-MMU-168256)
Initiation of nuclear envelope (ne) reformation
(R-MMU-2995383)
Interferon signaling
(R-MMU-913531)
Loss of nlp from mitotic centrosomes
(R-MMU-380259)
Loss of proteins required for interphase microtubule organization from the centrosome
(R-MMU-380284)
Mapk1/mapk3 signaling
(R-MMU-5684996)
Mapk3 (erk1) activation
(R-MMU-110056)
Mapk6/mapk4 signaling
(R-MMU-5687128)
Mapk family signaling cascades
(R-MMU-5683057)
Metabolism of proteins
(R-MMU-392499)
Mitotic anaphase
(R-MMU-68882)
Mitotic g2-g2/m phases
(R-MMU-453274)
Mitotic metaphase and anaphase
(R-MMU-2555396)
Mitotic prometaphase
(R-MMU-68877)
Mitotic prophase
(R-MMU-68875)
M phase
(R-MMU-68886)
Nuclear envelope (ne) reassembly
(R-MMU-2995410)
Nuclear envelope breakdown
(R-MMU-2980766)
Nuclear pore complex (npc) disassembly
(R-MMU-3301854)
Organelle biogenesis and maintenance
(R-MMU-1852241)
Ovarian tumor domain proteases
(R-MMU-5689896)
Phosphorylation of emi1
(R-MMU-176417)
Phosphorylation of the apc/c
(R-MMU-176412)
Pkr-mediated signaling
(R-MMU-9833482)
Post-translational protein modification
(R-MMU-597592)
Raf-independent mapk1/3 activation
(R-MMU-112409)
Recruitment of mitotic centrosome proteins and complexes
(R-MMU-380270)
Recruitment of numa to mitotic centrosomes
(R-MMU-380320)
Regulation of apc/c activators between g1/s and early anaphase
(R-MMU-176408)
Regulation of mitotic cell cycle
(R-MMU-453276)
Regulation of plk1 activity at g2/m transition
(R-MMU-2565942)
Regulation of tp53 activity
(R-MMU-5633007)
Regulation of tp53 degradation
(R-MMU-6804757)
Regulation of tp53 expression and degradation
(R-MMU-6806003)
Resolution of sister chromatid cohesion
(R-MMU-2500257)
Rna polymerase ii transcription
(R-MMU-73857)
Signal transduction
(R-MMU-162582)
The role of gtse1 in g2/m progression after g2 checkpoint
(R-MMU-8852276)
Tp53 regulates transcription of cell cycle genes
(R-MMU-6791312)
Tp53 regulates transcription of genes involved in g2 cell cycle arrest
(R-MMU-6804114)
Transcriptional regulation by runx2
(R-MMU-8878166)
Transcriptional regulation by tp53
(R-MMU-3700989)
Apoptotic process
(GO:0006915)
Atp binding
(GO:0005524)
Cell cycle
(GO:0007049)
Chromatin binding
(GO:0003682)
Cyclin-dependent protein kinase activity
(GO:0097472)
Cyclin-dependent protein serine/threonine kinase activity
(GO:0004693)
Cyclin binding
(GO:0030332)
G1/s transition of mitotic cell cycle
(GO:0000082)
G2/m transition of mitotic cell cycle
(GO:0000086)
Histone kinase activity
(GO:0035173)
Hsp70 protein binding
(GO:0030544)
Kinase activity
(GO:0016301)
Mitotic g2 dna damage checkpoint signaling
(GO:0007095)
Negative regulation of gene expression
(GO:0010629)
Nucleotide binding
(GO:0000166)
Positive regulation of g2/m transition of mitotic cell cycle
(GO:0010971)
Positive regulation of gene expression
(GO:0010628)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Response to organonitrogen compound
(GO:0010243)
Rna polymerase ii ctd heptapeptide repeat kinase activity
(GO:0008353)
Transferase activity
(GO:0016740)

Other Information

Proteins

Cyclin-dependent kinase 1

Genular Protein ID: 1101418882

Symbol: CDK1_MOUSE

Name: Cyclin-dependent kinase 1

UniProtKB Accession Codes:

P11440 P70337 Q3TI12

Database IDs:

Citations:

PubMed ID: 2208288

Title: The FT210 cell line is a mouse G2 phase mutant with a temperature-sensitive CDC2 gene product.

PubMed ID: 2208288

DOI: 10.1016/0092-8674(90)90164-a

PubMed ID: 2132958

Title: Cloning of the mouse homologue of the yeast cell cycle control gene cdc2.

PubMed ID: 2132958

DOI: 10.3109/10425179009041346

PubMed ID: 2662013

Title: Phosphorylation of RNA polymerase by the murine homologue of the cell-cycle control protein cdc2.

PubMed ID: 2662013

DOI: 10.1038/339679a0

PubMed ID: 9895127

Title: Characterization of the murine cdc2 gene.

PubMed ID: 9895127

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16169490

Title: Wee1B is an oocyte-specific kinase involved in the control of meiotic arrest in the mouse.

PubMed ID: 16169490

DOI: 10.1016/j.cub.2005.07.056

PubMed ID: 16007079

Title: Cdc2-cyclin E complexes regulate the G1/S phase transition.

PubMed ID: 16007079

DOI: 10.1038/ncb1284

PubMed ID: 17700700

Title: Cdk1 is sufficient to drive the mammalian cell cycle.

PubMed ID: 17700700

DOI: 10.1038/nature06046

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 17942597

Title: p21 Inhibits Cdk1 in the absence of Cdk2 to maintain the G1/S phase DNA damage checkpoint.

PubMed ID: 17942597

DOI: 10.1091/mbc.e07-06-0525

PubMed ID: 19131326

Title: Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry.

PubMed ID: 19131326

DOI: 10.1074/mcp.m800451-mcp200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 19917613

Title: The protein kinase Cdelta catalytic fragment is critical for maintenance of the G2/M DNA damage checkpoint.

PubMed ID: 19917613

DOI: 10.1074/jbc.m109.055392

PubMed ID: 21454751

Title: Protein tyrosine kinase Wee1B is essential for metaphase II exit in mouse oocytes.

PubMed ID: 21454751

DOI: 10.1126/science.1199211

PubMed ID: 22405274

Title: Tex14, a plk1-regulated protein, is required for kinetochore-microtubule attachment and regulation of the spindle assembly checkpoint.

PubMed ID: 22405274

DOI: 10.1016/j.molcel.2012.01.013

PubMed ID: 29518391

Title: Regulation of keratin 5/14 intermediate filaments by CDK1, Aurora-B, and Rho-kinase.

PubMed ID: 29518391

DOI: 10.1016/j.bbrc.2018.03.016

PubMed ID: 31437213

Title: The PSMA8 subunit of the spermatoproteasome is essential for proper meiotic exit and mouse fertility.

PubMed ID: 31437213

DOI: 10.1371/journal.pgen.1008316

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

PubMed ID: 36264786

Title: Mammalian oocytes store mRNAs in a mitochondria-associated membraneless compartment.

PubMed ID: 36264786

DOI: 10.1126/science.abq4835

Sequence Information:

Length: 297
Mass: 34107
Checksum: 9C399FCC41BA7F31
Sequence:

MEDYIKIEKI GEGTYGVVYK GRHRVTGQIV AMKKIRLESE EEGVPSTAIR EISLLKELRH 
PNIVSLQDVL MQDSRLYLIF EFLSMDLKKY LDSIPPGQFM DSSLVKSYLH QILQGIVFCH 
SRRVLHRDLK PQNLLIDDKG TIKLADFGLA RAFGIPIRVY THEVVTLWYR SPEVLLGSAR 
YSTPVDIWSI GTIFAELATK KPLFHGDSEI DQLFRIFRAL GTPNNEVWPE VESLQDYKNT 
FPKWKPGSLA SHVKNLDENG LDLLSKMLVY DPAKRISGKM ALKHPYFDDL DNQIKKM

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Cdk1

Associated with

Other Information

The FT210 cell line is a mouse G2 phase mutant with a temperature-sensitive CDC2 gene product. PubMed ID: 2208288

Cloning of the mouse homologue of the yeast cell cycle control gene cdc2. PubMed ID: 2132958

Phosphorylation of RNA polymerase by the murine homologue of the cell-cycle control protein cdc2. PubMed ID: 2662013

Characterization of the murine cdc2 gene. PubMed ID: 9895127

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Wee1B is an oocyte-specific kinase involved in the control of meiotic arrest in the mouse. PubMed ID: 16169490

Cdc2-cyclin E complexes regulate the G1/S phase transition. PubMed ID: 16007079

Cdk1 is sufficient to drive the mammalian cell cycle. PubMed ID: 17700700

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

p21 Inhibits Cdk1 in the absence of Cdk2 to maintain the G1/S phase DNA damage checkpoint. PubMed ID: 17942597

Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry. PubMed ID: 19131326

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

The protein kinase Cdelta catalytic fragment is critical for maintenance of the G2/M DNA damage checkpoint. PubMed ID: 19917613

Protein tyrosine kinase Wee1B is essential for metaphase II exit in mouse oocytes. PubMed ID: 21454751

Tex14, a plk1-regulated protein, is required for kinetochore-microtubule attachment and regulation of the spindle assembly checkpoint. PubMed ID: 22405274

Regulation of keratin 5/14 intermediate filaments by CDK1, Aurora-B, and Rho-kinase. PubMed ID: 29518391

The PSMA8 subunit of the spermatoproteasome is essential for proper meiotic exit and mouse fertility. PubMed ID: 31437213

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. PubMed ID: 23806337

Mammalian oocytes store mRNAs in a mitochondria-associated membraneless compartment. PubMed ID: 36264786