Genular: Defining Cellular Identity and Function

Details for: Cdk2

Gene ID: 12566

Symbol: Cdk2

Ensembl ID: ENSMUSG00000025358

Description: cyclin dependent kinase 2

Associated with

Activation of atr in response to replication stress
(R-MMU-176187)
Activation of the pre-replicative complex
(R-MMU-68962)
Apc/c-mediated degradation of cell cycle proteins
(R-MMU-174143)
Cdk-mediated phosphorylation and removal of cdc6
(R-MMU-69017)
Cell cycle, mitotic
(R-MMU-69278)
Cell cycle checkpoints
(R-MMU-69620)
Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular senescence
(R-MMU-2559583)
Chromosome maintenance
(R-MMU-73886)
Cyclin a/b1/b2 associated events during g2/m transition
(R-MMU-69273)
Cyclin a:cdk2-associated events at s phase entry
(R-MMU-69656)
Cyclin d associated events in g1
(R-MMU-69231)
Cyclin e associated events during g1/s transition
(R-MMU-69202)
Developmental biology
(R-MMU-1266738)
Dna damage/telomere stress induced senescence
(R-MMU-2559586)
Dna double-strand break repair
(R-MMU-5693532)
Dna replication
(R-MMU-69306)
Dna replication pre-initiation
(R-MMU-69002)
Extension of telomeres
(R-MMU-180786)
G0 and early g1
(R-MMU-1538133)
G1 phase
(R-MMU-69236)
G1/s dna damage checkpoints
(R-MMU-69615)
G1/s transition
(R-MMU-69206)
G2 phase
(R-MMU-68911)
G2/m checkpoints
(R-MMU-69481)
G2/m transition
(R-MMU-69275)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Hdr through homologous recombination (hrr) or single strand annealing (ssa)
(R-MMU-5693567)
Homology directed repair
(R-MMU-5693538)
Mitotic g1 phase and g1/s transition
(R-MMU-453279)
Mitotic g2-g2/m phases
(R-MMU-453274)
Orc1 removal from chromatin
(R-MMU-68949)
P53-dependent g1 dna damage response
(R-MMU-69563)
P53-dependent g1/s dna damage checkpoint
(R-MMU-69580)
Phosphorylation of proteins involved in g1/s transition by active cyclin e:cdk2 complexes
(R-MMU-69200)
Processing of dna double-strand break ends
(R-MMU-5693607)
Ptk6 regulates cell cycle
(R-MMU-8849470)
Regulation of apc/c activators between g1/s and early anaphase
(R-MMU-176408)
Regulation of mitotic cell cycle
(R-MMU-453276)
Regulation of tp53 activity
(R-MMU-5633007)
Regulation of tp53 activity through phosphorylation
(R-MMU-6804756)
Regulation of tp53 degradation
(R-MMU-6804757)
Regulation of tp53 expression and degradation
(R-MMU-6806003)
Rna polymerase ii transcription
(R-MMU-73857)
Scf(skp2)-mediated degradation of p27/p21
(R-MMU-187577)
Senescence-associated secretory phenotype (sasp)
(R-MMU-2559582)
Signaling by non-receptor tyrosine kinases
(R-MMU-9006927)
Signaling by ptk6
(R-MMU-8848021)
S phase
(R-MMU-69242)
Switching of origins to a post-replicative state
(R-MMU-69052)
Synthesis of dna
(R-MMU-69239)
Telomere extension by telomerase
(R-MMU-171319)
Telomere maintenance
(R-MMU-157579)
Tp53 regulates transcription of cell cycle genes
(R-MMU-6791312)
Tp53 regulates transcription of genes involved in g1 cell cycle arrest
(R-MMU-6804116)
Transcriptional regulation by tp53
(R-MMU-3700989)
Transcriptional regulation of granulopoiesis
(R-MMU-9616222)
Atp binding
(GO:0005524)
Cell cycle
(GO:0007049)
Centriole replication
(GO:0007099)
Cyclin-dependent protein kinase activity
(GO:0097472)
Cyclin-dependent protein serine/threonine kinase activity
(GO:0004693)
Cyclin binding
(GO:0030332)
Dna-templated transcription
(GO:0006351)
Dna damage response
(GO:0006974)
Dna repair
(GO:0006281)
G1/s transition of mitotic cell cycle
(GO:0000082)
Histone kinase activity
(GO:0035173)
Kinase activity
(GO:0016301)
Magnesium ion binding
(GO:0000287)
Metal ion binding
(GO:0046872)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleotide binding
(GO:0000166)
Peptidyl-serine phosphorylation
(GO:0018105)
Phosphorylation
(GO:0016310)
Positive regulation of cell population proliferation
(GO:0008284)
Potassium ion transport
(GO:0006813)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Protein kinase activity
(GO:0004672)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Regulation of g2/m transition of mitotic cell cycle
(GO:0010389)
Regulation of gene expression
(GO:0010468)
Response to organic substance
(GO:0010033)
Signal transduction
(GO:0007165)
Transferase activity
(GO:0016740)

Other Information

Proteins

Cyclin-dependent kinase 2
Q3U6X7_MOUSE

Genular Protein ID: 12239444

Symbol: CDK2_MOUSE

Name: Cyclin-dependent kinase 2

UniProtKB Accession Codes:

P97377 O55105

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11585773

Title: Cables enhances cdk2 tyrosine 15 phosphorylation by Wee1, inhibits cell growth, and is lost in many human colon and squamous cancers.

PubMed ID: 11585773

PubMed ID: 11733001

Title: ik3-1/Cables is a substrate for cyclin-dependent kinase 3 (cdk 3).

PubMed ID: 11733001

DOI: 10.1046/j.0014-2956.2001.02555.x

PubMed ID: 14561402

Title: Cdk2 knockout mice are viable.

PubMed ID: 14561402

DOI: 10.1016/j.cub.2003.09.024

PubMed ID: 12923533

Title: Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice.

PubMed ID: 12923533

DOI: 10.1038/ng1232

PubMed ID: 15107404

Title: Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP alpha growth inhibitory activity.

PubMed ID: 15107404

DOI: 10.1101/gad.1183304

PubMed ID: 17942597

Title: p21 Inhibits Cdk1 in the absence of Cdk2 to maintain the G1/S phase DNA damage checkpoint.

PubMed ID: 17942597

DOI: 10.1091/mbc.e07-06-0525

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23853094

Title: Foxp3 protein stability is regulated by cyclin-dependent kinase 2.

PubMed ID: 23853094

DOI: 10.1074/jbc.m113.467704

Sequence Information:

Length: 346
Mass: 38978
Checksum: D806BC2F150AEDFC
Sequence:

MENFQKVEKI GEGTYGVVYK AKNKLTGEVV ALKKIRLDTE TEGVPSTAIR EISLLKELNH 
PNIVKLLDVI HTENKLYLVF EFLHQDLKKF MDASALTGIP LPLIKSYLFQ LLQGLAFCHS 
HRVLHRDLKP QNLLINAEGS IKLADFGLAR AFGVPVRTYT HEVVTLWYRA PEILLGCKYY 
STAVDIWSLG CIFAEMHLVC TQHHAKCCGE HRRNGRHSLC PLCSYLEVAA SQGGGMTAVS 
APHPVTRRAL FPGDSEIDQL FRIFRTLGTP DEVVWPGVTS MPDYKPSFPK WARQDFSKVV 
PPLDEDGRSL LSQMLHYDPN KRISAKAALA HPFFQDVTKP VPHLRL

Genular Protein ID: 2657266797

Symbol: Q3U6X7_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3U6X7

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 298
Mass: 33887
Checksum: FB28DBD8BA587BDA
Sequence:

MENFQKVEKI GEGTYGVVYK AKNKLTGEVV ALKKIRLDTE TEGVPSTAIR EISLLKELNH 
PNIVKLLDVI HTENKLYLVF EFLHQDLKKF MDASALTGIP LPLIKSYLFQ LLQGLAFCHS 
HRVLHRDLKP QNLLINAEGS IKLADFGLAR AFGVPVRTYT HEVVTLWYRA PEILLGCKYY 
STAVDIWSLG CIFAEMVTRR ALFPGDSEID QLFRIFRTLG TPDEVVWPGV TSMPDYKPSF 
PKWARQDFSK VVPPLDEDGR SLLSQMLHYD PNKRISAKAA LAHPFFQDVT KPVPHLRL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Cdk2

Associated with

Other Information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Cables enhances cdk2 tyrosine 15 phosphorylation by Wee1, inhibits cell growth, and is lost in many human colon and squamous cancers. PubMed ID: 11585773

ik3-1/Cables is a substrate for cyclin-dependent kinase 3 (cdk 3). PubMed ID: 11733001

Cdk2 knockout mice are viable. PubMed ID: 14561402

Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice. PubMed ID: 12923533

Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP alpha growth inhibitory activity. PubMed ID: 15107404

p21 Inhibits Cdk1 in the absence of Cdk2 to maintain the G1/S phase DNA damage checkpoint. PubMed ID: 17942597

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Foxp3 protein stability is regulated by cyclin-dependent kinase 2. PubMed ID: 23853094

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073