Genular: Defining Cellular Identity and Function

Details for: Cdkn1b

Gene ID: 12576

Symbol: Cdkn1b

Ensembl ID: ENSMUSG00000003031

Description: cyclin dependent kinase inhibitor 1B

Associated with

Akt phosphorylates targets in the cytosol
(R-MMU-198323)
Cell cycle, mitotic
(R-MMU-69278)
Cell cycle checkpoints
(R-MMU-69620)
Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular senescence
(R-MMU-2559583)
Cyclin a:cdk2-associated events at s phase entry
(R-MMU-69656)
Cyclin d associated events in g1
(R-MMU-69231)
Cyclin e associated events during g1/s transition
(R-MMU-69202)
Cytokine signaling in immune system
(R-MMU-1280215)
Dna damage/telomere stress induced senescence
(R-MMU-2559586)
Esr-mediated signaling
(R-MMU-8939211)
Estrogen-dependent nuclear events downstream of esr-membrane signaling
(R-MMU-9634638)
Extra-nuclear estrogen signaling
(R-MMU-9009391)
Flt3 signaling
(R-MMU-9607240)
G1 phase
(R-MMU-69236)
G1/s dna damage checkpoints
(R-MMU-69615)
G1/s transition
(R-MMU-69206)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Immune system
(R-MMU-168256)
Intracellular signaling by second messengers
(R-MMU-9006925)
Mitotic g1 phase and g1/s transition
(R-MMU-453279)
P53-dependent g1 dna damage response
(R-MMU-69563)
P53-dependent g1/s dna damage checkpoint
(R-MMU-69580)
Pip3 activates akt signaling
(R-MMU-1257604)
Ptk6 regulates cell cycle
(R-MMU-8849470)
Rna polymerase ii transcription
(R-MMU-73857)
Scf(skp2)-mediated degradation of p27/p21
(R-MMU-187577)
Senescence-associated secretory phenotype (sasp)
(R-MMU-2559582)
Signaling by non-receptor tyrosine kinases
(R-MMU-9006927)
Signaling by nuclear receptors
(R-MMU-9006931)
Signaling by ptk6
(R-MMU-8848021)
Signal transduction
(R-MMU-162582)
S phase
(R-MMU-69242)
Tp53 regulates transcription of cell cycle genes
(R-MMU-6791312)
Tp53 regulates transcription of genes involved in g1 cell cycle arrest
(R-MMU-6804116)
Transcriptional regulation by tp53
(R-MMU-3700989)
Apoptotic process
(GO:0006915)
Autophagic cell death
(GO:0048102)
Cell cycle
(GO:0007049)
Cellular response to antibiotic
(GO:0071236)
Cellular response to lithium ion
(GO:0071285)
Cellular response to organic cyclic compound
(GO:0071407)
Cyclin-dependent protein kinase activating kinase regulator activity
(GO:0019914)
Cyclin-dependent protein serine/threonine kinase inhibitor activity
(GO:0004861)
Cyclin binding
(GO:0030332)
Epithelial cell apoptotic process
(GO:1904019)
Epithelial cell proliferation involved in prostate gland development
(GO:0060767)
G1/s transition of mitotic cell cycle
(GO:0000082)
Heart development
(GO:0007507)
Hsp70 protein binding
(GO:0030544)
Inner ear development
(GO:0048839)
Localization
(GO:0051179)
Molecular adaptor activity
(GO:0060090)
Molecular function inhibitor activity
(GO:0140678)
Negative regulation of cardiac muscle tissue regeneration
(GO:1905179)
Negative regulation of cell growth
(GO:0030308)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of cyclin-dependent protein kinase activity
(GO:1904030)
Negative regulation of cyclin-dependent protein serine/threonine kinase activity
(GO:0045736)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of epithelial cell apoptotic process
(GO:1904036)
Negative regulation of epithelial cell proliferation
(GO:0050680)
Negative regulation of epithelial cell proliferation involved in prostate gland development
(GO:0060770)
Negative regulation of kinase activity
(GO:0033673)
Negative regulation of mitotic cell cycle
(GO:0045930)
Negative regulation of phosphorylation
(GO:0042326)
Negative regulation of vascular associated smooth muscle cell proliferation
(GO:1904706)
Notch signaling pathway
(GO:0007219)
Nuclear export
(GO:0051168)
Placenta development
(GO:0001890)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of microtubule polymerization
(GO:0031116)
Positive regulation of protein phosphorylation
(GO:0001934)
Potassium ion transport
(GO:0006813)
Protein-containing complex binding
(GO:0044877)
Protein-folding chaperone binding
(GO:0051087)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Protein kinase inhibitor activity
(GO:0004860)
Protein phosphatase binding
(GO:0019903)
Regulation of cell cycle
(GO:0051726)
Regulation of cell cycle g1/s phase transition
(GO:1902806)
Regulation of cell migration
(GO:0030334)
Regulation of cyclin-dependent protein serine/threonine kinase activity
(GO:0000079)
Regulation of exit from mitosis
(GO:0007096)
Regulation of g1/s transition of mitotic cell cycle
(GO:2000045)
Regulation of lens fiber cell differentiation
(GO:1902746)
Regulation of mitotic cell cycle
(GO:0007346)
Sensory perception of sound
(GO:0007605)
Ubiquitin ligase activator activity
(GO:1990757)
Ubiquitin protein ligase binding
(GO:0031625)

Other Information

Proteins

Cyclin-dependent kinase inhibitor 1B

Genular Protein ID: 2019180070

Symbol: CDN1B_MOUSE

Name: Cyclin-dependent kinase inhibitor 1B

UniProtKB Accession Codes:

P46414 Q8BG74

Database IDs:

Citations:

PubMed ID: 8033213

Title: p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21.

PubMed ID: 8033213

DOI: 10.1016/0092-8674(94)90573-8

PubMed ID: 8033212

Title: Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals.

PubMed ID: 8033212

DOI: 10.1016/0092-8674(94)90572-x

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8534916

Title: Redistribution of the CDK inhibitor p27 between different cyclin.CDK complexes in the mouse fibroblast cell cycle and in cells arrested with lovastatin or ultraviolet irradiation.

PubMed ID: 8534916

DOI: 10.1091/mbc.6.9.1197

PubMed ID: 9399644

Title: Cdk2-dependent phosphorylation of p27 facilitates its Myc-induced release from cyclin E/cdk2 complexes.

PubMed ID: 9399644

DOI: 10.1038/sj.onc.1201440

PubMed ID: 10086358

Title: Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jab1.

PubMed ID: 10086358

DOI: 10.1038/18230

PubMed ID: 10811608

Title: Cyclin E-mediated elimination of p27 requires its interaction with the nuclear pore-associated protein mNPAP60.

PubMed ID: 10811608

DOI: 10.1093/emboj/19.10.2168

PubMed ID: 12093740

Title: A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression.

PubMed ID: 12093740

DOI: 10.1093/emboj/cdf343

PubMed ID: 12972555

Title: Spy1 interacts with p27Kip1 to allow G1/S progression.

PubMed ID: 12972555

DOI: 10.1091/mbc.e02-12-0820

PubMed ID: 15528185

Title: Role of serine 10 phosphorylation in p27 stabilization revealed by analysis of p27 knock-in mice harboring a serine 10 mutation.

PubMed ID: 15528185

DOI: 10.1074/jbc.m406117200

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 19767775

Title: Lysine 269 is essential for cyclin D1 ubiquitylation by the SCF(Fbx4/alphaB-crystallin) ligase and subsequent proteasome-dependent degradation.

PubMed ID: 19767775

DOI: 10.1038/onc.2009.287

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20228253

Title: Tumor suppressor p27(Kip1) undergoes endolysosomal degradation through its interaction with sorting nexin 6.

PubMed ID: 20228253

DOI: 10.1096/fj.09-138255

PubMed ID: 23707388

Title: Fbxl12 triggers G1 arrest by mediating degradation of calmodulin kinase I.

PubMed ID: 23707388

DOI: 10.1016/j.cellsig.2013.05.012

Sequence Information:

Length: 197
Mass: 22193
Checksum: BAC30D648B9BA3D6
Sequence:

MSNVRVSNGS PSLERMDARQ AEHPKPSACR NLFGPVNHEE LTRDLEKHCR DMEEASQRKW 
NFDFQNHKPL EGRYEWQEVE RGSLPEFYYR PPRPPKSACK VLAQESQDVS GSRQAVPLIG 
SQANSEDRHL VDQMPDSSDN PAGLAEQCPG MRKRPAAEDS SSQNKRANRT EENVSDGSPN 
AGTVEQTPKK PGLRRQT

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Cdkn1b

Associated with

Other Information

p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21. PubMed ID: 8033213

Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. PubMed ID: 8033212

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Redistribution of the CDK inhibitor p27 between different cyclin.CDK complexes in the mouse fibroblast cell cycle and in cells arrested with lovastatin or ultraviolet irradiation. PubMed ID: 8534916

Cdk2-dependent phosphorylation of p27 facilitates its Myc-induced release from cyclin E/cdk2 complexes. PubMed ID: 9399644

Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jab1. PubMed ID: 10086358

Cyclin E-mediated elimination of p27 requires its interaction with the nuclear pore-associated protein mNPAP60. PubMed ID: 10811608

A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression. PubMed ID: 12093740

Spy1 interacts with p27Kip1 to allow G1/S progression. PubMed ID: 12972555

Role of serine 10 phosphorylation in p27 stabilization revealed by analysis of p27 knock-in mice harboring a serine 10 mutation. PubMed ID: 15528185

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

Lysine 269 is essential for cyclin D1 ubiquitylation by the SCF(Fbx4/alphaB-crystallin) ligase and subsequent proteasome-dependent degradation. PubMed ID: 19767775

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Tumor suppressor p27(Kip1) undergoes endolysosomal degradation through its interaction with sorting nexin 6. PubMed ID: 20228253

Fbxl12 triggers G1 arrest by mediating degradation of calmodulin kinase I. PubMed ID: 23707388