Genular: Defining Cellular Identity and Function

Details for: Cdc37

Gene ID: 12539

Symbol: Cdc37

Ensembl ID: ENSMUSG00000019471

Description: cell division cycle 37

Associated with

Downregulation of erbb2 signaling
(R-MMU-8863795)
Drug-mediated inhibition of erbb2 signaling
(R-MMU-9652282)
Programmed cell death
(R-MMU-5357801)
Regulated necrosis
(R-MMU-5218859)
Regulation of necroptotic cell death
(R-MMU-5675482)
Rhobtb2 gtpase cycle
(R-MMU-9013418)
Rhobtb gtpase cycle
(R-MMU-9706574)
Rho gtpase cycle
(R-MMU-9012999)
Ripk1-mediated regulated necrosis
(R-MMU-5213460)
Signaling by erbb2
(R-MMU-1227986)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signaling by rho gtpases
(R-MMU-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-MMU-9716542)
Signal transduction
(R-MMU-162582)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Heat shock protein binding
(GO:0031072)
Hsp90 protein binding
(GO:0051879)
Hsp90-cdc37 chaperone complex
(GO:1990565)
Kinase binding
(GO:0019900)
Mitogen-activated protein kinase kinase kinase binding
(GO:0031435)
Positive regulation of mitophagy in response to mitochondrial depolarization
(GO:0098779)
Post-transcriptional regulation of gene expression
(GO:0010608)
Protein-containing complex
(GO:0032991)
Protein-folding chaperone binding
(GO:0051087)
Protein binding
(GO:0005515)
Protein folding
(GO:0006457)
Protein folding chaperone complex
(GO:0101031)
Protein kinase b binding
(GO:0043422)
Protein kinase binding
(GO:0019901)
Protein kinase regulator activity
(GO:0019887)
Protein stabilization
(GO:0050821)
Regulation of protein kinase activity
(GO:0045859)
Regulation of type ii interferon-mediated signaling pathway
(GO:0060334)
Regulation of type i interferon-mediated signaling pathway
(GO:0060338)
Ruffle membrane
(GO:0032587)
Scaffold protein binding
(GO:0097110)
Transcription corepressor binding
(GO:0001222)
Unfolded protein binding
(GO:0051082)

Other Information

Proteins

Hsp90 co-chaperone Cdc37

Genular Protein ID: 3012140290

Symbol: CDC37_MOUSE

Name: Hsp90 co-chaperone Cdc37

UniProtKB Accession Codes:

Q61081 Q3TGP0

Database IDs:

Citations:

PubMed ID: 8666233

Title: Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4.

PubMed ID: 8666233

DOI: 10.1101/gad.10.12.1491

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10409742

Title: Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization.

PubMed ID: 10409742

DOI: 10.1128/mcb.19.8.5523

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 379
Mass: 44593
Checksum: 847C146B4FE3AAF1
Sequence:

MVDYSVWDHI EVSDDEDETH PNIDTASLFR WRHQARVERM EQFQKEKEEL DRGCRECKRK 
VAECQRKLKE LEVAESDGQV ELERLRAEAQ QLRKEERSWE QKLEDMRKKE KNMPWNVDTL 
SKDGFSKSMV NTKPEKAEED SEEAREQKHK TFVEKYEKQI KHFGMLHRWD DSQKYLSDNV 
HLVCEETANY LVIWCIDLEV EEKCALMEQV AHQTMVMQFI LELAKSLKVD PRACFRQFFT 
KIKTADHQYM EGFKYELEAF KERVRGRAKL RIEKAMKEYE EEERKKRLGP GGLDPVEVYE 
SLPEELQKCF DVKDVQMLQD AISKMDPTDA KYHMQRCIDS GLWVPNSKSG EAKEGEEAGP 
GDPLLEAVPK AGNEKDVSA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Cdc37

Associated with

Other Information

Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4. PubMed ID: 8666233

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334