Details for: Cdkn2a

Gene ID: 12578

Symbol: Cdkn2a

Ensembl ID: ENSMUSG00000044303

Description: cyclin dependent kinase inhibitor 2A

Associated with

  • Activation of cysteine-type endopeptidase activity involved in apoptotic process
    (GO:0006919)
  • Amyloid fibril formation
    (GO:1990000)
  • Apoptotic mitochondrial changes
    (GO:0008637)
  • Apoptotic process
    (GO:0006915)
  • Apoptotic process involved in mammary gland involution
    (GO:0060057)
  • Autophagy of mitochondrion
    (GO:0000422)
  • Cell cycle
    (GO:0007049)
  • Cellular response to hydrogen peroxide
    (GO:0070301)
  • Cellular senescence
    (GO:0090398)
  • Cyclin-dependent protein serine/threonine kinase inhibitor activity
    (GO:0004861)
  • Disordered domain specific binding
    (GO:0097718)
  • Dna-binding transcription factor binding
    (GO:0140297)
  • Dna binding
    (GO:0003677)
  • Epidermis development
    (GO:0008544)
  • Glucose homeostasis
    (GO:0042593)
  • Keratinocyte differentiation
    (GO:0030216)
  • Keratinocyte proliferation
    (GO:0043616)
  • Mammary gland epithelial cell proliferation
    (GO:0033598)
  • Mdm2/mdm4 family protein binding
    (GO:0097371)
  • Mitochondrial depolarization
    (GO:0051882)
  • Negative regulation of b cell proliferation
    (GO:0030889)
  • Negative regulation of cell-matrix adhesion
    (GO:0001953)
  • Negative regulation of cell cycle
    (GO:0045786)
  • Negative regulation of cell growth
    (GO:0030308)
  • Negative regulation of cell population proliferation
    (GO:0008285)
  • Negative regulation of cyclin-dependent protein serine/threonine kinase activity
    (GO:0045736)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of hepatocyte proliferation
    (GO:2000346)
  • Negative regulation of immature t cell proliferation in thymus
    (GO:0033088)
  • Negative regulation of mammary gland epithelial cell proliferation
    (GO:0033600)
  • Negative regulation of nf-kappab transcription factor activity
    (GO:0032088)
  • Negative regulation of phosphorylation
    (GO:0042326)
  • Negative regulation of protein binding
    (GO:0032091)
  • Negative regulation of protein kinase activity
    (GO:0006469)
  • Negative regulation of protein localization to nucleolus
    (GO:1904750)
  • Negative regulation of proteolysis involved in protein catabolic process
    (GO:1903051)
  • Negative regulation of ribosome biogenesis
    (GO:0090071)
  • Negative regulation of ubiquitin-dependent protein catabolic process
    (GO:2000059)
  • Negative regulation of ubiquitin-protein transferase activity
    (GO:0051444)
  • Negative regulation of ubiquitin protein ligase activity
    (GO:1904667)
  • Nf-kappab binding
    (GO:0051059)
  • Nuclear body organization
    (GO:0030575)
  • Oncogene-induced cell senescence
    (GO:0090402)
  • P53 binding
    (GO:0002039)
  • Positive regulation of apoptotic process
    (GO:0043065)
  • Positive regulation of apoptotic process involved in mammary gland involution
    (GO:0060058)
  • Positive regulation of dna-binding transcription factor activity
    (GO:0051091)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of dna damage response, signal transduction by p53 class mediator
    (GO:0043517)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of macrophage apoptotic process
    (GO:2000111)
  • Positive regulation of protein localization to nucleus
    (GO:1900182)
  • Positive regulation of protein sumoylation
    (GO:0033235)
  • Positive regulation of signal transduction by p53 class mediator
    (GO:1901798)
  • Positive regulation of smooth muscle cell apoptotic process
    (GO:0034393)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Protein destabilization
    (GO:0031648)
  • Protein k63-linked ubiquitination
    (GO:0070534)
  • Protein kinase binding
    (GO:0019901)
  • Protein localization to nucleolus
    (GO:1902570)
  • Protein localization to nucleus
    (GO:0034504)
  • Protein polyubiquitination
    (GO:0000209)
  • Protein stabilization
    (GO:0050821)
  • Regulation of apoptotic dna fragmentation
    (GO:1902510)
  • Regulation of cell cycle
    (GO:0051726)
  • Regulation of cyclin-dependent protein serine/threonine kinase activity
    (GO:0000079)
  • Regulation of dna-binding transcription factor activity
    (GO:0051090)
  • Regulation of g1/s transition of mitotic cell cycle
    (GO:2000045)
  • Regulation of g2/m transition of mitotic cell cycle
    (GO:0010389)
  • Regulation of gene expression
    (GO:0010468)
  • Regulation of nucleocytoplasmic transport
    (GO:0046822)
  • Regulation of protein export from nucleus
    (GO:0046825)
  • Regulation of protein stability
    (GO:0031647)
  • Regulation of protein targeting to mitochondrion
    (GO:1903214)
  • Replicative senescence
    (GO:0090399)
  • Response to organic cyclic compound
    (GO:0014070)
  • Response to organonitrogen compound
    (GO:0010243)
  • Response to xenobiotic stimulus
    (GO:0009410)
  • Rna polymerase ii-specific dna-binding transcription factor binding
    (GO:0061629)
  • Rrna processing
    (GO:0006364)
  • Rrna transcription
    (GO:0009303)
  • Somatic stem cell division
    (GO:0048103)
  • Somatic stem cell population maintenance
    (GO:0035019)
  • Sumo transferase activity
    (GO:0019789)
  • Ubiquitin-protein transferase inhibitor activity
    (GO:0055105)
  • Ubiquitin ligase inhibitor activity
    (GO:1990948)

Other Information

Genular Protein ID: 1985157500

Symbol: CDN2A_MOUSE

Name: Cyclin-dependent kinase 4 inhibitor A

UniProtKB Accession Codes:

P51480 A2ANM1 A2ANM2 O89088 P97510 P97937 Q6PEA2 Q78E39 Q78E57 Q792X7 Q9QWH6 Q9QWH7 Q9QWH8

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 EMBL 18 Ensembl 1 ExpressionAtlas 1 GO 73 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 IntAct 1 InterPro 2 KEGG 1 MGI 2 NCBI Taxonomy 1 OMA 1 PANTHER 2 PROSITE 1 PeptideAtlas 1 Pfam 2 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 2 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 iPTMnet 1

Citations:

PubMed ID: 7651726

Title: Cloning and characterization of murine p16INK4a and p15INK4b genes.

PubMed ID: 7651726

PubMed ID: 9482902

Title: Cdkn2a, the cyclin-dependent kinase inhibitor encoding p16(INK4a) and p19(ARF), is a candidate for the plasmacytoma susceptibility locus, Pctr1.

PubMed ID: 9482902

DOI: 10.1073/pnas.95.5.2429

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 9178896

Title: Inactivation of the cyclin-dependent kinase inhibitor p15INK4b by deletion and de novo methylation with independence of p16INK4a alterations in murine primary T-cell lymphomas.

PubMed ID: 9178896

DOI: 10.1038/sj.onc.1200969

PubMed ID: 9021155

Title: Sequence variation and chromosomal mapping of the murine Cdkn2a tumor suppressor gene.

PubMed ID: 9021155

DOI: 10.1007/s003359900352

PubMed ID: 9667743

Title: Induction of mutations in Ki-ras and INK4a in liver tumors of mice exposed in utero to 3-methylcholanthrene.

PubMed ID: 9667743

DOI: 10.1093/carcin/19.6.1045

PubMed ID: 9012842

Title: Cancer-associated mutations at the INK4a locus cancel cell cycle arrest by p16INK4a but not by the alternative reading frame protein p19ARF.

PubMed ID: 9012842

DOI: 10.1073/pnas.94.2.669

Sequence Information:

  • Length: 168
  • Mass: 17941
  • Checksum: 9A6B0F24F34D5FEC
  • Sequence:
    • MESAADRLAR AAAQGRVHDV RALLEAGVSP NAPNSFGRTP IQVMMMGNVH VAALLLNYGA 
DSNCEDPTTF SRPVHDAARE GFLDTLVVLH GSGARLDVRD AWGRLPLDLA QERGHQDIVR 
YLRSAGCSLC SAGWSLCTAG NVAQTDGHSF SSSTPRALEL RGQSQEQS

Genular Protein ID: 925758470

Symbol: ARF_MOUSE

Name: Alternative reading frame

UniProtKB Accession Codes:

Q64364 Q4U255 Q9QXC7 Q9R051

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 DisProt 1 EMBL 12 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 84 Gene3D 1 GeneTree 1 Genevisible 1 GlyGen 1 HOGENOM 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 1 MGI 2 MaxQB 1 NCBI Taxonomy 1 PDB 2 PDBsum 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 1 SAM 1 SMR 1 STRING 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 8521522

Title: Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest.

PubMed ID: 8521522

DOI: 10.1016/0092-8674(95)90214-7

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10753221

Title: Characterization of the murine p19ARF promoter CpG island and its methylation pattern in primary lymphomas.

PubMed ID: 10753221

DOI: 10.1093/carcin/21.4.817

PubMed ID: 9021155

Title: Sequence variation and chromosomal mapping of the murine Cdkn2a tumor suppressor gene.

PubMed ID: 9021155

DOI: 10.1007/s003359900352

PubMed ID: 10097151

Title: Induction of ARF tumor suppressor gene expression and cell cycle arrest by transcription factor DMP1.

PubMed ID: 10097151

DOI: 10.1073/pnas.96.7.3993

PubMed ID: 9393858

Title: Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF.

PubMed ID: 9393858

DOI: 10.1016/s0092-8674(00)80452-3

PubMed ID: 9012842

Title: Cancer-associated mutations at the INK4a locus cancel cell cycle arrest by p16INK4a but not by the alternative reading frame protein p19ARF.

PubMed ID: 9012842

DOI: 10.1073/pnas.94.2.669

PubMed ID: 9529248

Title: The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53.

PubMed ID: 9529248

DOI: 10.1016/s0092-8674(00)81400-2

PubMed ID: 10359817

Title: P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2.

PubMed ID: 10359817

DOI: 10.1073/pnas.96.12.6937

PubMed ID: 10898794

Title: Disruption of the ARF transcriptional activator DMP1 facilitates cell immortalization, Ras transformation, and tumorigenesis.

PubMed ID: 10898794

PubMed ID: 12154087

Title: CARF is a novel protein that cooperates with mouse p19ARF (human p14ARF) in activating p53.

PubMed ID: 12154087

DOI: 10.1074/jbc.m204177200

PubMed ID: 15105443

Title: p19ARF determines the balance between normal cell proliferation rate and apoptosis during mammary gland development.

PubMed ID: 15105443

DOI: 10.1091/mbc.e03-11-0785

PubMed ID: 15361884

Title: p19ARF directly and differentially controls the functions of c-Myc independently of p53.

PubMed ID: 15361884

DOI: 10.1038/nature02958

PubMed ID: 15567177

Title: The ARF tumor suppressor inhibits BCL6-mediated transcriptional repression.

PubMed ID: 15567177

DOI: 10.1016/j.bbrc.2004.11.016

PubMed ID: 15601844

Title: Ras-Raf-Arf signaling critically depends on the Dmp1 transcription factor.

PubMed ID: 15601844

DOI: 10.1128/mcb.25.1.220-232.2005

PubMed ID: 16713577

Title: A short mitochondrial form of p19ARF induces autophagy and caspase-independent cell death.

PubMed ID: 16713577

DOI: 10.1016/j.molcel.2006.04.014

PubMed ID: 17936562

Title: Mutually exclusive inactivation of DMP1 and ARF/p53 in lung cancer.

PubMed ID: 17936562

DOI: 10.1016/j.ccr.2007.08.034

PubMed ID: 17110379

Title: A novel nuclear interactor of ARF and MDM2 (NIAM) that maintains chromosomal stability.

PubMed ID: 17110379

DOI: 10.1074/jbc.m609612200

PubMed ID: 17486078

Title: The autophagic inducer smARF interacts with and is stabilized by the mitochondrial p32 protein.

PubMed ID: 17486078

DOI: 10.1038/sj.onc.1210485

PubMed ID: 17546045

Title: Repression of Dmp1 and Arf transcription by anthracyclins: critical roles of the NF-kappaB subunit p65.

PubMed ID: 17546045

DOI: 10.1038/sj.onc.1210568

PubMed ID: 20513429

Title: The ARF tumor suppressor controls ribosome biogenesis by regulating the RNA polymerase I transcription factor TTF-I.

PubMed ID: 20513429

DOI: 10.1016/j.molcel.2010.03.015

PubMed ID: 11327858

Title: Solution structure of the p53 regulatory domain of the p19Arf tumor suppressor protein.

PubMed ID: 11327858

DOI: 10.1021/bi0024005

Sequence Information:

  • Length: 169
  • Mass: 19238
  • Checksum: 644505EFE1CBF478
  • Sequence:
    • MGRRFLVTVR IQRAGRPLQE RVFLVKFVRS RRPRTASCAL AFVNMLLRLE RILRRGPHRN 
PGPGDDDGQR SRSSSSAQLR CRFELRGPHY LLPPGARRSA GRLPGHAGGA ARVRGSAGCA 
RCLGSPAARL GPRAGTSRHR AIFAFRWVLF VFRWVVFVYR WERRPDRRA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.