Genular: Defining Cellular Identity and Function

Details for: Cdk6

Gene ID: 12571

Symbol: Cdk6

Ensembl ID: ENSMUSG00000040274

Description: cyclin dependent kinase 6

Associated with

Cell cycle, mitotic
(R-MMU-69278)
Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular senescence
(R-MMU-2559583)
Cyclin d associated events in g1
(R-MMU-69231)
Drug-mediated inhibition of cdk4/cdk6 activity
(R-MMU-9754119)
G1 phase
(R-MMU-69236)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Mitotic g1 phase and g1/s transition
(R-MMU-453279)
Oncogene induced senescence
(R-MMU-2559585)
Oxidative stress induced senescence
(R-MMU-2559580)
Regulation of runx1 expression and activity
(R-MMU-8934593)
Rna polymerase ii transcription
(R-MMU-73857)
Senescence-associated secretory phenotype (sasp)
(R-MMU-2559582)
Transcriptional regulation by runx1
(R-MMU-8878171)
Atp binding
(GO:0005524)
Cell cycle
(GO:0007049)
Cell dedifferentiation
(GO:0043697)
Cell differentiation
(GO:0030154)
Cell division
(GO:0051301)
Cell projection
(GO:0042995)
Cell quiescence
(GO:0044838)
Centrosome
(GO:0005813)
Cyclin-dependent protein kinase holoenzyme complex
(GO:0000307)
Cyclin-dependent protein serine/threonine kinase activity
(GO:0004693)
Cyclin binding
(GO:0030332)
Cyclin d2-cdk6 complex
(GO:0097132)
Cytoplasm
(GO:0005737)
Cytoskeleton
(GO:0005856)
Cytosol
(GO:0005829)
Dna damage response
(GO:0006974)
Fbxo family protein binding
(GO:0098770)
G1/s transition of mitotic cell cycle
(GO:0000082)
Gliogenesis
(GO:0042063)
Hematopoietic progenitor cell differentiation
(GO:0002244)
Hematopoietic stem cell differentiation
(GO:0060218)
Hemopoiesis
(GO:0030097)
Kinase activity
(GO:0016301)
Negative regulation of cell cycle
(GO:0045786)
Negative regulation of cellular senescence
(GO:2000773)
Negative regulation of epithelial cell proliferation
(GO:0050680)
Negative regulation of monocyte differentiation
(GO:0045656)
Negative regulation of myeloid cell differentiation
(GO:0045638)
Negative regulation of osteoblast differentiation
(GO:0045668)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Notch signaling pathway
(GO:0007219)
Nucleoplasm
(GO:0005654)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
Phosphorylation
(GO:0016310)
Positive regulation of cell-matrix adhesion
(GO:0001954)
Positive regulation of fibroblast proliferation
(GO:0048146)
Positive regulation of gene expression
(GO:0010628)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Regulation of cell population proliferation
(GO:0042127)
Regulation of erythrocyte differentiation
(GO:0045646)
Regulation of g2/m transition of mitotic cell cycle
(GO:0010389)
Regulation of gene expression
(GO:0010468)
Regulation of hematopoietic stem cell differentiation
(GO:1902036)
Response to 5-fluorouracil
(GO:0036275)
Response to organic substance
(GO:0010033)
Ruffle
(GO:0001726)
Signal transduction
(GO:0007165)
T cell differentiation in thymus
(GO:0033077)
Transferase activity
(GO:0016740)
Type b pancreatic cell development
(GO:0003323)

Other Information

Proteins

Cyclin-dependent kinase 6

Genular Protein ID: 1868930255

Symbol: CDK6_MOUSE

Name: Cyclin-dependent kinase 6

UniProtKB Accession Codes:

Q64261 Q9R1D2 Q9R1D3

Database IDs:

Citations:

PubMed ID: 10384057

Title: Human-mouse comparative mapping of the genomic region containing CDK6: localization of an evolutionary breakpoint.

PubMed ID: 10384057

DOI: 10.1007/s003359901088

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 8444355

Title: Novel CDC2-related protein kinases produced in murine hematopoietic stem cells.

PubMed ID: 8444355

DOI: 10.1016/0378-1119(93)90411-u

PubMed ID: 1459009

Title: Identification of new protein kinase genes, similar to kinases of the cdc2 family and expressed in murine hematopoietic stem cells.

PubMed ID: 1459009

PubMed ID: 15315761

Title: Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6.

PubMed ID: 15315761

DOI: 10.1016/j.cell.2004.08.002

PubMed ID: 16767702

Title: Changes in motility, gene expression and actin dynamics: Cdk6-induced cytoskeletal changes associated with differentiation in mouse astrocytes.

PubMed ID: 16767702

DOI: 10.1002/jcb.20966

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21508411

Title: CDK6 kinase activity is required for thymocyte development.

PubMed ID: 21508411

DOI: 10.1182/blood-2010-08-300517

PubMed ID: 21319271

Title: Cdk6-dependent regulation of G(1) length controls adult neurogenesis.

PubMed ID: 21319271

DOI: 10.1002/stem.616

PubMed ID: 23918663

Title: CDK6 associates with the centrosome during mitosis and is mutated in a large Pakistani family with primary microcephaly.

PubMed ID: 23918663

DOI: 10.1093/hmg/ddt374

Sequence Information:

Length: 326
Mass: 37028
Checksum: 127B7ECFFC54C3AC
Sequence:

MEKDSLSRAD QQYECVAEIG EGAYGKVFKA RDLKNGGRFV ALKRVRVQTS EEGMPLSTIR 
EVAVLRHLET FEHPNVVRLF DVCTVSRTDR ETKLTLVFEH VDQDLTTYLD KVPEPGVPTE 
TIKDMMFQLL RGLDFLHSHR VVHRDLKPQN ILVTSSGQIK LADFGLARIY SFQMALTSVV 
VTLWYRAPEV LLQSSYATPV DLWSVGCIFA EMFRRKPLFR GSSDVDQLGK ILDIIGLPGE 
EDWPRDVALP RQAFHSKSAQ PIEKFVTDID ELGKDLLLKC LTFNPAKRIS AYGALNHPYF 
QDLERYKDNL NSHLPSNQST SELNTA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Cdk6

Associated with

Other Information

Human-mouse comparative mapping of the genomic region containing CDK6: localization of an evolutionary breakpoint. PubMed ID: 10384057

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Novel CDC2-related protein kinases produced in murine hematopoietic stem cells. PubMed ID: 8444355

Identification of new protein kinase genes, similar to kinases of the cdc2 family and expressed in murine hematopoietic stem cells. PubMed ID: 1459009

Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6. PubMed ID: 15315761

Changes in motility, gene expression and actin dynamics: Cdk6-induced cytoskeletal changes associated with differentiation in mouse astrocytes. PubMed ID: 16767702

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

CDK6 kinase activity is required for thymocyte development. PubMed ID: 21508411

Cdk6-dependent regulation of G(1) length controls adult neurogenesis. PubMed ID: 21319271

CDK6 associates with the centrosome during mitosis and is mutated in a large Pakistani family with primary microcephaly. PubMed ID: 23918663