Genular: Defining Cellular Identity and Function

Details for: Cdkn1a

Gene ID: 12575

Symbol: Cdkn1a

Ensembl ID: ENSMUSG00000023067

Description: cyclin dependent kinase inhibitor 1A

Associated with

Akt phosphorylates targets in the cytosol
(R-MMU-198323)
Cell cycle, mitotic
(R-MMU-69278)
Cell cycle checkpoints
(R-MMU-69620)
Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cyclin a:cdk2-associated events at s phase entry
(R-MMU-69656)
Cyclin d associated events in g1
(R-MMU-69231)
Cyclin e associated events during g1/s transition
(R-MMU-69202)
Developmental biology
(R-MMU-1266738)
Dna damage/telomere stress induced senescence
(R-MMU-2559586)
G1 phase
(R-MMU-69236)
G1/s dna damage checkpoints
(R-MMU-69615)
G1/s transition
(R-MMU-69206)
G2/m transition
(R-MMU-69275)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Intracellular signaling by second messengers
(R-MMU-9006925)
Mitotic g1 phase and g1/s transition
(R-MMU-453279)
Mitotic g2-g2/m phases
(R-MMU-453274)
P53-dependent g1 dna damage response
(R-MMU-69563)
P53-dependent g1/s dna damage checkpoint
(R-MMU-69580)
Pip3 activates akt signaling
(R-MMU-1257604)
Rna polymerase ii transcription
(R-MMU-73857)
Scf(skp2)-mediated degradation of p27/p21
(R-MMU-187577)
Senescence-associated secretory phenotype (sasp)
(R-MMU-2559582)
Signal transduction
(R-MMU-162582)
S phase
(R-MMU-69242)
The role of gtse1 in g2/m progression after g2 checkpoint
(R-MMU-8852276)
Tp53 regulates transcription of cell cycle genes
(R-MMU-6791312)
Tp53 regulates transcription of genes involved in g1 cell cycle arrest
(R-MMU-6804116)
Transcriptional regulation by tp53
(R-MMU-3700989)
Transcriptional regulation of granulopoiesis
(R-MMU-9616222)
Cell cycle
(GO:0007049)
Cellular response to amino acid starvation
(GO:0034198)
Cellular response to extracellular stimulus
(GO:0031668)
Cellular response to gamma radiation
(GO:0071480)
Cellular response to ionizing radiation
(GO:0071479)
Cellular response to uv-b
(GO:0071493)
Cellular senescence
(GO:0090398)
Cyclin-dependent protein kinase activating kinase activity
(GO:0019912)
Cyclin-dependent protein serine/threonine kinase inhibitor activity
(GO:0004861)
Cyclin binding
(GO:0030332)
Dna damage response
(GO:0006974)
Dna damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
(GO:0006977)
Dna damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
(GO:0006978)
Epidermis development
(GO:0008544)
Fibroblast proliferation
(GO:0048144)
Heart development
(GO:0007507)
Intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator
(GO:0042771)
In utero embryonic development
(GO:0001701)
Keratinocyte differentiation
(GO:0030216)
Keratinocyte proliferation
(GO:0043616)
Metal ion binding
(GO:0046872)
Mitotic g2 dna damage checkpoint signaling
(GO:0007095)
Molecular function activator activity
(GO:0140677)
Molecular function inhibitor activity
(GO:0140678)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of cardiac muscle tissue regeneration
(GO:1905179)
Negative regulation of cell growth
(GO:0030308)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of cyclin-dependent protein kinase activity
(GO:1904030)
Negative regulation of cyclin-dependent protein serine/threonine kinase activity
(GO:0045736)
Negative regulation of g1/s transition of mitotic cell cycle
(GO:2000134)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of phosphorylation
(GO:0042326)
Negative regulation of protein binding
(GO:0032091)
Negative regulation of vascular associated smooth muscle cell proliferation
(GO:1904706)
Oncogene-induced cell senescence
(GO:0090402)
Positive regulation of b cell proliferation
(GO:0030890)
Positive regulation of fibroblast proliferation
(GO:0048146)
Positive regulation of programmed cell death
(GO:0043068)
Positive regulation of protein kinase activity
(GO:0045860)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein import into nucleus
(GO:0006606)
Protein kinase binding
(GO:0019901)
Protein kinase inhibitor activity
(GO:0004860)
Protein sequestering activity
(GO:0140311)
Regulation of cell cycle
(GO:0051726)
Regulation of cell cycle g1/s phase transition
(GO:1902806)
Regulation of cyclin-dependent protein serine/threonine kinase activity
(GO:0000079)
Regulation of dna biosynthetic process
(GO:2000278)
Regulation of g1/s transition of mitotic cell cycle
(GO:2000045)
Regulation of g2/m transition of mitotic cell cycle
(GO:0010389)
Regulation of mitotic cell cycle
(GO:0007346)
Response to uv
(GO:0009411)
Signal transduction by p53 class mediator
(GO:0072331)
Tissue regeneration
(GO:0042246)
Ubiquitin protein ligase binding
(GO:0031625)
Wound healing
(GO:0042060)

Other Information

Proteins

Cyclin-dependent kinase inhibitor 1

Genular Protein ID: 779762212

Symbol: CDN1A_MOUSE

Name: Cyclin-dependent kinase inhibitor 1

UniProtKB Accession Codes:

P39689

Database IDs:

Citations:

PubMed ID: 8084607

Title: Molecular cloning, sequencing, chromosomal localization and expression of mouse p21 (Waf1).

PubMed ID: 8084607

PubMed ID: 7796420

Title: Topological control of p21WAF1/CIP1 expression in normal and neoplastic tissues.

PubMed ID: 7796420

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8242752

Title: WAF1, a potential mediator of p53 tumor suppression.

PubMed ID: 8242752

DOI: 10.1016/0092-8674(93)90500-p

PubMed ID: 20154723

Title: An HDAC1-binding domain within FATS bridges p21 turnover to radiation-induced tumorigenesis.

PubMed ID: 20154723

DOI: 10.1038/onc.2010.19

PubMed ID: 25329316

Title: A mouse model uncovers LKB1 as an UVB-induced DNA damage sensor mediating CDKN1A (p21WAF1/CIP1) degradation.

PubMed ID: 25329316

DOI: 10.1371/journal.pgen.1004721

PubMed ID: 37178686

Title: p53-independent tumor suppression by cell-cycle arrest via CREB/ATF transcription factor OASIS.

PubMed ID: 37178686

DOI: 10.1016/j.celrep.2023.112479

Sequence Information:

Length: 159
Mass: 17785
Checksum: 37B7C22B9A2FD089
Sequence:

MSNPGDVRPV PHRSKVCRCL FGPVDSEQLR RDCDALMAGC LQEARERWNF DFVTETPLEG 
NFVWERVRSL GLPKVYLSPG SRSRDDLGGD KRPSTSSALL QGPAPEDHVA LSLSCTLVSE 
RPEDSPGGPG TSQGRKRRQT SLTDFYHSKR RLVFCKRKP

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Cdkn1a

Associated with

Other Information

Molecular cloning, sequencing, chromosomal localization and expression of mouse p21 (Waf1). PubMed ID: 8084607

Topological control of p21WAF1/CIP1 expression in normal and neoplastic tissues. PubMed ID: 7796420

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

WAF1, a potential mediator of p53 tumor suppression. PubMed ID: 8242752

An HDAC1-binding domain within FATS bridges p21 turnover to radiation-induced tumorigenesis. PubMed ID: 20154723

A mouse model uncovers LKB1 as an UVB-induced DNA damage sensor mediating CDKN1A (p21WAF1/CIP1) degradation. PubMed ID: 25329316

p53-independent tumor suppression by cell-cycle arrest via CREB/ATF transcription factor OASIS. PubMed ID: 37178686