Genular: Defining Cellular Identity and Function

Details for: Cdk5r1

Gene ID: 12569

Symbol: Cdk5r1

Ensembl ID: ENSMUSG00000048895

Description: cyclin dependent kinase 5, regulatory subunit 1

Associated with

Crmps in sema3a signaling
(R-MMU-399956)
Developmental biology
(R-MMU-1266738)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Nervous system development
(R-MMU-9675108)
Regulation of tp53 activity
(R-MMU-5633007)
Regulation of tp53 activity through phosphorylation
(R-MMU-6804756)
Rna polymerase ii transcription
(R-MMU-73857)
Semaphorin interactions
(R-MMU-373755)
Transcriptional regulation by tp53
(R-MMU-3700989)
Actin binding
(GO:0003779)
Actin filament binding
(GO:0051015)
Axon
(GO:0030424)
Axonal fasciculation
(GO:0007413)
Axon guidance
(GO:0007411)
Brain development
(GO:0007420)
Cadherin binding
(GO:0045296)
Calcium ion binding
(GO:0005509)
Cell projection
(GO:0042995)
Cerebellum development
(GO:0021549)
Cerebral cortex radially oriented cell migration
(GO:0021799)
Contractile fiber
(GO:0043292)
Cyclin-dependent protein kinase holoenzyme complex
(GO:0000307)
Cyclin-dependent protein serine/threonine kinase activator activity
(GO:0061575)
Cytoplasm
(GO:0005737)
Cytoskeletal protein binding
(GO:0008092)
Cytosol
(GO:0005829)
Dendrite
(GO:0030425)
Dendritic spine
(GO:0043197)
Embryo development ending in birth or egg hatching
(GO:0009792)
Ephrin receptor binding
(GO:0046875)
Ephrin receptor signaling pathway
(GO:0048013)
G1 to g0 transition involved in cell differentiation
(GO:0070315)
G protein-coupled acetylcholine receptor signaling pathway
(GO:0007213)
Growth cone
(GO:0030426)
Hippocampus development
(GO:0021766)
Hsp90 protein binding
(GO:0051879)
Intracellular membrane-bounded organelle
(GO:0043231)
Ionotropic glutamate receptor binding
(GO:0035255)
Ionotropic glutamate receptor signaling pathway
(GO:0035235)
Kinase activity
(GO:0016301)
Layer formation in cerebral cortex
(GO:0021819)
Membrane
(GO:0016020)
Negative regulation of dna-templated transcription
(GO:0045892)
Neuromuscular junction
(GO:0031594)
Neuronal cell body
(GO:0043025)
Neuron cell-cell adhesion
(GO:0007158)
Neuron differentiation
(GO:0030182)
Neuron migration
(GO:0001764)
Neuron projection development
(GO:0031175)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Peptidyl-serine phosphorylation
(GO:0018105)
Peptidyl-threonine phosphorylation
(GO:0018107)
Perinuclear region of cytoplasm
(GO:0048471)
Plasma membrane
(GO:0005886)
Positive regulation of mhc class ii biosynthetic process
(GO:0045348)
Positive regulation of neuron apoptotic process
(GO:0043525)
Positive regulation of protein kinase activity
(GO:0045860)
Positive regulation of protein targeting to membrane
(GO:0090314)
Positive regulation of signaling receptor activity
(GO:2000273)
Postsynaptic density
(GO:0014069)
Presynapse
(GO:0098793)
Protease binding
(GO:0002020)
Protein binding
(GO:0005515)
Protein kinase 5 complex
(GO:0016533)
Protein kinase binding
(GO:0019901)
Protein serine/threonine kinase activator activity
(GO:0043539)
Regulation of actin cytoskeleton organization
(GO:0032956)
Regulation of dendritic spine morphogenesis
(GO:0061001)
Regulation of microtubule cytoskeleton organization
(GO:0070507)
Regulation of synaptic vesicle cycle
(GO:0098693)
Rhythmic process
(GO:0048511)
Serine phosphorylation of stat protein
(GO:0042501)
Superior olivary nucleus maturation
(GO:0021722)

Other Information

Proteins

Cyclin-dependent kinase 5 activator 1

Genular Protein ID: 4102045652

Symbol: CD5R1_MOUSE

Name: Cyclin-dependent kinase 5 activator 1

UniProtKB Accession Codes:

P61809 Q62938

Database IDs:

Citations:

PubMed ID: 8661152

Title: Molecular cloning and chromosomal mapping of the mouse gene encoding cyclin-dependent kinase 5 regulatory subunit p35.

PubMed ID: 8661152

DOI: 10.1006/geno.1996.0370

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10830966

Title: Neurotoxicity induces cleavage of p35 to p25 by calpain.

PubMed ID: 10830966

DOI: 10.1038/35012636

PubMed ID: 11882646

Title: Identification of a neuronal Cdk5 activator-binding protein as Cdk5 inhibitor.

PubMed ID: 11882646

DOI: 10.1074/jbc.c200032200

PubMed ID: 17143272

Title: Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism.

PubMed ID: 17143272

DOI: 10.1038/nn1811

PubMed ID: 24235147

Title: Cyclin-dependent kinase 5 (Cdk5) regulates the function of CLOCK protein by direct phosphorylation.

PubMed ID: 24235147

DOI: 10.1074/jbc.m113.494856

Sequence Information:

Length: 307
Mass: 34031
Checksum: 165AA0747410B0C0
Sequence:

MGTVLSLSPS YRKATLFEDG AATVGHYTAV QNSKNAKDKN LKRHSIISVL PWKRIVAVSA 
KKKNSKKAQP NSSYQSNIAH LNNENLKKSL SCANLSTFAQ PPPAQPPAPP ASQLSGSQTG 
VSSSVKKAPH PAITSAGTPK RVIVQASTSE LLRCLGEFLC RRCYRLKHLS PTDPVLWLRS 
VDRSLLLQGW QDQGFITPAN VVFLYMLCRD VISSEVGSDH ELQAVLLTCL YLSYSYMGNE 
ISYPLKPFLV ESCKEAFWDR CLSVINLMSS KMLQINADPH YFTQVFSDLK NESGQEDKKR 
LLLGLDR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Cdk5r1

Associated with

Other Information

Molecular cloning and chromosomal mapping of the mouse gene encoding cyclin-dependent kinase 5 regulatory subunit p35. PubMed ID: 8661152

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Neurotoxicity induces cleavage of p35 to p25 by calpain. PubMed ID: 10830966

Identification of a neuronal Cdk5 activator-binding protein as Cdk5 inhibitor. PubMed ID: 11882646

Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism. PubMed ID: 17143272