Genular: Defining Cellular Identity and Function

Details for: Cdk4

Gene ID: 12567

Symbol: Cdk4

Ensembl ID: ENSMUSG00000006728

Description: cyclin dependent kinase 4

Associated with

Cell cycle, mitotic
(R-MMU-69278)
Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular senescence
(R-MMU-2559583)
Chromatin modifying enzymes
(R-MMU-3247509)
Chromatin organization
(R-MMU-4839726)
Cyclin a:cdk2-associated events at s phase entry
(R-MMU-69656)
Cyclin d associated events in g1
(R-MMU-69231)
Cyclin e associated events during g1/s transition
(R-MMU-69202)
Developmental biology
(R-MMU-1266738)
Drug-mediated inhibition of cdk4/cdk6 activity
(R-MMU-9754119)
G1 phase
(R-MMU-69236)
G1/s transition
(R-MMU-69206)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Mitotic g1 phase and g1/s transition
(R-MMU-453279)
Oncogene induced senescence
(R-MMU-2559585)
Oxidative stress induced senescence
(R-MMU-2559580)
Ptk6 regulates cell cycle
(R-MMU-8849470)
Rmts methylate histone arginines
(R-MMU-3214858)
Rna polymerase ii transcription
(R-MMU-73857)
Scf(skp2)-mediated degradation of p27/p21
(R-MMU-187577)
Senescence-associated secretory phenotype (sasp)
(R-MMU-2559582)
Signaling by non-receptor tyrosine kinases
(R-MMU-9006927)
Signaling by ptk6
(R-MMU-8848021)
S phase
(R-MMU-69242)
Transcriptional regulation by runx2
(R-MMU-8878166)
Transcriptional regulation of granulopoiesis
(R-MMU-9616222)
Ubiquitin-dependent degradation of cyclin d
(R-MMU-75815)
Atp binding
(GO:0005524)
Bicellular tight junction
(GO:0005923)
Cell cycle
(GO:0007049)
Cell division
(GO:0051301)
Cellular response to interleukin-4
(GO:0071353)
Cellular response to ionomycin
(GO:1904637)
Cellular response to lipopolysaccharide
(GO:0071222)
Cellular response to phorbol 13-acetate 12-myristate
(GO:1904628)
Chromatin
(GO:0000785)
Cyclin-dependent protein kinase holoenzyme complex
(GO:0000307)
Cyclin-dependent protein serine/threonine kinase activity
(GO:0004693)
Cyclin binding
(GO:0030332)
Cyclin d1-cdk4 complex
(GO:0097128)
Cyclin d2-cdk4 complex
(GO:0097129)
Cyclin d3-cdk4 complex
(GO:0097130)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
G1/s transition of mitotic cell cycle
(GO:0000082)
Kinase activity
(GO:0016301)
Membrane
(GO:0016020)
Nuclear membrane
(GO:0031965)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
Perinuclear region of cytoplasm
(GO:0048471)
Phosphorylation
(GO:0016310)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of cell size
(GO:0045793)
Positive regulation of epithelial cell proliferation
(GO:0050679)
Positive regulation of fibroblast proliferation
(GO:0048146)
Positive regulation of g2/m transition of mitotic cell cycle
(GO:0010971)
Positive regulation of translation
(GO:0045727)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Regulation of cell cycle
(GO:0051726)
Regulation of g2/m transition of mitotic cell cycle
(GO:0010389)
Regulation of gene expression
(GO:0010468)
Regulation of type b pancreatic cell proliferation
(GO:0061469)
Response to lead ion
(GO:0010288)
Response to organic substance
(GO:0010033)
Response to testosterone
(GO:0033574)
Signal transduction
(GO:0007165)
Transcription regulator complex
(GO:0005667)
Transferase activity
(GO:0016740)

Other Information

Proteins

Cyclin-dependent kinase 4

Genular Protein ID: 1352292409

Symbol: CDK4_MOUSE

Name: Cyclin-dependent kinase 4

UniProtKB Accession Codes:

P30285

Database IDs:

Citations:

PubMed ID: 1423597

Title: Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins.

PubMed ID: 1423597

DOI: 10.1016/0092-8674(92)90360-o

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1281307

Title: An Eph-related receptor protein tyrosine kinase gene segmentally expressed in the developing mouse hindbrain.

PubMed ID: 1281307

PubMed ID: 8444355

Title: Novel CDC2-related protein kinases produced in murine hematopoietic stem cells.

PubMed ID: 8444355

DOI: 10.1016/0378-1119(93)90411-u

PubMed ID: 8139570

Title: Regulation of cyclin D-dependent kinase 4 (cdk4) by cdk4-activating kinase.

PubMed ID: 8139570

DOI: 10.1128/mcb.14.4.2713-2721.1994

PubMed ID: 10580009

Title: Regulation of CDK4 activity by a novel CDK4-binding protein, p34(SEI-1).

PubMed ID: 10580009

DOI: 10.1101/gad.13.22.3027

PubMed ID: 15107404

Title: Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP alpha growth inhibitory activity.

PubMed ID: 15107404

DOI: 10.1101/gad.1183304

PubMed ID: 19767775

Title: Lysine 269 is essential for cyclin D1 ubiquitylation by the SCF(Fbx4/alphaB-crystallin) ligase and subsequent proteasome-dependent degradation.

PubMed ID: 19767775

DOI: 10.1038/onc.2009.287

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 303
Mass: 33751
Checksum: CB4F42A8AA13634A
Sequence:

MAATRYEPVA EIGVGAYGTV YKARDPHSGH FVALKSVRVP NGGAAGGGLP VSTVREVALL 
RRLEAFEHPN VVRLMDVCAT SRTDRDIKVT LVFEHIDQDL RTYLDKAPPP GLPVETIKDL 
MRQFLSGLDF LHANCIVHRD LKPENILVTS NGTVKLADFG LARIYSYQMA LTPVVVTLWY 
RAPEVLLQST YATPVDMWSV GCIFAEMFRR KPLFCGNSEA DQLGKIFDLI GLPPEDDWPR 
EVSLPRGAFA PRGPRPVQSV VPEMEESGAQ LLLEMLTFNP HKRISAFRAL QHSYLHKEES 
DAE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Cdk4

Associated with

Other Information

Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins. PubMed ID: 1423597

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

An Eph-related receptor protein tyrosine kinase gene segmentally expressed in the developing mouse hindbrain. PubMed ID: 1281307

Novel CDC2-related protein kinases produced in murine hematopoietic stem cells. PubMed ID: 8444355

Regulation of cyclin D-dependent kinase 4 (cdk4) by cdk4-activating kinase. PubMed ID: 8139570

Regulation of CDK4 activity by a novel CDK4-binding protein, p34(SEI-1). PubMed ID: 10580009

Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP alpha growth inhibitory activity. PubMed ID: 15107404

Lysine 269 is essential for cyclin D1 ubiquitylation by the SCF(Fbx4/alphaB-crystallin) ligase and subsequent proteasome-dependent degradation. PubMed ID: 19767775

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079