Genular: Defining Cellular Identity and Function

Details for: Cdh5

Gene ID: 12562

Symbol: Cdh5

Ensembl ID: ENSMUSG00000031871

Description: cadherin 5

Associated with

Adherens junctions interactions
(R-MMU-418990)
Cell-cell communication
(R-MMU-1500931)
Cell-cell junction organization
(R-MMU-421270)
Cell junction organization
(R-MMU-446728)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signaling by vegf
(R-MMU-194138)
Signal transduction
(R-MMU-162582)
Vegfa-vegfr2 pathway
(R-MMU-4420097)
Vegfr2 mediated vascular permeability
(R-MMU-5218920)
Adherens junction
(GO:0005912)
Adherens junction organization
(GO:0034332)
Anchoring junction
(GO:0070161)
Beta-catenin binding
(GO:0008013)
Bicellular tight junction
(GO:0005923)
Bicellular tight junction assembly
(GO:0070830)
Blood vessel endothelial cell migration
(GO:0043534)
Blood vessel maturation
(GO:0001955)
Bmp receptor binding
(GO:0070700)
Cadherin binding
(GO:0045296)
Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
(GO:0016339)
Calcium ion binding
(GO:0005509)
Catenin complex
(GO:0016342)
Cell-cell adhesion
(GO:0098609)
Cell-cell adhesion mediated by cadherin
(GO:0044331)
Cell-cell junction
(GO:0005911)
Cell-cell junction assembly
(GO:0007043)
Cell adhesion
(GO:0007155)
Cell junction
(GO:0030054)
Cell morphogenesis
(GO:0000902)
Cell periphery
(GO:0071944)
Cell surface
(GO:0009986)
External side of plasma membrane
(GO:0009897)
Fibrinogen binding
(GO:0070051)
Homophilic cell adhesion via plasma membrane adhesion molecules
(GO:0007156)
Intracellular calcium ion homeostasis
(GO:0006874)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Multicellular organism development
(GO:0007275)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of endothelial cell apoptotic process
(GO:2000352)
Negative regulation of inflammatory response
(GO:0050728)
Negative regulation of microtubule polymerization
(GO:0031115)
Nuclear membrane
(GO:0031965)
Nucleoplasm
(GO:0005654)
Plasma membrane
(GO:0005886)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of bmp signaling pathway
(GO:0030513)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of establishment of endothelial barrier
(GO:1903142)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of protein-containing complex assembly
(GO:0031334)
Positive regulation of protein dephosphorylation
(GO:0035307)
Protein binding
(GO:0005515)
Protein localization to bicellular tight junction
(GO:1902396)
Protein phosphatase binding
(GO:0019903)
Protein tyrosine kinase binding
(GO:1990782)
Regulation of establishment of cell polarity
(GO:2000114)
Regulation of protein phosphorylation
(GO:0001932)
Regulation of vascular permeability
(GO:0043114)
Signaling receptor binding
(GO:0005102)
Transforming growth factor beta receptor signaling pathway
(GO:0007179)
Transmembrane transporter binding
(GO:0044325)
Vascular endothelial growth factor receptor 2 binding
(GO:0043184)
Vasculature development
(GO:0001944)

Other Information

Proteins

Cadherin-5

Genular Protein ID: 2536280072

Symbol: CADH5_MOUSE

Name: Cadherin-5

UniProtKB Accession Codes:

P55284 O35542

Database IDs:

Citations:

PubMed ID: 8555485

Title: Molecular cloning and expression of murine vascular endothelial-cadherin in early stage development of cardiovascular system.

PubMed ID: 8555485

PubMed ID: 9220534

Title: In vivo evidence of the critical role of cadherin-5 in murine vascular integrity.

PubMed ID: 9220534

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12234928

Title: VE-PTP and VE-cadherin ectodomains interact to facilitate regulation of phosphorylation and cell contacts.

PubMed ID: 12234928

DOI: 10.1093/emboj/cdf497

Title:

DOI: 10.1093/sj.emboj.cdf497

PubMed ID: 19635461

Title: Impaired vascular development in the yolk sac and allantois in mice lacking RA-GEF-1.

PubMed ID: 19635461

DOI: 10.1016/j.bbrc.2009.07.108

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20332120

Title: CCM1 regulates vascular-lumen organization by inducing endothelial polarity.

PubMed ID: 20332120

DOI: 10.1242/jcs.059329

PubMed ID: 22492353

Title: SOX7 regulates the expression of VE-cadherin in the haemogenic endothelium at the onset of haematopoietic development.

PubMed ID: 22492353

DOI: 10.1242/dev.071282

PubMed ID: 27466317

Title: VE-cadherin interacts with cell polarity protein Pals1 to regulate vascular lumen formation.

PubMed ID: 27466317

DOI: 10.1091/mbc.e16-02-0127

PubMed ID: 28179430

Title: Polydom Is an Extracellular Matrix Protein Involved in Lymphatic Vessel Remodeling.

PubMed ID: 28179430

DOI: 10.1161/circresaha.116.308825

PubMed ID: 20047332

Title: Distal interactions within the par3-VE-cadherin complex.

PubMed ID: 20047332

DOI: 10.1021/bi9017335

Sequence Information:

Length: 784
Mass: 87903
Checksum: 7B75698DE2F7E160
Sequence:

MQRLTELATA LGAFLGLLAV AAMAGPNFPQ IDTPNMLPAH HRQKRDWIWN QMHIDEEKNE 
SLPHYVGKIK SNVNRQNAKY VLQGEFAGKI FGVDANTGNV LAYERLDREK VSEYFLTALI 
VDKNTNKNLE QPSSFTVKVH DINDNWPVFS HQVFNASVPE MSAIGTSVIR VTAVDADDPT 
VAGHATVLYQ IVKGNEYFSI DNSGLIFTKI KNLDREKQAE YKIVVETQDA LGLRGESGTA 
TVMIRLEDIN DNFPVFTQST YTFSVPEDIR VGKPLGFLTV VDPDEPQNRM TKYSIMQGEY 
RDTFTIETDP KRNEGIIKPT KSLDYEVIQQ YTFYIEATDP TIRYEYLSST SGKNKAMVTI 
NVLDVDEPPV FQRHFYHFKL PENQKKPLIG TVVAKDPDKA QRSIGYSIRK TSDRGQFFRI 
TKQGNIYNEK ELDRETYAWY NLTVEANELD SRGNPVGKES IVQVYIEVLD ENDNPPEFAQ 
PYEPKVCENA AQGKLVVQIS ATDKDVVPVN PKFKFALKNE DSNFTLINNH DNTANITVKY 
GQFNREHAKF HYLPVLISDN GVPSLTGTST LTVGVCKCNE QGEFTFCEEM AAQAGVSIQA 
LVAIFLCILT ITVITLLIIL RRRIRKQAHA HSKSALEIHE QLVTYDEEGG GEMDTTSYDV 
SVLNSVRGGS TKPLRSTMDA RPAVYTQVQK PPRLAPGLHG GPREMATMID VKKEEADNDG 
GGPPYDTLHI YGYEGAESIA ESLSSLSTNS SDSDIDYDFL NDWGPRFKML AELYGSDPQE 
ELII

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Cdh5

Associated with

Other Information

Molecular cloning and expression of murine vascular endothelial-cadherin in early stage development of cardiovascular system. PubMed ID: 8555485

In vivo evidence of the critical role of cadherin-5 in murine vascular integrity. PubMed ID: 9220534

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

VE-PTP and VE-cadherin ectodomains interact to facilitate regulation of phosphorylation and cell contacts. PubMed ID: 12234928

Impaired vascular development in the yolk sac and allantois in mice lacking RA-GEF-1. PubMed ID: 19635461

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

CCM1 regulates vascular-lumen organization by inducing endothelial polarity. PubMed ID: 20332120

SOX7 regulates the expression of VE-cadherin in the haemogenic endothelium at the onset of haematopoietic development. PubMed ID: 22492353

VE-cadherin interacts with cell polarity protein Pals1 to regulate vascular lumen formation. PubMed ID: 27466317

Polydom Is an Extracellular Matrix Protein Involved in Lymphatic Vessel Remodeling. PubMed ID: 28179430

Distal interactions within the par3-VE-cadherin complex. PubMed ID: 20047332