Genular: Defining Cellular Identity and Function

Details for: Cdk5

Gene ID: 12568

Symbol: Cdk5

Ensembl ID: ENSMUSG00000028969

Description: cyclin dependent kinase 5

Associated with

Axon guidance
(R-MMU-422475)
Crmps in sema3a signaling
(R-MMU-399956)
Darpp-32 events
(R-MMU-180024)
Developmental biology
(R-MMU-1266738)
G alpha (i) signalling events
(R-MMU-418594)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Gpcr downstream signalling
(R-MMU-388396)
Opioid signalling
(R-MMU-111885)
Regulation of tp53 activity
(R-MMU-5633007)
Regulation of tp53 activity through phosphorylation
(R-MMU-6804756)
Rna polymerase ii transcription
(R-MMU-73857)
Semaphorin interactions
(R-MMU-373755)
Signaling by gpcr
(R-MMU-372790)
Signal transduction
(R-MMU-162582)
Transcriptional regulation by tp53
(R-MMU-3700989)
Acetylcholine receptor activator activity
(GO:0030549)
Apoptotic process
(GO:0006915)
Associative learning
(GO:0008306)
Atp binding
(GO:0005524)
Axonogenesis
(GO:0007409)
Cell-matrix adhesion
(GO:0007160)
Cell cycle
(GO:0007049)
Cell migration
(GO:0016477)
Central nervous system neuron development
(GO:0021954)
Cerebellar cortex development
(GO:0021695)
Cerebellar cortex formation
(GO:0021697)
Cerebellum development
(GO:0021549)
Cerebral cortex development
(GO:0021987)
Corpus callosum development
(GO:0022038)
Cortical actin cytoskeleton organization
(GO:0030866)
Cyclin-dependent protein serine/threonine kinase activity
(GO:0004693)
Cytoskeletal protein binding
(GO:0008092)
Dna damage response
(GO:0006974)
Ephrin receptor binding
(GO:0046875)
Erbb-2 class receptor binding
(GO:0005176)
Erbb-3 class receptor binding
(GO:0043125)
Exocytosis
(GO:0006887)
Forebrain development
(GO:0030900)
Hippocampus development
(GO:0021766)
Histone kinase activity
(GO:0035173)
Hsp90 protein binding
(GO:0051879)
Intracellular protein transport
(GO:0006886)
Kinase activity
(GO:0016301)
Layer formation in cerebral cortex
(GO:0021819)
Mitochondrion organization
(GO:0007005)
Motor neuron axon guidance
(GO:0008045)
Negative regulation of axon extension
(GO:0030517)
Negative regulation of protein ubiquitination
(GO:0031397)
Negative regulation of synaptic plasticity
(GO:0031914)
Nervous system development
(GO:0007399)
Neuron differentiation
(GO:0030182)
Neuron migration
(GO:0001764)
Neuron projection development
(GO:0031175)
Nucleocytoplasmic transport
(GO:0006913)
Nucleotide binding
(GO:0000166)
P53 binding
(GO:0002039)
Peptidyl-serine phosphorylation
(GO:0018105)
Peptidyl-threonine phosphorylation
(GO:0018107)
Phosphorylation
(GO:0016310)
Positive regulation of glial cell apoptotic process
(GO:0034352)
Positive regulation of neuron apoptotic process
(GO:0043525)
Positive regulation of protein binding
(GO:0032092)
Positive regulation of protein phosphorylation
(GO:0001934)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein kinase binding
(GO:0019901)
Protein localization to synapse
(GO:0035418)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Receptor catabolic process
(GO:0032801)
Receptor clustering
(GO:0043113)
Regulation of cell migration
(GO:0030334)
Response to cocaine
(GO:0042220)
Schwann cell development
(GO:0014044)
Sensory perception of pain
(GO:0019233)
Serine phosphorylation of stat protein
(GO:0042501)
Skeletal muscle tissue development
(GO:0007519)
Synapse assembly
(GO:0007416)
Synaptic transmission, dopaminergic
(GO:0001963)
Synaptic transmission, glutamatergic
(GO:0035249)
Tau-protein kinase activity
(GO:0050321)
Telencephalon development
(GO:0021537)
Transferase activity
(GO:0016740)
Visual learning
(GO:0008542)

Other Information

Proteins

Cyclin-dependent-like kinase 5

Genular Protein ID: 97291044

Symbol: CDK5_MOUSE

Name: Cyclin-dependent-like kinase 5

UniProtKB Accession Codes:

P49615

Database IDs:

Citations:

PubMed ID: 7834371

Title: Expression of CDK5 (PSSALRE kinase), a neural cdc2-related protein kinase, in the mature and developing mouse central and peripheral nervous systems.

PubMed ID: 7834371

DOI: 10.1016/0006-8993(94)91197-5

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8444355

Title: Novel CDC2-related protein kinases produced in murine hematopoietic stem cells.

PubMed ID: 8444355

DOI: 10.1016/0378-1119(93)90411-u

PubMed ID: 7490100

Title: Molecular cloning and chromosomal mapping of the mouse cyclin-dependent kinase 5 gene.

PubMed ID: 7490100

DOI: 10.1006/geno.1995.1194

PubMed ID: 10896159

Title: Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth.

PubMed ID: 10896159

DOI: 10.1016/s0896-6273(00)81200-3

PubMed ID: 11517264

Title: p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment.

PubMed ID: 11517264

DOI: 10.1523/jneurosci.21-17-06758.2001

PubMed ID: 11226314

Title: Synergistic contributions of cyclin-dependant kinase 5/p35 and Reelin/Dab1 to the positioning of cortical neurons in the developing mouse brain.

PubMed ID: 11226314

DOI: 10.1073/pnas.051628498

PubMed ID: 11955625

Title: Ik3-2, a relative to ik3-1/cables, is associated with cdk3, cdk5, and c-abl.

PubMed ID: 11955625

DOI: 10.1016/s0167-4781(01)00367-0

PubMed ID: 12941275

Title: Serine 732 phosphorylation of FAK by Cdk5 is important for microtubule organization, nuclear movement, and neuronal migration.

PubMed ID: 12941275

DOI: 10.1016/s0092-8674(03)00605-6

PubMed ID: 16203963

Title: Aberrant motor axon projection, acetylcholine receptor clustering, and neurotransmission in cyclin-dependent kinase 5 null mice.

PubMed ID: 16203963

DOI: 10.1073/pnas.0507678102

PubMed ID: 16452087

Title: Comprehensive identification of phosphorylation sites in postsynaptic density preparations.

PubMed ID: 16452087

DOI: 10.1074/mcp.t500041-mcp200

PubMed ID: 17143272

Title: Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism.

PubMed ID: 17143272

DOI: 10.1038/nn1811

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20473298

Title: The role of Cdk5-mediated apurinic/apyrimidinic endonuclease 1 phosphorylation in neuronal death.

PubMed ID: 20473298

DOI: 10.1038/ncb2058

PubMed ID: 21210220

Title: Hypomyelination Phenotype caused by impaired differentiation of oligodendrocytes in Emx1-cre mediated Cdk5 conditional knockout mice.

PubMed ID: 21210220

DOI: 10.1007/s11064-010-0391-0

PubMed ID: 24235147

Title: Cyclin-dependent kinase 5 (Cdk5) regulates the function of CLOCK protein by direct phosphorylation.

PubMed ID: 24235147

DOI: 10.1074/jbc.m113.494856

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

PubMed ID: 25078650

Title: The serotonin 6 receptor controls neuronal migration during corticogenesis via a ligand-independent Cdk5-dependent mechanism.

PubMed ID: 25078650

DOI: 10.1242/dev.108043

Sequence Information:

Length: 292
Mass: 33288
Checksum: 4CB11CED9017D535
Sequence:

MQKYEKLEKI GEGTYGTVFK AKNRETHEIV ALKRVRLDDD DEGVPSSALR EICLLKELKH 
KNIVRLHDVL HSDKKLTLVF EFCDQDLKKY FDSCNGDLDP EIVKSFLFQL LKGLGFCHSR 
NVLHRDLKPQ NLLINRNGEL KLADFGLARA FGIPVRCYSA EVVTLWYRPP DVLFGAKLYS 
TSIDMWSAGC IFAELANAGR PLFPGNDVDD QLKRIFRLLG TPTEEQWPAM TKLPDYKPYP 
MYPATTSLVN VVPKLNATGR DLLQNLLKCN PVQRISAEEA LQHPYFSDFC PP

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Cdk5

Associated with

Other Information

Expression of CDK5 (PSSALRE kinase), a neural cdc2-related protein kinase, in the mature and developing mouse central and peripheral nervous systems. PubMed ID: 7834371

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Novel CDC2-related protein kinases produced in murine hematopoietic stem cells. PubMed ID: 8444355

Molecular cloning and chromosomal mapping of the mouse cyclin-dependent kinase 5 gene. PubMed ID: 7490100

Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth. PubMed ID: 10896159

p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment. PubMed ID: 11517264

Synergistic contributions of cyclin-dependant kinase 5/p35 and Reelin/Dab1 to the positioning of cortical neurons in the developing mouse brain. PubMed ID: 11226314

Ik3-2, a relative to ik3-1/cables, is associated with cdk3, cdk5, and c-abl. PubMed ID: 11955625

Serine 732 phosphorylation of FAK by Cdk5 is important for microtubule organization, nuclear movement, and neuronal migration. PubMed ID: 12941275

Aberrant motor axon projection, acetylcholine receptor clustering, and neurotransmission in cyclin-dependent kinase 5 null mice. PubMed ID: 16203963

Comprehensive identification of phosphorylation sites in postsynaptic density preparations. PubMed ID: 16452087

Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism. PubMed ID: 17143272

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

The role of Cdk5-mediated apurinic/apyrimidinic endonuclease 1 phosphorylation in neuronal death. PubMed ID: 20473298

Hypomyelination Phenotype caused by impaired differentiation of oligodendrocytes in Emx1-cre mediated Cdk5 conditional knockout mice. PubMed ID: 21210220

Cyclin-dependent kinase 5 (Cdk5) regulates the function of CLOCK protein by direct phosphorylation. PubMed ID: 24235147

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. PubMed ID: 23806337

The serotonin 6 receptor controls neuronal migration during corticogenesis via a ligand-independent Cdk5-dependent mechanism. PubMed ID: 25078650